Jay H Chung

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc AMPK regulates circadian rhythms in a tissue- and isoform-specific manner
    Jee Hyun Um
    Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e18450. 2011
  2. pmc CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage
    Hyeog Kang
    Laboratory of Biochemical Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 4:e6611. 2009
  3. pmc AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol
    Jee Hyun Um
    Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes 59:554-63. 2010
  4. pmc Resveratrol as a calorie restriction mimetic: therapeutic implications
    Jay H Chung
    Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Cell Biol 22:546-54. 2012
  5. pmc Using PDE inhibitors to harness the benefits of calorie restriction: lessons from resveratrol
    Jay H Chung
    Laboratory of Obesity and Aging Research, Genetics andDevelopmental Biology Center, National Heart Lung and BloodInstitute, National Institutes of Health, Bethesda, MD 20892, USA
    Aging (Albany NY) 4:144-5. 2012
  6. ncbi request reprint Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2
    Jee Hyun Um
    Laboratory of Biochemical Genetics, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:20794-8. 2007
  7. ncbi request reprint ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis
    Yeonsoo Joe
    Laboratory of Biochemical Genetics, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:28764-71. 2006
  8. pmc Promyelocytic leukemia inhibits adipogenesis, and loss of promyelocytic leukemia results in fat accumulation in mice
    Myung K Kim
    Laboratory of Obesity and Aging Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol Endocrinol Metab 301:E1130-42. 2011
  9. pmc The role of mPer2 clock gene in glucocorticoid and feeding rhythms
    Shutong Yang
    Laboratory of Biochemical Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 150:2153-60. 2009
  10. pmc Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
    Sung Jun Park
    Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 148:421-33. 2012

Collaborators

Detail Information

Publications17

  1. pmc AMPK regulates circadian rhythms in a tissue- and isoform-specific manner
    Jee Hyun Um
    Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e18450. 2011
    ..However, it is not known whether the catalytic activity of AMPK actually regulates circadian rhythm in vivo...
  2. pmc CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage
    Hyeog Kang
    Laboratory of Biochemical Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 4:e6611. 2009
    ..Since expression of both CK2 and SIRT1 is upregulated with tumorigenesis and downregulated with senescence, the CK2-SIRT1 link sheds new light on how CK2 may regulate cancer development and aging...
  3. pmc AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol
    Jee Hyun Um
    Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes 59:554-63. 2010
    ..Here, we use mice deficient in AMPKalpha1 or -alpha2 to determine whether the metabolic effects of resveratrol are mediated by AMPK...
  4. pmc Resveratrol as a calorie restriction mimetic: therapeutic implications
    Jay H Chung
    Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Cell Biol 22:546-54. 2012
    ..Here, we review the current literature on the metabolic and cardiovascular effects of resveratrol and attempt to shed light on the controversies surrounding its action...
  5. pmc Using PDE inhibitors to harness the benefits of calorie restriction: lessons from resveratrol
    Jay H Chung
    Laboratory of Obesity and Aging Research, Genetics andDevelopmental Biology Center, National Heart Lung and BloodInstitute, National Institutes of Health, Bethesda, MD 20892, USA
    Aging (Albany NY) 4:144-5. 2012
    ..In conclusion, the discovery of the resveratrol-PDE link suggests that PDE4 inhibitors, possibly in combination with other PDE inhibitors, may be useful for mimicking CR and for treating aging-related diseases...
  6. ncbi request reprint Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2
    Jee Hyun Um
    Laboratory of Biochemical Genetics, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:20794-8. 2007
    ..We conclude that metformin and AMPK have a previously unrecognized role in regulating the circadian rhythm...
  7. ncbi request reprint ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis
    Yeonsoo Joe
    Laboratory of Biochemical Genetics, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:28764-71. 2006
    ....
  8. pmc Promyelocytic leukemia inhibits adipogenesis, and loss of promyelocytic leukemia results in fat accumulation in mice
    Myung K Kim
    Laboratory of Obesity and Aging Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol Endocrinol Metab 301:E1130-42. 2011
    ....
  9. pmc The role of mPer2 clock gene in glucocorticoid and feeding rhythms
    Shutong Yang
    Laboratory of Biochemical Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 150:2153-60. 2009
    ....
  10. pmc Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
    Sung Jun Park
    Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 148:421-33. 2012
    ..Therefore, administration of PDE4 inhibitors may also protect against and ameliorate the symptoms of metabolic diseases associated with aging...
  11. pmc Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination
    Jee Hyun Um
    Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 110:9873-8. 2013
    ..Our results suggest that V(D)J recombination can be regulated by AMPK activation, providing a potential new link between metabolic stress and development of B and T lymphocytes...
  12. pmc Peptide switch is essential for Sirt1 deacetylase activity
    Hyeog Kang
    Laboratory of Obesity and Aging Research, Genetics and Development Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 44:203-13. 2011
    ..Therefore, the ESA region is a potential target for development of therapies to regulate Sirt1...
  13. ncbi request reprint Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation
    Shutong Yang
    Laboratory of Biochemical Genetics, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:26645-54. 2006
    ..Thus, by fusing PML with RARalpha, the APL cells appear to have achieved functional suppression of Chk2 compromising the Chk2-p53 apoptotic pathway...
  14. ncbi request reprint Human T-cell leukemia virus type 1 Tax interacts with Chk1 and attenuates DNA-damage induced G2 arrest mediated by Chk1
    Hyeon Ung Park
    Virus Tumor Biology Section, Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 23:4966-74. 2004
    ..The G(2) arrest did not require Chk2 or p53. These studies provide the first example of a viral transforming protein targeting Chk1 and provide important insights into checkpoint pathway regulation...
  15. ncbi request reprint Oxygen tension regulates the stability of insulin receptor substrate-1 (IRS-1) through caspase-mediated cleavage
    Sung Gyun Kang
    Laboratory of Biochemical Genetics, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:6090-7. 2007
    ..In conclusion, our study elucidates a mechanism by which insulin and IGF-1 signaling can be matched to the oxygen level that is available to support growth and energy metabolism...
  16. pmc Epigallocatechin gallate induces expression of heme oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-α
    Philomena Pullikotil
    Diabetes Unit, National Center for Complementary and Alternative Medicine, Bethesda, MD 20892, USA
    J Nutr Biochem 23:1134-45. 2012
    ..Increased HO-1 expression may underlie anti-inflammatory actions of EGCG in vascular endothelium that may help mediate beneficial cardiovascular actions of green tea...