Research Topics
Genomes and Genes | John A CidlowskiSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Glucocorticoids and their actions in cellsJohn A Cidlowski
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Retina 29:S21-3. 2009..Recent progress predicts an increasing precision with which GC steroids can be used to influence biologic functions...
Ligand-independent phosphorylation of the glucocorticoid receptor integrates cellular stress pathways with nuclear receptor signalingAmy Jo Galliher-Beckley
Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Mol Cell Biol 31:4663-75. 2011..This posttranslational modification allows prior cellular stress signals to dictate the transcriptional response to glucocorticoids...
Functional analysis of the LXXLL motifs of the human glucocorticoid receptor: association with altered ligand affinityDiane D Dong
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, United States
J Steroid Biochem Mol Biol 101:106-17. 2006..These data suggest that although LXXLL motifs in helices 1 and 10 appear to lie outside the predicted ligand binding pocket they may contribute to receptor ligand binding affinity...- Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genesNick Z Lu
Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Mol Cell 18:331-42. 2005..Based on these observations, we propose that cell-type specific GR isoforms generate specificity in glucocorticoid control of transcription in different tissues... - Human glucocorticoid receptor beta binds RU-486 and is transcriptionally activeLaura J Lewis Tuffin
Laboratory of Signal Transduciton, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Mol Cell Biol 27:2266-82. 2007.... - Ligand-selective targeting of the glucocorticoid receptor to nuclear subdomains is associated with decreased receptor mobilityMarcel J M Schaaf
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Mol Endocrinol 19:1501-15. 2005..Thus, glucocorticoid receptors can be targeted (depending on the ligand) to relatively immobile nuclear subdomains. The transient association of receptor with these domains decreases the mobility of the receptor... - Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptorNick Z Lu
Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Mol Cell Biol 27:7143-60. 2007..Together, these findings provide new evidence that translational glucocorticoid receptor isoforms can elicit distinct glucocorticoid responses and may be useful for the development of safe glucocorticoids with reduced side effects... - Molecular evidence for a link between the N363S glucocorticoid receptor polymorphism and altered gene expressionChristine M Jewell
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD F3 07, Research Triangle Park, North Carolina 27709, USA
J Clin Endocrinol Metab 92:3268-77. 2007..However, molecular studies in vitro using reporter gene expression systems have failed, for the most part, to define a link between this polymorphism and altered glucocorticoid receptor function... - Development of a flow cytometric assay to study glucocorticoid receptor-mediated gene activation in living cellsBrian M Necela
Department of Health and Human Services, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Building 101, MD F3-07, Research Triangle Park, NC 27709, USA
Steroids 68:341-50. 2003..Taken together, these data suggest the reporter-based flow cytometry assay is an effective method for analyzing glucocorticoid receptor-mediated gene expression at the single cell level in living cells... - Molecular origins for the dominant negative function of human glucocorticoid receptor betaMatthew R Yudt
Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Mol Cell Biol 23:4319-30. 2003..Molecular modeling of wild-type and mutant hGRalpha and hGRbeta provides structural insight and a potential physical explanation for the lack of hormone binding and the dominant negative actions of hGRbeta... - Activation of intrinsic and extrinsic pathways in apoptotic signaling during UV-C-induced death of Jurkat cells: the role of caspase inhibitionAlyson B Scoltock
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, NC 27709, USA
Exp Cell Res 297:212-23. 2004..Thus, both intrinsic and extrinsic pathways are activated during UV-induced apoptosis in Jurkat cells and this redundancy appears to assure cell death during selective caspase inhibition... - Complex human glucocorticoid receptor dim mutations define glucocorticoid induced apoptotic resistance in bone cellsChristine M Jewell
National Institute of Environmental Health Sciences National Institutes of Health, Laboratory of Signal Transduction, Research Triangle Park, North Carolina 27709, USA
Mol Endocrinol 26:244-56. 2012..These studies challenge conclusions drawn from previous studies of GR dim mutants... - Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistanceKatherine L Gross
Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Mol Endocrinol 25:1087-99. 2011..These data suggest that the N-terminal translational isoforms of GRα selectively regulate antiapoptotic genes and that the GRα-D isoform may contribute to the resistance of certain cancer cells to glucocorticoid-induced apoptosis... - DAX-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X-chromosome, gene 1) selectively inhibits transactivation but not transrepression mediated by the glucocorticoid receptor in a LXXLL-dependent mannerJunguo Zhou
Laboratory of Signal Transduction, NIEHS NIH, Research Triangle Park, NC 27709, USA
Mol Endocrinol 22:1521-34. 2008..Thus we demonstrate that DAX-1 directly modulates GR signaling in addition to affecting glucocorticoid hormone levels... - Glutathione depletion and disruption of intracellular ionic homeostasis regulate lymphoid cell apoptosisRodrigo Franco
Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 283:36071-87. 2008..These results suggest that deregulation of GSH and ionic homeostasis converge in the regulation of apoptosis in lymphoid cells... - Stimulation of Kv1.3 potassium channels by death receptors during apoptosis in Jurkat T lymphocytesNina M Storey
Membrane Signaling Group, Laboratory of Signal Transduction, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 278:33319-26. 2003..Thus, Fas ligand increases Kv1.3 channel activity through the same canonical apoptotic signaling cascade that is required for potassium efflux, cell shrinkage, and apoptosis... - Glucocorticoid receptor isoforms generate transcription specificityNick Z Lu
Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH/DHHS, Research Triangle Park, NC 27709, USA
Trends Cell Biol 16:301-7. 2006..Here, we discuss a new molecular model potentially underlying tissue-specific glucocorticoid resistance and selectivity... - Ouabain-induced perturbations in intracellular ionic homeostasis regulate death receptor-mediated apoptosisMihalis I Panayiotidis
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health, Research Triangle Park, NC, 27709, USA
Apoptosis 15:834-49. 2010..Our data suggest that the impairment of the Na(+)-K(+)-ATPase activity during apoptosis is linked to perturbations in cell Ca(2+) homeostasis that modulate apoptosis induced by the activation of Fas by FasL... - Selective role of intracellular chloride in the regulation of the intrinsic but not extrinsic pathway of apoptosis in Jurkat T-cellsGerd Heimlich
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences/NIH, Research Triangle Park, NC 27709, USA
J Biol Chem 281:2232-41. 2006..Thus, an alteration of intracellular chloride plays an important role in the activation of signaling molecules upstream of the mitochondria, specifically impairing the intrinsic but not extrinsic apoptotic pathway... - Cationic gradient reversal and cytoskeleton-independent volume regulatory pathways define an early stage of apoptosisCarl D Bortner
Laboratory of Signal Transduction, National Institutes of Health Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 283:7219-29. 2008..Together these studies demonstrate that AVD occurs in two distinct stages with the earliest stage reflecting a cellular cationic gradient reversal... - The human glucocorticoid receptor: one gene, multiple proteins and diverse responsesJunguo Zhou
Molecular Endocrinology Group, The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences NIEHS NIH, DHHS, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
Steroids 70:407-17. 2005..We speculate that the composition and proportion of individual isoforms expressed in particular cellular contexts account for the diverse effects of glucocorticoid hormones... - New approaches for determining apoptotic volume decrease in cellsCarl D Bortner
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Department of Health and Human Services, National Institutes of Health, Research Triangle Park, North Carolina, USA
Methods Enzymol 428:161-81. 2007..This chapter describes several methods for using the Cell Lab Quanta SC to study AVD during apoptosis... - An endogenous calcium-dependent, caspase-independent intranuclear degradation pathway in thymocyte nuclei: antagonism by physiological concentrations of K(+) ionsKozo Ajiro
Laboratory of Signal Transduction, National Institute of Environmental Health Science, National Institute of Health, Research Triangle Park, NC 27709, USA
Exp Cell Res 314:1237-49. 2008..Together, these data define an inherent caspase-independent catabolic pathway in thymocyte nuclei that is sensitive to physiological concentrations of intracellular cations... - Sexually dimorphic actions of glucocorticoids provide a link to inflammatory diseases with gender differences in prevalenceDanielle Duma
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, MD F3 07, Research Triangle Park, NC 27709, USA
Sci Signal 3:ra74. 2010..These gender-specific actions of glucocorticoids in liver were substantiated in vivo with a sepsis model of systemic inflammation... - Uncoupling cell shrinkage from apoptosis reveals that Na+ influx is required for volume loss during programmed cell deathCarl D Bortner
Laboratory of Signal Transduction, NIEHS, Department of Health and Human Services, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 278:39176-84. 2003..Therefore cell shrinkage can be separated from other features of apoptosis... - Molecular mechanisms of glucocorticoid action and resistanceMarcel J M Schaaf
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, P.O. Box 12233, Research Triangle Park, NC 27709, USA
J Steroid Biochem Mol Biol 83:37-48. 2002..It has been shown that these mechanisms can significantly inhibit glucocorticoid signaling, and could therefore seriously decrease the efficacy of glucocorticoids used clinically... - Estradiol antagonism of glucocorticoid-induced GILZ expression in human uterine epithelial cells and murine uterusShannon Whirledge
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Endocrinology 154:499-510. 2013..Regulation of the antiinflammatory gene GILZ by glucocorticoids and E(2) suggests cross talk between the immune modulating functions of glucocorticoids and the reproductive actions of estradiol signaling... - Proinflammatory actions of glucocorticoids: glucocorticoids and TNFα coregulate gene expression in vitro and in vivoErica A Lannan
Laboratory of Signal Transduction, National Institutes of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, North Carolina 27709, USA
Endocrinology 153:3701-12. 2012..This discovery may underlie the basis of some of the adverse effects associated with long-term glucocorticoid therapy... - Osmotic stress resistance imparts acquired anti-apoptotic mechanisms in lymphocytesCarl D Bortner
Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 287:6284-95. 2012..These results define a critical role of volume regulation mechanisms in apoptotic resistance... - Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modificationDanielle Duma
Laboratory of Signal Transduction, Molecular Endocrinology Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Steroid Biochem Mol Biol 102:11-21. 2006..We outline the recent advances made in identifying the processes that generate and modify multiple GR isoforms and the post-translational modifications that contribute to the increasing diversity in the glucocorticoid signaling pathway... - Glucocorticoids regulate tristetraprolin synthesis and posttranscriptionally regulate tumor necrosis factor alpha inflammatory signalingKathleen Smoak
Department of Health and Human Services, Laboratory of Signal Transduction, National Institute of Environmental Health Services, National Institutes of Health, Building 101, Research Triangle Park, NC 27709, USA
Mol Cell Biol 26:9126-35. 2006..These studies provide the molecular evidence for glucocorticoid regulation of human TTP and reflect a novel inductive anti-inflammatory signaling pathway for glucocorticoids that acts via posttranscriptional mechanisms... - Glucocorticoids modulate microRNA expression and processing during lymphocyte apoptosisLindsay K Smith
Molecular Endocrinology Group, Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 285:36698-708. 2010.... - Dual role for glucocorticoids in cardiomyocyte hypertrophy and apoptosisRongqin Ren
Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Endocrinology 153:5346-60. 2012..These studies reveal a direct and dynamic role for glucocorticoids and GR signaling in the modulation of cardiomyocyte function... - Molecular mechanisms regulating glucocorticoid sensitivity and resistanceKatherine L Gross
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
Mol Cell Endocrinol 300:7-16. 2009..The potential role of glucocorticoid receptor isoforms in determining cellular responsiveness to glucocorticoids is emphasized... - Mechanisms of glucocorticoid receptor action in noninflammatory and inflammatory cellsBrian M Necela
Laboratory of Signal Transduction, Building 101, MD F3-07, National Institute of Environmental Health Sciences/NIH, Research Triangle Park, NC 27709, USA
Proc Am Thorac Soc 1:239-46. 2004 - Life and death of lymphocytes: a volume regulation affairCarl D Bortner
The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
Cell Physiol Biochem 28:1079-88. 2011..Here we review studies that suggest that AVD plays an active role during apoptosis and the underlying flux of ions that results in this morphological event regulates the programmed cell death process... - Cell shrinkage and monovalent cation fluxes: role in apoptosisCarl D Bortner
The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Department of Health and Human Services, National Institutes of Health, Research Triangle Park, NC 27709, USA
Arch Biochem Biophys 462:176-88. 2007..This review examines the relationship between this morphological change and intracellular monovalent ions during apoptosis... - Apoptosis and cell volume regulation: the importance of ions and ion channelsGerd Heimlich
National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Adv Exp Med Biol 559:189-203. 2004 - The origin and functions of multiple human glucocorticoid receptor isoformsNick Z Lu
The Laboratory of Signal Transduction, Molecular Endocrinology Group, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
Ann N Y Acad Sci 1024:102-23. 2004..Unchecked expression of some isoforms, for example hGRbeta, has been implicated in various diseases... - A single amino acid change in the first zinc finger of the DNA binding domain of the glucocorticoid receptor regulates differential promoter selectivityBrian M Necela
Laboratory of Signal Transduction, NIEHS, and Department of Health and Human Services, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 279:39279-88. 2004..Our findings support a model by which the presence of a valine residue at position 437 of mGR induces a conformational change that leads to alterations in affinity and/or transcriptional activation in a promoter-dependent context... - The role of apoptotic volume decrease and ionic homeostasis in the activation and repression of apoptosisCarl D Bortner
The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Department of Health and Human Services, National Institutes of Health, Research Triangle Park, NC 27709, USA
Pflugers Arch 448:313-8. 2004..On going studies continue to support the hypothesis that the change in intracellular ions can alter a cells decision to die by apoptosis... - Glucocorticoids and tumor necrosis factor alpha cooperatively regulate toll-like receptor 2 gene expressionMarcela A Hermoso
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Mol Cell Biol 24:4743-56. 2004..Together, these studies define novel signaling mechanism for these three transcription factors, with a profound impact on discrimination of innate and adaptive immune responses... - Mechanisms of glucocorticoid receptor signaling during inflammationKathleen A Smoak
Department of Health and Human Services, Laboratory of Signal Transduction, National Institute of Environmental Health Services, National Institutes of Health, Building 101, Research Triangle Park, NC 27709, USA
Mech Ageing Dev 125:697-706. 2004..In this review, we discuss the molecular mechanisms underlying GR inhibition of inflammatory responses, with an emphasis on repression of NF-kappaB and AP-1 and their respective signaling pathways... - Molecular determinants of glucocorticoid receptor mobility in living cells: the importance of ligand affinityMarcel J M Schaaf
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH DHHS, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
Mol Cell Biol 23:1922-34. 2003..In addition, this conformational change blocks immobilization of the receptor by MG132... - Glucocorticoids regulate arrestin gene expression and redirect the signaling profile of G protein-coupled receptorsRobert H Oakley
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Proc Natl Acad Sci U S A 109:17591-6. 2012.... - Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoidsRobert H Oakley
Laboratory of Signal Transduction, NIEHS, National Institutes of Heath, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 286:3177-84. 2011..Here, we discuss the origin and molecular properties of the GR isoforms and their contribution to the sensitivity and specificity of the glucocorticoid response... - Glucocorticoid-induced apoptosis of healthy and malignant lymphocytesLindsay K Smith
Molecular Endocrinology Group, Laboratory of Signal Transduction, NIEHS, NIH, DHHS, Research Triangle Park, NC, USA
Prog Brain Res 182:1-30. 2010..The development of novel therapies designed to overcome glucocorticoid resistance will dramatically improve the efficacy of glucocorticoid therapy in the treatment of haematological malignancies... - Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formationRodrigo Franco
Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 282:30452-65. 2007..These results document a necessary and critical role for GSH loss in apoptosis and clearly uncouple for the first time GSH depletion from ROS formation... - Estrogens and glucocorticoids have opposing effects on the amount and latent activity of complement proteins in the rat uterusTurk Rhen
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Biol Reprod 74:265-74. 2006.... - The physiology of human glucocorticoid receptor beta (hGRbeta) and glucocorticoid resistanceLaura J Lewis-Tuffin
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, P.O. Box 12233, Research Triangle Park, NC 27709, USA
Ann N Y Acad Sci 1069:1-9. 2006..Higher ratios correlate with glucocorticoid sensitivity, while lower ratios correlate with glucocorticoid resistance. Thus hGRbeta can be an important modulator of glucocorticoid responsiveness... - Dexamethasone blocks the rapid biological effects of 17beta-estradiol in the rat uterus without antagonizing its global genomic actionsTurk Rhen
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Dr, Research Triangle Park, North Carolina 27709, USA
FASEB J 17:1849-70. 2003..Together, these results indicate strong discord between the early biologic and genomic actions of estrogens and glucocorticoids and highlight a complex regulatory role for glucocorticoids and GR in the mammalian uterus... - Emerging roles of glucocorticoid receptor phosphorylation in modulating glucocorticoid hormone action in health and diseaseAmy J Galliher-Beckley
Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
IUBMB Life 61:979-86. 2009..In doing so, we will review current knowledge about each phosphorylated residue within the GR and their contributions to modulating GC signaling in normal homeostatic physiology and during the progression of disease... - Cell volume and ion changes during apoptotic cell deathMireia Gómez-Angelats
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Adv Cancer Res 85:175-201. 2002 - Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasomeJohn M Busillo
Department of Health and Human Services, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 286:38703-13. 2011..This effect was specific for glucocorticoids and dependent on the glucocorticoid receptor. These studies demonstrate a novel role for glucocorticoids in sensitizing the initial inflammatory response by the innate immune system... - Tissue-specific glucocorticoid action: a family affairKatherine L Gross
Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Trends Endocrinol Metab 19:331-9. 2008..Furthermore, we evaluate the impact of tissue- and individual-specific diversity in the glucocorticoid pathway on human health and disease... - Mechanisms generating diversity in glucocorticoid receptor signalingJavier R Revollo
Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences NIEHS NIH, Research Triangle Park, North Carolina, USA
Ann N Y Acad Sci 1179:167-78. 2009..In this chapter, we review the biological and physiological implications of glucocorticoids, the GR, and many of the signal transduction mechanisms that mediate their action... - International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptorsNick Z Lu
Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Pharmacol Rev 58:782-97. 2006 - Cellular mechanisms for the repression of apoptosisCarl D Bortner
The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Annu Rev Pharmacol Toxicol 42:259-81. 2002..In this review, we examine several modes of repression of apoptosis that exist in cells... - Glucocorticoids regulate gene expression and repress cellular proliferation in human uterine leiomyoma cellsShannon Whirledge
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
Horm Cancer 3:79-92. 2012.... - The glucocorticoid receptor: coding a diversity of proteins and responses through a single geneMatthew R Yudt
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709 2233, USA
Mol Endocrinol 16:1719-26. 2002..We propose that the multiplicity of receptor forms have unique tissue- specific actions on the downstream biology providing a mechanism to create GR signaling networks... - SLCO/OATP-like transport of glutathione in FasL-induced apoptosis: glutathione efflux is coupled to an organic anion exchange and is necessary for the progression of the execution phase of apoptosisRodrigo Franco
Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 281:29542-57. 2006..Together these results suggest that GSH efflux during FasL-induced apoptosis is mediated by a SLCO/OATP-like transport mechanism that modulates the progression of the execution phase of apoptosis... - Phosphorylation status modulates Bcl-2 function during glucocorticoid-induced apoptosis in T lymphocytesSe Te J Huang
The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
FASEB J 16:825-32. 2002..Mutation of T74 only partially impaired the ability of Bcl-2 to block glucocorticoid-induced apoptosis whereas mutation of S70 in Bcl-2 did not alter its ability to block glucocorticoid-induced apoptosis... - Crystallization of the human glucocorticoid receptor ligand binding domain: a step towards selective glucocorticoidsBrian M Necela
Laboratory of Signal Transduction, Building 101, MD F3-07, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Trends Pharmacol Sci 24:58-61. 2003..The GR ligand binding domain also has a steroid binding pocket that is distinct from other nuclear receptors and might explain its selectivity for glucocorticoids and its diversity of responses... - Molecular interplay between ion channels and the regulation of apoptosisMona A Razik
Laboratory of Signal Transduction, Molecular Endocrinology Group, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
Biol Res 35:203-7. 2002..Understanding the components and steps involved in this intricate process can further our insight to diseases and reveal new approaches for therapeutic treatment... - Putting the brake on inflammatory responses: the role of glucocorticoidsMarcela A Hermoso
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
IUBMB Life 55:497-504. 2003..In this article, we discuss the physiological and molecular interaction that occurs between GR and proinflammatory cytokines signaling pathways... - Cell volume control and signal transduction in apoptosisMireia Gómez-Angelats
The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 30:541-51. 2002..In this review, we will focus on the importance of the apoptotic volume decrease in the context of signaling and modulation of programmed cell death...