James A Crowell

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Is inducible nitric oxide synthase a target for chemoprevention?
    James A Crowell
    National Cancer Institute, Division of Cancer Prevention, Chemopreventive Agent Development Research Group, Bethesda, Maryland 20892, USA
    Mol Cancer Ther 2:815-23. 2003
  2. ncbi request reprint A phase I study of indole-3-carbinol in women: tolerability and effects
    Gregory A Reed
    Department of Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Cancer Epidemiol Biomarkers Prev 14:1953-60. 2005
  3. ncbi request reprint The mammalian target of rapamycin pathway as a potential target for cancer chemoprevention
    Levy Kopelovich
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:1330-40. 2007
  4. doi request reprint Effects of 5,6-benzoflavone, indole-3-carbinol (I3C) and diindolylmethane (DIM) on chemically-induced mammary carcinogenesis: is DIM a substitute for I3C?
    Ronald A Lubet
    Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, NIH, NCI, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Oncol Rep 26:731-6. 2011
  5. ncbi request reprint Targeting the AKT protein kinase for cancer chemoprevention
    James A Crowell
    Division of Cancer Prevention, National Cancer Institute, NIH, Executive Plaza North, Room 2117, 900 Rockville Pike, Bethesda, MD 20892, USA
    Mol Cancer Ther 6:2139-48. 2007
  6. doi request reprint Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeys
    Izet M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, Rm 2116, Bethesda, MD 20892, USA
    Cancer Chemother Pharmacol 65:1109-16. 2010
  7. ncbi request reprint Indole-3-carbinol, but not its major digestive product 3,3'-diindolylmethane, induces reversible hepatocyte hypertrophy and cytochromes P450
    James A Crowell
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892 7322, USA
    Toxicol Appl Pharmacol 211:115-23. 2006
  8. ncbi request reprint The chemopreventive agent development research program in the Division of Cancer Prevention of the US National Cancer Institute: an overview
    James A Crowell
    Division of Cancer Prevention, National Cancer Institute, DHHS, Bethesda, MD 20892, USA
    Eur J Cancer 41:1889-910. 2005
  9. ncbi request reprint Resveratrol-associated renal toxicity
    James A Crowell
    Division of Cancer Prevention, National Cancer Institute, Rockville, Maryland 20892 7322, USA
    Toxicol Sci 82:614-9. 2004
  10. ncbi request reprint Preventive effects of polyphenon E on urinary bladder and mammary cancers in rats and correlations with serum and urine levels of tea polyphenols
    Ronald A Lubet
    National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
    Mol Cancer Ther 6:2022-8. 2007

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Is inducible nitric oxide synthase a target for chemoprevention?
    James A Crowell
    National Cancer Institute, Division of Cancer Prevention, Chemopreventive Agent Development Research Group, Bethesda, Maryland 20892, USA
    Mol Cancer Ther 2:815-23. 2003
    ....
  2. ncbi request reprint A phase I study of indole-3-carbinol in women: tolerability and effects
    Gregory A Reed
    Department of Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Cancer Epidemiol Biomarkers Prev 14:1953-60. 2005
    ..If the ratio of hydroxylated estrone metabolites is a biomarker for chemoprevention, as suggested, then 400 mg I3C daily will elicit a maximal protective effect...
  3. ncbi request reprint The mammalian target of rapamycin pathway as a potential target for cancer chemoprevention
    Levy Kopelovich
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:1330-40. 2007
    ..These findings, together with the intriguing possibility that mTOR suppression may be associated with antitumor actions of caloric restriction, suggest that mTOR signaling may be an important target for chemopreventive drugs...
  4. doi request reprint Effects of 5,6-benzoflavone, indole-3-carbinol (I3C) and diindolylmethane (DIM) on chemically-induced mammary carcinogenesis: is DIM a substitute for I3C?
    Ronald A Lubet
    Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, NIH, NCI, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Oncol Rep 26:731-6. 2011
    ..In contrast, DIM had minimal effects in either model; arguing that administration of DIM is not analogous to administration of I3C...
  5. ncbi request reprint Targeting the AKT protein kinase for cancer chemoprevention
    James A Crowell
    Division of Cancer Prevention, National Cancer Institute, NIH, Executive Plaza North, Room 2117, 900 Rockville Pike, Bethesda, MD 20892, USA
    Mol Cancer Ther 6:2139-48. 2007
    ....
  6. doi request reprint Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeys
    Izet M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, Rm 2116, Bethesda, MD 20892, USA
    Cancer Chemother Pharmacol 65:1109-16. 2010
    ..However, it exhibited a very poor oral bioavailability (<1%) in both rats and dogs. Therefore, a study was initiated to develop and evaluate in dogs and non-human primates formulations with a more favorable oral bioavailability...
  7. ncbi request reprint Indole-3-carbinol, but not its major digestive product 3,3'-diindolylmethane, induces reversible hepatocyte hypertrophy and cytochromes P450
    James A Crowell
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892 7322, USA
    Toxicol Appl Pharmacol 211:115-23. 2006
    ..The results show that I-3-C, but not DIM, induces reversible adaptive responses in the liver...
  8. ncbi request reprint The chemopreventive agent development research program in the Division of Cancer Prevention of the US National Cancer Institute: an overview
    James A Crowell
    Division of Cancer Prevention, National Cancer Institute, DHHS, Bethesda, MD 20892, USA
    Eur J Cancer 41:1889-910. 2005
    ..Continued commitment to cancer prevention will significantly reduce the economic and medical burden of cancer...
  9. ncbi request reprint Resveratrol-associated renal toxicity
    James A Crowell
    Division of Cancer Prevention, National Cancer Institute, Rockville, Maryland 20892 7322, USA
    Toxicol Sci 82:614-9. 2004
    ..Under the conditions of this study, the no observed adverse effect level was 300 mg resveratrol per kilogram body weight per day in rats...
  10. ncbi request reprint Preventive effects of polyphenon E on urinary bladder and mammary cancers in rats and correlations with serum and urine levels of tea polyphenols
    Ronald A Lubet
    National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
    Mol Cancer Ther 6:2022-8. 2007
    ..The bioavailability of these tea polyphenols to different organ sites may contribute to the differing preventive efficacy of Polyphenon E against urinary bladder and mammary cancers...
  11. ncbi request reprint The epigenome as a target for cancer chemoprevention
    Levy Kopelovich
    Chemopreventive Agent Development Research Group, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 95:1747-57. 2003
    ....
  12. ncbi request reprint Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals
    H H Sherry Chow
    Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724, USA
    Clin Cancer Res 11:4627-33. 2005
    ..Tea catechin concentrations in plasma and urine samples collected after dosing were determined by high-pressure liquid chromatography analysis...
  13. ncbi request reprint Effects of repeated green tea catechin administration on human cytochrome P450 activity
    H H Sherry Chow
    Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724, USA
    Cancer Epidemiol Biomarkers Prev 15:2473-6. 2006
    ..We conducted this clinical study to determine the effect of repeated green tea catechin administration on human cytochrome P450 (CYP) enzyme activities...
  14. ncbi request reprint Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane
    Gregory A Reed
    Department of Internal Medicien, University of Kansas Medical Center, MS 1018, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Cancer Epidemiol Biomarkers Prev 15:2477-81. 2006
    ..Possible reasons for this disparity between apparent t1/2 of DIM and the high predose values are discussed...
  15. ncbi request reprint Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent
    David J Boocock
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, Leicester University, Leicester LE2 7LX, United Kingdom
    Cancer Epidemiol Biomarkers Prev 16:1246-52. 2007
    ..However, the high systemic levels of resveratrol conjugate metabolites suggest that their cancer chemopreventive properties warrant investigation...
  16. ncbi request reprint Modulation of human glutathione s-transferases by polyphenon e intervention
    H H Sherry Chow
    Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724, USA
    Cancer Epidemiol Biomarkers Prev 16:1662-6. 2007
    ..We conducted this clinical study to determine the effect of repeated green tea polyphenol administration on a major group of detoxification enzymes, glutathione S-transferases (GST)...
  17. ncbi request reprint Safety and efficacy of weekly oral oltipraz in chronic smokers
    Michael J Kelley
    Department of Medicine, Duke University and Durham Veterans Affairs Hospital, Hematology Oncology 111G, 508 Fulton Street, Durham, NC 27705, USA
    Cancer Epidemiol Biomarkers Prev 14:892-9. 2005
    ..Other agents with lower toxicity and greater activity to induce phase II enzymes are needed to definitively test the detoxification-induction paradigm in smokers...
  18. ncbi request reprint Phase I pharmacokinetic and pharmacodynamic analysis of unconjugated soy isoflavones administered to individuals with cancer
    Chris H Takimoto
    Department of Medicine, Northwestern University Medical School and the Robert H Lurie Cancer Center of Northwestern University, Chicago, Illinois, USA
    Cancer Epidemiol Biomarkers Prev 12:1213-21. 2003
    ..Oral administration of soy isoflavones gives plasma concentrations of genistein that have been associated with antimetastatic activity in vitro...
  19. ncbi request reprint Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals
    H H Sherry Chow
    Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724, USA
    Clin Cancer Res 9:3312-9. 2003
    ..In an exploratory fashion, we have also determined the effect of chronic green tea polyphenol administration on UV-induced erythema response...
  20. ncbi request reprint Absorption, tissue distribution and elimination of 4-[(3)h]-epigallocatechin gallate in beagle dogs
    Robert R Swezey
    Department of Drug Metabolism and Pharmacokinetics, SRI International, Menlo Park, California 94025, USA
    Int J Toxicol 22:187-93. 2003
    ..These results are generally in accord with previous studies in rodents and indicate that, after oral administration, EGCG (as parent compound and metabolites) is widely distributed to tissues where it can exert a chemopreventive effect...
  21. ncbi request reprint Genotoxicity and toxicity of the potential cancer-preventive agent polyphenon E
    Polly Y Chang
    Biopharmaceutical Development Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Environ Mol Mutagen 41:43-54. 2003
    ..In addition, these studies highlight the importance of using both in vitro and in vivo systems in genetic toxicity screening of pharmaceuticals before they are administered to humans...
  22. ncbi request reprint A physiological pharmacokinetic model describing the disposition of lycopene in healthy men
    Veda Diwadkar-Navsariwala
    Department of Human Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Lipid Res 44:1927-39. 2003
    ..This may have important implications for planning clinical trials with pharmacological doses of lycopene in cancer control and prevention if absorption saturation occurs at levels that are already being consumed in the population...
  23. ncbi request reprint AKT and the phosphatidylinositol 3-kinase/AKT pathway: important molecular targets for lung cancer prevention and treatment
    James A Crowell
    J Natl Cancer Inst 95:252-3. 2003
  24. ncbi request reprint Toxicogenomics of resveratrol in rat liver
    Vidya Hebbar
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, 160 Frelinghuysen Road, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, United States
    Life Sci 76:2299-314. 2005
    ..In summary, at lower doses of resveratrol there are few significant changes in gene expression whereas the modulation of liver genes at the high dose of resveratrol may implicate the potential toxicity observed...
  25. ncbi request reprint Detection of Bowman-Birk inhibitor and anti-Bowman-Birk inhibitor antibodies in sera of humans and animals treated with Bowman-Birk inhibitor concentrate
    X Steven Wan
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nutr Cancer 43:167-73. 2002
    ..These results suggest that orally ingested BBI is absorbed by human subjects and animals and that some animals develop antibodies to BBI in response to treatment with BBIC...
  26. doi request reprint Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects
    Shaiju K Vareed
    Department of Internal Medicine, University of Michigan Medical School and Veterans Affairs Medical Center, Ann Arbor, Michigan, USA
    Cancer Epidemiol Biomarkers Prev 17:1411-7. 2008
    ..Curcumin is a polyphenol, found in the spice turmeric, that has promising anticancer properties, but previous studies suggest that absorption of curcumin may be limited...
  27. pmc One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis
    Anthony T Yeung
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Cancer Res 68:7579-86. 2008
    ..These changes may represent the earliest biomarkers of colorectal cancer development, potentially leading to the identification of molecular targets for cancer prevention...
  28. ncbi request reprint Peroxisome proliferator-activated receptor modulators as potential chemopreventive agents
    Levy Kopelovich
    CCS Associates, Mountain View, California 94043, USA
    Mol Cancer Ther 1:357-63. 2002
    ..This review presents a rationale for using PPAR modulators as cancer chemopreventive drugs...
  29. ncbi request reprint Searchable high-resolution 2D gel proteome of the human colon crypt
    Bhavinkumar B Patel
    Division of Basic Science, Medical Science, and Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Proteome Res 6:2232-8. 2007
    ..These interactive, searchable, hyperlink-enabled proteome maps and gene ontology analyses will facilitate future studies to discover the earliest markers and intervention targets during progression to colon cancer...
  30. ncbi request reprint Evaluation of chemopreventive agents for genotoxic activity
    Rupa S Doppalapudi
    SRI International, Biosciences Division, Menlo Park, CA 94025, USA
    Mutat Res 629:148-60. 2007
    ..The results with geraniol remain inconclusive. I3C, BBIC and BTP were not tested in the chromosomal aberration assay. None of the 11 agents induced micronuclei in mouse bone marrow erythrocytes...
  31. ncbi request reprint Targeting epigenetic regulatory mechanisms in cancer chemoprevention
    Judith R Fay
    CCS Associates, 2005 Landings Dr, Mountain View, CA 94043, USA
    Expert Opin Ther Targets 9:315-28. 2005
    ..This review discusses the potential for restoring epigenetic balance as a means to prevent cancer...
  32. ncbi request reprint Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations
    Radka Stoyanova
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 3:1313-21. 2004
    ..The inherently complex signaling networks of tumors result from genetic and epigenetic alterations that occur during cancer initiation and progression...
  33. ncbi request reprint Evaluation of hydrogen ion concentrations in prostates from rats and dogs using fluorescent confocal microscopy
    Alexander V Lyubimov
    Toxicology Research Laboratory, University of Illinois at Chicago, Chicago IL 60612 7353, USA
    J Photochem Photobiol B 80:225-34. 2005
    ..Besides the direct measurement of the pH in rat and dog tissues (pH approximately 7.0), a method of pH measurement in prostate tissue (rather than in cell culture) was developed...
  34. ncbi request reprint Clinical characteristics and pharmacokinetics of purified soy isoflavones: multiple-dose administration to men with prostate neoplasia
    Leslie Fischer
    Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7461, USA
    Nutr Cancer 48:160-70. 2004
    ..Pharmacokinetic data for chronic dose administration were similar to single-dose administration for the isoflavones investigated except that we observed slightly longer circulation time for daidzein...
  35. ncbi request reprint Single-dose pharmacokinetic study of lycopene delivered in a well-defined food-based lycopene delivery system (tomato paste-oil mixture) in healthy adult male subjects
    David M Gustin
    Division of Hematology Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Cancer Epidemiol Biomarkers Prev 13:850-60. 2004
    ..Pharmacokinetic parameters for trans- and cis-lycopene isomers were calculated and are reported here. The formulation was well tolerated with minimal side effects, which were mainly of gastrointestinal nature and of very low grade...
  36. ncbi request reprint Oncogenicity evaluations of chemopreventive soy components in p53((+/-)) (p53 knockout) mice
    William D Johnson
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Int J Toxicol 25:219-28. 2006
    ..By contrast, the positive-control article, p-cresidine, induced urinary bladder cancers in both studies. Neither PTI G-2535 nor BBIC demonstrates any evidence of oncogenicity in the p53((+/-)) mouse model...
  37. pmc Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography
    David J Boocock
    Department of Cancer Studies and Molecular Medicine, Cancer Biomarkers and Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 848:182-7. 2007
    ..The data presented in this report demonstrate a rapid, sensitive and accurate method for the analysis of resveratrol and its metabolites in human plasma and urine for pharmacokinetic studies...
  38. ncbi request reprint Pharmacokinetics and tissue distribution of orally administered lycopene in male dogs
    Peter J Korytko
    Toxicology Research Laboratory, University of Illinois at Chicago, Chicago, IL, USA
    J Nutr 133:2788-92. 2003
    ..2 nmol/g both 1 and 5 d after dosing ceased (<0.4% of liver concentrations). Although 70% trans-lycopene was used in the dosing material, most of the lycopene identified in plasma and tissues was cis-lycopene...
  39. ncbi request reprint Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men
    Marjorie G Busby
    Department of Nutrition, The School of Public Health, The School of Medicine, The University of North Carolina, Chapel Hill 27599 7400, USA
    Am J Clin Nutr 75:126-36. 2002
    ..Soy isoflavones are potential cancer chemoprevention treatments...