Deborah E Citrin

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species
    Michael G Espey
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 962:195-206. 2002
  2. pmc Determination of cytokine protein levels in oral secretions in patients undergoing radiotherapy for head and neck malignancies
    Deborah E Citrin
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Radiat Oncol 7:64. 2012
  3. pmc Comparison of T2 and FLAIR imaging for target delineation in high grade gliomas
    Bronwyn Stall
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Radiat Oncol 5:5. 2010
  4. pmc A dosimetric comparison of four treatment planning methods for high grade glioma
    Leor Zach
    Radiation Oncology Branch, National Cancer Institute, 10 Center Drive Building 10, CRC, Bethesda, MD 20892, USA
    Radiat Oncol 4:45. 2009
  5. pmc Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin
    Ronan J Kelly
    Department of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    Mol Cancer 10:35. 2011
  6. pmc A pilot feasibility study of TNFerade™ biologic with capecitabine and radiation therapy followed by surgical resection for the treatment of rectal cancer
    Deborah Citrin
    Section of Translational Radiation Oncology, Radiation Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
    Oncology 79:382-8. 2010
  7. pmc Radioprotectors and mitigators of radiation-induced normal tissue injury
    Deborah Citrin
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Oncologist 15:360-71. 2010
  8. pmc Long-term outcomes and toxicity of concurrent paclitaxel and radiotherapy for locally advanced head-and-neck cancer
    Deborah Citrin
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 74:1040-6. 2009
  9. ncbi request reprint Inverse treatment planning based on MRI for HDR prostate brachytherapy
    Deborah Citrin
    Radiation Oncology Branch, CCR, NCI, National Institutes of Health, Department of Health and Human Services, Bldg 10, Rm B3B69, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 61:1267-75. 2005
  10. ncbi request reprint Combining radiotherapy and angiogenesis inhibitors: clinical trial design
    Deborah Citrin
    Radiation Oncology Branch, NCI, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 64:15-25. 2006

Detail Information

Publications47

  1. ncbi request reprint A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species
    Michael G Espey
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 962:195-206. 2002
    ..From this perspective of NO chemistry, the type, magnitude, location, and duration of either ROS or RNOS reactions may be predicted...
  2. pmc Determination of cytokine protein levels in oral secretions in patients undergoing radiotherapy for head and neck malignancies
    Deborah E Citrin
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Radiat Oncol 7:64. 2012
    ..The purpose of this pilot study was to determine the feasibility of measuring local salivary cytokine levels using buccal sponges in patients receiving chemo-radiation for head and neck malignancies...
  3. pmc Comparison of T2 and FLAIR imaging for target delineation in high grade gliomas
    Bronwyn Stall
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Radiat Oncol 5:5. 2010
    ..Although these sequences have inherent physical differences there is limited data on the clinical and dosimetric impact of using either or both sequences...
  4. pmc A dosimetric comparison of four treatment planning methods for high grade glioma
    Leor Zach
    Radiation Oncology Branch, National Cancer Institute, 10 Center Drive Building 10, CRC, Bethesda, MD 20892, USA
    Radiat Oncol 4:45. 2009
    ..The purpose of the current study was to compare normal tissue sparing and tumor coverage using four different radiotherapy planning methods in patients with high grade glioma...
  5. pmc Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin
    Ronan J Kelly
    Department of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    Mol Cancer 10:35. 2011
    ..This review discusses the complex circuitry of survivin in human cancers and highlights clinical trials involving novel agents that target this important protein...
  6. pmc A pilot feasibility study of TNFerade™ biologic with capecitabine and radiation therapy followed by surgical resection for the treatment of rectal cancer
    Deborah Citrin
    Section of Translational Radiation Oncology, Radiation Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
    Oncology 79:382-8. 2010
    ....
  7. pmc Radioprotectors and mitigators of radiation-induced normal tissue injury
    Deborah Citrin
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Oncologist 15:360-71. 2010
    ..Few agents are approved for clinical use, but many new compounds show promising results in preclinical testing...
  8. pmc Long-term outcomes and toxicity of concurrent paclitaxel and radiotherapy for locally advanced head-and-neck cancer
    Deborah Citrin
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 74:1040-6. 2009
    ..To report the long-term outcomes and toxicity of a regimen of infusion paclitaxel delivered concurrently with radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck...
  9. ncbi request reprint Inverse treatment planning based on MRI for HDR prostate brachytherapy
    Deborah Citrin
    Radiation Oncology Branch, CCR, NCI, National Institutes of Health, Department of Health and Human Services, Bldg 10, Rm B3B69, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 61:1267-75. 2005
    ..To develop and optimize a technique for inverse treatment planning based solely on magnetic resonance imaging (MRI) during high-dose-rate brachytherapy for prostate cancer...
  10. ncbi request reprint Combining radiotherapy and angiogenesis inhibitors: clinical trial design
    Deborah Citrin
    Radiation Oncology Branch, NCI, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 64:15-25. 2006
    ..We discuss important considerations for designing clinical trials of angiogenesis inhibitors with RT...
  11. ncbi request reprint Optical imaging of mice in oncologic research
    Deborah Citrin
    Imaging and Molecular Theraputics Section, Radiation Oncology and Vascular Biology Faculty, National Cancer Institute, Bethesda, MD USA
    Expert Rev Anticancer Ther 4:857-64. 2004
    ..Furthermore, the availability of mice genetically altered to express photo and fluorescent proteins have spurred tremendous growth in this area of research...
  12. pmc Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
    Steven A Rosenberg
    Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Clin Cancer Res 17:4550-7. 2011
    ..We investigated the ability of adoptive cell transfer utilizing autologous tumor-infiltrating lymphocytes (TIL) to mediate durable complete regressions in heavily pretreated patients with metastatic melanoma...
  13. pmc Early observed transient prostate-specific antigen elevations on a pilot study of external beam radiation therapy and fractionated MRI guided high dose rate brachytherapy boost
    Anurag K Singh
    Radiation Oncology Branch, National Cancer Institute, NIH DHHS, Bldg 10, CRC Rm B2 3561, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Radiat Oncol 1:28. 2006
    ..To report early observation of transient PSA elevations on this pilot study of external beam radiation therapy and magnetic resonance imaging (MRI) guided high dose rate (HDR) brachytherapy boost...
  14. pmc Role of type II pneumocyte senescence in radiation-induced lung fibrosis
    Deborah E Citrin
    Affiliations of authors Radiation Oncology Branch DEC, US, JAH, WS, SZ, HA, Ay, EJC and Radiation Biology Branch AS, AT, Center for Cancer Research, National Institutes of Health, Bethesda, MD
    J Natl Cancer Inst 105:1474-84. 2013
    ..Radiation is a commonly delivered therapeutic modality for cancer. The causes underlying the chronic, progressive nature of radiation injury in the lung are poorly understood...
  15. pmc Evaluation of the fullerene compound DF-1 as a radiation protector
    Aaron P Brown
    Radiation Oncology Branch, National Cancer Institute, Building 10 CRC B2 3500, Bethesda, MD 20892, USA
    Radiat Oncol 5:34. 2010
    ..The purpose of this study was to evaluate the radioprotective effects of DF-1 in a murine model of lethal total body irradiation and to assess for selective radioprotection of normal cells versus tumor cells...
  16. pmc Enhancement of 5-fluorouracil-induced in vitro and in vivo radiosensitization with MEK inhibition
    Mary Ellen Urick
    Radiation Oncology Branch and Radiation Biology Branch, National Institutes of Health, Bethesda, Maryland, USA
    Clin Cancer Res 17:5038-47. 2011
    ..We previously reported radiosensitization with selumetinib, an inhibitor of MEK1/2. The purpose of the current study was to evaluate if selumetinib could enhance radiosensitivity induced by 5-FU...
  17. pmc MEK1/2 inhibition enhances the radiosensitivity of cancer cells by downregulating survival and growth signals mediated by EGFR ligands
    Eun Joo Chung
    Section of Translational Radiation Oncology, Radiation Oncology Branch, National Institutes of Health, Bethesda 20892, MD, USA
    Int J Oncol 42:2028-36. 2013
    ..These data suggest that the inhibition of MEK1/2 with selumetinib may provide a mechanism to sensitize tumor cells to IR in a fashion that prevents the activation of the TGF-α autocrine loop following IR...
  18. doi request reprint Inhibition of radiation-induced skin fibrosis with imatinib
    Jason A Horton
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Int J Radiat Biol 89:162-70. 2013
    ..We tested the hypothesis that imatinib, a clinically available inhibitor of PDGFR-β, Mast/stem cell growth factor receptor (c-kit) and cAbl, would reduce the severity of dermal fibrosis in a murine model...
  19. pmc CD8+ enriched "young" tumor infiltrating lymphocytes can mediate regression of metastatic melanoma
    Mark E Dudley
    Surgery Branch and Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892 1201, USA
    Clin Cancer Res 16:6122-31. 2010
    ..However, the generation of a unique tumor-reactive TIL culture for each patient may be prohibitively difficult. We therefore investigated the clinical and immunologic impact of unscreened, CD8+ enriched "young" TIL...
  20. pmc Molecular and clinical responses in a pilot study of gefitinib with paclitaxel and radiation in locally advanced head-and-neck cancer
    Carter Van Waes
    Head and Neck Surgery Branch, National Institute of Deafness and Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Int J Radiat Oncol Biol Phys 77:447-54. 2010
    ....
  21. pmc Clinical biomarkers of angiogenesis inhibition
    Aaron P Brown
    National Institutes of Health, Building 10 3B42, Bethesda, MD 20892, USA
    Cancer Metastasis Rev 27:415-34. 2008
    ..We review currently available candidate biomarkers and surrogate markers of anti-angiogenic agent effect...
  22. pmc Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens
    Mark E Dudley
    Surgery Branch, National Cancer Institute, NIH, Bethesda, MD 20892 1201, USA
    J Clin Oncol 26:5233-9. 2008
    ..Here, we update that study and evaluate the safety and efficacy of two increased-intensity myeloablative lymphodepleting regimens...
  23. doi request reprint Surgical management of melanoma brain metastases in patients treated with immunotherapy
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 3D20, Bethesda, Maryland 20892, USA
    J Neurosurg 115:30-6. 2011
    ..The authors undertook this study to determine the effectiveness of resection and the effects of immunotherapy on brain metastasis management...
  24. doi request reprint Mesenchymal stem cells inhibit cutaneous radiation-induced fibrosis by suppressing chronic inflammation
    Jason A Horton
    Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Stem Cells 31:2231-41. 2013
    ..Taken together, these data demonstrate that systemic infusion of BMSC can durably alter the progression of radiation-induced fibrosis by altering macrophage phenotype and suppressing local inflammation in a TNF-R2-dependent fashion...
  25. pmc Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction
    Bruce J Baum
    Molecular Physiology and Therapeutics Branch, and Neurobiology and Pain Therapeutics Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:19403-7. 2012
    ..AdhAQP1 vector delivery to a single parotid gland was safe and transfer of the hAQP1 cDNA increased parotid flow and relieved symptoms in a subset of subjects...
  26. ncbi request reprint In vivo tumor imaging in mice with near-infrared labeled endostatin
    Deborah Citrin
    Imaging and Molecular Therapeutics Section, Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Mol Cancer Ther 3:481-8. 2004
    ..5 will migrate from a distant i.p. injection site to a tumor. These data indicate that endostatin-Cy5.5 is appropriate for selectively imaging tumors in uninjured experimental animals...
  27. pmc In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762
    James B Mitchell
    Radiation Biology and Radiation Oncology Branches, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Clin Cancer Res 16:2076-84. 2010
    ..A novel checkpoint kinase 1/2 inhibitor, AZD7762, was evaluated for potential enhancement of radiosensitivity for human tumor cells in vitro and in vivo xenografts...
  28. ncbi request reprint Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation
    Hisataka Kobayashi
    Metabolism Branch, Radiation Biology Branch, and Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 1002, USA
    Clin Cancer Res 10:7712-20. 2004
    ..Such information might be applied to optimize the efficacy of subsequent or concurrent therapies including radiolabeled antibodies or other anticancer agents in combination with external beam therapies...
  29. doi request reprint A novel analytical approach to the prediction of respiratory diaphragm motion based on external torso volume change
    Guang Li
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Phys Med Biol 54:4113-30. 2009
    ..This analytical approach provides a patient-independent technique to calculate the patient-specific diaphragm motion, using the anatomical and respiratory volumetric constraints...
  30. ncbi request reprint Accuracy of 3D volumetric image registration based on CT, MR and PET/CT phantom experiments
    Guang Li
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD, USA
    J Appl Clin Med Phys 9:2781. 2008
    ..35 mm for PET/CT images. This accuracy is consistent with the detection limit, suggesting an absence of detectable systematic error. This 3DVIR technique provides a superior alternative to the 3P fusion method for clinical applications...
  31. ncbi request reprint In vivo tumor imaging using a near-infrared-labeled endostatin molecule
    Deborah Citrin
    Imaging and Molecular Therapeutics Section, Radiation Oncology Branch, National Cancer Institute NIH, Building 10, 10 Center Drive, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 58:536-41. 2004
    ..The goal of this study was to determine whether endostatin labeled with a NIR probe (Cy5.5) could be detected in an animal after intraperitoneal injection and whether it would selectively localize in a tumor...
  32. pmc Post-collection, pre-measurement variables affecting VEGF levels in urine biospecimens
    Robert M Hayward
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1002, USA
    J Cell Mol Med 12:343-50. 2008
    ..In addition, we recommend the use of samples within five freeze-thaw cycles...
  33. pmc In vitro and in vivo radiosensitization with AZD6244 (ARRY-142886), an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase
    Eun Joo Chung
    Office of the Director, NIH, Bethesda, MD, USA
    Clin Cancer Res 15:3050-7. 2009
    ..The MAP kinase pathway is also activated after exposure to ionizing radiation. We investigated the effects of AZD6244 (ARRY-142886), an inhibitor of MAP kinase/extracellular signal-regulated kinase 1/2, on radiation response...
  34. ncbi request reprint A dosimetric analysis of dose escalation using two intensity-modulated radiation therapy techniques in locally advanced pancreatic carcinoma
    Michael W Brown
    Radiation Oncology Branch, CCR, National Institutes of Health, Bethesda, MD 20892 1002, USA
    Int J Radiat Oncol Biol Phys 65:274-83. 2006
    ..To perform an analysis of three-dimensional conformal radiation therapy (3D-CRT), sequential boost intensity-modulated radiation therapy (IMRTs), and integrated boost IMRT (IMRTi) for dose escalation in unresectable pancreatic carcinoma...
  35. pmc Increased intensity lymphodepletion and adoptive immunotherapy--how far can we go?
    Pawel Muranski
    Clinical Research Center, National Institutes of Health, Room 3 5762, Bethesda, MD 20892, USA
    Nat Clin Pract Oncol 3:668-81. 2006
    ..We also address safety issues associated with translating experimental animal results of total lymphoid ablation into clinical practice...
  36. ncbi request reprint Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation
    Douglas D Thomas
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Antioxid Redox Signal 5:307-17. 2003
    ..Here the basic chemistry of nitrosylation and the interactions of NO and other nitrogen oxides with metal-oxo species such as found in peroxidases and monoxygenases are discussed...
  37. ncbi request reprint Advancement of antiangiogenic and vascular disrupting agents combined with radiation
    Deborah Citrin
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD, USA
    Cancer Treat Res 139:153-71. 2008
  38. doi request reprint Localization of sclerotic-type chronic graft-vs-host disease to sites of skin injury: potential insight into the mechanism of isomorphic and isotopic responses
    Kathryn J Martires
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892, USA
    Arch Dermatol 147:1081-6. 2011
    ....
  39. ncbi request reprint Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS
    Katrina M Miranda
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room B3 B69, Bethesda, MD 20892, USA
    J Inorg Biochem 93:52-60. 2003
    ....
  40. ncbi request reprint A pilot trial of a carcinoembryonic antigen/ TRICOM-based vaccine and radiation to liver metastases in patients with carcinoembryonic antigen-positive solid tumors
    Christoph M Ahlers
    Medical Oncology Branch, Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health 20892, USA
    Clin Colorectal Cancer 6:72-5. 2006
  41. pmc Craniospinal irradiation with spinal IMRT to improve target homogeneity
    Atmaram Pai Panandiker
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 68:1402-9. 2007
    ..To report a new technique for the spinal component of craniospinal irradiation (CSI) in the supine position, to describe a verification procedure for this method, and to compare this technique with conventional plans...
  42. doi request reprint Quantitative prediction of respiratory tidal volume based on the external torso volume change: a potential volumetric surrogate
    Guang Li
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Phys Med Biol 54:1963-78. 2009
    ..28 +/- 0.44 and 0.82 +/- 0.30, respectively) and location-dependent phase shifts. This novel approach establishes the foundation for developing an external volumetric respiratory surrogate...
  43. pmc The role of radiation therapy in the management of sarcomas
    Aradhana Kaushal
    Radiation Oncology Branch, National Cancer Center, National Cancer Institute, Building 10, Hatfield CRC, B2 3500, 10 Center Drive, Bethesda, MD 20892, USA
    Surg Clin North Am 88:629-46, viii. 2008
    ..Finally, the authors describe current controversies surrounding the appropriate management of sarcomas with radiotherapy and describe ongoing studies and future areas of research...
  44. ncbi request reprint Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems
    Douglas D Thomas
    Tumor Biology Section, Radiation Biology Branch, National Institutes of Health National Cancer Institute, Bethesda, Maryland 20892, USA
    Methods Enzymol 359:84-105. 2002
  45. pmc Performing nondiagnostic research biopsies in irradiated tissue: a review of scientific, clinical, and ethical considerations
    Aaron P Brown
    Radiation Oncology Branch, National Cancer Institute, 10 CRC, B2 3500, Bethesda, MD 20892, USA
    J Clin Oncol 26:3987-94. 2008
    ....
  46. doi request reprint Urine analysis and protein networking identify met as a marker of metastatic prostate cancer
    Andrea L Russo
    Radiation Oncology Branch, National Cancer Institute, H Lee Moffitt Cancer Center, Tampa, Florida, USA
    Clin Cancer Res 15:4292-8. 2009
    ..Metastatic prostate cancer is a major cause of death of men in the United States. Expression of met, a receptor tyrosine kinase, has been associated with progression of prostate cancer...
  47. ncbi request reprint Implications for tumor control during protection of normal tissues with antioxidants
    Kevin Camphausen
    J Clin Oncol 23:5455-7. 2005