R M Costa
Affiliation: National Institutes of Health
- Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1Rui M Costa
Departments of Neurobiology, Psychiatry and Psychology, BRI, University of California at Los Angeles, Los Angeles, California 90095 1761, USA
Nature 415:526-30. 2002..Our findings have implications for the development of treatments for learning deficits associated with NF1...
- High on habitsMONICA R F HILARIO
Section on In Vivo Neural Function, Laboratory for Integrative Neuroscience, NIAAA, NIH Bethesda, MD, USA
Front Neurosci 2:208-17. 2008..Using those procedures, and a combination of genetic and pharmacological tools, the authors showed that endocannabinoid signaling is critical for habit formation...
- Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunctionRui M Costa
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Neuron 52:359-69. 2006..Thus, dopamine-related disorders like Parkinson's disease may not stem from changes in the overall levels of cortical activity, but from dysfunctional activity coordination in corticostriatal circuits...
- Dopamine levels modulate the updating of tastant valuesR M Costa
Department of Neurobiology and Center of Neuroengineering, Duke University Medical Center, Durham, NC, USA
Genes Brain Behav 6:314-20. 2007..These data suggest that dopamine levels can modulate the updating of tastant values, a finding with implications for understanding sensory-specific motivation and reward seeking...
- Plastic corticostriatal circuits for action learning: what's dopamine got to do with it?Rui M Costa
Section on In Vivo Neural Function, Laboratory for Integrative Neuroscience, NIAAA, NIH, Bethesda, MD 20852 9411, USA
Ann N Y Acad Sci 1104:172-91. 2007..These diverse effects may subserve different roles for dopamine in reinforcement and action learning...
- Differential corticostriatal plasticity during fast and slow motor skill learning in miceRui M Costa
Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA
Curr Biol 14:1124-34. 2004..However, the nature and dynamics of the plastic changes in each of these brain structures during the different phases of motor learning remain unclear...
- Start/stop signals emerge in nigrostriatal circuits during sequence learningXin Jin
Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892 9412, USA
Nature 466:457-62. 2010..These results have important implications for understanding the functional organization of actions and the sequence initiation and termination impairments observed in basal ganglia disorders...
- Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skillHenry H Yin
Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, 5625 Fishers Lane, MSC 9411, Bethesda, Maryland 20852 9411, USA
Nat Neurosci 12:333-41. 2009..These findings demonstrate that region- and pathway-specific plasticity sculpts the circuits involved in the performance of the skill as it becomes automatized...
- Pharmacologically regulated induction of silent mutations (PRISM): combined pharmacological and genetic approaches for learning and memoryPaul W Frankland
Department of Neurobiology, University of California, Los Angeles, USA
Neuroscientist 9:104-9. 2003..This approach is easily set up and can be used to study the functional interactions between molecules in signaling pathways...
- Neurofibromin regulation of ERK signaling modulates GABA release and learningYijun Cui
Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
Cell 135:549-60. 2008..Importantly, our results also revealed lasting increases in GABA release triggered by learning, indicating that the mechanisms uncovered here are of general importance for learning...
- Gustatory effects of capsaicin that are independent of TRPV1 receptorsRui M Costa
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Chem Senses 30:i198-200. 2005
- Molecular and cellular mechanisms underlying the cognitive deficits associated with neurofibromatosis 1Rui M Costa
Department of Neurobiology, Brain Research Institute, University of California, Los Angeles 90095 1761, USA
J Child Neurol 17:622-6; discussion 627-9, 646-51. 2002..These findings have brought us closer than ever to the development of possible treatments for the learning disabilities associated with neurofibromatosis 1...
- Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficitsMatthias Groszer
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
Curr Biol 18:354-62. 2008....
- Dopaminergic mechanisms in actions and habitsJeffery R Wickens
Okinawa Institute of Science and Technology, Okinawa 904 2234, Japan
J Neurosci 27:8181-3. 2007..The locus of these actions within the cortical and corticostriatal circuitry is a focus on ongoing research...
- Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memoryVanja Nagy
Fishberg Department of Neuroscience, The Mount Sinai School of Medicine, New York, New York 10029 6574, USA
J Neurosci 26:1923-34. 2006..Together, these data reveal new functions for MMPs in synaptic and behavioral plasticity...
- The RAS effector RIN1 modulates the formation of aversive memoriesAjay Dhaka
Molecular Biology Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1737, USA
J Neurosci 23:748-57. 2003..These results indicate that RIN1 serves as an inhibitory modulator of neuronal plasticity in aversive memory formation...
- Notch to rememberRui M Costa
Departments of Neurobiology, Psychiatry, and Psychology, University of California Los Angeles, 695 Young Drive South, Room 2554, Box 951761, Los Angeles, CA 90095 1761, USA
Trends Neurosci 28:429-35. 2005..We also consider the possible involvement of Notch signaling in cognitive disorders...
- Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunctionInbal Israely
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
Curr Biol 14:1657-63. 2004....
- Mouse models of neurofibromatosis type I: bridging the GAPRui M Costa
Department of Neurobiology and Brain Research Institute, University of California, Los Angeles, Room 2554, 95 Young Drive South, 90095 1761, USA
Trends Mol Med 9:19-23. 2003..This knowledge will aid the development of treatments for the different pathological processes associated with NF1...
- Central nervous system myelination in mice with deficient expression of Notch1 receptorMaria I Givogri
Neurobiochemistry Group, Mental Retardation Research Center, School of Medicine, University of California, Los Angeles, California 90024, USA
J Neurosci Res 67:309-20. 2002....