Jeff W Chou

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Systematic variation normalization in microarray data to get gene expression comparison unbiased
    Jeff W Chou
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Bioinform Comput Biol 3:225-41. 2005
  2. pmc Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories
    Michael J Boedigheimer
    CDER, US FDA, Silver Spring, MD 20993, USA
    BMC Genomics 9:285. 2008
  3. pmc Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes
    Jeff W Chou
    Microarray Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    BMC Bioinformatics 8:427. 2007
  4. pmc Comparative toxicogenomic responses of mercuric and methyl-mercury
    Matthew K McElwee
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, 111 T, W Alexander Drive, Research Triangle Park, P, O, Box 12233, 27709 Durham, NC, USA
    BMC Genomics 14:698. 2013
  5. doi request reprint Sexually dimorphic actions of glucocorticoids provide a link to inflammatory diseases with gender differences in prevalence
    Danielle Duma
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, MD F3 07, Research Triangle Park, NC 27709, USA
    Sci Signal 3:ra74. 2010
  6. pmc Complexes of vesicular stomatitis virus matrix protein with host Rae1 and Nup98 involved in inhibition of host transcription
    Karishma R Rajani
    Department of Biochemistry, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    PLoS Pathog 8:e1002929. 2012
  7. pmc An iron regulatory gene signature predicts outcome in breast cancer
    Lance D Miller
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 71:6728-37. 2011
  8. pmc Discernment of possible mechanisms of hepatotoxicity via biological processes over-represented by co-expressed genes
    Jeff W Chou
    Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
    BMC Genomics 10:272. 2009
  9. pmc Profiles of global gene expression in ionizing-radiation-damaged human diploid fibroblasts reveal synchronization behind the G1 checkpoint in a G0-like state of quiescence
    Tong Zhou
    Department of Pathology and Laboratory Medicine, Center for Environmental Health and Susceptibility, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Environ Health Perspect 114:553-9. 2006

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Systematic variation normalization in microarray data to get gene expression comparison unbiased
    Jeff W Chou
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Bioinform Comput Biol 3:225-41. 2005
    ..Biologically meaningful comparisons of gene expression patterns between control and test channels or among multiple arrays are therefore unbiased using normalized but not unnormalized datasets...
  2. pmc Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories
    Michael J Boedigheimer
    CDER, US FDA, Silver Spring, MD 20993, USA
    BMC Genomics 9:285. 2008
    ....
  3. pmc Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes
    Jeff W Chou
    Microarray Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    BMC Bioinformatics 8:427. 2007
    ..The approach utilizes the underlying structure of gene expression data to extract patterns and identify co-expressed genes that are responsive to experimental conditions...
  4. pmc Comparative toxicogenomic responses of mercuric and methyl-mercury
    Matthew K McElwee
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, 111 T, W Alexander Drive, Research Triangle Park, P, O, Box 12233, 27709 Durham, NC, USA
    BMC Genomics 14:698. 2013
    ..Mercury is a ubiquitous environmental toxicant that exists in multiple chemical forms. A paucity of information exists regarding the differences or similarities by which different mercurials act at the molecular level...
  5. doi request reprint Sexually dimorphic actions of glucocorticoids provide a link to inflammatory diseases with gender differences in prevalence
    Danielle Duma
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, MD F3 07, Research Triangle Park, NC 27709, USA
    Sci Signal 3:ra74. 2010
    ..These gender-specific actions of glucocorticoids in liver were substantiated in vivo with a sepsis model of systemic inflammation...
  6. pmc Complexes of vesicular stomatitis virus matrix protein with host Rae1 and Nup98 involved in inhibition of host transcription
    Karishma R Rajani
    Department of Biochemistry, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    PLoS Pathog 8:e1002929. 2012
    ..They also support the idea that Rae1-Nup98 complexes play a previously under-appreciated role in regulation of transcription...
  7. pmc An iron regulatory gene signature predicts outcome in breast cancer
    Lance D Miller
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 71:6728-37. 2011
    ....
  8. pmc Discernment of possible mechanisms of hepatotoxicity via biological processes over-represented by co-expressed genes
    Jeff W Chou
    Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
    BMC Genomics 10:272. 2009
    ..However, there are no straightforward ways of using co-expressed genes anchored to a phenotype or constrained by the experimental design for discerning mechanisms of a biological response...
  9. pmc Profiles of global gene expression in ionizing-radiation-damaged human diploid fibroblasts reveal synchronization behind the G1 checkpoint in a G0-like state of quiescence
    Tong Zhou
    Department of Pathology and Laboratory Medicine, Center for Environmental Health and Susceptibility, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Environ Health Perspect 114:553-9. 2006
    ....