Research Topics
Genomes and Genes | Hye Youn ChoSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal miceHye Youn Cho
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Antioxid Redox Signal 17:1066-82. 2012....- Signal transduction pathways of tumor necrosis factor--mediated lung injury induced by ozone in miceHye Youn Cho
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Building 101, MD D 201, Research Triangle Park, NC 27709, USA
Am J Respir Crit Care Med 175:829-39. 2007..We previously determined that mice genetically deficient in TNF response are protected from lung inflammation and epithelial injury after O(3) exposure... - Nrf2 defends the lung from oxidative stressHye Youn Cho
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Antioxid Redox Signal 8:76-87. 2006.... - Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus diseaseHye Youn Cho
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709, USA
Am J Respir Crit Care Med 179:138-50. 2009..The transcription factor Nrf2 protects lungs from oxidative injury and inflammation via antioxidant response element (ARE)-mediated gene induction... - Role of Toll-like receptor-4 in genetic susceptibility to lung injury induced by residual oil fly ashHye Youn Cho
Department of Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
Physiol Genomics 22:108-17. 2005..Results support an important contribution of genetic background to particle-mediated lung injury, and Tlr4 is a candidate susceptibility gene... - Gene expression profiling of NRF2-mediated protection against oxidative injuryHye Youn Cho
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
Free Radic Biol Med 38:325-43. 2005..These NRF2-dependent gene products might have key roles in protection against hyperoxic lung injury. Results from our global gene expression profiles provide putative downstream molecular mechanisms of oxygen tissue toxicity... - Nrf2 protects against airway disordersHye Youn Cho
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Building 101, MD D 201, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 244:43-56. 2010..In the current review, we address the role of Nrf2 in airways based on emerging evidence from experimental oxidative disease models and human studies... - The transcription factor NRF2 protects against pulmonary fibrosisHye Youn Cho
Department of Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
FASEB J 18:1258-60. 2004..This study has important implications for the development of intervention strategies against fibrosis... - Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in miceHye Youn Cho
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr, Building 101, MD D 201, Research Triangle Park, NC 27709, USA
Am J Respir Crit Care Med 182:170-82. 2010..PPARgamma has pleiotropic beneficial effects including antiinflammation in multiple tissues... - Genetic mechanisms of susceptibility to oxidative lung injury in miceHye Youn Cho
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 42:433-45. 2007.... - Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate geneHye Youn Cho
Department of Environmental Health Sciences, Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
Am J Respir Cell Mol Biol 26:42-51. 2002..Results from this study have important implications for understanding the mechanisms through which oxidants mediate the pathogenesis of lung disease... - NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cellsSrinivas Papaiahgari
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
J Biol Chem 279:42302-12. 2004..Collectively, our findings suggest that hyperoxia-induced, ARE-driven, Nrf2-dependent transcription is controlled by NADPH oxidase and ERK-1 signaling... - Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidantsNarsa M Reddy
The Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, 615 North Wolfe Street, Baltimore, MD 21205, USA
Am J Respir Cell Mol Biol 37:3-8. 2007..Our data suggest that dysfunctional Nrf2-regulated GSH-induced signaling is associated with deregulation of type II cell proliferation, which contributes to abnormal injury and repair and leads to respiratory impairment... - Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injuryJacqui M Marzec
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
FASEB J 21:2237-46. 2007..Furthermore, these findings may have important implications in other oxidative stress related illnesses... - Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesisAlison K Bauer
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Natl Cancer Inst 97:1778-81. 2005..To our knowledge, this is the first model to demonstrate a modulatory role for Tlr4 in chronic lung inflammation and tumorigenesis... - Protective role of matrix metalloproteinase-9 in ozone-induced airway inflammationHyoung Kyu Yoon
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 115:1557-63. 2007..Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of oxidative lung disorders including acute lung injury, asthma, and chronic obstructive pulmonary disease... - Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2Dianne M Walters
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Antioxid Redox Signal 10:321-32. 2008..Pulmonary fibrosis is a highly complex disease and involves multiple genes and processes, and new therapies for cellular and molecular targets involved in pathogenic mechanisms are needed... - Identification of polymorphic antioxidant response elements in the human genomeXuting Wang
Environmental Genomics Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA
Hum Mol Genet 16:1188-200. 2007.... - Role of NRF2 in protection against hyperoxic lung injury in miceHye-Youn Cho
Department of Environmental Health Sciences, The Bloomberg School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland, USA
Am J Respir Cell Mol Biol 26:175-82. 2002..Results demonstrated that NRF2 has a significant protective role against pulmonary hyperoxic injury in mice, possibly through transcriptional activation of lung antioxidant defense enzymes... - Protective role of interleukin-10 in ozone-induced pulmonary inflammationGillian S Backus
National Institute of Environmental Health Sciences, Laboratory of Respiratory Biology, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 118:1721-7. 2010..The mechanisms underlying ozone (O₃)-induced pulmonary inflammation remain unclear. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is known to inhibit inflammatory mediators... - Hyperoxia stimulates an Nrf2-ARE transcriptional response via ROS-EGFR-PI3K-Akt/ERK MAP kinase signaling in pulmonary epithelial cellsSrinivas Papaiahgari
Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
Antioxid Redox Signal 8:43-52. 2006..Collectively, our data suggest that EGFR-PI3K signaling through Akt and ERK kinases regulates ROS-dependent, hyperoxia-induced Nrf2 activation in pulmonary epithelial cells... - Gene-environment interactions in environmental lung diseasesSteven R Kleeberger
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Novartis Found Symp 293:168-78; discussion 178-83. 2008..This 'bench to bedside' approach may provide an understanding of gene-environment interactions in complex lung diseases is essential to the development of new strategies for lung disease prevention and treatment...