Research Topics
Genomes and Genes | HONG W CHUSummaryAffiliation: National Jewish Medical and Research Center Country: USA Publications
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Publications
Collagen deposition in large airways may not differentiate severe asthma from milder forms of the diseaseH W Chu
Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colorado, USA
Am J Respir Crit Care Med 158:1936-44. 1998..These results suggest that although increased collagen deposition in the SBM at the large airway level is a characteristic of asthma, it may not explain the differences in severity of asthma...- Repeated respiratory Mycoplasma pneumoniae infections in mice: effect of host genetic backgroundHong Wei Chu
Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80206, USA
Microbes Infect 8:1764-72. 2006..Our results suggest that hosts with different genetic background may have different susceptibility to repeated respiratory Mp infections along with inflammatory responses... - Mycoplasma pneumoniae infection increases airway collagen deposition in a murine model of allergic airway inflammationHong Wei Chu
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
Am J Physiol Lung Cell Mol Physiol 289:L125-33. 2005..Our results suggest that Mp infections could modulate airway collagen deposition in a murine model of allergic airway inflammation with TGF-beta1 involved in the collagen deposition process... - Toll-like receptor 2 down-regulation in established mouse allergic lungs contributes to decreased mycoplasma clearanceQun Wu
National Jewish Medical and Research Center, 1400 Jackson Street, Room A639, Denver, CO 80206, USA
Am J Respir Crit Care Med 177:720-9. 2008..Objectives: To test whether the established allergic airway inflammation compromises host innate immunity (e.g., Toll-like receptor 2 [TLR2]) to hinder the elimination of Mp from the lungs... - Function and regulation of SPLUNC1 protein in Mycoplasma infection and allergic inflammationHong Wei Chu
Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80206, USA
J Immunol 179:3995-4002. 2007.... - Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthmaHong Wei Chu
Department of Medicine, National Jewish Medical and Research Center, D104, 1400 Jackson St, Denver, CO 80206, USA
Am J Pathol 165:1097-106. 2004..These data suggest that TGF-beta2 production by asthmatic bronchial epithelial cells may increase airway mucin expression. IL-13-induced mucin expression may occur in part through TGF-beta2 up-regulation... - Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen depositionH W Chu
Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, D104, Denver 80206, Colorado, USA
Clin Exp Allergy 32:1558-65. 2002..Although 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), a product of 15-lipoxygenase (15-LO), may be involved in mild to moderate asthma, little is known about its potential roles in severe asthma... - TLR2 signaling is critical for Mycoplasma pneumoniae-induced airway mucin expressionHong Wei Chu
Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
J Immunol 174:5713-9. 2005..These results clearly demonstrate that respiratory Mp infection increases airway mucin expression, which is dependent on the activation of TLR2 signaling... - Inhaled fluticasone propionate reduces concentration of Mycoplasma pneumoniae, inflammation, and bronchial hyperresponsiveness in lungs of miceHong Wei Chu
Department of Medicine, National Jewish Medical and Research Center, and the University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
J Infect Dis 189:1119-27. 2004..pneumoniae by up to 20-fold in lung tissue but not in BALF. CONCLUSION: Inhaled FP suppresses airway inflammation and BHR, which may be caused, in part, by its ability to reduce concentrations of M. pneumoniae in lung tissue... - beta2-agonists promote host defense against bacterial infection in primary human bronchial epithelial cellsClaire A Gross
Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, Colorado 80206, USA
BMC Pulm Med 10:30. 2010..beta2-agonists are mainstay of COPD and asthma therapy, but whether beta2-agonists directly affect airway epithelial host defense functions is unclear... - IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infectionQun Wu
Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80206, USA
Microbes Infect 9:78-86. 2007..These results demonstrate that IL-17/IL-17F production is IL-23-dependent in an acute Mp infection, and contributes to neutrophil recruitment and activity in the lung defense against the infection... - A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic miceQun Wu
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Am J Physiol Lung Cell Mol Physiol 292:L1064-72. 2007..A bacterial infection in asthmatic subjects with weakened TLR2-IFN-gamma signaling may result in an exaggerated airway mucin production... - Cigarette smoke decreases MARCO expression in macrophages: implication in Mycoplasma pneumoniae infectionMisbah Baqir
Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
Respir Med 102:1604-10. 2008..Our results indicate that cigarette smoke exposure down-regulates MARCO expression in macrophages, which may be in part responsible for impaired bacterial (e.g., Mp) clearance... - Selective downregulation of prostaglandin E2-related pathways by the Th2 cytokine IL-13John Trudeau
Department of Medicine, Division of Pulmonary, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 117:1446-54. 2006.... - TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblastsSally E Wenzel
National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
J Immunol 169:4613-9. 2002..These results support the concept that interactions of innate and adaptive immune systems may be important in promoting the tissue eosinophilia of asthma, particularly in those with more severe disease... - Effects of respiratory Mycoplasma pneumoniae infection on allergen-induced bronchial hyperresponsiveness and lung inflammation in miceHong Wei Chu
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
Infect Immun 71:1520-6. 2003..Our animal models may also provide a new means to understand the role of infection in asthma pathogenesis and give evidence for the asthma hygiene hypothesis... - Interaction between cigarette smoke and mycoplasma infection: a murine modelRichard J Martin
National Jewish Medical and Research Center, Denver, Colorado 80206, USA
COPD 3:3-8. 2006.... - Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injurySamithamby Jeyaseelan
Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson St, Neustadt D 403, Denver, CO 80206, USA
Infect Immun 73:1754-63. 2005.... - Increased TGF-beta2 in severe asthma with eosinophiliaSilvana Balzar
Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver 80206, USA
J Allergy Clin Immunol 115:110-7. 2005..However, little is known regarding the expression of specific TGF-beta isoforms (TGF-beta1, TGF-beta2, and TGF-beta3) in asthma, despite recent evidence suggesting that isoforms may have differing biologic activities... - Arhgef1 regulates alpha5beta1 integrin-mediated matrix metalloproteinase expression and is required for homeostatic lung immunityJohn M Hartney
Integrated Department of Immunology, University of Colorado Denver and National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA
Am J Pathol 176:1157-68. 2010..Together these data demonstrate that Arhgef1 regulates alpha5beta1-mediated MMP expression by macrophages and that loss of Arhgef1 by leukocytes leads to pulmonary pathology... - Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repairSally E Wenzel
National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
J Allergy Clin Immunol 111:1345-52. 2003..Although MMP-9 is increased in lavage fluid and sputum in patients with asthma, controversy exists as to the role of tissue MMP-9... - Mycoplasma pneumoniae infection and environmental tobacco smoke inhibit lung glutathione adaptive responses and increase oxidative stressChirag Kariya
University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
Infect Immun 76:4455-62. 2008..These studies suggest that M. pneumoniae infection synergizes with ETS and suppresses the lung's ability to respond appropriately to environmental challenges leading to enhanced oxidative stress... - Increased matrix metalloproteinase-9 with elastolysis in nocturnal asthmaDavid N Pham
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Ann Allergy Asthma Immunol 90:72-8. 2003..CONCLUSIONS: Our results from these two pilot studies suggest that increased MMP-9 and decreased TIMP-1 at night in NA may lead to reduced elastin density... - Relationship of small airway chymase-positive mast cells and lung function in severe asthmaSilvana Balzar
Department of Medicine and Division of Biostatistics, National Jewish Medical and Research Center, 1400 Jackson St, J 226, Denver, CO 80206, USA
Am J Respir Crit Care Med 171:431-9. 2005..89; p </= 0.001 for all correlations). These data suggest that induction of chymase-positive mast cells, particularly in the small airway outer wall/alveolar attachments region, may be protective for lung function in severe asthma... - Transcriptional profiling of lipopolysaccharide-induced acute lung injurySamithamby Jeyaseelan
Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson St, Neustadt D 403, Denver, CO 80206, USA
Infect Immun 72:7247-56. 2004..Moreover, we identified a role for LIX in the induction of ALI, and therefore LIX may serve as a novel therapeutic target for the minimization of ALI... - Aging adversely affects the cigarette smoke-induced glutathione adaptive response in the lungNeal S Gould
Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
Am J Respir Crit Care Med 182:1114-22. 2010..A prominent defense against the oxidant burden caused by CS is the glutathione (GSH) adaptive response in the lung epithelial lining fluid (ELF) and tissue. However, as one ages the ability to maintain GSH levels declines... - Roflumilast increases Clara cell secretory protein in cigarette smoke-exposed miceXiao Na Ge
Department of Medicine, National Jewish Health and the University of Colorado Denver, Denver, CO 80206, USA
COPD 6:185-91. 2009..Our results demonstrate that one of the therapeutic mechanisms of roflumilast is to reverse CS-induced downward trend in CCSP levels of BAL fluid, which may be mediated by down-regulating ERK1/2 activity... - Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus-induced inflammation and infectionMari Numata
Department of Medicine, Program in Cell Biology, National Jewish Health, Denver, CO 80206, USA
Proc Natl Acad Sci U S A 107:320-5. 2010..These findings demonstrate an important approach to prevention and treatment of RSV infections using exogenous administration of a specific surfactant phospholipid... - Airway fibroblasts exhibit a synthetic phenotype in severe asthmaChristina C Lewis
Division of Pulmonary Sciences and Critical Care Medicine, National Jewish Medical and Research Center, Denver, Colo, USA
J Allergy Clin Immunol 115:534-40. 2005..Platelet-derived growth factor (PDGF) may have a significant role in airway remodeling in asthma, because it is a powerful inductor of many airway fibroblast activities such as collagen synthesis... - Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activationRaweewan Hoontrakoon
Department of Pediatrics, Division of Allergy and Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Am J Respir Cell Mol Biol 26:404-12. 2002..Thus, our results suggest that IL-15, either alone or in combination with TNF-alpha, may perpetuate allergic inflammation by reduction of spontaneous eosinophil apoptosis through autocrine production of GM-CSF and NF-kappaB activation... - Hygiene hypothesis of asthma: a murine asthma model with Mycoplasma pneumoniae infectionHong Wei Chu
National Jewish Medical and Research Center, Denver, CO 80206, USA
Chest 123:390S. 2003 - Effects of inhaled fluticasone on bronchial hyperresponsiveness and airway inflammation in Mycoplasma pneumoniae-infected miceHong Wei Chu
National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
Chest 123:427S. 2003 - Increased expression of platelet-derived growth factor receptor-beta in airway fibroblasts of severe asthmaticsChristina C Lewis
National Jewish Medical and Research Center, Denver, CO 80206, USA
Chest 123:428S-9S. 2003 - A trial of clarithromycin for the treatment of suboptimally controlled asthmaE Rand Sutherland
National Jewish Health, Denver, CO 80206, USA
J Allergy Clin Immunol 126:747-53. 2010..PCR studies have demonstrated evidence of Mycoplasma pneumoniae and Chlamydophila pneumoniae in the lower airways of patients with asthma... - Impact of cigarette smoke exposure on innate immunity: a Caenorhabditis elegans modelRebecca M Green
Department of Medicine, National Jewish Health, Denver, Colorado, United States of America
PLoS ONE 4:e6860. 2009..Cigarette smoking is the major cause of chronic obstructive pulmonary disease (COPD) and lung cancer. Respiratory bacterial infections have been shown to be involved in the development of COPD along with impaired airway innate immunity... - Analysis of nitric oxide synthase and nitrotyrosine expression in human pulmonary tuberculosisHyung-Seok Choi
Department of Medicine, Program in Cell Biology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Am J Respir Crit Care Med 166:178-86. 2002..This descriptive study provides evidence that in human TB, NOS isoenzymes and NO are present in specialized areas of the tuberculous granulomas; their precise role in human TB remains to be determined... - Do neutrophils actively participate in airway inflammation and remodeling in asthma?Yong chang Sun
Department of Respiratory Medicine, Peking University Third Hospital, Beijing 100083, China
Chin Med J (Engl) 117:1739-42. 2004 - Ensuring quality in pharmaceutical studiesSally E Wenzel
Am J Respir Crit Care Med 168:1010-1; author reply 1011-2. 2003
Research Grants
- CORE--Histopathology and MicrobiologyHONG CHU; Fiscal Year: 2007..pneumoniae treated with surfactant protein-A (SP-A) Thus, Core B will be an integral part of the Program Project Grant and in doing so will have the projects function at a high standard. ..