Research Topics
| Tae Wook ChunSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Tracking replication-competent HIV reservoirs in infected individualsTae Wook Chun
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Curr Opin HIV AIDS 8:111-6. 2013....- HIV reservoirs: pathogenesis and obstacles to viral eradication and cureTae Wook Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
AIDS 26:1261-8. 2012..In this review, we discuss the pathophysiology of CD4 T-cell HIV reservoirs, including recent advances in our understanding of the mechanisms of persistent viral infection and perspectives for eradication of HIV in infected individuals... 
Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapyTae Wook Chun
Laboratory of Immunoregulation, National Institutes of Health, Bethesda, MD, USA
J Infect Dis 204:135-8. 2011..Novel therapeutic strategies aimed at targeting the source of residual viremia may be necessary to achieve viral eradication...- Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapyTae Wook Chun
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Infect Dis 197:714-20. 2008.... 
Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: implications for eradication of virusTae Wook Chun
Laboratory of Immunoregulation, Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 195:1762-4. 2007..6 months. It is projected that it will take up to 7.7 years of continuous therapy to completely eliminate latently infected resting CD4+ T cells in infected individuals who initiate antiviral therapy early in HIV infection...- Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradicationTae Wook Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
AIDS 24:2803-8. 2010..It is of great interest to identify individuals who had received ART for prolonged periods of time with extremely low or undetectable HIV reservoirs and monitor plasma viremia following discontinuation of therapy... - HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoirTae Wook Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 115:3250-5. 2005..Such events may allow continual replenishment of the CD4+ T cell reservoir and resetting of the half-life of the latently infected, resting CD4+ T cells despite prolonged periods of aviremia... - Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individualsTae Wook Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:2464-9. 2004.... - Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individualsTae Wook Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:1908-13. 2003.... - Relationship between the size of the human immunodeficiency virus type 1 (HIV-1) reservoir in peripheral blood CD4+ T cells and CD4+:CD8+ T cell ratios in aviremic HIV-1-infected individuals receiving long-term highly active antiretroviral therapyTae Wook Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10 Room GA32, Bethesda, MD 20892, USA
J Infect Dis 185:1672-6. 2002.... - Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells: implications for the development of therapeutic strategiesT W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 98:253-8. 2001.... - Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapyT W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 6:757-61. 2000.... - Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapyT W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 94:13193-7. 1997..In addition, the presence of unintegrated HIV-1 DNA in infected resting CD4+ T cells from patients receiving HAART, even those with undetectable plasma viremia, suggests persistent active virus replication in vivo... - Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infectionT W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 95:8869-73. 1998.... - Latent reservoirs of HIV: obstacles to the eradication of virusT W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 96:10958-61. 1999..Here we discuss recent developments in studies of the latent reservoir of HIV in patients receiving HAART and implications for the long-term treatment of infected individuals and eradication of the infection... - Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapyT W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 5:651-5. 1999..These results indicate that the intermittent administration of IL-2 with continuous HAART may lead to a substantial reduction in the pool of resting CD4+ T cells that contain replication-competent HIV... - Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokinesT W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 188:83-91. 1998.... - Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamilySusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Rm 6A02, 10 Center Dr, Bethesda, MD 20892, USA
J Exp Med 200:587-99. 2004.... - Perturbations in B cell responsiveness to CD4+ T cell help in HIV-infected individualsSusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:6057-62. 2003..These data provide new insight into the mechanisms associated with ineffective humoral responses in HIV disease... - Pilot study of the effects of intermittent interleukin-2 on human immunodeficiency virus (HIV)-specific immune responses in patients treated during recently acquired HIV infectionMark Dybul
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 185:61-8. 2002..Thus, although intermittent IL-2 plus HAART quantitatively increased CD4+ T cells, this increase was not selective for HIV-specific CD4+ or CD8+ T cell responses in recently infected persons... - Innate immunity in human immunodeficiency virus infection: effect of viremia on natural killer cell functionShyam Kottilil
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases NIH, 9000 Wiscoinsin Avenue, Building 10, Room 6A08A, Bethesda, MD 20892, USA
J Infect Dis 187:1038-45. 2003.... - Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individualsSusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 205:1797-805. 2008..These data suggest that HIV-associated premature exhaustion of B cells may contribute to poor antibody responses against HIV in infected individuals... - Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptorsLela Kardava
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 1576, USA
J Clin Invest 121:2614-24. 2011..These findings on HIV-associated B cell exhaustion define potential targets for reversing the deleterious effect of inhibitory receptors on immune responses against persistent viral infections... - Effect of histone deacetylase inhibitors on HIV production in latently infected, resting CD4(+) T cells from infected individuals receiving effective antiretroviral therapyJana Blazkova
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Infect Dis 206:765-9. 2012..Here we demonstrate that HDACis do not induce HIV production in the latent viral reservoir of aviremic individuals. Therefore, alternative therapeutic strategies may be necessary to eliminate HIV in the latent viral reservoir... - Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamilySusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 200:587-99. 2004.... - Genetic characterization of rebounding human immunodeficiency virus type 1 in plasma during multiple interruptions of highly active antiretroviral therapyMark Dybul
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 77:3229-37. 2003..In addition, the data suggest that there may be multiple compartments contributing to the rebound of plasma viremia and to viral diversity from cycle to cycle of intermittent therapy... - Deleterious effect of HIV-1 plasma viremia on B cell costimulatory functionAngela Malaspina
Department of Health and Human Services, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 170:5965-72. 2003.... - Paucity of HIV DNA methylation in latently infected, resting CD4+ T cells from infected individuals receiving antiretroviral therapyJana Blazkova
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Virol 86:5390-2. 2012.... - B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapySusan Moir
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Blood 116:5571-9. 2010..These findings provide new insights on B cells in HIV infection and how early initiation of ART may prevent irreversible immune system damage... - Evaluation of the pathogenesis of decreasing CD4(+) T cell counts in human immunodeficiency virus type 1-infected patients receiving successfully suppressive antiretroviral therapyElizabeth Nies-Kraske
National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, USA
J Infect Dis 199:1648-56. 2009..All 4 patients had significant fibrosis of the T cell zone of lymphoid tissue, which appeared to be an important factor in the failure to reconstitute T cells... - Normalization of B cell counts and subpopulations after antiretroviral therapy in chronic HIV diseaseSusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Infect Dis 197:572-9. 2008..However, little is known regarding the effect of antiretroviral therapy (ART)-induced decrease in HIV viremia on B cell numbers and subpopulations... - Impact of HIV on cell survival and antiviral activity of plasmacytoid dendritic cellsJennifer Hartt Meyers
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, Maryland, United States of America
PLoS ONE 2:e458. 2007..Elucidation of the mechanism by which pDCs suppress HIV replication in vivo may have clinically relevant implications for future therapeutic strategies... - Human immunodeficiency virus type 1 bound to B cells: relationship to virus replicating in CD4+ T cells and circulating in plasmaAngela Malaspina
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 76:8855-63. 2002..These findings also indicate that most of the virus in plasma originates from cells other than CD4(+) T cells in the peripheral blood and lymph nodes... - Humans with chronic granulomatous disease maintain humoral immunologic memory despite low frequencies of circulating memory B cellsSusan Moir
Laboratories of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes ofHealth, Bethesda, MD 20892, USA
Blood 120:4850-8. 2012..Together, these findings show that, despite reduced circulating CD27(+) memory B cells, CGD patients maintain an intact humoral immunologic memory, with potential contribution from CD27(-) B cells... - Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategiesJames Arthos
Laboratory of Immunoregulation, NIAID, and the Molecular Interactions Resource Division of Bioengineering and Physical Science, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:11456-64. 2002..This protein does not enhance viral replication at suboptimal concentrations. These observations may aid in the design of new therapeutics and vaccines... - Rational design of drugs that induce human immunodeficiency virus replicationDean H Hamer
Laboratory of Biochemistry, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 77:10227-36. 2003..These studies demonstrate the potential for the rational design of agents that, in conjunction with HAART and HIV-specific toxins, can be used to decrease or eliminate the pool of latently infected reservoirs by forcing viral expression... - Enhancing effects of adjuvanted 2009 pandemic H1N1 influenza A vaccine on memory B-cell responses in HIV-infected individualsJason Ho
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
AIDS 25:295-302. 2011..To assess the humoral immune response to low-dose AS03-adjuvanted and standard-dose nonadjuvanted 2009 pandemic H1N1 influenza A vaccine in HIV-infected aviremic individuals receiving antiretroviral therapy and in uninfected individuals... - Role for CD21 in the establishment of an extracellular HIV reservoir in lymphoid tissuesJason Ho
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 178:6968-74. 2007..Our findings demonstrate a critical role for CD21 in HIV trapping by LN cells and suggest a new therapeutic avenue for reducing HIV reservoirs... - R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cellsClaudia Cicala
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 103:3746-51. 2006..Additionally, signaling by R5 gp120 may facilitate the transmission of R5 viruses by inducing a permissive environment for HIV replication... - Appearance of immature/transitional B cells in HIV-infected individuals with advanced disease: correlation with increased IL-7Angela Malaspina
Laboratory of Immunoregulation, and Office of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 103:2262-7. 2006..Taken together, these data offer insight into human B cell development as well as B cell dysfunction in advanced HIV disease that may be linked to IL-7-dependent homeostatic events... - Pathogenic mechanisms of HIV diseaseSusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Annu Rev Pathol 6:223-48. 2011..Further advances in therapeutics and informative technologies, combined with a better understanding of the immunologic and virologic components of HIV disease, hold promise for new preventative and even curative strategies... - High frequencies of resting CD4+ T cells containing integrated viral DNA are found in rhesus macaques during acute lentivirus infectionsYoshiaki Nishimura
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:8015-20. 2009..Prompt and sustained interventions are therefore required to block the rapid systemic dissemination of virus and prevent an otherwise fatal clinical outcome... - Comprehensive analysis of unique cases with extraordinary control over HIV replicationDaniel Mendoza
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
Blood 119:4645-55. 2012..Additional insight into the full spectrum of immune-mediated suppression over HIV replication may enhance our understanding of the associated mechanisms, which should inform the design of efficacious HIV vaccines and immunotherapies... - Two overrepresented B cell populations in HIV-infected individuals undergo apoptosis by different mechanismsJason Ho
Laboratory of Immunoregulation and Office of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 103:19436-41. 2006..Our data suggest that two distinct mechanisms of apoptosis are associated with B cells of HIV-infected individuals, and both may contribute to the depletion and dysfunction of B cells in these individuals... - Continuous flow leukapheresis induces expression of stress genes in lymphocytes: impact on microarray analysesSusan Moir
Blood 102:3852-3. 2003 - Detection assays for HIV proteinsMario A Ostrowski
University of Toronto, Toronto, Canada
Curr Protoc Immunol . 2006.... - Structural and functional characterization of CC chemokine CCL14Katherine Y Blain
Structural Biology Laboratory, The Salk Institute, La Jolla, California 92037, USA
Biochemistry 46:10008-15. 2007..These results together suggest that the ability of CCL14 [9-74] to monomerize can play a role for cellular activation...