Research Topics
Genomes and Genes
| Jacqueline N CrawleySummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Social approach behaviors in oxytocin knockout mice: comparison of two independent lines tested in different laboratory environmentsJacqueline N Crawley
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA
Neuropeptides 41:145-63. 2007....
Behavioral phenotyping strategies for mutant miceJacqueline N Crawley
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892 3730, USA
Neuron 57:809-18. 2008..This Primer addresses experimental design issues and offers examples of high-throughput batteries, learning and memory tasks, and anxiety-related tests...- Mouse behavioral assays relevant to the symptoms of autismJacqueline N Crawley
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892 3730 USA
Brain Pathol 17:448-59. 2007.... - Medicine. Testing hypotheses about autismJacqueline N Crawley
Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892-3730, USA
Science 318:56-7. 2007 
Galanin impairs cognitive abilities in rodents: relevance to Alzheimer's diseaseJ N Crawley
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Porter Neuroscience Research, Center Building 35, Room 1C 903, Mail Code 3730, Bethesda, Maryland 20892 3730, USA
Cell Mol Life Sci 65:1836-41. 2008....- Galanin impairs cognitive abilities in rodents: relevance to Alzheimer's diseaseJ N Crawley
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Porter Neuroscience Research Center, Building 35, Room 1C 903, Mail Code 3730, Bethesda, MA 208923730, USA
EXS 102:133-41. 2010.... - Galanin overexpressing transgenic miceJacqueline N Crawley
Section on Behavioral Genomics, National Institute of Mental Health, Bethesda, MD 20815, USA
Neuropeptides 36:145-56. 2002..GAL-tg represent a new model for investigating the biological actions of endogenous galanin, and for testing novel therapeutics based on galanin receptor ligands... - Designing mouse behavioral tasks relevant to autistic-like behaviorsJacqueline N Crawley
Mouse Behavioral Phenotyping Laboratory, Neurodevelopmental Disorders Research Center, University of North Carolina, Chapel Hill, North Carolina, USA
Ment Retard Dev Disabil Res Rev 10:248-58. 2004.... - Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behaviorAndrew Holmes
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
Neuropsychopharmacology 28:2077-88. 2003..5-HTT null mutant mice provide a model to investigate the role of the 5-HTT in mood and anxiety disorders... - Development of a mouse test for repetitive, restricted behaviors: relevance to autismSheryl S Moy
Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Behav Brain Res 188:178-94. 2008..Further work is required to determine the characteristics of optimal mouse social stimuli in the olfactory hole-board test... - The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in miceRose Marie Karlsson
Laboratory of Clinical and Translational Studies, NIH, National Institute of Alcohol Abuse and Alcoholism, NIH, 10 Center Drive, 1 15330, Bethesda, MD 20892 1375, USA
Psychopharmacology (Berl) 195:547-57. 2008..Neuropeptide Y (NPY) is implicated in the pathophysiology of affective illness. Multiple receptor subtypes (Y1R, Y2R, and Y5R) have been suggested to contribute to NPY's effects on rodent anxiety and depression-related behaviors... - Galanin impairs performance on learning and memory tasks: findings from galanin transgenic and GAL-R1 knockout miceNathan R Rustay
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
Neuropeptides 39:239-43. 2005..The growing body of rodent literature implicating excess GAL in cognitive impairment is relevant to the overexpression of GAL in the basal forebrain during the progression of Alzheimer's disease... - Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotypeJessica J Nadler
Department of Genetics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill 27599-7264, USA
Genetics 174:1229-36. 2006..Thus we can begin to identify expression profiles contributing to behavioral phenotypes through variation in gene expression... - Social approach and repetitive behavior in eleven inbred mouse strainsSheryl S Moy
Neurodevelopmental Disorders Research Center, CB 7146, University of North Carolina School of Medicine, Chapel Hill, NC 27599, United States
Behav Brain Res 191:118-29. 2008..Overall, this set of tasks and observational methods provides a strategy for evaluating novel mouse models in behavioral domains relevant to the autism phenotype... - The female urine sniffing test: a novel approach for assessing reward-seeking behavior in rodentsOz Malkesman
Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 67:864-71. 2010..We describe a novel approach for monitoring reward-seeking behavior in rodents: sniffing of estrus female urine by male mice, along with number of ultrasonic vocalizations (USVs) emitted during the test... - Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant miceMu Yang
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
J Neurosci 32:6525-41. 2012..These results demonstrate the exquisite specificity of deletions in discrete domains within the Shank3 gene in determining severity of symptoms... - Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behaviorMarkus Wohr
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, Maryland, United States of America
PLoS ONE 6:e20631. 2011..The reduced levels of ultrasonic vocalizations and scent marking behavior in Shank1(-/-) mice are consistent with a phenotype relevant to social communication deficits in autism... - Phenotypic assessment of galanin overexpressing and galanin receptor R1 knockout mice in the tail suspension test for depression-related behaviorAndrew Holmes
Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Building 10, Room 3C217, Bethesda, MD 20892 1375, USA
Psychopharmacology (Berl) 178:276-85. 2005.... - Learning and memory performance in mice lacking the GAL-R1 subtype of galanin receptorCraige C Wrenn
Laboratory of Behavioural Neuroscience, National Institute of Mental Health, Bethesda, MD 20892 1375, USA
Eur J Neurosci 19:1384-96. 2004..The generally normal phenotype of GAL-R1 null mutants supports the use of this line for identification of the receptor subtypes that mediate the cognitive deficits produced by exogenous galanin... - Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strainsSheryl S Moy
North Carolina STAART Center for Autism Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Behav Brain Res 176:4-20. 2007..Our multitask strategy for modeling symptoms of autism will be useful for investigating targeted and random gene mutations, QTLs, and microarray analyses... - Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depressionAndrew Holmes
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892 1375, USA
Biol Psychiatry 54:953-9. 2003..Serotonin transporter null mutant mice provide a model system to study how genetic variation in serotonin transporter function affects risk for neuropsychiatric disease... - Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in miceFrancesco Papaleo
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 28:8709-23. 2008..Our data indicate a critical role for the COMT gene in an apparent evolutionary trade-off between cognitive and affective functions... - Olfactory cues are sufficient to elicit social approach behaviors but not social transmission of food preference in C57BL/6J miceBryce C Ryan
Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Behav Brain Res 193:235-42. 2008.... - Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behavior specific to the elevated plus-mazeAndrew Holmes
Section on Behavioral Genomics, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
Neuropsychopharmacology 28:1031-44. 2003..These behavioral findings in the first galanin receptor null mutant mouse are consistent with the hypothesis that galanin exerts anxiolytic actions via the GAL-R1 receptor under conditions of relatively high stress... - Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporterAndrew Holmes
Section on Behavioral Genomics, National Institute of Mental Health, NIH, Bethesda, MD 20892 1375, USA
Neuropsychopharmacology 27:914-23. 2002..5-HTT knockout mice provide a valuable tool for delineating the neuropsychopharmacological actions of antidepressants... - Deficits in social behavior and reversal learning are more prevalent in male offspring of VIP deficient female miceConor M Stack
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Exp Neurol 211:67-84. 2008.... - Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociabilityMu Yang
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, NIH Building 35, Room 1C 909, Mail Code 3730, Bethesda, MD 20892 3730, USA
Eur J Neurosci 29:1663-77. 2009.... - Sociability and motor functions in Shank1 mutant miceJill L Silverman
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
Brain Res 1380:120-37. 2011..Our findings support the interpretation that Shank1 null mice do not demonstrate autism-relevant social interaction deficits, but confirm and extend a role for Shank1 in motor functions... - Performance of galanin transgenic mice in the 5-choice serial reaction time attentional taskCraige C Wrenn
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
Pharmacol Biochem Behav 83:428-40. 2006..Moreover, intraventricular injection of galanin in WT mice did not affect sustained attention. These data indicate that previously reported learning and memory effects of galanin are not secondary to attentional dysfunction... - Social peers rescue autism-relevant sociability deficits in adolescent miceMu Yang
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, Maryland 20892 3730, USA
Autism Res 4:17-27. 2011..This novel paradigm may prove useful for discovering factors that are essential for effective behavioral treatments, and biological mechanisms underlying effective behavioral interventions... - Galanin peptide levels in hippocampus and cortex of galanin-overexpressing transgenic mice evaluated for cognitive performanceC C Wrenn
Section on Behavioral Genomics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Neuropeptides 36:413-26. 2002..Several interpretations of these findings are discussed, including the possibility that a threshold level of galanin overexpression is sufficient to impair performance on learning and memory tasks in mice... - Social approach in genetically engineered mouse lines relevant to autismS S Moy
Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Genes Brain Behav 8:129-42. 2009..Findings from the fragile X model suggest that the FVB/129 background confers enhanced susceptibility to consequences of Fmr1 mutation on social approach... - Neurogranin null mutant mice display performance deficits on spatial learning tasks with anxiety related componentsT Miyakawa
Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, Maryland 20892-1375, USA
Hippocampus 11:763-75. 2001..These findings of apparent deficits in spatial learning and anxiety-like tendencies in Ng -/- support a role for neurogranin in the hippocampally-mediated interaction between stress and performance... - Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEPJill L Silverman
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Porter Neuroscience Research Center, Bethesda, MD 20892, USA
Neuropsychopharmacology 35:976-89. 2010..Our findings suggest that antagonists of mGluR5 receptors may have selective therapeutic efficacy in treating repetitive behaviors in autism... - Social deficits in BTBR T+tf/J mice are unchanged by cross-fostering with C57BL/6J mothersMu Yang
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892 1375, USA
Int J Dev Neurosci 25:515-21. 2007..These findings favor a genetic interpretation of the unusual social behaviors and self-grooming traits of BTBR, and support the use of the BTBR inbred strain as a mouse model to study genetic mechanism of autism... - Autism-relevant social abnormalities and cognitive deficits in engrailed-2 knockout miceJennifer Brielmaier
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, Maryland, USA
PLoS ONE 7:e40914. 2012.... - Anxiolytic-like actions of centrally-administered neuropeptide Y, but not galanin, in C57BL/6J miceRose Marie Karlsson
Division of Psychiatry, Neurotec, Karolinska Institute, Stockholm Laboratory of Clinical Science, NIAAA, NIH, Bethesda, MD, USA
Pharmacol Biochem Behav 80:427-36. 2005..These findings provide a basis for future studies of mice with targeted gene mutations, directed at delineating the anatomical regions and receptor subtypes mediating the effects of NPY and GAL on emotion... - Simple behavioral assessment of mouse olfactionMu Yang
National Institute of Mental Health, NIH, Bethesda, Maryland, USA
Curr Protoc Neurosci . 2009..The tests described in this unit only require simple equipment and can be adopted readily by most laboratories... - Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin miceKathryn K Chadman
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland 20892 3730, USA
Autism Res 1:147-58. 2008..The humanized R451C mutation in mice did not result in apparent autism-like phenotypes, but produced detectable functional consequences that may be interpreted in terms of physical development and/or reduced sensitivity to stimuli... - Social transmission of food preference in mice: methodology and application to galanin-overexpressing transgenic miceCraige C Wrenn
Section on Behavioral Genomics, National Institute of Mental Health, Bethesda, Maryland 20892 1375, USA
Behav Neurosci 117:21-31. 2003..The current studies describe an expanded method for using STFP in mice and confirm a deficit in olfactory memory in GAL-tg mice... - Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic miceJefferson W Kinney
Section on Behavioral Genomics, National Institute of Mental Health, Bethesda, Maryland 20892, USA
Learn Mem 9:178-90. 2002..These findings are the first demonstration that galanin impairs performance on an emotional memory task and support the hypothesis that galanin-induced deficits are specific to more difficult cognitive tasks... - Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient miceR Paylor
Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
Learn Mem 5:302-16. 1998..Future studies will examine the contribution of alpha7 nAChR to the enhancement of learning and sensorimotor gating following nicotine treatments... - Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in miceS S Moy
North Carolina STAART Center for Autism Research, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Genes Brain Behav 3:287-302. 2004..This new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism... - Low sociability in BTBR T+tf/J mice is independent of partner strainMu Yang
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892 3730, USA
Physiol Behav 107:649-62. 2012..Our findings suggest that BTBR has poor abilities to modulate its responses to different social partners, which may be analogous to social cognition deficits in autism, adding to the value of this strain as a mouse model of autism... - Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autismJill L Silverman
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892 3730, USA
Sci Transl Med 4:131ra51. 2012..These findings raise the possibility that a single targeted pharmacological intervention may alleviate multiple diagnostic behavioral symptoms of autism... - Behavioural phenotyping assays for mouse models of autismJill L Silverman
National Institute of Mental Health, Porter Neuroscience Research Center, Bethesda, MD 20892 3730, USA
Nat Rev Neurosci 11:490-502. 2010..Robust phenotypes in mouse models hold great promise as translational tools for discovering effective treatments for components of autism spectrum disorders... - Evaluation of an anxiety-related phenotype in galanin overexpressing transgenic miceAndrew Holmes
Section on Behavioral Neuropharmacology, National Institute of Mental Health, NIH, Bethesda, MD 20892 1375, USA
J Mol Neurosci 18:151-65. 2002..A specific role for galanin in extreme anxiety states represents an attractive target for the development of novel anxiolytic treatments... - Behavioral phenotyping of transgenic and knockout mice: practical concerns and potential pitfallsKathleen R Bailey
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892 3730, USA
ILAR J 47:124-31. 2006..Strategies aimed at minimizing environmental variability and contributions of background genes will enhance the robustness of mouse behavioral phenotyping assays... - Female urine-induced male mice ultrasonic vocalizations, but not scent-marking, is modulated by social experienceFlorence I Roullet
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
Behav Brain Res 216:19-28. 2011.... - Central galanin administration blocks consolidation of spatial learningJefferson W Kinney
Section on Behavioral Genomics, National Institute of Mental Health, Galanin Inhibits Consolidation, Building 10 Room 4011, Bethesda, MD 20892 1375, USA
Neurobiol Learn Mem 80:42-54. 2003..A potential mechanism by which galanin produces this impairment may involve the inhibition of adenylate cyclase activity, leading to inhibition of downstream molecular events that are necessary for consolidation of long-term memory... - Mouse models of autism spectrum disorders: the challenge for behavioral geneticsSheryl S Moy
Neurodevelopmental Disorders Research Center, CB 7146, University of North Carolina, Chapel Hill, NC 27599, USA
Am J Med Genet C Semin Med Genet 142:40-51. 2006..Research focusing on genes that mediate social behavior in mice may help identify neural circuitry essential for normal social interaction, and lead to novel genetic animal models of the autism behavioral phenotype... - Unusual repertoire of vocalizations in the BTBR T+tf/J mouse model of autismMaria Luisa Scattoni
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, Maryland, USA
PLoS ONE 3:e3067. 2008..Particularly intriguing is the unusual pattern of vocalizations and the more frequent, loud harmonics evident in the BTBR mouse model of autism that may resemble the atypical vocalizations seen in some autistic infants... - Reduced aggression in mice lacking the serotonin transporterAndrew Holmes
Section on Behavioral Genomics, National Institute of Mental Health, Building 10 Room 4D11, Bethesda, MD 20892 1375, USA
Psychopharmacology (Berl) 161:160-7. 2002..As a key regulator of central serotonergic activity, dysfunction of the serotonin transporter (5-HTT) represents a potential mechanism mediating pathological aggression... - Autism-like behavioral phenotypes in BTBR T+tf/J miceH G McFarlane
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892 3730, USA
Genes Brain Behav 7:152-63. 2008.... - Learning impairments and motor dysfunctions in adult Lhx5-deficient mice displaying hippocampal disorganizationR Paylor
Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room 4D11, Bethesda, MD 20892 1375, USA
Physiol Behav 73:781-92. 2001..These results reveal functional outcomes of Lhx5 gene deletion on the integrity of hippocampal neuroanatomy and behavior in the adult mouse... - Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal functionJayanth S Chandran
Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A116, MSC 3707, 35 Convent Drive, Bethesda, MD 20892, USA
Neurobiol Dis 29:505-14. 2008..Taken together, our findings suggest that loss of DJ-1 leads to progressive behavioral changes without significant alterations in nigrostriatal dopaminergic and spinal motor systems... - Automated three-chambered social approach task for miceMu Yang
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, NIH, Bethesda, Maryland, USA
Curr Protoc Neurosci . 2011..The Basic Protocol describes procedures for testing one subject at a time in a single apparatus. A Support Protocol addresses data collection... - Galanin receptor subtype 2 (GalR2) null mutant mice display an anxiogenic-like phenotype specific to the elevated plus-mazeKathleen R Bailey
Pharmacol Biochem Behav 86:8-20. 2007..The discovery of an anxiogenic phenotype specific to the elevated plus-maze, similar to findings in GalR1 null mutants, highlights the potential therapeutic efficacy of targeting GalR1 and GalR2 receptors in treating anxiety disorders... - The role of galanin in feeding behaviorJ N Crawley
Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Neuropeptides 33:369-75. 1999.... - Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in miceA Holmes
Section on Behavioral Genomics, National Institute of Mental Health, NIH, Bethesda MD 20892 1375, USA
Genes Brain Behav 1:55-69. 2002..A DBA/2J background may be particularly useful for investigating the genetic basis of emotional memory using fear conditioning... - Reduced ultrasonic vocalizations in vasopressin 1b knockout miceM L Scattoni
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD, USA
Behav Brain Res 187:371-8. 2008..These results indicate that Avpr1b null mutant mice are impaired in the modulation of ultrasonic vocalizations within different social contexts at infant and adult ages... - Pharmacological evidence supporting a role for galanin in cognition and affectC C Wrenn
Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, MD 20892-1375, USA
Prog Neuropsychopharmacol Biol Psychiatry 25:283-99. 2001..6. Intraventricular galanin has anxiolytic effects in a punished drinking test. Intra-amygdala galanin has anxiogenic effects in a punished drinking test... - Behavioral characterization of dopamine D5 receptor null mutant miceA Holmes
Section on Behavioral Genomics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1375, USA
Behav Neurosci 115:1129-44. 2001.... - Inbred strain differences in prepulse inhibition of the mouse startle responseR Paylor
Section on Behavioral Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892 1375, USA
Psychopharmacology (Berl) 132:169-80. 1997..There was no correlation between the level of prepulse inhibition and the amplitude of the startle response. These findings indicate that inbred strains of mice may be a useful tool to study the genetic basis of sensorimotor gating... - Galanin receptor antagonist M40 blocks galanin-induced choice accuracy deficits on a delayed-nonmatching-to-position taskM P McDonald
Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
Behav Neurosci 110:1025-32. 1996..M40 appears to be an effective galanin antagonist in a rodent memory paradigm, indicating that this compound may prove useful in investigating the role of endogenous galanin in learning and memory... - Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1N Lijam
Laboratory of Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Cell 90:895-905. 1997..These results are consistent with an interpretation that common genetic mechanisms underlie abnormal social behavior and sensorimotor gating deficits and implicate Dvl1 in processes underlying complex behaviors... - Analysis of galanin and the galanin antagonist M40 on delayed non-matching-to-position performance in rats lesioned with the cholinergic immunotoxin 192 IgG-saporinM P McDonald
Section on Behavioral Neuropharmacology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
Behav Neurosci 111:552-63. 1997..These results suggest that excess galanin can produce further deficits in DNMTP performance in a lesion model of AD, but blocking endogenous galanin is not sufficient alone to improve performance in lesioned rats... - Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autismJ L Silverman
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA
Neuroscience 171:1197-208. 2010..Our findings support the interpretation that autism-relevant social deficits, vocalizations, and repetitive behaviors are not the result of abnormal stress reactivity in the BTBR mouse model of autism... - Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic backgroundA Holmes
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Building 10, Room 4D11, Bethesda, MD 20892 1375, USA
Genes Brain Behav 2:365-80. 2003..Furthermore, these data highlight the utility of conducting behavioral phenotyping of mutant mice on multiple genetic backgrounds... - Minireview. Galanin-acetylcholine interactions: relevance to memory and Alzheimer's diseaseJ N Crawley
Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, MD 20892 1380, USA
Life Sci 58:2185-99. 1996..Selective galanin receptor antagonists provide a novel approach for increasing cholinergic function, as a potential adjunct to the clinical treatment of dementias... - Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral testsJ N Crawley
Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Building 10, Room 4D11, Bethesda, MD 20892 1375, USA
Brain Res 835:18-26. 1999.... - Disruption of axo-glial junctions causes cytoskeletal disorganization and degeneration of Purkinje neuron axonsGerman P Garcia-Fresco
Curriculum in Neurobiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 103:5137-42. 2006..Together, these findings establish a physiologically relevant link between AGJs and axonal cytoskeleton and raise the possibility that some neurodegenerative disorders arise from disruption of the AGJs... - Behavioral phenotyping of rodentsJacqueline N Crawley
Section on Behavioral Genomics, Intramural Research Program, National Institute of Mental Health, Building 10 Room 4D11, Bethesda, Maryland, USA
Comp Med 53:140-6. 2003..A rigorous six-tiered behavioral phenotyping strategy is described. Recommendations are offered for the design of mouse behavioral testing suites in animal housing facilities... - Criteria for validating mouse models of psychiatric diseasesKathryn K Chadman
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda 20892 3730, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 150:1-11. 2009..We address the common question raised by molecular geneticists and clinical researchers in psychiatry, "what is a 'good enough' mouse model"?.. - Automated apparatus for quantitation of social approach behaviors in miceJ J Nadler
Department of Genetics, Neurodevelopmental Disorders Research Center, North Carolina STAART Center for Autism Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7264, USA
Genes Brain Behav 3:303-14. 2004..The automated equipment provides an accurate and objective approach to measuring social tendencies in mice. Its use may allow higher-throughput scoring of mouse social behaviors in mouse models of social dysfunction... - Galanin microinjected into the medial septum inhibits scopolamine-induced acetylcholine overflow in the rat ventral hippocampusJ K Robinson
Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
Brain Res 709:81-7. 1996..These results are consistent with an interpretation that galanin terminals synapsing on cholinergic cell bodies of the basal forebrain may serve to inhibit the release of acetylcholine in the terminal fields of the cholinergic neurons... - Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolismK Sango
Section on Biochemical Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 11:170-6. 1995..In contrast, the Sandhoff model was severely affected. The phenotypic difference between the two mouse models is the result of differences in the ganglioside degradation pathway between mice and humans... - A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorderY Liu
Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Invest 103:497-505. 1999..The results support the validity of the substrate deprivation therapy and also highlight some limitations... - Bone marrow transplantation prolongs life span and ameliorates neurologic manifestations in Sandhoff disease miceF Norflus
Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Invest 101:1881-8. 1998..These results may be important for the design of treatment approaches for the GM2 gangliosidoses... - Mouse model of GM2 activator deficiency manifests cerebellar pathology and motor impairmentY Liu
Section on Biochemical Genetics, Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 94:8138-43. 1997..The results demonstrate that the activator protein is required for GM2 degradation and also may indicate a role for the GM2 activator in GA2 degradation... - Low home cage social behaviors in BTBR T+tf/J mice during juvenile developmentBrooke A Babineau
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA Electronic address
Physiol Behav 114:49-54. 2013.... - Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autismJill L Silverman
Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892 3730, USA
Neuropharmacology 68:210-22. 2013..This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'... - A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg geneYau Sheng Tsai
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, 27599, USA
Mamm Genome 17:716-22. 2006..Our findings represent a cautionary example since, although rare, spontaneous mutations do arise in ES cells during culture and hitchhike onto the targeted gene mutation... - Motor deficits in fibroblast growth factor receptor-3 null mutant miceM P McDonald
Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, MD 20892 1375, USA
Behav Pharmacol 12:477-86. 2001..Simple, robust behavioural symptoms, such as poor rotorod performance in Fgfr3 knockout mice, can provide useful surrogate markers to evaluate pharmacological treatments and gene therapies for human genetic diseases... - Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizuresH Kawai
Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 276:6885-8. 2001..These results demonstrate unequivocally that gangliosides play an essential role in the proper functioning of the CNS... - Mice lacking both subunits of lysosomal beta-hexosaminidase display gangliosidosis and mucopolysaccharidosisK Sango
Section on Biochemical Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1810, USA
Nat Genet 14:348-52. 1996..This result demonstrates that glycosaminoglycans are crucial substrates for beta-hexosaminidase and that their lack of storage in Tay-Sachs and Sandhoff diseases is due to functional redundancy in the beta-hexosaminidase enzyme system... - Light phase testing of social behaviors: not a problemMu Yang
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health Bethesda, MD, USA
Front Neurosci 2:186-91. 2008..Here we offer a comprehensive review on mouse social behaviors measured in light and dark phases and explain why it is reasonable to test laboratory mice in experimental social tasks in the light phase... - Mouse models of autism: testing hypotheses about molecular mechanismsFlorence I Roullet
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Building 35 Room 1C 903 909, Mail Code 3730, Bethesda, MD, 20892 3730, USA
Curr Top Behav Neurosci 7:187-212. 2011..Robust endophenotypes that are highly relevant to the core symptoms of autism are enabling the search for the genetic and environmental causes of autism, and the discovery of effective treatments... - Expression of tyrosine hydroxylase in cerebellar Purkinje neurons of the mutant tottering and leaner mouseM C Austin
Unit on Behavioral Neuropharmarcology, National Institute of Mental Health, Bethesda, MD 20892
Brain Res Mol Brain Res 15:227-40. 1992..The present findings demonstrate that the classically GABAergic Purkinje cells in the cerebellum express low levels of TH, and that the mutant tottering and leaner strains of mice express extremely high levels of mRNA and protein for TH... - Atm-deficient mice: a paradigm of ataxia telangiectasiaC Barlow
Laboratory of Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Cell 86:159-71. 1996..Atm-disrupted mice recapitulate the ataxia telangiectasia phenotype in humans, providing a mammalian model in which to study the pathophysiology of this pleiotropic disorder... - Opioidergic and dopaminergic gene expression in the caudate-putamen and accumbens of the mutant mouse, tottering (tg/tg)A de Bartolomeis
Experimental Therapeutics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Brain Res Mol Brain Res 46:321-4. 1997..No differences were observed in the expression of dynorphin and D2 receptor mRNA distribution in brain regions examined in the mutant mice as compared to wild-type controls... - Biochemical and morphometric analyses show that myelination in the insulin-like growth factor 1 null brain is proportionate to its neuronal compositionC M Cheng
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 18:5673-81. 1998..These data make a strong case for the primacy of axonal factors, not including IGF1, in determining oligodendrocyte survival and myelination... - Pain responses, anxiety and aggression in mice deficient in pre-proenkephalinM Konig
Unit on Developmental Biology, Laboratory of Cell Biology, Section on Neuroanatomy, Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
Nature 383:535-8. 1996..Unexpectedly, enk-/- mice exhibit normal stress-induced analgesia. Our results show that enkephalins modulate responses to painful stimuli. Thus, genetic factors may contribute significantly to the experience of pain... - Social cognition in schizophrenia: recommendations from the measurement and treatment research to improve cognition in schizophrenia new approaches conferenceMichael F Green
Department of Psychiatry and Behavioral Sciences, Geffen School of Medicine, Los Angeles, CA 90095, USA
Schizophr Bull 31:882-7. 2005..One of the objectives of this group was to generate recommendations for subsequent human and animal studies, and these research agendas are summarized in this report... - Flexor reflex excitability in mice lacking galanin receptor galanin-R1Stefan Grass
Department of Laboratory Medicine, Division of Clinical Neurophysiology, Huddinge University Hospital, Karolinska Institutet, S 141 86 Stockholm, Sweden
Neurosci Lett 345:153-6. 2003..These results confirm previous studies in rats, showing that intrathecal galanin reduces the central sensitization following wind-up. The present data indicate that this effect is probably mediated by receptors other than GAL-R1... - Galanin and spinal nociceptive mechanisms: recent results from transgenic and knock-out modelsZsuzsanna Wiesenfeld-Hallin
Department of Neurotec, Division of Clinical Neurophysiology, Karolinska Institute, Stockholm, Sweden
Neuropeptides 39:207-10. 2005..These results support an inhibitory effect of galanin on nociception, but the physiological role played by galanin via GALR1 receptors needs to be further studied... - Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming testTakashi Yoshitake
Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 101:354-9. 2004..The present findings support a role of galanin in the regulation of release of NA and 5-HT, two neurotransmitters involved in mood control... - Selective reduction in ventral hippocampal acetylcholine release in awake galanin-treated rats and galanin-overexpressing transgenic miceFrancois Laplante
Douglas Hospital Research Centre, Department of Pharmacology Therapeutics and Department of Psychiatry, McGill University, 6875 Boul LaSalle Verdun, QC, Canada H4H 1R3
Regul Pept 122:91-8. 2004..These results are of interest in the context of galanin receptor subtypes in the dorsal and ventral hippocampus, and the differential alterations of hippocampal subregions in neurological diseases such as Alzheimer's dementia... - Galanin inhibits tyrosine hydroxylase expression in midbrain dopaminergic neuronsScott E Counts
Department of Neurological Sciences and Pharmacology, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
J Neurochem 83:442-51. 2002..GAL inhibition of midbrain DA activity may involve a GALR1- mediated reduction of TH in midbrain dopaminergic neurons... - Galanin over-expression decreases the development of neuropathic pain-like behaviors in mice after partial sciatic nerve injuryKarin Hygge-Blakeman
Department of Laboratory Medicine, Division of Clinical Neurophysiology, Huddinge University Hospital, S 141 86 Huddinge, Sweden
Brain Res 1025:152-8. 2004.... - Learning and memory impairments in a congenic C57BL/6 strain of mice that lacks the M2 muscarinic acetylcholine receptor subtypeNatalie K Bainbridge
College of Pharmacy and Health Sciences, Drake University, 2507 University Avenue, Des Moines, IA 50311, USA
Behav Brain Res 190:50-8. 2008..These findings replicate and extend earlier findings in a hybrid strain and solidify the interpretation that the M(2) receptor plays a critical role in specific components of cognitive abilities...