Patricia C Chulada

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
    R Langenbach
    Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cell 83:483-92. 1995
  2. ncbi request reprint Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice
    P C Chulada
    Laboratory of Experimental Carcinogenesis and Mutagenesis, NIH, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 60:4705-8. 2000
  3. pmc The Environmental Polymorphism Registry: a unique resource that facilitates translational research of environmental disease
    Patricia C Chulada
    Clinical Research Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1523-7. 2011
  4. doi request reprint The Environmental Polymorphisms Registry: a DNA resource to study genetic susceptibility loci
    Patricia C Chulada
    Clinical Research Program, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Hum Genet 123:207-14. 2008
  5. pmc The feasibility of creating a population-based national twin registry in the United States
    Patricia C Chulada
    Program in Clinical Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Twin Res Hum Genet 9:919-26. 2006
  6. pmc Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis
    James C Bonner
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Pathol 161:459-70. 2002
  7. pmc Allergic lung responses are increased in prostaglandin H synthase-deficient mice
    S H Gavett
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Clin Invest 104:721-32. 1999
  8. pmc The Head-off Environmental Asthma in Louisiana (HEAL) study--methods and study population
    Patricia C Chulada
    Clinical Research Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 120:1592-9. 2012
  9. ncbi request reprint Breast-feeding and the prevalence of asthma and wheeze in children: analyses from the Third National Health and Nutrition Examination Survey, 1988-1994
    Patricia C Chulada
    Office of Clinical Research, National Institute of Environmental Health Sciences NIH, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 111:328-36. 2003
  10. ncbi request reprint Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis
    Haruna Takeda
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Cancer Res 63:4872-7. 2003

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
    R Langenbach
    Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cell 83:483-92. 1995
    ..Ptgs1 homozygous mutant females mated to homozygous mutant males produce few live offspring. COX-1-deficient mice provide a useful model to distinguish the physiological roles of COX-1 and COX-2...
  2. ncbi request reprint Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice
    P C Chulada
    Laboratory of Experimental Carcinogenesis and Mutagenesis, NIH, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 60:4705-8. 2000
    ..The results indicate that COX-1, as well as COX-2, plays a key role in intestinal tumorigenesis and that COX-1 may also be a chemotherapeutic target for nonsteroidal anti-inflammatory drugs...
  3. pmc The Environmental Polymorphism Registry: a unique resource that facilitates translational research of environmental disease
    Patricia C Chulada
    Clinical Research Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1523-7. 2011
    ..Objective: We have developed a resource of subjects and their DNA to use for translational research of environmental disease...
  4. doi request reprint The Environmental Polymorphisms Registry: a DNA resource to study genetic susceptibility loci
    Patricia C Chulada
    Clinical Research Program, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Hum Genet 123:207-14. 2008
    ..The success of the EPR based on the number of subjects recruited and genetic studies underway, suggests that it will be a model for future DNA resources...
  5. pmc The feasibility of creating a population-based national twin registry in the United States
    Patricia C Chulada
    Program in Clinical Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Twin Res Hum Genet 9:919-26. 2006
    ....
  6. pmc Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis
    James C Bonner
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Pathol 161:459-70. 2002
    ..These findings indicate that the COX-2 enzyme is protective against pulmonary fibrogenesis, and we suggest that COX-2 generation of PGE(2) is an important factor in resolving inflammation...
  7. pmc Allergic lung responses are increased in prostaglandin H synthase-deficient mice
    S H Gavett
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Clin Invest 104:721-32. 1999
    ....
  8. pmc The Head-off Environmental Asthma in Louisiana (HEAL) study--methods and study population
    Patricia C Chulada
    Clinical Research Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 120:1592-9. 2012
    ..In the city of New Orleans, Louisiana, and surrounding parishes (NOLA), children with asthma were perilously impacted by Hurricane Katrina as a result of disrupted health care, high home mold and allergen levels, and high stress...
  9. ncbi request reprint Breast-feeding and the prevalence of asthma and wheeze in children: analyses from the Third National Health and Nutrition Examination Survey, 1988-1994
    Patricia C Chulada
    Office of Clinical Research, National Institute of Environmental Health Sciences NIH, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 111:328-36. 2003
    ..Breast-feeding might protect children against asthma and related conditions (recurrent wheeze), and this protective effect might depend on the duration and exclusivity of the breast-feeding regimen...
  10. ncbi request reprint Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis
    Haruna Takeda
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Cancer Res 63:4872-7. 2003
    ....