Affiliation: National Institutes of Health
- Pds1p of budding yeast has dual roles: inhibition of anaphase initiation and regulation of mitotic exitO Cohen-Fix
The Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive Kidney Diseases NIDDK, National Institutes of Health, Bethesda, Maryland 20982, USA
Genes Dev 13:1950-9. 1999..Finally, these observations provide a novel regulatory paradigm in which the sequential degradation of two substrates is determined by the substrates themselves, such that an early substrate inhibits the degradation of a later one...
- Sister chromatid separation: falling apart at the seamsO Cohen-Fix
The Laboratory of Molecular and Cellular Biology, NIDDK, NIH, 8 Center Drive, Bethesda, Maryland 20892 0840, USA
Curr Biol 10:R816-9. 2000..Recent studies reveal that the principles of cohesion dissolution in mitosis and meiosis are the same, but that there are important differences that stem from the distinct natures of these two processes...
- The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent mannerZ Hilioti
The Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Curr Biol 11:1347-52. 2001..We also find that Pds1 does not interact with Cdh1. Finally, the effect of spindle assembly checkpoint activation, known to inhibit APC/C function , on the Pds1-Cdc20 interaction is examined...