R M Costa

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1
    Rui M Costa
    Departments of Neurobiology, Psychiatry and Psychology, BRI, University of California at Los Angeles, Los Angeles, California 90095 1761, USA
    Nature 415:526-30. 2002
  2. pmc High on habits
    MONICA R F HILARIO
    Section on In Vivo Neural Function, Laboratory for Integrative Neuroscience, NIAAA, NIH Bethesda, MD, USA
    Front Neurosci 2:208-17. 2008
  3. ncbi request reprint Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction
    Rui M Costa
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuron 52:359-69. 2006
  4. ncbi request reprint Dopamine levels modulate the updating of tastant values
    R M Costa
    Department of Neurobiology and Center of Neuroengineering, Duke University Medical Center, Durham, NC, USA
    Genes Brain Behav 6:314-20. 2007
  5. ncbi request reprint Plastic corticostriatal circuits for action learning: what's dopamine got to do with it?
    Rui M Costa
    Section on In Vivo Neural Function, Laboratory for Integrative Neuroscience, NIAAA, NIH, Bethesda, MD 20852 9411, USA
    Ann N Y Acad Sci 1104:172-91. 2007
  6. ncbi request reprint Differential corticostriatal plasticity during fast and slow motor skill learning in mice
    Rui M Costa
    Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA
    Curr Biol 14:1124-34. 2004
  7. pmc Start/stop signals emerge in nigrostriatal circuits during sequence learning
    Xin Jin
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892 9412, USA
    Nature 466:457-62. 2010
  8. pmc Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill
    Henry H Yin
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, 5625 Fishers Lane, MSC 9411, Bethesda, Maryland 20852 9411, USA
    Nat Neurosci 12:333-41. 2009
  9. ncbi request reprint Pharmacologically regulated induction of silent mutations (PRISM): combined pharmacological and genetic approaches for learning and memory
    Paul W Frankland
    Department of Neurobiology, University of California, Los Angeles, USA
    Neuroscientist 9:104-9. 2003
  10. pmc Neurofibromin regulation of ERK signaling modulates GABA release and learning
    Yijun Cui
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 135:549-60. 2008

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1
    Rui M Costa
    Departments of Neurobiology, Psychiatry and Psychology, BRI, University of California at Los Angeles, Los Angeles, California 90095 1761, USA
    Nature 415:526-30. 2002
    ..Our findings have implications for the development of treatments for learning deficits associated with NF1...
  2. pmc High on habits
    MONICA R F HILARIO
    Section on In Vivo Neural Function, Laboratory for Integrative Neuroscience, NIAAA, NIH Bethesda, MD, USA
    Front Neurosci 2:208-17. 2008
    ..Using those procedures, and a combination of genetic and pharmacological tools, the authors showed that endocannabinoid signaling is critical for habit formation...
  3. ncbi request reprint Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction
    Rui M Costa
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuron 52:359-69. 2006
    ..Thus, dopamine-related disorders like Parkinson's disease may not stem from changes in the overall levels of cortical activity, but from dysfunctional activity coordination in corticostriatal circuits...
  4. ncbi request reprint Dopamine levels modulate the updating of tastant values
    R M Costa
    Department of Neurobiology and Center of Neuroengineering, Duke University Medical Center, Durham, NC, USA
    Genes Brain Behav 6:314-20. 2007
    ..These data suggest that dopamine levels can modulate the updating of tastant values, a finding with implications for understanding sensory-specific motivation and reward seeking...
  5. ncbi request reprint Plastic corticostriatal circuits for action learning: what's dopamine got to do with it?
    Rui M Costa
    Section on In Vivo Neural Function, Laboratory for Integrative Neuroscience, NIAAA, NIH, Bethesda, MD 20852 9411, USA
    Ann N Y Acad Sci 1104:172-91. 2007
    ..These diverse effects may subserve different roles for dopamine in reinforcement and action learning...
  6. ncbi request reprint Differential corticostriatal plasticity during fast and slow motor skill learning in mice
    Rui M Costa
    Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA
    Curr Biol 14:1124-34. 2004
    ..However, the nature and dynamics of the plastic changes in each of these brain structures during the different phases of motor learning remain unclear...
  7. pmc Start/stop signals emerge in nigrostriatal circuits during sequence learning
    Xin Jin
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892 9412, USA
    Nature 466:457-62. 2010
    ..These results have important implications for understanding the functional organization of actions and the sequence initiation and termination impairments observed in basal ganglia disorders...
  8. pmc Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill
    Henry H Yin
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, 5625 Fishers Lane, MSC 9411, Bethesda, Maryland 20852 9411, USA
    Nat Neurosci 12:333-41. 2009
    ..These findings demonstrate that region- and pathway-specific plasticity sculpts the circuits involved in the performance of the skill as it becomes automatized...
  9. ncbi request reprint Pharmacologically regulated induction of silent mutations (PRISM): combined pharmacological and genetic approaches for learning and memory
    Paul W Frankland
    Department of Neurobiology, University of California, Los Angeles, USA
    Neuroscientist 9:104-9. 2003
    ..This approach is easily set up and can be used to study the functional interactions between molecules in signaling pathways...
  10. pmc Neurofibromin regulation of ERK signaling modulates GABA release and learning
    Yijun Cui
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 135:549-60. 2008
    ..Importantly, our results also revealed lasting increases in GABA release triggered by learning, indicating that the mechanisms uncovered here are of general importance for learning...
  11. ncbi request reprint Gustatory effects of capsaicin that are independent of TRPV1 receptors
    Rui M Costa
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Chem Senses 30:i198-200. 2005
  12. ncbi request reprint Molecular and cellular mechanisms underlying the cognitive deficits associated with neurofibromatosis 1
    Rui M Costa
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles 90095 1761, USA
    J Child Neurol 17:622-6; discussion 627-9, 646-51. 2002
    ..These findings have brought us closer than ever to the development of possible treatments for the learning disabilities associated with neurofibromatosis 1...
  13. pmc Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits
    Matthias Groszer
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Curr Biol 18:354-62. 2008
    ....
  14. ncbi request reprint Dopaminergic mechanisms in actions and habits
    Jeffery R Wickens
    Okinawa Institute of Science and Technology, Okinawa 904 2234, Japan
    J Neurosci 27:8181-3. 2007
    ..The locus of these actions within the cortical and corticostriatal circuitry is a focus on ongoing research...
  15. ncbi request reprint Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory
    Vanja Nagy
    Fishberg Department of Neuroscience, The Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurosci 26:1923-34. 2006
    ..Together, these data reveal new functions for MMPs in synaptic and behavioral plasticity...
  16. ncbi request reprint The RAS effector RIN1 modulates the formation of aversive memories
    Ajay Dhaka
    Molecular Biology Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1737, USA
    J Neurosci 23:748-57. 2003
    ..These results indicate that RIN1 serves as an inhibitory modulator of neuronal plasticity in aversive memory formation...
  17. ncbi request reprint Notch to remember
    Rui M Costa
    Departments of Neurobiology, Psychiatry, and Psychology, University of California Los Angeles, 695 Young Drive South, Room 2554, Box 951761, Los Angeles, CA 90095 1761, USA
    Trends Neurosci 28:429-35. 2005
    ..We also consider the possible involvement of Notch signaling in cognitive disorders...
  18. ncbi request reprint Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction
    Inbal Israely
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Curr Biol 14:1657-63. 2004
    ....
  19. ncbi request reprint Mouse models of neurofibromatosis type I: bridging the GAP
    Rui M Costa
    Department of Neurobiology and Brain Research Institute, University of California, Los Angeles, Room 2554, 95 Young Drive South, 90095 1761, USA
    Trends Mol Med 9:19-23. 2003
    ..This knowledge will aid the development of treatments for the different pathological processes associated with NF1...
  20. ncbi request reprint Central nervous system myelination in mice with deficient expression of Notch1 receptor
    Maria I Givogri
    Neurobiochemistry Group, Mental Retardation Research Center, School of Medicine, University of California, Los Angeles, California 90024, USA
    J Neurosci Res 67:309-20. 2002
    ....