C Norman Coleman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Emergency medical preparedness for radiological/nuclear incidents in the United States
    C Norman Coleman
    Office of the Assistant Secretary for Preparedness and Response ASPR, and National Cancer Institute NCI, Department of Health and Human Service DHHS, Washington, DC, USA
    J Radiol Prot 32:N27-32. 2012
  2. doi request reprint Medical response to a radiologic/nuclear event: integrated plan from the Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services
    C Norman Coleman
    Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC 20201, USA
    Ann Emerg Med 53:213-22. 2009
  3. ncbi request reprint Linking radiation oncology and imaging through molecular biology (or now that therapy and diagnosis have separated, it's time to get together again!)
    C Norman Coleman
    National Cancer Institute, Radiation Oncology Branch, Bldg 10, B3 B69, National Institutes of Health, Bethesda, MD 20892 1002, USA
    Radiology 228:29-35. 2003
  4. ncbi request reprint Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001
    C Norman Coleman
    Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Radiat Res 159:812-34. 2003
  5. ncbi request reprint The Harvard Joint Center for Radiation Therapy, 1968-1999: a unique concept and its relationship to the prevailing times in academic medicine
    C N Coleman
    Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 47:1357-69. 2000
  6. pmc The road not taken and choices in radiation oncology
    C Norman Coleman
    Radiation Research Program, 6130 Executive Boulevard, Bethesda, Maryland 20892, USA
    Oncologist 15:332-7. 2010
  7. ncbi request reprint Phase III study of ibuprofen versus placebo for radiation-induced genitourinary side effects
    C Norman Coleman
    Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 54:191-4. 2002
  8. ncbi request reprint Radiation oncology--linking technology and biology in the treatment of cancer
    C Norman Coleman
    Radiation Oncology Sciences Program, Center for Cancer Research and Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1002, USA
    Acta Oncol 41:6-13. 2002
  9. ncbi request reprint International Conference on Translational Research ICTR 2003 Conference Summary: marshalling resources in a complex time
    C Norman Coleman
    Radiation Oncology Sciences Program, Center for Cancer Research, Division of Cancer Treatment and Diagnosis, National Cancer Institute NIH, Bldg 10, B3 B69, Bethesda, MD 20892 1002, USA
    Int J Radiat Oncol Biol Phys 58:307-19. 2004
  10. ncbi request reprint Education and training for radiation scientists: radiation research program and American Society of Therapeutic Radiology and Oncology Workshop, Bethesda, Maryland, May 12-14, 2003
    C Norman Coleman
    Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, USA
    Radiat Res 160:729-37. 2003

Detail Information

Publications74

  1. doi request reprint Emergency medical preparedness for radiological/nuclear incidents in the United States
    C Norman Coleman
    Office of the Assistant Secretary for Preparedness and Response ASPR, and National Cancer Institute NCI, Department of Health and Human Service DHHS, Washington, DC, USA
    J Radiol Prot 32:N27-32. 2012
    ..Participation and collaboration among nations helping the Japanese response to the Fukushima earthquake, tsunami and NPP disaster demonstrated the benefit of preparation and ongoing worldwide cooperation among experts...
  2. doi request reprint Medical response to a radiologic/nuclear event: integrated plan from the Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services
    C Norman Coleman
    Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC 20201, USA
    Ann Emerg Med 53:213-22. 2009
    ..The logic behind and components of this response are presented to allow for active collaboration among emergency planners and responders and federal, state, local, and tribal governments...
  3. ncbi request reprint Linking radiation oncology and imaging through molecular biology (or now that therapy and diagnosis have separated, it's time to get together again!)
    C Norman Coleman
    National Cancer Institute, Radiation Oncology Branch, Bldg 10, B3 B69, National Institutes of Health, Bethesda, MD 20892 1002, USA
    Radiology 228:29-35. 2003
    ..It is timely to develop new collaborative research, training, and education agendas by building on one another's expertise and adopting new fields of microtechnology, nanotechnology, and mathematical analysis and optimization...
  4. ncbi request reprint Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001
    C Norman Coleman
    Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Radiat Res 159:812-34. 2003
    ..Communicate knowledge of the effects of radiation exposure to the general public and to investigators, policy makers and agencies involved in response to nuclear accidents/events and protection/treatment of the general public...
  5. ncbi request reprint The Harvard Joint Center for Radiation Therapy, 1968-1999: a unique concept and its relationship to the prevailing times in academic medicine
    C N Coleman
    Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 47:1357-69. 2000
    ....
  6. pmc The road not taken and choices in radiation oncology
    C Norman Coleman
    Radiation Research Program, 6130 Executive Boulevard, Bethesda, Maryland 20892, USA
    Oncologist 15:332-7. 2010
    ....
  7. ncbi request reprint Phase III study of ibuprofen versus placebo for radiation-induced genitourinary side effects
    C Norman Coleman
    Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 54:191-4. 2002
    ..This study examined whether the inflammatory response within the prostate during radiotherapy would respond to the standard dose of ibuprofen as assessed by a symptom score...
  8. ncbi request reprint Radiation oncology--linking technology and biology in the treatment of cancer
    C Norman Coleman
    Radiation Oncology Sciences Program, Center for Cancer Research and Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1002, USA
    Acta Oncol 41:6-13. 2002
    ....
  9. ncbi request reprint International Conference on Translational Research ICTR 2003 Conference Summary: marshalling resources in a complex time
    C Norman Coleman
    Radiation Oncology Sciences Program, Center for Cancer Research, Division of Cancer Treatment and Diagnosis, National Cancer Institute NIH, Bldg 10, B3 B69, Bethesda, MD 20892 1002, USA
    Int J Radiat Oncol Biol Phys 58:307-19. 2004
    ....
  10. ncbi request reprint Education and training for radiation scientists: radiation research program and American Society of Therapeutic Radiology and Oncology Workshop, Bethesda, Maryland, May 12-14, 2003
    C Norman Coleman
    Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, USA
    Radiat Res 160:729-37. 2003
    ..5) Educate other scientists and the general public on the quantitative, basic, molecular, translational and applied aspects of radiation sciences...
  11. doi request reprint Triage and treatment tools for use in a scarce resources-crisis standards of care setting after a nuclear detonation
    C Norman Coleman
    Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Services, Rockville, MD 20852, USA
    Disaster Med Public Health Prep 5:S111-21. 2011
    ..Included in this article are printable triage cards that reflect our recommendations. These are not formal guidelines. With new research, data, and discussion, these recommendations will undoubtedly evolve...
  12. pmc Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC score
    Nicole L Simone
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 70:90-5. 2008
    ..To test whether intrarectal amifostine limits symptoms of radiation proctitis, measured by using the Radiation Therapy Oncology Group (RTOG) gastrointestinal (GI) toxicity score and the Expanded Prostate Cancer Index Composite (EPIC) score...
  13. ncbi request reprint Gene expression profiling of breast, prostate, and glioma cells following single versus fractionated doses of radiation
    Mong Hsun Tsai
    Radiation Biology, Center for Cancer Research, National Cancer Institute NIH, Bethesda, MD 20892, USA
    Cancer Res 67:3845-52. 2007
    ....
  14. doi request reprint Fractionated radiation therapy can induce a molecular profile for therapeutic targeting
    Molykutty John-Aryankalayil
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Radiat Res 174:446-58. 2010
    ..This study suggests that fractionated radiation may be a uniquely exploitable, non-oncogene-addiction stress pathway for molecular therapeutic targeting...
  15. pmc NS-398, ibuprofen, and cyclooxygenase-2 RNA interference produce significantly different gene expression profiles in prostate cancer cells
    Molykutty John-Aryankalayil
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Room B3 B 406, Building 10, Bethesda, MD 20892, USA
    Mol Cancer Ther 8:261-73. 2009
    ....
  16. pmc Early observed transient prostate-specific antigen elevations on a pilot study of external beam radiation therapy and fractionated MRI guided high dose rate brachytherapy boost
    Anurag K Singh
    Radiation Oncology Branch, National Cancer Institute, NIH DHHS, Bldg 10, CRC Rm B2 3561, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Radiat Oncol 1:28. 2006
    ..To report early observation of transient PSA elevations on this pilot study of external beam radiation therapy and magnetic resonance imaging (MRI) guided high dose rate (HDR) brachytherapy boost...
  17. pmc Intra- and inter-radiation therapist reproducibility of daily isocenter verification using prostatic fiducial markers
    Karen L Ullman
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bldg 10, CRC Rm B2 SW 3500, 9000 Rockville Pike, Bethesda, MD, 20892, USA
    Radiat Oncol 1:2. 2006
    ..We sought to determine the intra- and inter-radiation therapist reproducibility of a previously established matching technique for daily verification and correction of isocenter position relative to intraprostatic fiducial markers (FM)...
  18. ncbi request reprint Intrarectal amifostine suspension may protect against acute proctitis during radiation therapy for prostate cancer: a pilot study
    Anurag K Singh
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 65:1008-13. 2006
    ..Our goal was to test the ability of intrarectal amifostine to limit symptoms of radiation proctitis...
  19. ncbi request reprint Radiation sensitivity of human carcinoma cells transfected with small interfering RNA targeted against cyclooxygenase-2
    Sanjeewani T Palayoor
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 1002, USA
    Clin Cancer Res 11:6980-6. 2005
    ..However, the precise role of COX-2 in radiation response is not clear. The purpose of the present study was to investigate the in vitro radiosensitivity of tumor cells as a function of COX-2 expression...
  20. ncbi request reprint The requirement of multimodal therapy (vaccine, local tumor radiation, and reduction of suppressor cells) to eliminate established tumors
    Chie Kudo-Saito
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:4533-44. 2005
    ..The elimination of well-established tumors often proves elusive. Here we show that a multimodal immune-based therapy can be successfully employed to eliminate established tumors...
  21. ncbi request reprint External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing
    Mala Chakraborty
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Res 64:4328-37. 2004
    ..Thus, these studies demonstrate a new paradigm for the use of local tumor irradiation in combination with active specific vaccine therapy to elicit durable antitumor responses of established tumors...
  22. ncbi request reprint Isoprostane levels in the urine of patients with prostate cancer receiving radiotherapy are not elevated
    Kevin Camphausen
    Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1002, USA
    Int J Radiat Oncol Biol Phys 58:1536-9. 2004
    ....
  23. ncbi request reprint Comparing measures of acute bowel toxicity in patients with prostate cancer treated with external beam radiation therapy
    Thierry M Muanza
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 62:1316-21. 2005
    ..This study strives to compare early measures of bowel toxicity in patients with prostate cancer receiving definitive or adjuvant 3D conformal external beam radiation therapy and concurrent daily endorectal application of amifostine...
  24. ncbi request reprint Fractionated radiation alters oncomir and tumor suppressor miRNAs in human prostate cancer cells
    Molykutty John-Aryankalayil
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Radiat Res 178:105-17. 2012
    ..Our data support the potential for using fractionated radiation to induce molecular targets and radiation-induced miRNAs may have a significant role in predicting radiosensitivity...
  25. pmc Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects
    Sanjeewani T Palayoor
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, Room B3B406, Bethesda, MD 20892, USA
    J Cardiovasc Pharmacol 59:487-99. 2012
    ....
  26. doi request reprint The U.S. government's medical countermeasure portfolio management for nuclear and radiological emergencies: synergy from interagency cooperation
    Marcy B Grace
    Division of CBRN Countermeasures, Biomedical Advanced Research and Development Authority BARDA, Office of the Assistant Secretary for Preparedness and Response, Office of the Secretary, Department of Health and Human Services, 330 Independence Avenue SW, Room 644G, Washington, DC 20201, USA
    Health Phys 101:238-47. 2011
    ..Interagency coordination has also continued to increase to more efficiently and effectively leverage federal resources toward emergency medical preparedness for both civilian and military populations...
  27. doi request reprint PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells
    Sanjeewani T Palayoor
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 123:2430-7. 2008
    ..Although the precise mechanism of enhancement of radiosensitivity remains to be identified, this study suggests a potential role for PX-478 as a clinical radiation enhancer...
  28. ncbi request reprint Effect of radiation and ibuprofen on normoxic renal carcinoma cells overexpressing hypoxia-inducible factors by loss of von Hippel-Lindau tumor suppressor gene function
    Sanjeewani T Palayoor
    Radiation Oncology Branch, Center for Cancer Research and the Molecular Radiation Therapeutics Branch, Division of Cancer and Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Clin Cancer Res 10:4158-64. 2004
    ..The purpose of the present study was to investigate the impact of HIFs on radiosensitivity...
  29. doi request reprint Allocation of scarce resources after a nuclear detonation: setting the context
    Ann R Knebel
    Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, USA
    Disaster Med Public Health Prep 5:S20-31. 2011
    ..With thoughtful and realistic planning, the medical response in the chaotic environment may be made more effective and efficient for both victims and medical responders...
  30. doi request reprint Medical response to a nuclear detonation: creating a playbook for state and local planners and responders
    Paula Murrain-Hill
    Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Services, USA
    Disaster Med Public Health Prep 5:S89-97. 2011
    ..This playbook template is designed to be a practical tool with sufficient background information and options for step-by-step individualized planning and response...
  31. pmc Assessment of biodosimetry methods for a mass-casualty radiological incident: medical response and management considerations
    Julie M Sullivan
    Office of Emergency Management, Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC AAAS Science and Technology Policy Fellow, Washington DC Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD Biomedical Advanced Research and Development Authority, Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC
    Health Phys 105:540-54. 2013
    ....
  32. doi request reprint User-managed inventory: an approach to forward-deployment of urgently needed medical countermeasures for mass-casualty and terrorism incidents
    C Norman Coleman
    Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Services, Washington, DC, USA
    Disaster Med Public Health Prep 6:408-14. 2012
    ..The UMI can be more cost-effective than stockpiling by avoiding costs due to drug expiration, disposal of expired stockpiled supplies, and repurchase for replacement...
  33. ncbi request reprint The "RTR" medical response system for nuclear and radiological mass-casualty incidents: a functional TRiage-TReatment-TRansport medical response model
    Chad M Hrdina
    Office of the Assistance Secretary for Preparedness and Respone, US Department of Health and Human Services, Washington, DC 20201, USA
    Prehosp Disaster Med 24:167-78. 2009
    ..The US Department of Health and Human Services is working on a long-term project to generate a database for potential medical care sites and assembly centers so that information is immediately available should an incident occur...
  34. ncbi request reprint Current status and future potential of advanced technologies in radiation oncology. Part 2. State of the science by anatomic site
    Bhadrasain Vikram
    Clinical Radiation Oncology Branch, Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute Rockville, Maryland 20852, USA
    Oncology (Williston Park) 23:380-5. 2009
    ..This month, part 2 will outline the state of the science for each disease site...
  35. ncbi request reprint A novel 3D volumetric voxel registration technique for volume-view-guided image registration of multiple imaging modalities
    Guang Li
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 63:261-73. 2005
    ..To provide more clinically useful image registration with improved accuracy and reduced time, a novel technique of three-dimensional (3D) volumetric voxel registration of multimodality images is developed...
  36. ncbi request reprint Medicine. Modulation of radiation injury
    C Norman Coleman
    Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA
    Science 304:693-4. 2004
  37. pmc Transrectal prostate biopsy and fiducial marker placement in a standard 1.5T magnetic resonance imaging scanner
    Robert C Susil
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Urol 175:113-20. 2006
    ..We investigated the accuracy and feasibility of a system that provides transrectal needle access to the prostate concurrent with 1.5 Tesla MRI which previously has not been possible...
  38. ncbi request reprint Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer
    James L Gulley
    Laboratory of Tumor Immunology and Biology, Medical Oncology Clinical Research Unit, Radiation Oncology Branch, and Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:3353-62. 2005
    ..One potential solution is the utilization of a well-tolerated systemic therapy (e.g., vaccine) in concert with local therapy...
  39. ncbi request reprint Inverse treatment planning based on MRI for HDR prostate brachytherapy
    Deborah Citrin
    Radiation Oncology Branch, CCR, NCI, National Institutes of Health, Department of Health and Human Services, Bldg 10, Rm B3B69, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 61:1267-75. 2005
    ..To develop and optimize a technique for inverse treatment planning based solely on magnetic resonance imaging (MRI) during high-dose-rate brachytherapy for prostate cancer...
  40. doi request reprint Assessing surge capacity for radiation victims with marrow toxicity
    Matthew S Davids
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Biol Blood Marrow Transplant 16:1436-41. 2010
    ..The exercises highlighted shortcomings in current planning and future steps for improving surge capacity that are applicable to various mass casualty scenarios...
  41. ncbi request reprint Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group
    Jamie K Waselenko
    Walter Reed Army Medical Center and Catholic University of America, Washington, DC 20307, USA
    Ann Intern Med 140:1037-51. 2004
    ..For terrorist or accidental events involving exposure to radioiodines, prophylaxis against malignant disease of the thyroid is also recommended, particularly for children and adolescents...
  42. pmc Radiation survivors: understanding and exploiting the phenotype following fractionated radiation therapy
    Adeola Y Makinde
    National Institutes of Health National Cancer Institute, 9000 Rockville Pike, Bldg 10, B3B406, Bethesda, MD 20892, USA
    Mol Cancer Res 11:5-12. 2013
    ..Given that more normal tissue is treated, albeit to lower doses with these newer techniques, the response of the normal tissue may also influence long-term treatment outcome...
  43. ncbi request reprint Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003
    Helen B Stone
    National Cancer Institute, Bethesda, Maryland 20892, USA
    Radiat Res 162:711-28. 2004
    ....
  44. ncbi request reprint Urinary VEGF and MMP levels as predictive markers of 1-year progression-free survival in cancer patients treated with radiation therapy: a longitudinal study of protein kinetics throughout tumor progression and therapy
    Linda W Chan
    Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, Room B3 B69, Bethesda, MD, 20892 1002, USA
    J Clin Oncol 22:499-506. 2004
    ....
  45. pmc Radiation injury after a nuclear detonation: medical consequences and the need for scarce resources allocation
    Andrea L DiCarlo
    Radiation Nuclear Countermeasures Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA
    Disaster Med Public Health Prep 5:S32-44. 2011
    ..Finally, expert guidance and surge capacity for casualties with ARS are available from the Radiation Emergency Medical Management Web site and the Radiation Injury Treatment Network...
  46. ncbi request reprint Clinical trial of endorectal amifostine for radioprotection in patients with prostate cancer: rationale and early results
    Cynthia Menard
    Radiation Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institute of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Semin Oncol 30:63-7. 2003
    ..The initial trial will proceed until 18 patients are accrued, at which time an interval evaluation of both early and late toxicity endpoints will be conducted...
  47. ncbi request reprint Discovering clinical biomarkers of ionizing radiation exposure with serum proteomic analysis
    Cynthia Menard
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH DHHS, Building 10, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Cancer Res 66:1844-50. 2006
    ..The composition of proteins in serum seems to change with ionizing radiation exposure. Proteomic analysis for the discovery of clinical biomarkers of radiation exposure warrants further study...
  48. ncbi request reprint Evaluation of copper chelation agents as anti-angiogenic therapy
    Kevin Camphausen
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, Room B3B69, Bethesda, MD 20892 1002, USA
    Bioorg Med Chem 11:4287-93. 2003
    ....
  49. ncbi request reprint Effects of radiation on normal tissue: consequences and mechanisms
    Helen B Stone
    Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, MD 20892 7440, USA
    Lancet Oncol 4:529-36. 2003
    ..Treatments that reduce the risk or severity of damage to normal tissue or that facilitate the healing of radiation injury are being developed. These could greatly improve the quality of life of patients treated for cancer...
  50. ncbi request reprint Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells
    Sanjeewani T Palayoor
    Radiation Oncology Branch, Center for Cancer Research and the Molecular Radiation Therapeutics Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, Maryland, 20892 1002, USA
    Clin Cancer Res 9:3150-7. 2003
    ..HIF-regulated proteins, vascular endothelial growth factor (VEGF) and glucose transporter-1 (Glut-1), were analyzed by ELISA and Western blot analysis, respectively...
  51. doi request reprint Radiation terrorism: what society needs from the radiobiology-radiation protection and radiation oncology communities
    C Norman Coleman
    Office of Preparedness and Emergency Response, Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC, USA
    J Radiol Prot 29:A159-69. 2009
    ....
  52. ncbi request reprint Evaluation of radiation-induced oral mucositis by optical coherence tomography
    Thierry M Muanza
    Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:5121-7. 2005
    ..Optical coherence tomography (OCT) imaging was evaluated to determine if radiation-induced mucosal damage could be noninvasively monitored in real time and correlated with histopathologic findings...
  53. pmc Radiologic and nuclear events: contingency planning for hematologists/oncologists
    David M Weinstock
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 111:5440-5. 2008
    ..Practitioners and institutions across the country are encouraged to become involved and participate in the planning...
  54. ncbi request reprint The medical decision model and decision maker tools for management of radiological and nuclear incidents
    JOHN F KOERNER
    Office of Emergency Management, Office of the Assistant Secretary for Preparedness and Response, U S Department of Health and Human Services, Washington, DC 20201 Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD AAAS Science and Technology Policy Fellow, Washington DC
    Health Phys 106:645-51. 2014
    ....
  55. pmc An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement
    Cynthia Menard
    National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Mol Imaging 4:63-6. 2005
    ..Here we demonstrate the feasibility of precisely colocalizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in a patients with prostate cancer...
  56. pmc MRI-guided HDR prostate brachytherapy in standard 1.5T scanner
    Cynthia Menard
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bldg 10, Rm B3B69, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 59:1414-23. 2004
    ..This pilot study was performed to determine the feasibility and dosimetric quality achieved when placing high-dose-rate prostate brachytherapy catheters under MRI guidance in a standard "closed-bore" 1.5T scanner...
  57. ncbi request reprint Current status and future potential of advanced technologies in radiation oncology. Part 1. Challenges and resources
    Bhadrasain Vikram
    Clinical Radiation Oncology Branch, Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, Maryland 20852, USA
    Oncology (Williston Park) 23:279-83. 2009
    ..Part 2, which will appear in next month's issue of ONCOLOGY, will address the state of the science for each disease site...
  58. ncbi request reprint Modifying normal tissue damage postirradiation. Report of a workshop sponsored by the Radiation Research Program, National Cancer Institute, Bethesda, Maryland, September 6-8, 2000
    Helen B Stone
    Radiation Research Program, National Cancer Institute, 6130 Executive Boulevard, 6010, Bethesda, Maryland 20892 7440, USA
    Radiat Res 157:204-23. 2002
    ..New developments in biomedical imaging should provide useful tools in all these endeavors. The ultimate goals are to improve the quality of life and efficacy of treatment for cancer patients treated with radiotherapy...
  59. ncbi request reprint Development of investigational radiation modifiers
    A Dimitrios Colevas
    National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 95:646-51. 2003
  60. ncbi request reprint Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy
    Mala Chakraborty
    Laboratory of Tumor Immunology and Biology and Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:6338-47. 2003
    ....
  61. doi request reprint Rapid radiation dose assessment for radiological public health emergencies: roles of NIAID and BARDA
    Marcy B Grace
    Biomedical Advanced Research and Development Authority, Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC 20201, USA
    Health Phys 98:172-8. 2010
    ....
  62. pmc Lessons learned from radiation oncology clinical trials
    Fei Fei Liu
    Authors Affiliations Department of Radiation Oncology, Princess Margaret Cancer Center, Toronto, Ontario, Canada Department of Radiation Oncology, University of Florida Shands Cancer Center, Gainesville, Florida Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda Molecular Radiation Therapeutics Branch, Division of Cancer Treatment and Diagnosis, and Clinical Radiation Oncology Branch, National Cancer Institute, Rockville, Maryland Department of Radiation Oncology, Stanford University, Palo Alto, California Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa and Department of Radiation Oncology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York
    Clin Cancer Res 19:6089-100. 2013
    ..It is important to understand the reasons underlying such null results, however, to effectively merge the technologic innovations with the rapidly evolving biology for maximal patient benefit through the design of future clinical trials...
  63. ncbi request reprint New directions in brachytherapy
    Richard L Cumberlin
    Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, EPN 6002, Bethesda, MD 20892, USA corrected
    Int J Radiat Oncol Biol Phys 53:6-11. 2002
  64. pmc Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner
    David Cerna
    Molecular Radiation Therapeutics Branch Support, SAIC Frederick, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 287:22408-17. 2012
    ..Exposure to GMX1778 may be a novel way of inducing ROS selectively in NAPRT1-negative tumors without inducing cytotoxic ROS in normal tissue...
  65. ncbi request reprint A phase I trial of etanidazole and hyperfractionated radiotherapy in children with diffuse brainstem glioma
    Karen J Marcus
    Department of Medicine, Division of Radiation Oncology, Children s Hospital, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 55:1182-5. 2003
    ..To determine the toxicity and maximum tolerated dose of etanidazole administered concurrently with hyperfractionated radiation therapy (HRT) for children with brainstem glioma...
  66. ncbi request reprint Evaluation of hybridization conditions for spotted oligonucleotide-based DNA microarrays
    Mong Hsun Tsai
    Radiation Oncology Sciences Program, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 8717 Grovemont Cr, Room 109J, Gaithersburg, MD 20878, USA
    Mol Biotechnol 29:221-4. 2005
    ..Statistical analysis showed that better results were obtained when spotted, presynthesized long oligonucleotide arrays were blocked with succinic anhydride and hybridized at 42 degrees C in the presence of 50% formamide...
  67. ncbi request reprint CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment
    Andy Trotti
    H Lee Moffitt Cancer Center at the University of South Florida, Tampa, FL 33612, USA
    Semin Radiat Oncol 13:176-81. 2003
    ..This article updates recent progress in the evolution of adverse effects grading systems and reviews the development of CTCAE v3.0...
  68. ncbi request reprint Adverse event reporting and developments in radiation biology after normal tissue injury: International Atomic Energy Agency consultation
    Yuhchyau Chen
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8647, USA
    Int J Radiat Oncol Biol Phys 64:1442-51. 2006
    ....
  69. pmc System for prostate brachytherapy and biopsy in a standard 1.5 T MRI scanner
    Robert C Susil
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Magn Reson Med 52:683-7. 2004
    ..Because 1.5 T MR images are directly acquired during the interventional procedure, dependence on deformable registration is reduced and online image quality is maximized...
  70. ncbi request reprint Walking forward: the South Dakota Native American project
    Daniel G Petereit
    John T Vucurevich Cancer Institute, Rapid City, SD 57701, USA
    J Cancer Educ 20:65-70. 2005
    ..It is hypothesized that a conventional course of cancer treatment lasting 6 to 8 weeks may be a barrier...
  71. ncbi request reprint Molecular targets for radiation therapy: bringing preclinical data into clinical trials
    Philip J Tofilon
    Clin Cancer Res 9:3518-20. 2003
  72. ncbi request reprint Are radiation oncologists serious about systemic radiation therapy and if not, should we be?
    Paul E Wallner
    Int J Radiat Oncol Biol Phys 60:1-2. 2004
  73. ncbi request reprint Tumor hypoxia: chicken, egg, or a piece of the farm?
    C Norman Coleman
    J Clin Oncol 20:610-5. 2002
  74. ncbi request reprint Inflammatory breast issue
    C Norman Coleman
    J Natl Cancer Inst 95:1182-3. 2003