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Species | Peter D CromptonSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Sickle cell trait is associated with a delayed onset of malaria: implications for time-to-event analysis in clinical studies of malariaPeter D Crompton
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
J Infect Dis 198:1265-75. 2008..Although common red blood cell (RBC) polymorphisms such as sickle hemoglobin (HbS) are known to protect against malaria in Africa, their impact on this end point has not been investigated...- A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarrayPeter D Crompton
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
Proc Natl Acad Sci U S A 107:6958-63. 2010.... - High efficiency human memory B cell assay and its application to studying Plasmodium falciparum-specific memory B cells in natural infectionsGreta E Weiss
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
J Immunol Methods 375:68-74. 2012..Thus, this highly efficient assay appears to be well suited to field studies of the generation and maintenance of MBCs where the volumes of blood obtainable are often limiting... - The TLR9 ligand CpG promotes the acquisition of Plasmodium falciparum-specific memory B cells in malaria-naive individualsPeter D Crompton
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
J Immunol 182:3318-26. 2009..These results provide important insights into the human MBC response, which can inform the development of vaccines against malaria and other pathogens that disrupt immunological memory... - In vitro growth-inhibitory activity and malaria risk in a cohort study in maliPeter D Crompton
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, 12441 Parklawn Drive, Twinbrook 2 Bldg, Room 200F, Rockville, MD 20832, USA
Infect Immun 78:737-45. 2010..These data suggest that antibodies which block merozoite invasion of RBC and/or inhibit the intra-RBC growth of the parasite contribute to but are not sufficient for the acquisition of malaria immunity... - The Plasmodium falciparum-specific human memory B cell compartment expands gradually with repeated malaria infectionsGreta E Weiss
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
PLoS Pathog 6:e1000912. 2010..These observations lend new insights into the cellular basis of the delayed acquisition of malaria immunity... - A positive correlation between atypical memory B cells and Plasmodium falciparum transmission intensity in cross-sectional studies in Peru and MaliGreta E Weiss
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
PLoS ONE 6:e15983. 2011..In this study we examined B cell subsets of Pf -infected adults in Peru and Mali to determine if Pf transmission intensity correlates with atypical memory B cell expansion... - B cell analysis of ethnic groups in Mali with differential susceptibility to malariaSilvia Portugal
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
Malar J 11:162. 2012..However, the proportions of B cell subsets in the Fulani and Dogon that may account for differences in the levels of Ig have not been characterized... - Atypical memory B cells are greatly expanded in individuals living in a malaria-endemic areaGreta E Weiss
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
J Immunol 183:2176-82. 2009..This is the first description of an atypical MBC phenotype associated with malaria. Understanding the origin and function of these MBCs could be important in informing the design of malaria vaccines... - Advances and challenges in malaria vaccine developmentPeter D Crompton
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Disease NIAID, NIH, Rockville, Maryland, USA
J Clin Invest 120:4168-78. 2010..A better understanding of the mechanisms of naturally acquired immunity to malaria may lead to insights for vaccine development... - Young lives lost as B cells falter: what we are learning about antibody responses in malariaSilvia Portugal
Laboratory of Immunogenetics, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
J Immunol 190:3039-46. 2013..We suggest ways in which advances in immunology and genomics-based technology can further improve our understanding of the B cell response in malaria and perhaps illuminate new pathways to the development of effective vaccines... - Systems immunology of human malariaTuan M Tran
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
Trends Parasitol 28:248-57. 2012..Here, we review the tools of systems immunology, their current limitations in the context of human malaria research, and the human 'models' of malaria immunity to which these tools can be applied...