J L Cmarik
Affiliation: National Cancer Institute
- Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformationJ L Cmarik
Basic Research Laboratory, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 96:14037-42. 1999..The antisense-transfected cells were reverted to their initial P- phenotype by overexpression of a Pdcd4 sense fragment. These observations demonstrate that the Pdcd4 protein inhibits neoplastic transformation...
- A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-kappaB or ODC transactivationH S Yang
Gene Regulation Section, Basic Research Laboratory, National Cancer Institute, Frederick, MD 21702, USA
Oncogene 20:669-76. 2001..Pdcd4 may thus constitute a useful molecular target for cancer prevention...
- cDNA cloning and mapping of mouse pleckstrin (Plek), a gene upregulated in transformation-resistant cellsJ L Cmarik
Basic Research Laboratory, National Cancer Institute, Frederick, Maryland, 21702, USA
Genomics 66:204-12. 2000..We report the complete mouse cDNA sequence of pleckstrin and the localization of the gene to chromosome 11, its expression in a nonhematopoetic cell line, and its potential role in blocking neoplastic transformation...