Hyeseon Cho

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The loss of RGS protein-Gα(i2) interactions results in markedly impaired mouse neutrophil trafficking to inflammatory sites
    Hyeseon Cho
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cell Biol 32:4561-71. 2012
  2. ncbi request reprint Beyond the plasma membrane: new Functions for heterotrimeric G-protein signaling in asymmetric and symmetric cell division
    Hyeseon Cho
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Cycle 7:573-7. 2008
  3. pmc Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division
    Hyeseon Cho
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Cell Biol 178:245-55. 2007
  4. pmc Rgs5 targeting leads to chronic low blood pressure and a lean body habitus
    Hyeseon Cho
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Room 11B08, 10 Center Dr MSC 1876, Bethesda, MD 20892, USA
    Mol Cell Biol 28:2590-7. 2008
  5. pmc The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling
    Hyeseon Cho
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, Room 11B 08, Building 10, National Institute of Allergy and Infectious Diseases, 10 Center Drive, MSC 1876, National Institutes of Health, Bethesda, MD 20892 1876, USA
    Biochem J 371:973-80. 2003
  6. ncbi request reprint RGS14 is a centrosomal and nuclear cytoplasmic shuttling protein that traffics to promyelocytic leukemia nuclear bodies following heat shock
    Hyeseon Cho
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892 1876, USA
    J Biol Chem 280:805-14. 2005
  7. ncbi request reprint Rgs1 and Gnai2 regulate the entrance of B lymphocytes into lymph nodes and B cell motility within lymph node follicles
    Sang Bae Han
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious, Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 22:343-54. 2005
  8. pmc Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle
    Geoffrey E Woodard
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, 10 Center Drive, MSC 1888, Bethesda, MD 20892 1752, USA
    Mol Cell Biol 30:3519-30. 2010
  9. pmc Beta-agonist-associated reduction in RGS5 expression promotes airway smooth muscle hyper-responsiveness
    Zhao Yang
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:11444-55. 2011
  10. doi request reprint Resistance to Inhibitors of Cholinesterase (Ric)-8A and Gαi Contribute to Cytokinesis Abscission by Controlling Vacuolar Protein-Sorting (Vps)34 Activity
    Cedric Boularan
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 9:e86680. 2014

Collaborators

Detail Information

Publications14

  1. pmc The loss of RGS protein-Gα(i2) interactions results in markedly impaired mouse neutrophil trafficking to inflammatory sites
    Hyeseon Cho
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cell Biol 32:4561-71. 2012
    ..Neutrophil RGS proteins establish a threshold for Gα(i) activation, helping to coordinate desensitization mechanisms. Their loss renders neutrophils functionally incompetent...
  2. ncbi request reprint Beyond the plasma membrane: new Functions for heterotrimeric G-protein signaling in asymmetric and symmetric cell division
    Hyeseon Cho
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Cycle 7:573-7. 2008
    ..Together the evidence argues for a more direct role of non-canonical heterotrimeric G protein signaling in microtubule- and actin cytoskeleton-mediated cellular processes...
  3. pmc Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division
    Hyeseon Cho
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Cell Biol 178:245-55. 2007
    ..These results suggest that G(ialpha) proteins and their regulators at these sites may play essential roles during mammalian cell division...
  4. pmc Rgs5 targeting leads to chronic low blood pressure and a lean body habitus
    Hyeseon Cho
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Room 11B08, 10 Center Dr MSC 1876, Bethesda, MD 20892, USA
    Mol Cell Biol 28:2590-7. 2008
    ..Blocking the function or the expression of RGS5 may provide an alternative approach to treat hypertension...
  5. pmc The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling
    Hyeseon Cho
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, Room 11B 08, Building 10, National Institute of Allergy and Infectious Diseases, 10 Center Drive, MSC 1876, National Institutes of Health, Bethesda, MD 20892 1876, USA
    Biochem J 371:973-80. 2003
    ....
  6. ncbi request reprint RGS14 is a centrosomal and nuclear cytoplasmic shuttling protein that traffics to promyelocytic leukemia nuclear bodies following heat shock
    Hyeseon Cho
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892 1876, USA
    J Biol Chem 280:805-14. 2005
    ..The multifunctional domains and the dynamic subcellular localization of RGS14 implicate it in a diverse set of cellular processes including centrosome and nuclear functions and stress-induced signaling pathways...
  7. ncbi request reprint Rgs1 and Gnai2 regulate the entrance of B lymphocytes into lymph nodes and B cell motility within lymph node follicles
    Sang Bae Han
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious, Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 22:343-54. 2005
    ..These results demonstrate opposing roles for Rgs1 and Gnai2 in B cell trafficking into and within lymph nodes...
  8. pmc Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle
    Geoffrey E Woodard
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, 10 Center Drive, MSC 1888, Bethesda, MD 20892 1752, USA
    Mol Cell Biol 30:3519-30. 2010
    ..These data indicate that Ric-8A signaling leads to assembly of a cortical signaling complex that functions to orient the mitotic spindle...
  9. pmc Beta-agonist-associated reduction in RGS5 expression promotes airway smooth muscle hyper-responsiveness
    Zhao Yang
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:11444-55. 2011
    ..Repetitive β(2)-agonist use may not only lead to reduced bronchoprotection but also to sensitization of excitation-contraction signaling pathways as a result of reduced RGS5 expression...
  10. doi request reprint Resistance to Inhibitors of Cholinesterase (Ric)-8A and Gαi Contribute to Cytokinesis Abscission by Controlling Vacuolar Protein-Sorting (Vps)34 Activity
    Cedric Boularan
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 9:e86680. 2014
    ..During cytokinesis, Ric-8A co-localized with Vps34 at the midbody along with Gαi and LGN, where these proteins functioned to regulate Vps34 phosphatidylinositol 3-kinase activity. ..
  11. doi request reprint Regulation of immune function by G protein-coupled receptors, trimeric G proteins, and RGS proteins
    Hyeseon Cho
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1876, USA
    Prog Mol Biol Transl Sci 86:249-98. 2009
    ....
  12. ncbi request reprint Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation
    Hyeseon Cho
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1876, USA
    FASEB J 17:440-2. 2003
    ..Together these results indicate that RGS5 exerts control over PDGFR-beta and GPCR-mediated signaling pathways active during fetal vascular maturation...
  13. pmc Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells
    Cecilia Bondjers
    Department of Medical Biochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Am J Pathol 162:721-9. 2003
    ..With RGS5 as a proof-of-principle, our data demonstrate the usefulness of microarray analysis of mouse models for abnormal pericyte development in the identification of new pericyte-specific markers...
  14. ncbi request reprint Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogen-activated protein pathway
    Chawon Yun
    Department of Biochemistry and Molecular Biology, Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, South Korea
    Mol Cancer Res 2:159-69. 2004
    ..These findings may provide a possible mechanism by which HBx promotes phenotypic progression by predisposing chromosomal alteration in HBV-infected liver...