Chang Yi Cui

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 109:1199-203. 2012
  2. pmc Shh is required for Tabby hair follicle development
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Cell Cycle 10:3379-86. 2011
  3. pmc Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 103:9142-7. 2006
  4. ncbi request reprint EDA targets revealed by skin gene expression profiles of wild-type, Tabby and Tabby EDA-A1 transgenic mice
    Chang Yi Cui
    Laboratory of Genetics, National Institutes of Health National Institute on Aging, Baltimore, Maryland 21224, USA
    Hum Mol Genet 11:1763-73. 2002
  5. ncbi request reprint Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles
    Chang Yi Cui
    Laboratory of Genetics, National Institutes of Health National Institute on Aging, Baltimore, MD 21224, USA
    Hum Mol Genet 12:2931-40. 2003
  6. ncbi request reprint Lymphotoxin-beta regulates periderm differentiation during embryonic skin development
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Hum Mol Genet 16:2583-90. 2007
  7. ncbi request reprint Repertoire of mouse ectodysplasin-A (EDA-A) isoforms
    Tsuyoshi Hashimoto
    Laboratory of Genetics, NIH National Institute on Aging, Baltimore, MD 21224, USA
    Gene 371:42-51. 2006
  8. pmc Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 5:e10009. 2010
  9. pmc Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice
    Diana Esibizione
    Laboratory of Genetics, National Institute on Aging, NIH Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA
    Gene 427:42-6. 2008
  10. pmc X-linked anhidrotic ectodermal dysplasia disruption yields a mouse model for ocular surface disease and resultant blindness
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Am J Pathol 167:89-95. 2005

Detail Information

Publications16

  1. pmc Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 109:1199-203. 2012
    ..These mechanistic components can be pharmaceutical targets to defend against hyperthermia and alleviate defective thermoregulation in the elderly, and may provide a model relevant to more complex secretory processes...
  2. pmc Shh is required for Tabby hair follicle development
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Cell Cycle 10:3379-86. 2011
    ..Thus, Shh is required for primary and secondary hair down-growth and full secondary hair length, but is not itself sufficient to replace Eda or make fully normal secondary hair...
  3. pmc Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 103:9142-7. 2006
    ..Thus, as an EDA target, LTbeta regulates the form of hair in developing hair follicles; and when EDA is defective, failure of LTbeta activation can account for part of the Ta phenotype...
  4. ncbi request reprint EDA targets revealed by skin gene expression profiles of wild-type, Tabby and Tabby EDA-A1 transgenic mice
    Chang Yi Cui
    Laboratory of Genetics, National Institutes of Health National Institute on Aging, Baltimore, Maryland 21224, USA
    Hum Mol Genet 11:1763-73. 2002
    ..These data are consistent with the regulation of the NF-kappa B pathway by EDA, and support its involvement in the regulation of the JNK pathway as well...
  5. ncbi request reprint Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles
    Chang Yi Cui
    Laboratory of Genetics, National Institutes of Health National Institute on Aging, Baltimore, MD 21224, USA
    Hum Mol Genet 12:2931-40. 2003
    ..The results thus reveal both initiating and trophic isoform-specific effects of the EDA gene, and suggest a possible balance of isoform interactions in skin appendage formation...
  6. ncbi request reprint Lymphotoxin-beta regulates periderm differentiation during embryonic skin development
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Hum Mol Genet 16:2583-90. 2007
    ..Overall, LTbeta shows a primary early function in periderm differentiation, with later transient effects on epidermal and hair follicle differentiation...
  7. ncbi request reprint Repertoire of mouse ectodysplasin-A (EDA-A) isoforms
    Tsuyoshi Hashimoto
    Laboratory of Genetics, NIH National Institute on Aging, Baltimore, MD 21224, USA
    Gene 371:42-51. 2006
    ..Other isoforms, EDA-A5 and A5', for example, activated NF-kappaB through receptors EDAR and XEDAR. These properties make new isoforms candidates for modulators of EDA function...
  8. pmc Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 5:e10009. 2010
    ..The results thus reveal two complex molecular pathways that distinctly regulate subtype-based morphogenesis of hair follicles, and provide a resolution for the longstanding puzzle of hair formation in Tabby mice lacking Eda...
  9. pmc Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice
    Diana Esibizione
    Laboratory of Genetics, National Institute on Aging, NIH Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA
    Gene 427:42-6. 2008
    ..Thus, by the analysis of keratinocytes, novel candidate pathways downstream of EDA were detected...
  10. pmc X-linked anhidrotic ectodermal dysplasia disruption yields a mouse model for ocular surface disease and resultant blindness
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Am J Pathol 167:89-95. 2005
    ..This can be further tested in Tabby and Tabby-EDA transgenic mice, which provide unique models of severe ocular surface disease...
  11. ncbi request reprint Troy binding to lymphotoxin-alpha activates NF kappa B mediated transcription
    Tsuyoshi Hashimoto
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Cell Cycle 7:106-11. 2008
    ..The present study thus suggested a subtle function of the newly identified LTalpha-Troy pathway in skin appendage development, however, it may have an additional action compensated by a parallel EDA signaling pathway...
  12. doi request reprint Analysis of the temporal requirement for eda in hair and sweat gland development
    Chang Yi Cui
    Laboratory of Genetics, NIH Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Invest Dermatol 129:984-93. 2009
    ..Similarly, sweat gland pegs require Eda-A1 at an early stage to form mature glands. Thus we infer that EDA signaling is needed for the determination and development of various skin appendages at spatiotemporally restricted intervals...
  13. pmc EDA signaling and skin appendage development
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Cell Cycle 5:2477-83. 2006
    ..In mice, transgenic and knockout strains have increasingly revealed features of the mechanism, and suggest possible non-invasive interventions to alleviate EDA deficiency, especially in sweat glands and eyes...
  14. pmc Requirement for Shh and Fox family genes at different stages in sweat gland development
    Makoto Kunisada
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, Baltimore, MD 21224, USA
    Hum Mol Genet 18:1769-78. 2009
    ..The results provide a framework for the further analysis of phased down-stream regulation of gene action, possibly by a signaling cascade, in response to Eda...
  15. pmc Frizzled6 deficiency disrupts the differentiation process of nail development
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Invest Dermatol 133:1990-7. 2013
    ..Thus, Fzd6-mediated Wnt signaling likely regulates the overall differentiation process of nail/claw formation. ..
  16. ncbi request reprint The EDA gene is a target of, but does not regulate Wnt signaling
    Meredith C Durmowicz
    Laboratory of Genetics, National Institute on Aging, TRIAD Technology Center, Suite 4000, 333 Cassell Drive, Baltimore, MD 21224, USA
    Gene 285:203-11. 2002
    ..Taken together, our results demonstrate that Wnt signaling does control EDA gene expression, but ectodysplasin-A does not feedback on the Wnt pathway...