Jeff W Chou

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Systematic variation normalization in microarray data to get gene expression comparison unbiased
    Jeff W Chou
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Bioinform Comput Biol 3:225-41. 2005
  2. ncbi Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories
    Michael J Boedigheimer
    CDER, US FDA, Silver Spring, MD 20993, USA
    BMC Genomics 9:285. 2008
  3. ncbi Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes
    Jeff W Chou
    Microarray Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    BMC Bioinformatics 8:427. 2007
  4. ncbi Sexually dimorphic actions of glucocorticoids provide a link to inflammatory diseases with gender differences in prevalence
    Danielle Duma
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, MD F3 07, Research Triangle Park, NC 27709, USA
    Sci Signal 3:ra74. 2010
  5. ncbi An iron regulatory gene signature predicts outcome in breast cancer
    Lance D Miller
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 71:6728-37. 2011
  6. ncbi Discernment of possible mechanisms of hepatotoxicity via biological processes over-represented by co-expressed genes
    Jeff W Chou
    Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
    BMC Genomics 10:272. 2009
  7. ncbi Profiles of global gene expression in ionizing-radiation-damaged human diploid fibroblasts reveal synchronization behind the G1 checkpoint in a G0-like state of quiescence
    Tong Zhou
    Department of Pathology and Laboratory Medicine, Center for Environmental Health and Susceptibility, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Environ Health Perspect 114:553-9. 2006

Detail Information

Publications7

  1. ncbi Systematic variation normalization in microarray data to get gene expression comparison unbiased
    Jeff W Chou
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Bioinform Comput Biol 3:225-41. 2005
    ..Biologically meaningful comparisons of gene expression patterns between control and test channels or among multiple arrays are therefore unbiased using normalized but not unnormalized datasets...
  2. ncbi Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories
    Michael J Boedigheimer
    CDER, US FDA, Silver Spring, MD 20993, USA
    BMC Genomics 9:285. 2008
    ....
  3. ncbi Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes
    Jeff W Chou
    Microarray Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    BMC Bioinformatics 8:427. 2007
    ..The approach utilizes the underlying structure of gene expression data to extract patterns and identify co-expressed genes that are responsive to experimental conditions...
  4. ncbi Sexually dimorphic actions of glucocorticoids provide a link to inflammatory diseases with gender differences in prevalence
    Danielle Duma
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, MD F3 07, Research Triangle Park, NC 27709, USA
    Sci Signal 3:ra74. 2010
    ..These gender-specific actions of glucocorticoids in liver were substantiated in vivo with a sepsis model of systemic inflammation...
  5. ncbi An iron regulatory gene signature predicts outcome in breast cancer
    Lance D Miller
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 71:6728-37. 2011
    ....
  6. ncbi Discernment of possible mechanisms of hepatotoxicity via biological processes over-represented by co-expressed genes
    Jeff W Chou
    Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
    BMC Genomics 10:272. 2009
    ..However, there are no straightforward ways of using co-expressed genes anchored to a phenotype or constrained by the experimental design for discerning mechanisms of a biological response...
  7. ncbi Profiles of global gene expression in ionizing-radiation-damaged human diploid fibroblasts reveal synchronization behind the G1 checkpoint in a G0-like state of quiescence
    Tong Zhou
    Department of Pathology and Laboratory Medicine, Center for Environmental Health and Susceptibility, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Environ Health Perspect 114:553-9. 2006
    ....