Brian R Cornwell

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Anticipation of public speaking in virtual reality reveals a relationship between trait social anxiety and startle reactivity
    Brian R Cornwell
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20895, USA
    Biol Psychiatry 59:664-6. 2006
  2. pmc Synaptic potentiation is critical for rapid antidepressant response to ketamine in treatment-resistant major depression
    Brian R Cornwell
    Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 72:555-61. 2012
  3. pmc Distinct contributions of human hippocampal theta to spatial cognition and anxiety
    Brian R Cornwell
    Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hippocampus 22:1848-59. 2012
  4. pmc Abnormal hippocampal functioning and impaired spatial navigation in depressed individuals: evidence from whole-head magnetoencephalography
    Brian R Cornwell
    Mood and Anxiety Disorders Program, NIMH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 167:836-44. 2010
  5. pmc Anxiety overrides the blocking effects of high perceptual load on amygdala reactivity to threat-related distractors
    Brian R Cornwell
    National Institute of Mental Health, Bethesda, MD, USA
    Neuropsychologia 49:1363-8. 2011
  6. pmc Evoked amygdala responses to negative faces revealed by adaptive MEG beamformers
    Brian R Cornwell
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 15 North Drive, MSC 2670, Bethesda, MD 20892, USA
    Brain Res 1244:103-12. 2008
  7. pmc Modality-specific attention under imminent but not remote threat of shock: evidence from differential prepulse inhibition of startle
    Brian R Cornwell
    Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Psychol Sci 19:615-22. 2008
  8. pmc Human hippocampal and parahippocampal theta during goal-directed spatial navigation predicts performance on a virtual Morris water maze
    Brian R Cornwell
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:5983-90. 2008
  9. pmc Neural responses to auditory stimulus deviance under threat of electric shock revealed by spatially-filtered magnetoencephalography
    Brian R Cornwell
    Mood and Anxiety Disorders Program, National Institute of Mental Health, 15K North Drive, MSC 2670, Bethesda, MD 20892, USA
    Neuroimage 37:282-9. 2007
  10. pmc Sensitivity to masked conditioned stimuli predicts conditioned response magnitude under masked conditions
    Brian R Cornwell
    National Institute of Mental Health, National Institutes of Health, 15K North Drive, Bethesda, MD 20892, USA
    Psychophysiology 44:403-6. 2007

Detail Information

Publications20

  1. ncbi request reprint Anticipation of public speaking in virtual reality reveals a relationship between trait social anxiety and startle reactivity
    Brian R Cornwell
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20895, USA
    Biol Psychiatry 59:664-6. 2006
    ..Startle reflex modification has become valuable to the study of fear and anxiety, but few studies have explored startle reactivity in socially threatening situations...
  2. pmc Synaptic potentiation is critical for rapid antidepressant response to ketamine in treatment-resistant major depression
    Brian R Cornwell
    Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 72:555-61. 2012
    ..Acutely, ketamine increases extracellular glutamate levels, neuronal excitability, and spontaneous γ oscillations, but it is unknown whether these effects are key to the mechanism of antidepressant action of ketamine...
  3. pmc Distinct contributions of human hippocampal theta to spatial cognition and anxiety
    Brian R Cornwell
    Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hippocampus 22:1848-59. 2012
    ..Supporting contemporary theory, these findings highlight simultaneous involvement of the human hippocampus in spatial cognition and anxiety, and clarify their distinct correlates...
  4. pmc Abnormal hippocampal functioning and impaired spatial navigation in depressed individuals: evidence from whole-head magnetoencephalography
    Brian R Cornwell
    Mood and Anxiety Disorders Program, NIMH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 167:836-44. 2010
    ..The authors aimed to link spatial navigation deficits previously documented in depressed patients to abnormal hippocampal functioning using a virtual reality navigation task...
  5. pmc Anxiety overrides the blocking effects of high perceptual load on amygdala reactivity to threat-related distractors
    Brian R Cornwell
    National Institute of Mental Health, Bethesda, MD, USA
    Neuropsychologia 49:1363-8. 2011
    ..We conclude that anxiety elicited by looming threat promotes neurocognitive processes that broaden attention and enhance sensitivity to potential danger cues, even when perceptual systems are taxed...
  6. pmc Evoked amygdala responses to negative faces revealed by adaptive MEG beamformers
    Brian R Cornwell
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 15 North Drive, MSC 2670, Bethesda, MD 20892, USA
    Brain Res 1244:103-12. 2008
    ..This demonstration should encourage the use of MEG for elucidating functional networks mediating fear-related neural phenomena that likely unfold rapidly in time across cortical and subcortical structures...
  7. pmc Modality-specific attention under imminent but not remote threat of shock: evidence from differential prepulse inhibition of startle
    Brian R Cornwell
    Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Psychol Sci 19:615-22. 2008
    ..This finding supports the notion that imminent threat, but not remote threat, elicits attention focused toward the relevant modality, potentially reflecting preparatory activity to minimize the impact of the noxious stimulus...
  8. pmc Human hippocampal and parahippocampal theta during goal-directed spatial navigation predicts performance on a virtual Morris water maze
    Brian R Cornwell
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:5983-90. 2008
    ....
  9. pmc Neural responses to auditory stimulus deviance under threat of electric shock revealed by spatially-filtered magnetoencephalography
    Brian R Cornwell
    Mood and Anxiety Disorders Program, National Institute of Mental Health, 15K North Drive, MSC 2670, Bethesda, MD 20892, USA
    Neuroimage 37:282-9. 2007
    ....
  10. pmc Sensitivity to masked conditioned stimuli predicts conditioned response magnitude under masked conditions
    Brian R Cornwell
    National Institute of Mental Health, National Institutes of Health, 15K North Drive, Bethesda, MD 20892, USA
    Psychophysiology 44:403-6. 2007
    ..Without consensus on how awareness should be defined, these findings bring balance to previous studies that have typically used less sensitive assessments of awareness...
  11. ncbi request reprint Attentional blink and prepulse inhibition of startle are positively correlated
    Brian R Cornwell
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Psychophysiology 43:504-10. 2006
    ..Whereas prepulse inhibition may reveal the strength of inhibition to protect stimulus processing, attentional blink may index the rate of recovery from similar inhibitory processes...
  12. pmc Becoming the center of attention in social anxiety disorder: startle reactivity to a virtual audience during speech anticipation
    Brian R Cornwell
    Mood and Anxiety Disorders Program, National Institute of Mental Health, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    J Clin Psychiatry 72:942-8. 2011
    ..Our aim was to isolate the specific components of public speaking that trigger fear in vulnerable individuals and best discriminate between SAD and healthy individuals...
  13. pmc Increased anterior cingulate cortical activity in response to fearful faces: a neurophysiological biomarker that predicts rapid antidepressant response to ketamine
    Giacomo Salvadore
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 65:289-95. 2009
    ..We also investigated patterns of ACC activity to rapid presentation of fearful faces compared with the normal habituation observed in healthy subjects...
  14. pmc Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamine
    Giacomo Salvadore
    Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 35:1415-22. 2010
    ..73, p=0.0021, FDR <0.05).These data implicate the pgACC and its putative interaction with the amygdala in predicting antidepressant response to ketamine in a working memory task context...
  15. pmc Anxiety, a benefit and detriment to cognition: behavioral and magnetoencephalographic evidence from a mixed-saccade task
    Brian R Cornwell
    Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Cogn 78:257-67. 2012
    ..These findings suggest that, in an anxiety state, reduced cognitive-behavioral flexibility may stem from enhanced stimulus-driven attention, which may serve the adaptive function of optimizing threat detection...
  16. pmc Emotion regulation and potentiated startle across affective picture and threat-of-shock paradigms
    Shmuel Lissek
    Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, DHHS, 15K North Drive, Bethesda, MD 20892 2670, USA
    Biol Psychol 76:124-33. 2007
    ....
  17. pmc Passive avoidance is linked to impaired fear extinction in humans
    Brian R Cornwell
    Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Learn Mem 20:164-9. 2013
    ..We conclude that a deeper understanding of what motivates avoidance may offer a target for early intervention, before fears transition from the rational to the irrational...
  18. pmc Generalization of conditioned fear-potentiated startle in humans: experimental validation and clinical relevance
    Shmuel Lissek
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Intramural Research Program, NIH, DHHS, 15K North Drive, Rm 200, Bethesda, MD 20892 2670, USA
    Behav Res Ther 46:678-87. 2008
    ..The current paradigm represents an updated and efficacious tool with which to study fear generalization--a central, yet understudied conditioning-correlate of pathologic anxiety...
  19. pmc The impact of anxiety upon cognition: perspectives from human threat of shock studies
    Oliver J Robinson
    Section on the Neurobiology of Fear and Anxiety, National Institute of Mental Health Bethesda, MD, USA
    Front Hum Neurosci 7:203. 2013
    ..g., response to threat) and maladaptive (e.g., pathological) anxiety. We conclude by raising a number of unresolved questions regarding the role of anxiety in cognition that may provide fruitful avenues for future research...
  20. pmc The complex interaction between anxiety and cognition: insight from spatial and verbal working memory
    Katherine E Vytal
    Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health Bethesda, MD, USA
    Front Hum Neurosci 7:93. 2013
    ....