Peter D Crompton

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Sickle cell trait is associated with a delayed onset of malaria: implications for time-to-event analysis in clinical studies of malaria
    Peter D Crompton
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    J Infect Dis 198:1265-75. 2008
  2. pmc A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray
    Peter D Crompton
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    Proc Natl Acad Sci U S A 107:6958-63. 2010
  3. pmc High efficiency human memory B cell assay and its application to studying Plasmodium falciparum-specific memory B cells in natural infections
    Greta E Weiss
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Immunol Methods 375:68-74. 2012
  4. pmc A positive correlation between atypical memory B cells and Plasmodium falciparum transmission intensity in cross-sectional studies in Peru and Mali
    Greta E Weiss
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 6:e15983. 2011
  5. pmc Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection
    Noah S Butler
    Department of Microbiology, University of Iowa, Iowa City, Iowa, USA
    Nat Immunol 13:188-95. 2012
  6. pmc The TLR9 ligand CpG promotes the acquisition of Plasmodium falciparum-specific memory B cells in malaria-naive individuals
    Peter D Crompton
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    J Immunol 182:3318-26. 2009
  7. pmc In vitro growth-inhibitory activity and malaria risk in a cohort study in mali
    Peter D Crompton
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, 12441 Parklawn Drive, Twinbrook 2 Bldg, Room 200F, Rockville, MD 20832, USA
    Infect Immun 78:737-45. 2010
  8. pmc The Plasmodium falciparum-specific human memory B cell compartment expands gradually with repeated malaria infections
    Greta E Weiss
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 6:e1000912. 2010
  9. pmc Plasmodium falciparum malaria in the Peruvian Amazon, a region of low transmission, is associated with immunologic memory
    Eva H Clark
    Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Infect Immun 80:1583-92. 2012
  10. pmc Naturally Acquired Antibodies Specific for Plasmodium falciparum Reticulocyte-Binding Protein Homologue 5 Inhibit Parasite Growth and Predict Protection From Malaria
    Tuan M Tran
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland
    J Infect Dis 209:789-98. 2014

Collaborators

Detail Information

Publications17

  1. pmc Sickle cell trait is associated with a delayed onset of malaria: implications for time-to-event analysis in clinical studies of malaria
    Peter D Crompton
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    J Infect Dis 198:1265-75. 2008
    ..Although common red blood cell (RBC) polymorphisms such as sickle hemoglobin (HbS) are known to protect against malaria in Africa, their impact on this end point has not been investigated...
  2. pmc A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray
    Peter D Crompton
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    Proc Natl Acad Sci U S A 107:6958-63. 2010
    ....
  3. pmc High efficiency human memory B cell assay and its application to studying Plasmodium falciparum-specific memory B cells in natural infections
    Greta E Weiss
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Immunol Methods 375:68-74. 2012
    ..Thus, this highly efficient assay appears to be well suited to field studies of the generation and maintenance of MBCs where the volumes of blood obtainable are often limiting...
  4. pmc A positive correlation between atypical memory B cells and Plasmodium falciparum transmission intensity in cross-sectional studies in Peru and Mali
    Greta E Weiss
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 6:e15983. 2011
    ..In this study we examined B cell subsets of Pf -infected adults in Peru and Mali to determine if Pf transmission intensity correlates with atypical memory B cell expansion...
  5. pmc Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection
    Noah S Butler
    Department of Microbiology, University of Iowa, Iowa City, Iowa, USA
    Nat Immunol 13:188-95. 2012
    ..Thus, chronic malaria drives specific T cell dysfunction, and proper function can be restored by inhibitory therapies to enhance parasite control...
  6. pmc The TLR9 ligand CpG promotes the acquisition of Plasmodium falciparum-specific memory B cells in malaria-naive individuals
    Peter D Crompton
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    J Immunol 182:3318-26. 2009
    ..These results provide important insights into the human MBC response, which can inform the development of vaccines against malaria and other pathogens that disrupt immunological memory...
  7. pmc In vitro growth-inhibitory activity and malaria risk in a cohort study in mali
    Peter D Crompton
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, 12441 Parklawn Drive, Twinbrook 2 Bldg, Room 200F, Rockville, MD 20832, USA
    Infect Immun 78:737-45. 2010
    ..These data suggest that antibodies which block merozoite invasion of RBC and/or inhibit the intra-RBC growth of the parasite contribute to but are not sufficient for the acquisition of malaria immunity...
  8. pmc The Plasmodium falciparum-specific human memory B cell compartment expands gradually with repeated malaria infections
    Greta E Weiss
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 6:e1000912. 2010
    ..These observations lend new insights into the cellular basis of the delayed acquisition of malaria immunity...
  9. pmc Plasmodium falciparum malaria in the Peruvian Amazon, a region of low transmission, is associated with immunologic memory
    Eva H Clark
    Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Infect Immun 80:1583-92. 2012
    ..This evidence supports our hypothesis that effective antimalaria humoral immunity can develop in low-transmission regions...
  10. pmc Naturally Acquired Antibodies Specific for Plasmodium falciparum Reticulocyte-Binding Protein Homologue 5 Inhibit Parasite Growth and Predict Protection From Malaria
    Tuan M Tran
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland
    J Infect Dis 209:789-98. 2014
    ..These findings strongly support efforts to develop PfRH5 as an urgently needed blood-stage malaria vaccine. Clinical Trials Registration‚ÄÉNCT01322581. ..
  11. pmc Atypical memory B cells are greatly expanded in individuals living in a malaria-endemic area
    Greta E Weiss
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 183:2176-82. 2009
    ..This is the first description of an atypical MBC phenotype associated with malaria. Understanding the origin and function of these MBCs could be important in informing the design of malaria vaccines...
  12. pmc An intensive longitudinal cohort study of Malian children and adults reveals no evidence of acquired immunity to Plasmodium falciparum infection
    Tuan M Tran
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Clin Infect Dis 57:40-7. 2013
    ..However, it remains unclear whether individuals in malaria-endemic areas acquire such immunity...
  13. pmc B cell analysis of ethnic groups in Mali with differential susceptibility to malaria
    Silvia Portugal
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Malar J 11:162. 2012
    ..However, the proportions of B cell subsets in the Fulani and Dogon that may account for differences in the levels of Ig have not been characterized...
  14. pmc Young lives lost as B cells falter: what we are learning about antibody responses in malaria
    Silvia Portugal
    Laboratory of Immunogenetics, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 190:3039-46. 2013
    ..We suggest ways in which advances in immunology and genomics-based technology can further improve our understanding of the B cell response in malaria and perhaps illuminate new pathways to the development of effective vaccines...
  15. pmc Exposure-dependent control of malaria-induced inflammation in children
    Silvia Portugal
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS Pathog 10:e1004079. 2014
    ..These data provide mechanistic insight into the observation that P. falciparum-infected children in endemic areas are often afebrile and tend to control parasite replication. ..
  16. pmc Advances and challenges in malaria vaccine development
    Peter D Crompton
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Disease NIAID, NIH, Rockville, Maryland, USA
    J Clin Invest 120:4168-78. 2010
    ..A better understanding of the mechanisms of naturally acquired immunity to malaria may lead to insights for vaccine development...
  17. pmc Systems immunology of human malaria
    Tuan M Tran
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Trends Parasitol 28:248-57. 2012
    ..Here, we review the tools of systems immunology, their current limitations in the context of human malaria research, and the human 'models' of malaria immunity to which these tools can be applied...