Research Topics
| Brian R CornwellSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Anticipation of public speaking in virtual reality reveals a relationship between trait social anxiety and startle reactivityBrian R Cornwell
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20895, USA
Biol Psychiatry 59:664-6. 2006..Startle reflex modification has become valuable to the study of fear and anxiety, but few studies have explored startle reactivity in socially threatening situations...
Synaptic potentiation is critical for rapid antidepressant response to ketamine in treatment-resistant major depressionBrian R Cornwell
Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 72:555-61. 2012..Acutely, ketamine increases extracellular glutamate levels, neuronal excitability, and spontaneous γ oscillations, but it is unknown whether these effects are key to the mechanism of antidepressant action of ketamine...- Distinct contributions of human hippocampal theta to spatial cognition and anxietyBrian R Cornwell
Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Hippocampus 22:1848-59. 2012..Supporting contemporary theory, these findings highlight simultaneous involvement of the human hippocampus in spatial cognition and anxiety, and clarify their distinct correlates... - Anxiety overrides the blocking effects of high perceptual load on amygdala reactivity to threat-related distractorsBrian R Cornwell
National Institute of Mental Health, Bethesda, MD, USA
Neuropsychologia 49:1363-8. 2011..We conclude that anxiety elicited by looming threat promotes neurocognitive processes that broaden attention and enhance sensitivity to potential danger cues, even when perceptual systems are taxed... - Becoming the center of attention in social anxiety disorder: startle reactivity to a virtual audience during speech anticipationBrian R Cornwell
Mood and Anxiety Disorders Program, National Institute of Mental Health, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
J Clin Psychiatry 72:942-8. 2011..Our aim was to isolate the specific components of public speaking that trigger fear in vulnerable individuals and best discriminate between SAD and healthy individuals... - Abnormal hippocampal functioning and impaired spatial navigation in depressed individuals: evidence from whole-head magnetoencephalographyBrian R Cornwell
Mood and Anxiety Disorders Program, NIMH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
Am J Psychiatry 167:836-44. 2010..The authors aimed to link spatial navigation deficits previously documented in depressed patients to abnormal hippocampal functioning using a virtual reality navigation task... - Evoked amygdala responses to negative faces revealed by adaptive MEG beamformersBrian R Cornwell
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 15 North Drive, MSC 2670, Bethesda, MD 20892, USA
Brain Res 1244:103-12. 2008..This demonstration should encourage the use of MEG for elucidating functional networks mediating fear-related neural phenomena that likely unfold rapidly in time across cortical and subcortical structures... - Modality-specific attention under imminent but not remote threat of shock: evidence from differential prepulse inhibition of startleBrian R Cornwell
Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
Psychol Sci 19:615-22. 2008..This finding supports the notion that imminent threat, but not remote threat, elicits attention focused toward the relevant modality, potentially reflecting preparatory activity to minimize the impact of the noxious stimulus... - Neural responses to auditory stimulus deviance under threat of electric shock revealed by spatially-filtered magnetoencephalographyBrian R Cornwell
Mood and Anxiety Disorders Program, National Institute of Mental Health, 15K North Drive, MSC 2670, Bethesda, MD 20892, USA
Neuroimage 37:282-9. 2007.... - Human hippocampal and parahippocampal theta during goal-directed spatial navigation predicts performance on a virtual Morris water mazeBrian R Cornwell
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 28:5983-90. 2008.... - Attentional blink and prepulse inhibition of startle are positively correlatedBrian R Cornwell
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Psychophysiology 43:504-10. 2006..Whereas prepulse inhibition may reveal the strength of inhibition to protect stimulus processing, attentional blink may index the rate of recovery from similar inhibitory processes... - Sensitivity to masked conditioned stimuli predicts conditioned response magnitude under masked conditionsBrian R Cornwell
National Institute of Mental Health, National Institutes of Health, 15K North Drive, Bethesda, MD 20892, USA
Psychophysiology 44:403-6. 2007..Without consensus on how awareness should be defined, these findings bring balance to previous studies that have typically used less sensitive assessments of awareness... - Increased anterior cingulate cortical activity in response to fearful faces: a neurophysiological biomarker that predicts rapid antidepressant response to ketamineGiacomo Salvadore
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Biol Psychiatry 65:289-95. 2009..We also investigated patterns of ACC activity to rapid presentation of fearful faces compared with the normal habituation observed in healthy subjects... - Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamineGiacomo Salvadore
Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Neuropsychopharmacology 35:1415-22. 2010..73, p=0.0021, FDR <0.05).These data implicate the pgACC and its putative interaction with the amygdala in predicting antidepressant response to ketamine in a working memory task context... - Anxiety, a benefit and detriment to cognition: behavioral and magnetoencephalographic evidence from a mixed-saccade taskBrian R Cornwell
Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Brain Cogn 78:257-67. 2012..These findings suggest that, in an anxiety state, reduced cognitive-behavioral flexibility may stem from enhanced stimulus-driven attention, which may serve the adaptive function of optimizing threat detection... - Emotion regulation and potentiated startle across affective picture and threat-of-shock paradigmsShmuel Lissek
Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, DHHS, 15K North Drive, Bethesda, MD 20892 2670, USA
Biol Psychol 76:124-33. 2007.... - Generalization of conditioned fear-potentiated startle in humans: experimental validation and clinical relevanceShmuel Lissek
Mood and Anxiety Disorders Program, National Institute of Mental Health, Intramural Research Program, NIH, DHHS, 15K North Drive, Rm 200, Bethesda, MD 20892 2670, USA
Behav Res Ther 46:678-87. 2008..The current paradigm represents an updated and efficacious tool with which to study fear generalization--a central, yet understudied conditioning-correlate of pathologic anxiety... - Passive avoidance is linked to impaired fear extinction in humansBrian R Cornwell
Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Learn Mem 20:164-9. 2013..We conclude that a deeper understanding of what motivates avoidance may offer a target for early intervention, before fears transition from the rational to the irrational... 
The complex interaction between anxiety and cognition: insight from spatial and verbal working memoryKatherine E Vytal
Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health Bethesda, MD, USA
Front Hum Neurosci 7:93. 2013....