Hye Youn Cho

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Genomic structure and variation of nuclear factor (erythroid-derived 2)-like 2
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr, Building 101, MD D 201, Research Triangle Park, NC 27709, USA
    Oxid Med Cell Longev 2013:286524. 2013
  2. pmc Exacerbated airway toxicity of environmental oxidant ozone in mice deficient in Nrf2
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Oxid Med Cell Longev 2013:254069. 2013
  3. pmc Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Antioxid Redox Signal 17:1066-82. 2012
  4. pmc Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709, USA
    Am J Respir Crit Care Med 179:138-50. 2009
  5. ncbi request reprint Nrf2 protects against airway disorders
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Building 101, MD D 201, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 244:43-56. 2010
  6. pmc Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr, Building 101, MD D 201, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 182:170-82. 2010
  7. ncbi request reprint Genetic mechanisms of susceptibility to oxidative lung injury in mice
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 42:433-45. 2007
  8. pmc Signal transduction pathways of tumor necrosis factor--mediated lung injury induced by ozone in mice
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Building 101, MD D 201, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 175:829-39. 2007
  9. ncbi request reprint Nrf2 defends the lung from oxidative stress
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Antioxid Redox Signal 8:76-87. 2006
  10. ncbi request reprint Role of Toll-like receptor-4 in genetic susceptibility to lung injury induced by residual oil fly ash
    Hye Youn Cho
    Department of Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    Physiol Genomics 22:108-17. 2005

Detail Information

Publications27

  1. pmc Genomic structure and variation of nuclear factor (erythroid-derived 2)-like 2
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr, Building 101, MD D 201, Research Triangle Park, NC 27709, USA
    Oxid Med Cell Longev 2013:286524. 2013
    ..Comprehensive information from the current review addresses association of NRF2 variation and disease phenotypes and supports the new insights into therapeutic strategies. ..
  2. pmc Exacerbated airway toxicity of environmental oxidant ozone in mice deficient in Nrf2
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Oxid Med Cell Longev 2013:254069. 2013
    ..Relative to Nrf2(+/+), O3 augmented lung protein and lipid oxidation more highly in Nrf2(-/-) mice. Results suggest that Nrf2 deficiency exacerbates oxidative stress and airway injury caused by the environmental pollutant O3...
  3. pmc Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Antioxid Redox Signal 17:1066-82. 2012
    ....
  4. pmc Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709, USA
    Am J Respir Crit Care Med 179:138-50. 2009
    ..The transcription factor Nrf2 protects lungs from oxidative injury and inflammation via antioxidant response element (ARE)-mediated gene induction...
  5. ncbi request reprint Nrf2 protects against airway disorders
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Building 101, MD D 201, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 244:43-56. 2010
    ..In the current review, we address the role of Nrf2 in airways based on emerging evidence from experimental oxidative disease models and human studies...
  6. pmc Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr, Building 101, MD D 201, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 182:170-82. 2010
    ..PPARgamma has pleiotropic beneficial effects including antiinflammation in multiple tissues...
  7. ncbi request reprint Genetic mechanisms of susceptibility to oxidative lung injury in mice
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 42:433-45. 2007
    ....
  8. pmc Signal transduction pathways of tumor necrosis factor--mediated lung injury induced by ozone in mice
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Building 101, MD D 201, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 175:829-39. 2007
    ..We previously determined that mice genetically deficient in TNF response are protected from lung inflammation and epithelial injury after O(3) exposure...
  9. ncbi request reprint Nrf2 defends the lung from oxidative stress
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Antioxid Redox Signal 8:76-87. 2006
    ....
  10. ncbi request reprint Role of Toll-like receptor-4 in genetic susceptibility to lung injury induced by residual oil fly ash
    Hye Youn Cho
    Department of Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    Physiol Genomics 22:108-17. 2005
    ..Results support an important contribution of genetic background to particle-mediated lung injury, and Tlr4 is a candidate susceptibility gene...
  11. ncbi request reprint Gene expression profiling of NRF2-mediated protection against oxidative injury
    Hye Youn Cho
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Free Radic Biol Med 38:325-43. 2005
    ..These NRF2-dependent gene products might have key roles in protection against hyperoxic lung injury. Results from our global gene expression profiles provide putative downstream molecular mechanisms of oxygen tissue toxicity...
  12. ncbi request reprint The transcription factor NRF2 protects against pulmonary fibrosis
    Hye Youn Cho
    Department of Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    FASEB J 18:1258-60. 2004
    ..This study has important implications for the development of intervention strategies against fibrosis...
  13. ncbi request reprint Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate gene
    Hye Youn Cho
    Department of Environmental Health Sciences, Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 26:42-51. 2002
    ..Results from this study have important implications for understanding the mechanisms through which oxidants mediate the pathogenesis of lung disease...
  14. ncbi request reprint Role of NRF2 in protection against hyperoxic lung injury in mice
    Hye Youn Cho
    Department of Environmental Health Sciences, The Bloomberg School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 26:175-82. 2002
    ..Results demonstrated that NRF2 has a significant protective role against pulmonary hyperoxic injury in mice, possibly through transcriptional activation of lung antioxidant defense enzymes...
  15. ncbi request reprint NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells
    Srinivas Papaiahgari
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Biol Chem 279:42302-12. 2004
    ..Collectively, our findings suggest that hyperoxia-induced, ARE-driven, Nrf2-dependent transcription is controlled by NADPH oxidase and ERK-1 signaling...
  16. pmc Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants
    Narsa M Reddy
    The Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Am J Respir Cell Mol Biol 37:3-8. 2007
    ..Our data suggest that dysfunctional Nrf2-regulated GSH-induced signaling is associated with deregulation of type II cell proliferation, which contributes to abnormal injury and repair and leads to respiratory impairment...
  17. ncbi request reprint Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury
    Jacqui M Marzec
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 21:2237-46. 2007
    ..Furthermore, these findings may have important implications in other oxidative stress related illnesses...
  18. pmc Identification of polymorphic antioxidant response elements in the human genome
    Xuting Wang
    Environmental Genomics Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA
    Hum Mol Genet 16:1188-200. 2007
    ....
  19. ncbi request reprint Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis
    Alison K Bauer
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 97:1778-81. 2005
    ..To our knowledge, this is the first model to demonstrate a modulatory role for Tlr4 in chronic lung inflammation and tumorigenesis...
  20. pmc Protective role of matrix metalloproteinase-9 in ozone-induced airway inflammation
    Hyoung Kyu Yoon
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 115:1557-63. 2007
    ..Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of oxidative lung disorders including acute lung injury, asthma, and chronic obstructive pulmonary disease...
  21. ncbi request reprint Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2
    Dianne M Walters
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Antioxid Redox Signal 10:321-32. 2008
    ..Pulmonary fibrosis is a highly complex disease and involves multiple genes and processes, and new therapies for cellular and molecular targets involved in pathogenic mechanisms are needed...
  22. pmc Protective role of interleukin-10 in ozone-induced pulmonary inflammation
    Gillian S Backus
    National Institute of Environmental Health Sciences, Laboratory of Respiratory Biology, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 118:1721-7. 2010
    ..The mechanisms underlying ozone (O₃)-induced pulmonary inflammation remain unclear. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is known to inhibit inflammatory mediators...
  23. ncbi request reprint Hyperoxia stimulates an Nrf2-ARE transcriptional response via ROS-EGFR-PI3K-Akt/ERK MAP kinase signaling in pulmonary epithelial cells
    Srinivas Papaiahgari
    Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
    Antioxid Redox Signal 8:43-52. 2006
    ..Collectively, our data suggest that EGFR-PI3K signaling through Akt and ERK kinases regulates ROS-dependent, hyperoxia-induced Nrf2 activation in pulmonary epithelial cells...
  24. ncbi request reprint Gene-environment interactions in environmental lung diseases
    Steven R Kleeberger
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Novartis Found Symp 293:168-78; discussion 178-83. 2008
    ..This 'bench to bedside' approach may provide an understanding of gene-environment interactions in complex lung diseases is essential to the development of new strategies for lung disease prevention and treatment...
  25. pmc Noblesse oblige: NRF2 functions in the airways
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina
    Am J Respir Cell Mol Biol 50:844-7. 2014
    ..Future investigations of NRF2 should yield further insight into its contribution to normal and pathophysiological conditions in the airways, and alternative treatment strategies to protect against oxidative respiratory disease...
  26. ncbi request reprint Genome-wide association mapping of acute lung injury in neonatal inbred mice
    Jennifer L Nichols
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, U S National Institutes of Health, Research Triangle Park, North Carolina, USA Curriculum in Toxicology, Center for Environmental Medicine, Asthma, and Lung Biology, and
    FASEB J 28:2538-50. 2014
    ..Nichols, J. L., Gladwell, W., Verhein, K. C., Cho, H.-Y., Wess, J., Suzuki, O., Wiltshire, T., Kleeberger, S. R. Genome-wide association mapping of acute lung injury in neonatal inbred mice. ..