G P Chrousos

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Hypothalamic-pituitary-adrenal axis suppression and inhaled corticosteroid therapy. 2. Review of the literature
    G P Chrousos
    Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, MD, USA
    Neuroimmunomodulation 5:288-308. 1998
  2. ncbi request reprint Hypothalamic-pituitary-adrenal axis suppression and inhaled corticosteroid therapy. 1. General principles
    G P Chrousos
    Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, MD, USA
    Neuroimmunomodulation 5:277-87. 1998
  3. ncbi request reprint Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines
    D A Papanicolaou
    National Institute of Child Health and Human Development, Department of Physiology, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol 271:E601-5. 1996
  4. pmc Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates
    K E Habib
    Clinical Neuroendocrinology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Proc Natl Acad Sci U S A 97:6079-84. 2000
  5. ncbi request reprint High intensity exercise promotes escape of adrenocorticotropin and cortisol from suppression by dexamethasone: sexually dimorphic responses
    P A Deuster
    Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Clin Endocrinol Metab 83:3332-8. 1998
  6. ncbi request reprint Inferior petrosal sinus AVP in patients with Cushing's syndrome
    J A Yanovski
    Department of Diagnostic Radiology, Warren Grant Magnuson Clinical Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    Clin Endocrinol (Oxf) 47:199-206. 1997
  7. ncbi request reprint Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration. A new test to distinguish Cushing's syndrome from pseudo-Cushing's states
    J A Yanovski
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    JAMA 269:2232-8. 1993
  8. ncbi request reprint Urine free cortisol in the high-dose dexamethasone suppression test for the differential diagnosis of the Cushing syndrome
    M R Flack
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
    Ann Intern Med 116:211-7. 1992
  9. ncbi request reprint Cytogenetic and microsatellite alterations in tumors from patients with the syndrome of myxomas, spotty skin pigmentation, and endocrine overactivity (Carney complex)
    C A Stratakis
    Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    J Clin Endocrinol Metab 81:3607-14. 1996
  10. ncbi request reprint Plasma levels of corticotropin-releasing hormone in the inferior petrosal sinuses of healthy volunteers, patients with Cushing's syndrome, and patients with pseudo-Cushing states
    J A Yanovski
    Office of the Director, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 83:1485-8. 1998

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Hypothalamic-pituitary-adrenal axis suppression and inhaled corticosteroid therapy. 2. Review of the literature
    G P Chrousos
    Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, MD, USA
    Neuroimmunomodulation 5:288-308. 1998
    ....
  2. ncbi request reprint Hypothalamic-pituitary-adrenal axis suppression and inhaled corticosteroid therapy. 1. General principles
    G P Chrousos
    Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, MD, USA
    Neuroimmunomodulation 5:277-87. 1998
    ....
  3. ncbi request reprint Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines
    D A Papanicolaou
    National Institute of Child Health and Human Development, Department of Physiology, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol 271:E601-5. 1996
    ..These findings suggest that IL-6 secretion is stimulated during exercise, possibly by catecholamines, whereas exogenous glucocorticoids attenuate this effect without affecting the catecholamine levels...
  4. pmc Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates
    K E Habib
    Clinical Neuroendocrinology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Proc Natl Acad Sci U S A 97:6079-84. 2000
    ....
  5. ncbi request reprint High intensity exercise promotes escape of adrenocorticotropin and cortisol from suppression by dexamethasone: sexually dimorphic responses
    P A Deuster
    Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Clin Endocrinol Metab 83:3332-8. 1998
    ....
  6. ncbi request reprint Inferior petrosal sinus AVP in patients with Cushing's syndrome
    J A Yanovski
    Department of Diagnostic Radiology, Warren Grant Magnuson Clinical Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    Clin Endocrinol (Oxf) 47:199-206. 1997
    ....
  7. ncbi request reprint Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration. A new test to distinguish Cushing's syndrome from pseudo-Cushing's states
    J A Yanovski
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    JAMA 269:2232-8. 1993
    ..CONCLUSION--The dexamethasone-CRH test is a more accurate test to distinguish Cushing's syndrome from pseudo-Cushing's states in patients with mild hypercortisolism...
  8. ncbi request reprint Urine free cortisol in the high-dose dexamethasone suppression test for the differential diagnosis of the Cushing syndrome
    M R Flack
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
    Ann Intern Med 116:211-7. 1992
    ..The diagnostic performance of the test is improved by measuring both urine free cortisol and 17-hydroxysteroid excretion and by requiring greater suppression of both steroids...
  9. ncbi request reprint Cytogenetic and microsatellite alterations in tumors from patients with the syndrome of myxomas, spotty skin pigmentation, and endocrine overactivity (Carney complex)
    C A Stratakis
    Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    J Clin Endocrinol Metab 81:3607-14. 1996
    ..This gene(s) appears to be involved in the regulation of genomic stability of dividing cells, in particular the structure of telomeres in replicating chromosomes and/or the function of the mitotic apparatus...
  10. ncbi request reprint Plasma levels of corticotropin-releasing hormone in the inferior petrosal sinuses of healthy volunteers, patients with Cushing's syndrome, and patients with pseudo-Cushing states
    J A Yanovski
    Office of the Director, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 83:1485-8. 1998
    ..We conclude that inferior petrosal sinus human CRH levels are not easily measured in the inferior petrosal sinuses and cannot be used to determine whether individual patients may have hypersecretion of CRH causing their ACTH secretion...
  11. ncbi request reprint Neuroendocrine responses to running in women after zinc and vitamin E supplementation
    A Singh
    Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, and Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20814 4799, USA
    Med Sci Sports Exerc 31:536-42. 1999
    ..The study was undertaken to determine whether acute supplementation with zinc or vitamin E would modify neuroendocrine responses to physiologic stress...
  12. ncbi request reprint Urocortin and inflammation: confounding effects of hypotension on measures of inflammation
    D J Torpy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892 1862, USA
    Neuroimmunomodulation 6:182-6. 1999
    ..The use of inflammatory models which rely on extravasation may be inappropriate for the study of substances that produce hypotension...
  13. ncbi request reprint The dexamethasone-suppressed corticotropin-releasing hormone stimulation test differentiates mild Cushing's disease from normal physiology
    J A Yanovski
    Office of the Director, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    J Clin Endocrinol Metab 83:348-52. 1998
    ..These results suggest that the Dex-CRH test may be useful in the evaluation of CS in patients without significant hypercortisoluria. However, its value in patients with episodic hormonogenesis has not been tested...
  14. ncbi request reprint Differential hypothalamic-pituitary-adrenal axis reactivity to psychological and physical stress
    A Singh
    Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Clin Endocrinol Metab 84:1944-8. 1999
    ..This suggests that the adrenal cortexes of the HR are hypertropic and/or hypersensitive to ACTH. We conclude that men who are highly responsive to exercise stress are also highly responsive to psychological stress...
  15. ncbi request reprint Effect of cholinergic agonists and antagonists on rat hypothalamic corticotropin-releasing hormone secretion in vitro
    A E Calogero
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD
    Neuroendocrinology 47:303-8. 1988
    ..We conclude that ACh stimulates hypothalamic CRH secretion via both muscarinic and nicotinic receptor mechanisms.(ABSTRACT TRUNCATED AT 250 WORDS)..
  16. ncbi request reprint The differential effect of food intake and beta-adrenergic stimulation on adipose-derived hormones and cytokines in man
    Z Orban
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 1862, USA
    J Clin Endocrinol Metab 84:2126-33. 1999
    ..The regulations of adipose leptin, TNF alpha, and IL-6 secretion seem distinct from each other and different in the fed vs. fasting state...
  17. ncbi request reprint A single midnight serum cortisol measurement distinguishes Cushing's syndrome from pseudo-Cushing states
    D A Papanicolaou
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 83:1163-7. 1998
    ..5 microg/dL at midnight discriminates CS from PCS with higher sensitivity than 24-h urinary cortisol or 17OHCS, or other individual or combined measures of serum cortisol...
  18. ncbi request reprint Lymphocytes stimulate dehydroepiandrosterone production through direct cellular contact with adrenal zona reticularis cells: a novel mechanism of immune-endocrine interaction
    G W Wolkersdörfer
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 84:4220-7. 1999
    ..This study provides evidence for a novel mechanism of immune-endocrine interactions of direct T lymphocyte-adrenocortical cell contact-mediated stimulation of adrenal androgen secretion...
  19. ncbi request reprint Arachidonic acid metabolites modulate rat hypothalamic corticotropin-releasing hormone secretion in vitro
    R Bernardini
    Developmental Endocrinology, Branch, NICHD, Bethesda, MD
    Neuroendocrinology 50:708-15. 1989
    ..These findings suggest that eicosanoids may be involved in the regulation of hypothalamic CRH secretion, either as autocrine/paracrine or as endocrine factors...
  20. ncbi request reprint Role of preoperative iodocholesterol scintiscanning in patients undergoing adrenalectomy for Cushing's syndrome
    K C Yu
    Surgical Metabolism Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Surgery 118:981-6; discussion 986-7. 1995
    ..Iodocholesterol scintiscanning (IS) is a noninvasive, functional diagnostic test. We report our experience with IS as an adjunct for adrenal surgery for Cushing's syndrome...
  21. ncbi request reprint The interaction between leptin and the hypothalamic-pituitary-thyroid axis
    Z Orban
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892 1862, USA
    Horm Metab Res 30:231-5. 1998
    ..The following discussion summarizes knowledge that has accumulated regarding the interaction between leptin and the hypothalamic-pituitary-thyroid axis...
  22. ncbi request reprint Endocrine response to high-intensity exercise: dose-dependent effects of dexamethasone
    P A Deuster
    Department of Military and Emergency Medicine, Uniformed Services, University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Clin Endocrinol Metab 85:1066-73. 2000
    ..The question of whether these differences in reactivity of the ACTH-cortisol axis between the HR and LR groups have implications for individual short term function or long term health remains to be answered...
  23. ncbi request reprint The aromatase excess syndrome is associated with feminization of both sexes and autosomal dominant transmission of aberrant P450 aromatase gene transcription
    C A Stratakis
    Section on Pediatric Endocrinology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 83:1348-57. 1998
    ....
  24. ncbi request reprint Endocrine and metabolic evaluation of human immunodeficiency virus-infected patients with evidence of protease inhibitor-associated lipodystrophy
    J A Yanovski
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 84:1925-31. 1999
    ..The cause remains to be elucidated...
  25. ncbi request reprint Adrenocorticotropin, glucocorticoid, and androgen secretion in patients with new onset synovitis/rheumatoid arthritis: relations with indices of inflammation
    K S Kanik
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 85:1461-6. 2000
    ....
  26. ncbi request reprint Neuroendocrine regulation of IL-12 and TNF-alpha/IL-10 balance. Clinical implications
    I J Elenkov
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 917:94-105. 2000
    ..Thus, better understanding of the neuroendocrine regulation of IL-12, TNF-alpha/IL-10 balance might help the development of new therapeutic strategies for the treatment of Th1- and Th2-mediated human diseases...
  27. ncbi request reprint Dose-dependent effects of recombinant human interleukin-6 on the pituitary-testicular axis
    C Tsigos
    Developmental Endocrinology Branch, NICHD, NIH, Bethesda, MD 20892, USA
    J Interferon Cytokine Res 19:1271-6. 1999
    ..This suggests that IL-6 might induce persistent testicular resistance to LH action or suppression of Leydig cell steroidogenesis or both, with potential adverse effects on male reproductive function...
  28. ncbi request reprint Androgen receptor-mediated hypersensitivity to androgens in women with nonhyperandrogenic hirsutism: skewing of X-chromosome inactivation
    A Vottero
    Section of Pediatric Endocrinology, DEB, NICHD, NIH, Bethesda, Maryland 20892 1862, USA
    J Clin Endocrinol Metab 84:1091-5. 1999
    ..Further studies need to be performed to investigate whether this phenomenon is present in androgen-sensitive tissues in these patients...
  29. pmc Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. Potential implications for the sexual dimophism of the stress response and immune/inflammatory reaction
    N C Vamvakopoulos
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    J Clin Invest 92:1896-902. 1993
    ..These findings may constitute the basis of sexual dimorphism in the expression of the CRH gene in the central nervous system and periphery, and might shed light in existing gender differences in stress response and immune regulation...
  30. ncbi request reprint Differences in corticotropin-releasing hormone-stimulated adrenocorticotropin and cortisol before and after weight loss
    J A Yanovski
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 82:1874-8. 1997
    ..We conclude that when obese women lose large amounts of weight with a 3350 kJ/day, very low energy diet, such weight reduction does not significantly affect the HPA axis...
  31. ncbi request reprint Major depression and the stress system: a life span perspective
    S E Meyer
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
    Dev Psychopathol 13:565-80. 2001
    ..The authors highlight the importance of multidisciplinary, longitudinal studies in attempting to gain a deeper understanding of the complex developmental processes involved in the onset and course of depression...
  32. ncbi request reprint Corticotropin-releasing hormone and inflammation
    E L Webster
    Pediatric Endocrinology Section, National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 840:21-32. 1998
    ....
  33. ncbi request reprint Lack of linkage between the corticotropin-releasing hormone (CRH) gene and bipolar affective disorder
    C A Stratakis
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Psychiatry 2:483-5. 1997
    ....
  34. ncbi request reprint Paradoxical response to dexamethasone in the diagnosis of primary pigmented nodular adrenocortical disease
    C A Stratakis
    National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    Ann Intern Med 131:585-91. 1999
    ..Primary pigmented nodular adrenocortical disease causes the Cushing syndrome in children and young adults and is most frequently associated with the Carney complex...
  35. ncbi request reprint The development of a potential single photon emission computed tomography (SPECT) imaging agent for the corticotropin-releasing hormone receptor type
    X Tian
    Laboratory of Medicinal Chemistry, NIDDK, NIH, Bethesda, MD 20892, USA
    Bioorg Med Chem Lett 11:331-3. 2001
    ..The 5-chloro-N-cyclopropylmethyl-N-(2,6-dichloro-4-iodophenyl)-2-methyl-N-propylpyrimidine-4,6-diamine (6b, Ki = 14 nM), and the corresponding 4-bromophenyl analogue (6a, Ki = 21 nM), were synthesized in four steps from compound 3...
  36. ncbi request reprint Glucocorticoids suppress human immunodeficiency virus type-1 long terminal repeat activity in a cell type-specific, glucocorticoid receptor-mediated fashion: direct protective effects at variance with clinical phenomenology
    T Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, Building 10, Room 9D42, National Institutes of Health, 10 Center Drive MSC 1583, Bethesda, MD 20892, USA
    J Steroid Biochem Mol Biol 75:283-90. 2000
    ..We conclude that glucocorticoids suppress, rather than stimulate, the HIV-1 promoter, thus acting, protectively for the host. Their apparent negative clinical association with AIDS is most likely due to immunosuppression of the host...
  37. ncbi request reprint Circulating plasma leptin and IGF-1 levels in girls with premature adrenarche: potential implications of a preliminary study
    G Cizza
    Pediatric and Reproductive Endocrinology Branch, NICHD, NIH, Bethesda, MD, USA
    Horm Metab Res 33:138-43. 2001
    ....
  38. ncbi request reprint Adrenocortical-pituitary hybrid tumor causing Cushing's syndrome
    N Hiroi
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 86:2631-7. 2001
    ....
  39. ncbi request reprint Skin manifestations of Cushing disease in children and adolescents before and after the resolution of hypercortisolemia
    C A Stratakis
    Section on Pediatric Endocrinology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    Pediatr Dermatol 15:253-8. 1998
    ..With the exception of striae, cutaneous effects of endogenous hypercortisolism completely heal within the first year after surgical cure of the disease...
  40. ncbi request reprint Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls
    N Hiroi
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 6:540-6. 2001
    ..Strong expression of both CRH-R1 and CRH-R2 in human pituitaries suggests that particularly under stress, activation of the HPA axis can be maintained through both receptors...
  41. ncbi request reprint The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes
    G P Chrousos
    Pediatric Endocrinology Section, PREB, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Obes Relat Metab Disord 24:S50-5. 2000
    ..Stress-induced hypercortisolism and visceral obesity and their cardiovascular and other sequelae increase the all-cause mortality risk of affected subjects by 2-3-fold and curtail their life expectancy by several years...
  42. ncbi request reprint Conditional modulation of glucocorticoid receptor activities by CREB-binding protein (CBP) and p300
    T Kino
    Section on Pediatric Endocrinology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1862, USA
    J Steroid Biochem Mol Biol 70:15-25. 1999
    ..These findings suggest that CBP and p300 may function additively or antagonistically to each other depending on their relative concentrations and type of target tissue, to influence the sensitivity of tissues to glucocorticoids...
  43. ncbi request reprint Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation
    Z Orban
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD, USA
    Neuroimmunomodulation 7:99-105. 2000
    ..These findings may suggest that novel anti-inflammatory therapies can be based upon activation of NF-kappaB-mediated transcription of genes curbing the inflammatory response and that CAPE or its analogs hold therapeutic promise...
  44. ncbi request reprint Endocrine aspects of growth deficiency in OI
    J C Marini
    Human Genetics Branch, NICHD, NIH, Bethesda, MD 20892, USA
    Connect Tissue Res 31:S55-7. 1995
    ..Our current focus is on the effect of growth hormone treatment on linear growth, bony mineral and bony matrix in OI...
  45. ncbi request reprint Marked suppression of gastric ulcerogenesis and intestinal responses to stress by a novel class of drugs
    K E Gabry
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892 11284, USA
    Mol Psychiatry 7:474-83, 433. 2002
    ....
  46. ncbi request reprint Nelson's syndrome associated with a somatic frame shift mutation in the glucocorticoid receptor gene
    M Karl
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 81:124-9. 1996
    ..We suggest that a somatic GR defect might have played a pathophysiological role in the tumorigenesis of the corticotropinoma bearing this mutation...
  47. ncbi request reprint Depression: a major, unrecognized risk factor for osteoporosis?
    G Cizza
    Clinical Neuroendocrinology Branch, NIMH, Bethesda, MD, USA
    Trends Endocrinol Metab 12:198-203. 2001
    ....
  48. ncbi request reprint Steroidogenic factor 1 messenger ribonucleic acid expression in steroidogenic and nonsteroidogenic human tissues: Northern blot and in situ hybridization studies
    M S Ramayya
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 82:1799-806. 1997
    ..These findings suggest that hSF-1 may play a role in reticuloendothelial/immune cell maturation and/or function, as well as nervous system development and/or neurosteroid biosynthesis...
  49. ncbi request reprint Adrenocortical tumors: recent advances in basic concepts and clinical management
    S R Bornstein
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1862, USA
    Ann Intern Med 130:759-71. 1999
    ....
  50. ncbi request reprint Self-reported sensitivity to chemical exposures in five clinical populations and healthy controls
    S S Nawab
    Section on Biological Rhythms, National Institute of Mental Health, Bethesda, MD 20892 1390, USA
    Psychiatry Res 95:67-74. 2000
    ..A possible relationship between reported chemical sensitivity and hypothalamic-pituitary-adrenal (HPA)-axis functioning is discussed...
  51. ncbi request reprint Frequent occurrence of asplenism and cholelithiasis in patients with autoimmune polyglandular disease type I
    T C Friedman
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    Am J Med 91:625-30. 1991
    ..This study assesses the occurrence of asplenism and gallstones in patients with autoimmune polyglandular disease type I (APG I)...
  52. ncbi request reprint Low glucocorticoid receptor alpha/beta ratio in T-cell lymphoblastic leukemia
    C A Longui
    Section on Pediatric Endocrinology, DEB, NICHD, NIH, Bethesda, USA
    Horm Metab Res 32:401-6. 2000
    ....
  53. ncbi request reprint Procaine and lidocaine stimulate corticotropin-releasing hormone secretion by explanted rat hypothalami through a sodium conductance-independent mechanism
    A E Calogero
    Developmental Endocrinology Branch, National Institute of Child Health and Human Developmental, National Institute of Mental Health, Bethesda, Maryland
    Horm Metab Res 22:25-8. 1990
    ..abstract truncated at 250 words)..
  54. ncbi request reprint Hyper- and hypoaldosteronism
    D J Torpy
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Vitam Horm 57:177-216. 1999
    ..This review aims to provide a survey of the clinical disorders of aldosterone excess and deficiency and their clinical management, with a focus on primary aldosteronism and isolated aldosterone deficiency...
  55. ncbi request reprint Plasma dehydroepiandrosterone levels during experimental endotoxemia and anti-inflammatory therapy in humans
    S R Bornstein
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Crit Care Med 28:2103-6. 2000
    ..To measure the effect of experimental endotoxemia and anti-inflammatory therapy on plasma dehydroepiandrosterone (DHEA) levels in humans...
  56. ncbi request reprint Neuroendocrinology of stress
    K E Habib
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Endocrinol Metab Clin North Am 30:695-728; vii-viii. 2001
    ..Moreover, the promise of nonpeptide CRH type-1 receptor antagonists to directly target the stress system in the brain is highlighted...
  57. ncbi request reprint Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
    P W Gold
    Clinical Neuroendocrinology Branch, Intramural Research Program, NIMH NIH, NIH Clinical Center, Room 2D 46 1284, Bethesda, MD 20892 1284, USA
    Mol Psychiatry 7:254-75. 2002
    ....
  58. ncbi request reprint Allelic imbalance of the mutant and wild-type RET allele in MEN 2A-associated medullary thyroid carcinoma
    C A Koch
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Disease NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    Oncogene 20:7809-11. 2001
    ..Taken together, our results suggest allelic imbalance between mutated and wild-type RET as a possible mechanism for tumor formation in some patients with MEN 2A-related MTC...
  59. ncbi request reprint IL-12, TNF-alpha, and hormonal changes during late pregnancy and early postpartum: implications for autoimmune disease activity during these times
    I J Elenkov
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 86:4933-8. 2001
    ....
  60. ncbi request reprint Glucocorticoid excess during adolescence leads to a major persistent deficit in bone mass and an increase in central body fat
    V Abad
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    J Bone Miner Res 16:1879-85. 2001
    ..These observations suggest that hypercortisolism (exogenous or endogenous) during adolescence may have persistent adverse effects on bone and fat mass...
  61. ncbi request reprint Carney complex and the familial lentiginosis syndromes: link to inherited neoplasias and developmental disorders, and genetic loci
    G P Chrousos
    Section on Pediatric Endocrinology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1862, USA
    J Intern Med 243:573-9. 1998
    ....
  62. ncbi request reprint Transient elevation of serum thyroid hormone levels following lithium discontinuation
    C A Stratakis
    NIH Georgetown University, NIH NICHD, DEB, Bethesda, MD 20892, USA
    Eur J Pediatr 155:939-41. 1996
    ..The lack of clinical hyperthyroidism and the gradual resolution of the biochemical abnormalities in this patient pointed to the benign character of his condition known as "euthyroid hyperthyroxinemia"...
  63. ncbi request reprint The PPARdelta agonist GW501516 suppresses interleukin-6-mediated hepatocyte acute phase reaction via STAT3 inhibition
    T Kino
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    Eur J Clin Invest 37:425-33. 2007
    ..Peroxisome proliferator-activated receptor delta (PPARdelta), which binds to and is activated by a variety of fatty acids, was recently shown to have anti-inflammatory actions...