Research Topics
Genomes and GenesSpecies | G S CooperSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
The role of genetic factors in autoimmune disease: implications for environmental researchG S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Environ Health Perspect 107:693-700. 1999..The multifactorial nature of the genetic risk factors and the low penetrance of disease underscore the potential influence of environmental factors and gene-environment interactions on the etiology of autoimmune diseases...
Hormonal and reproductive risk factors for development of systemic lupus erythematosus: results of a population-based, case-control studyGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina 27709, USA
Arthritis Rheum 46:1830-9. 2002..In humans, 85% of lupus patients are women, which also suggests the importance of hormonal factors in disease pathogenesis. The purpose of this study was to examine hormonal and reproductive risk factors for lupus among women...- Organochlorine exposure and age at natural menopauseGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA
Epidemiology 13:729-33. 2002..The effect of potential endocrine-modulating organochlorines on menopause has not been extensively examined... - Risk factors for development of systemic lupus erythematosus: allergies, infections, and family historyGlinda S Cooper
Epidemiology Branch A3 05, National Institute of Environmental Health Sciences, PO Box 12233, Durham, NC 27709, USA
J Clin Epidemiol 55:982-9. 2002..3, 95% CI 1.2-8.6). Further research is needed to clarify whether medication allergies and specific infectious agents are involved in the etiology of SLE. Published by Elsevier Science Inc... - Polychlorinated biphenyls and menstrual cycle characteristicsGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Epidemiology 16:191-200. 2005..Few studies have examined these associations in humans... - Ovarian cancer risk and use of phenolphthalein-containing laxativesGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC 27709, USA
Pharmacoepidemiol Drug Saf 13:35-9. 2004..Ovarian cancer was one of the cancers observed in these studies. We examined the association between epithelial ovarian cancer and use of phenolphthalein-containing laxatives in a population-based case-control study... - The epidemiology of autoimmune diseasesGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA
Autoimmun Rev 2:119-25. 2003..Thus although there are commonalities, there are also important demographic differences between diseases. Disease-specific research, as well as studies that focus on potentially related diseases, needs to be conducted... - Occupational and environmental exposures as risk factors for systemic lupus erythematosusGlinda S Cooper
Epidemiology Branch MDA3 05, National Institute of Environmental Health Sciences, PO Box 12233, Durham, NC 27709, USA
Curr Rheumatol Rep 6:367-74. 2004..There are numerous avenues with respect to environmental factors in SLE that need additional research... - N-acetyl transferase genotypes in relation to risk of developing systemic lupus erythematosusGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina 27709, USA
J Rheumatol 31:76-80. 2004..To examine the association between N-acetyl transferase (NAT) genotype (NAT1 and NAT2) and risk of developing systemic lupus erythematosus (SLE)... - Differences by race, sex and age in the clinical and immunologic features of recently diagnosed systemic lupus erythematosus patients in the southeastern United StatesG S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina 27709, USA
Lupus 11:161-7. 2002..The prevalence of oral or nasal ulcers and anti-DNA autoantibodies declined with age. The extent to which the differences we observed reflect genetic or environmental influences on the disease process should be investigated... - Pregnancy recency and risk of ovarian cancerG S Cooper
Epidemiology Branch A3 05, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Cancer Causes Control 10:397-402. 1999.... - Smoking and use of hair treatments in relation to risk of developing systemic lupus erythematosusG S Cooper
From the Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina 27709, USA
J Rheumatol 28:2653-6. 2001..To examine the association between smoking and hair treatments (dyes, permanents) and risk of developing systemic lupus erythematosus (SLE)... - Menstrual patterns and risk of adult-onset diabetes mellitusG S Cooper
Epidemiology Branch A3 05, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, Durham, NC 27709, USA
J Clin Epidemiol 53:1170-3. 2000..These results do not support the association of long or irregular menstrual cycles with post-menopausal diabetes incidence, but do suggest a possible association of longer bleeding duration with subsequent onset of diabetes... - FSH levels in relation to hysterectomy and to unilateral oophorectomyG S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Obstet Gynecol 94:969-72. 1999..To examine the association between hysterectomy, unilateral oophorectomy, and ovarian status, measured by FSH concentrations, in women aged 35-49 years... - Measures of menopausal status in relation to demographic, reproductive, and behavioral characteristics in a population-based study of women aged 35-49 yearsG S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC Westat, Inc, Research Triangle Park, NC 27709, USA
Am J Epidemiol 153:1159-65. 2001..Menstrual-based definitions of menopause can be misclassified for women with menstrual irregularity. This might explain why obese women were classified menstrually as menopausal while remaining hormonally premenopausal... - CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United StatesC G Parks
Epidemiology Branch, A3 05, NIEHS, NIH, DHHS, PO Box 12233, Durham, North Carolina 27709 12233, USA
Lupus 13:784-91. 2004..These findings suggest allelic variation in this region of CTLA4 is not a major independent risk factor for SLE, but may contribute to risk of disease in younger African-Americans or in the presence of certain immunogenetic markers... 
Systemic lupus erythematosus and genetic variation in the interleukin 1 gene cluster: a population based study in the southeastern United StatesC G Parks
National Institute of Environmental Health Sciences, NIH, DHHS, Durham, NC, USA
Ann Rheum Dis 63:91-4. 2004..Interleukin (IL)1alpha and IL1beta, and their endogenous receptor antagonist (IL1Ra), have been related to the pathology of systemic lupus erythematosus (SLE), but the role of IL1 polymorphisms in the aetiology of SLE is unknown...- Age at natural menopause and the risk of epithelial ovarian cancerJ M Schildkraut
Program for Prevention, Detection, and Control Research, Duke Comprehensive Cancer Center, Durham, North Carolina 27710, USA
Obstet Gynecol 98:85-90. 2001..To investigate the relationship between age at natural menopause and risk of developing epithelial ovarian cancer... - Risk of ovarian cancer in relation to use of phenolphthalein-containing laxativesG S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC 27709, USA
Br J Cancer 83:404-6. 2000..4 for any use of phenolphthalein-containing laxatives and OR 1.5 for 75 or more days of use).. - Comparing questionnaire-based methods to assess occupational silica exposureChristine G Parks
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Epidemiology 15:433-41. 2004.... - Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositisGulnara Mamyrova
National Institute of Environmental Health Sciences, NIH, Bethesda, Maryland 20892 1301, USA
Arthritis Rheum 58:3941-50. 2008.... - Association of Epstein-Barr virus with systemic lupus erythematosus: effect modification by race, age, and cytotoxic T lymphocyte-associated antigen 4 genotypeChristine G Parks
National Institute of Environmental Health Sciences, Durham, North Carolina, USA
Arthritis Rheum 52:1148-59. 2005..This study examined the seroprevalence of EBV in a population-based study of SLE patients from the southeastern United States, and potential interactions with CTLA-4 polymorphisms were assessed... - Occupational exposure to crystalline silica and autoimmune diseaseC G Parks
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Environ Health Perspect 107:793-802. 1999..The specific manifestation of this effect may depend on underlying differences in genetic susceptibility or other environmental exposures... 
Total serum IgE levels in systemic lupus erythematosus and associations with childhood onset allergiesC G Parks
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, NC 27599, USA
Lupus 19:1614-22. 2010..Future studies may want to explore potentially shared risk factors for development of allergy, atopy, and SLE...- Childhood agricultural and adult occupational exposures to organic dusts in a population-based case-control study of systemic lupus erythematosusC G Parks
Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
Lupus 17:711-9. 2008.... - Occupational risk factors for the development of systemic lupus erythematosusGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina 27709, USA
J Rheumatol 31:1928-33. 2004..We examined the association between the risk of SLE and occupational exposures (mercury, solvents, and pesticides), specific jobs (ever worked in teaching, healthcare, and cosmetology), and working night or rotating shifts... - Occupational and environmental associations with antinuclear antibodies in a general population sampleGlinda S Cooper
National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina 27709, USA
J Toxicol Environ Health A 69:2063-9. 2006..Larger studies addressing these exposures may provide insights into the mechanisms by which various environmental factors affect the development of autoantibodies and the progression to clinical disease... - Associations between plasma DDE levels and immunologic measures in African-American farmers in North CarolinaGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 112:1080-4. 2004..32-11.3; for > or = 12.0 microg/L compared with < 3.0 microg/L p,p'-DDE), but this difference was not statistically significant. These analyses provide evidence that p,p'-DDE modulates immune responses in humans... - Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic lupus erythematosus: associations and interaction with the interleukin-1alpha-889 C/T polymorphismChristine G Parks
National Institute of Environmental Health Sciences, Durham, NC, USA
Hum Immunol 65:622-31. 2004..0, p < 0.00001) for the combined "HLA-DR3, TNF-alpha -308A, IL-1alpha -889C/C" genotype. These findings provide evidence of cytokine gene epistasis in SLE susceptibility... - Assessing exposure to crystalline silica from farm work: a population-based study in the Southeastern United StatesChristine G Parks
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Ann Epidemiol 13:385-92. 2003..This study examines aspects of farm work that were used to estimate potential silica dust exposure in a population-based study conducted in the southeastern United States... - Occupational exposure to crystalline silica and risk of systemic lupus erythematosus: a population-based, case-control study in the southeastern United StatesChristine G Parks
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina 27709, USA
Arthritis Rheum 46:1840-50. 2002..We undertook this population-based study to examine the association between occupational silica exposure and SLE in the southeastern US... - Pesticide exposure and timing of menopause: the Agricultural Health StudySherry L Farr
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Am J Epidemiol 163:731-42. 2006..78, 0.97) and by approximately 5 months for women who used hormonally active pesticides (hazard ratio = 0.77, 95% confidence interval: 0.65, 0.92). Pesticide use may be associated with a later age at menopause... - Occupational exposures and autoimmune diseasesGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Int Immunopharmacol 2:303-13. 2002.... - Employment and disability issues in systemic lupus erythematosus: a reviewLacie Scofield
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Arthritis Rheum 59:1475-9. 2008..To summarize research pertaining to work disability in lupus patients, discuss challenges patients face applying for federal disability assistance in the US, and make recommendations for clinical and health policy research... - Personal and family medical history correlates of rheumatoid arthritisAnneclaire J De Roos
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center and Department of Epidemiology, University of Washington, Seattle, WA 98109, USA
Ann Epidemiol 18:433-9. 2008..We studied personal and family medical history correlates of incident and prevalent RA in women... - Effect of glutathione S-transferase polymorphisms and proximity to hazardous waste sites on time to systemic lupus erythematosus diagnosis: results from the Roxbury lupus projectElizabeth W Karlson
Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Arthritis Rheum 56:244-54. 2007..Our goal was to assess association of residential proximity to hazardous waste sites and genetic variation in 3 glutathione Stransferase (GST) genes (GSTM1, GSTT1, and GSTP1) with age at diagnosis of SLE... - Sociodemographic associations with early disease damage in patients with systemic lupus erythematosusGlinda S Cooper
US Environmental Protection Agency, Washington, DC 20460, USA
Arthritis Rheum 57:993-9. 2007..To examine the extent of organ damage among recently diagnosed patients with systemic lupus erythematosus (SLE), and to assess the association between sociodemographic variables and total damage and organ-specific damage scores... - Association of silica exposure with anti-neutrophil cytoplasmic autoantibody small-vessel vasculitis: a population-based, case-control studySusan L Hogan
UNC Kidney Center and Division of Nephrology and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7155, USA
Clin J Am Soc Nephrol 2:290-9. 2007..Exposure to silica from specific farming tasks related to harvesting may be of particular importance in the southeastern United States. Interval of time since last exposure did not influence development of ANCA-SVV... - Two aspects of the clinical and humanistic burden of systemic lupus erythematosus: mortality risk and quality of life early in the course of diseaseRobert Campbell
Medical University of South Carolina, Charleston, SC, USA
Arthritis Rheum 59:458-64. 2008..To evaluate mortality risk and predictors among recently diagnosed systemic lupus erythematosus (SLE) patients... - Pentachlorophenol and cancer risk: focusing the lens on specific chlorophenols and contaminantsGlinda S Cooper
National Center for Environmental Assessment, US Environmental Protection Agency, Washington, DC 20460, USA
Environ Health Perspect 116:1001-8. 2008..We reviewed currently available data to determine the extent to which recent studies assist in distinguishing the effect of pentachlorophenol from that of its contaminants (e.g., dioxins and other chlorophenols)... - Occupational silica and solvent exposures and risk of systemic lupus erythematosus in urban womenAxel Finckh
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 54:3648-54. 2006..To assess the risk of systemic lupus erythematosus (SLE) associated with occupational exposure to silica dust and organic solvents in an urban population... - A novel polymorphic CAAT/enhancer-binding protein beta element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythematosus patientsJianming Wu
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, AL 35294 0006, USA
J Immunol 170:132-8. 2003..This functionally significant SNP demonstrates the potential importance of SNPs in regulatory regions and suggests that differences in the regulation of FasL expression may contribute to the development of the autoimmune phenotype... - Glutathione S-transferase M null homozygosity and risk of systemic lupus erythematosus associated with sun exposure: a possible gene-environment interaction for autoimmunityPatricia A Fraser
Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA
J Rheumatol 30:276-82. 2003..We hypothesized that risk of SLE associated with occupational sun exposure is modulated by GSTM1, GSTT1, and GSTP1 genotypes... - Vitamin D deficiency in systemic lupus erythematosusDiane L Kamen
Medical University of South Carolina, Charleston, SC, USA
Autoimmun Rev 5:114-7. 2006..9, p<0.01). These results suggest vitamin D deficiency as a possible risk factor for SLE and provide guidance for future studies looking at a potential role of vitamin D in the prevention and/or treatment of SLE... - Occupational exposures and risk of systemic lupus erythematosusChristine G Parks
Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Autoimmunity 38:497-506. 2005..g. high-titer autoantibodies) in occupational cohorts with well-characterized exposure histories may reveal occupational risk factors for autoimmunity, and may also provide baseline data for studies of determinants of progression to SLE... - Childbearing and the risk of scleroderma: a population-based study in SwedenMats Lambe
Department of Epidemiology, Karolinska Institutet, Stockholm, Sweden
Am J Epidemiol 159:162-6. 2004.... - Rheumatoid arthritis among women in the Agricultural Health Study: risk associated with farming activities and exposuresAnneclaire J De Roos
University of Washington Department of Epidemiology and Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Ann Epidemiol 15:762-70. 2005..We studied risk factors for RA in the Agricultural Health Study, a cohort of over 57,000 licensed pesticide applicators and their spouses... - Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americansJim C Oates
Department of Medicine, Ralph H Johnson VA Medical Center VAMC and Medical University of South Carolina, Charleston 29425, USA
J Rheumatol 30:60-7. 2003..This study was designed to determine if these polymorphisms are associated with SLE... - A novel polymorphism in the Fcgamma receptor IIB (CD32B) transmembrane region alters receptor signalingXiaoli Li
University of Alabama at Birmingham, AL 35294 0006, USA
Arthritis Rheum 48:3242-52. 2003..The transmembrane domain of FcgammaRIIb may also contribute to receptor signaling. Therefore, we investigated the biologic significance of single-nucleotide polymorphisms (SNPs) throughout the coding region... - Exposure to respirable crystalline silica in eastern North Carolina farm workersJohn D Archer
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, CB #7400, Rosenau Hall, Chapel Hill, NC 27599-7400, USA
AIHA J (Fairfax, Va) 63:750-5. 2002..In agriculture, respirable silica exposure is highly variable, but the potential for exposures above the threshold limit value of 0.05 mg/m3 exists during particular agricultural activities... - Associations with menopause and menopausal transition in a nationally representative US sampleKate M Brett
Division of Epidemiology, National Center for Health Statistics OAEHP, CDC DHHS, 3311 Toledo Road, Room 6420, Hyattsville, MD 20782, USA
Maturitas 45:89-97. 2003..The purpose of this study was to assess sociodemographic and behavioral factors in relation to menopausal status in a representative sample of the United States population... - Hormone replacement following early menopauseGlinda S Cooper
JAMA 288:2824-5; author reply 2825. 2002 - Cancer screening in patients with systemic lupus erythematosusSasha R Bernatsky
Montreal General Hospital Research Institute, the Department of Rheumatology and the Divisions of Clinical Immunology and Allergy and Clinical Epidemiology, Montreal General Hospital, McGill University Health Centre, Montreal, Canada
J Rheumatol 33:45-9. 2006..CONCLUSION: These data suggest that appropriate cancer screening may be overlooked in patients with SLE... - A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosusKaihong Su
Division of Clinical Immunology and Rheumatology, Departments of Medicine and Microbiology, University of Alabama, Birmingham, AL 35294, USA
J Immunol 172:7186-91. 2004..72; p = 0.0083). These results suggest that an expression variant of FCGR2B is a risk factor for human lupus and implicate FCGR2B in disease pathogenesis...