Ajay B Chitnis

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Building the posterior lateral line system in zebrafish
    Ajay B Chitnis
    the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Dev Neurobiol 72:234-55. 2012
  2. ncbi request reprint Control of neurogenesis--lessons from frogs, fish and flies
    A B Chitnis
    Laboratory of Molecular Genetics National Institute of Child Health and Human Development National Institutes of Health Unit on Vertebrate Neural Development, Bethesda Maryland 20892 USA
    Curr Opin Neurobiol 9:18-25. 1999
  3. pmc Why is delta endocytosis required for effective activation of notch?
    Ajay Chitnis
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 6 Center Drive, 3B 315, Bethesda, MD 20892, USA
    Dev Dyn 235:886-94. 2006
  4. ncbi request reprint Exploring alternative models of rostral-caudal patterning in the zebrafish neurectoderm with computer simulations
    Ajay B Chitnis
    Unit on Vertebrate Neural Development, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Building 6B, Room 3B 315, 6 Center Drive, Bethesda, Maryland 20892, USA
    Curr Opin Genet Dev 14:415-21. 2004
  5. pmc Lef1 regulates Dusp6 to influence neuromast formation and spacing in the zebrafish posterior lateral line primordium
    Miho Matsuda
    Program in Genomics of Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20852, USA
    Development 140:2387-97. 2013
  6. pmc Interaction with Notch determines endocytosis of specific Delta ligands in zebrafish neural tissue
    Miho Matsuda
    Laboratory of Molecular Genetics, Section on Neural Developmental Dynamics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 136:197-206. 2009
  7. pmc Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish
    Miho Matsuda
    Laboratory of Molecular Genetics, Section on Neural Developmental Dynamics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 137:3477-87. 2010
  8. ncbi request reprint Keeping single minded expression on the straight and narrow
    Ajay B Chitnis
    Laboratory of Molecular Genetics, The National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell 21:450-2. 2006
  9. ncbi request reprint Insights into the evolutionary history of the vertebrate zic3 locus from a teleost-specific zic6 gene in the zebrafish, Danio rerio
    Michael J Keller
    Laboratory of Molecular Genetics, NIH NICHD, 6 Center Drive, 6B 3B315, Bethesda, MD 20892, USA
    Dev Genes Evol 217:541-7. 2007
  10. ncbi request reprint Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta
    Motoyuki Itoh
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
    Dev Cell 4:67-82. 2003

Collaborators

  • Gavin J Wright
  • Yun Jin Jiang
  • Andrew G York
  • Robert S Fischer
  • Sang Yeob Yeo
  • Michael J Keller
  • Tetsuhiro Kudoh
  • Allan M Weissman
  • Julian Lewis
  • Prisca Chapouton
  • Alexandra Tallafuss
  • Sung Kook Hong
  • Didier Y R Stainier
  • Laure Bally-Cuif
  • Miho Matsuda
  • Cheol Hee Kim
  • Motoyuki Itoh
  • Evan R Ball
  • Sander H Diks
  • Tohru Ishitani
  • Bon Kyoung Koo
  • Kyeong Won Yoo
  • Yutaka Kikuchi
  • Andrea Geling
  • Su Hyeon Park
  • Myungchull Rhee
  • Seok Hyung Kim
  • Kathleen Martin
  • Chongmin Wang
  • Damian Dalle Nogare
  • Katherine Somers
  • Louis Dye
  • Miho M Matsuda
  • Victoria Hoffmann
  • Adam Rich
  • Eva Szarek
  • Patricia M Zerfas
  • Constantine A Stratakis
  • Maikel P Peppelenbosch
  • Danica Zivkovic
  • Maria A Sartori da Silva
  • Jan Luuk Hillebrands
  • Carina van Rooijen
  • Anke Brouwers
  • Henri H Versteeg
  • Robert J Bink
  • Kunihiro Matsumoto
  • Mi Jeong Yoon
  • Myung Phil Kong
  • Young Woong Kim
  • Jinie Lee
  • Ki Jun Yoon
  • Min Chul Kwon
  • Hyoung Soo Lim
  • Young Yun Kong
  • Ran Song
  • Jin Sook Moon
  • Atsushi Kuroiwa
  • Heather Verkade
  • Jeremy F Reiter
  • Linda Ariza-McNaughton
  • Donovan Maust
  • Settara C Chandrasekharappa
  • Kevin Lorick
  • Takaya Oda
  • John Y Kuwada
  • Birgit Tannhäuser
  • Gregory Palardy
  • Suman Lee
  • Michael Dedekian
  • Jimann Shin
  • Tae Lin Huh
  • Sangtae Han
  • Hae Chul Park

Detail Information

Publications22

  1. pmc Building the posterior lateral line system in zebrafish
    Ajay B Chitnis
    the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Dev Neurobiol 72:234-55. 2012
    ..These studies also illustrate how the pLL system is contributing much more broadly to our understanding of mechanisms operating during the growth, regeneration, and self-organization of other organ systems during development and disease...
  2. ncbi request reprint Control of neurogenesis--lessons from frogs, fish and flies
    A B Chitnis
    Laboratory of Molecular Genetics National Institute of Child Health and Human Development National Institutes of Health Unit on Vertebrate Neural Development, Bethesda Maryland 20892 USA
    Curr Opin Neurobiol 9:18-25. 1999
    ..The analysis of these genes has begun to fill gaps in our understanding of events that lead from neural induction to the generation of neurons within three longitudinal columns in the Xenopus and zebrafish neural plate...
  3. pmc Why is delta endocytosis required for effective activation of notch?
    Ajay Chitnis
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 6 Center Drive, 3B 315, Bethesda, MD 20892, USA
    Dev Dyn 235:886-94. 2006
    ..Though it is still not clear how either or both mechanisms contribute, recent evidence points to the importance of both endocytosis and recycling in Delta signaling...
  4. ncbi request reprint Exploring alternative models of rostral-caudal patterning in the zebrafish neurectoderm with computer simulations
    Ajay B Chitnis
    Unit on Vertebrate Neural Development, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Building 6B, Room 3B 315, 6 Center Drive, Bethesda, Maryland 20892, USA
    Curr Opin Genet Dev 14:415-21. 2004
    ..The models illustrate how a hypothetical genetic network based on auto-activation and cross-repression could lead to establishment of discrete non-overlapping gene-expression domains...
  5. pmc Lef1 regulates Dusp6 to influence neuromast formation and spacing in the zebrafish posterior lateral line primordium
    Miho Matsuda
    Program in Genomics of Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20852, USA
    Development 140:2387-97. 2013
    ..This is associated with progressively slower PLLp migration, reduced spacing between deposited neuromasts and premature termination of the PLLp system...
  6. pmc Interaction with Notch determines endocytosis of specific Delta ligands in zebrafish neural tissue
    Miho Matsuda
    Laboratory of Molecular Genetics, Section on Neural Developmental Dynamics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 136:197-206. 2009
    ....
  7. pmc Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish
    Miho Matsuda
    Laboratory of Molecular Genetics, Section on Neural Developmental Dynamics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 137:3477-87. 2010
    ..Together, our observations reveal a genetic regulatory network that explains why atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the pLLp...
  8. ncbi request reprint Keeping single minded expression on the straight and narrow
    Ajay B Chitnis
    Laboratory of Molecular Genetics, The National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell 21:450-2. 2006
    ..This allows precise control of Notch signaling and restriction of single minded expression to a single row of cells...
  9. ncbi request reprint Insights into the evolutionary history of the vertebrate zic3 locus from a teleost-specific zic6 gene in the zebrafish, Danio rerio
    Michael J Keller
    Laboratory of Molecular Genetics, NIH NICHD, 6 Center Drive, 6B 3B315, Bethesda, MD 20892, USA
    Dev Genes Evol 217:541-7. 2007
    ..We present evidence that zic6 is an ancestral locus arising by chromosomal duplication early in the Euteleostomi that was subsequently lost in the terrestrial vertebrates...
  10. ncbi request reprint Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta
    Motoyuki Itoh
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
    Dev Cell 4:67-82. 2003
    ..This facilitates intramembranous cleavage of the remaining Notch receptor, release of the Notch intracellular fragment, and activation of target genes in neighboring cells...
  11. ncbi request reprint A role for iro1 and iro7 in the establishment of an anteroposterior compartment of the ectoderm adjacent to the midbrain-hindbrain boundary
    Motoyuki Itoh
    Laboratory of Molecular Genetics, NICHD NIH, Bethesda, MD 20892, USA
    Development 129:2317-27. 2002
    ....
  12. pmc Ultra-structural identification of interstitial cells of Cajal in the zebrafish Danio rerio
    Evan R Ball
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1 3330, 10 Center Drive, MSC1103, Bethesda, MD 20892, USA
    Cell Tissue Res 349:483-91. 2012
    ..Taken together, these data represent the first ultra-structural characterization of cells in the muscularis of the zebrafish Danio rerio and suggest that ICC differentiation in vertebrate evolution dates back to the teleost lineage...
  13. pmc Resolution doubling in live, multicellular organisms via multifocal structured illumination microscopy
    Andrew G York
    Section on High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, US National Institutes of Health NIH, Bethesda, Maryland, USA
    Nat Methods 9:749-54. 2012
    ..Our method uses commercially available parts and open-source software and is simpler than existing SIM implementations, allowing easy integration with wide-field microscopes...
  14. doi request reprint d-Asb11 is an essential mediator of canonical Delta-Notch signalling
    Sander H Diks
    Deptartment of Cell Biology, University Medical Center Groningen, University of Groningen, A Deusinglaan 1, NL 9713 AV Groningen, The Netherlands
    Nat Cell Biol 10:1190-8. 2008
    ..We conclude that d-Asb11 is a component in the regulation of Delta-Notch signalling, important in fine-tuning the lateral inhibition gradients between DeltaA and Notch through a cell non-autonomous mechanism...
  15. ncbi request reprint Zath3, a neural basic helix-loop-helix gene, regulates early neurogenesis in the zebrafish
    Su Hyeon Park
    Department of Biology, Chungnam National University, Daejeon 305 764, South Korea
    Biochem Biophys Res Commun 308:184-90. 2003
    ..This study suggests that zath3 and ngn1 have partially overlapping roles in early neurogenesis...
  16. ncbi request reprint Fluorescent protein expression driven by her4 regulatory elements reveals the spatiotemporal pattern of Notch signaling in the nervous system of zebrafish embryos
    Sang Yeob Yeo
    Department of Genetic Engineering, Kyungpook National University, Daegu 702 701, Korea
    Dev Biol 301:555-67. 2007
    ..The establishment of a reporter line with Notch-Su(H)-dependent fluorescent gene expression provides a tool to explore the complex role of Notch signaling in the development of vertebrate nervous system...
  17. ncbi request reprint Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish
    Seok Hyung Kim
    Department of Genetic Engineering, Kyungpook National University, Daegu 702 701, Korea
    Development 129:4443-55. 2002
    ..In conclusion, we suggest that a gradient of Fz8a-mediated Wnt8b signalling may play crucial role in patterning the posterior diencephalon and midbrain regions in the late gastrula...
  18. ncbi request reprint Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability
    Tohru Ishitani
    Unit on Nervous System Development, Laboratory of Cell Regulation, Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464 8602, Japan
    Nat Cell Biol 7:1106-12. 2005
    ..Furthermore, activation of LEF1 does not affect Notch activity or vice versa. These findings reveal that Nrarp independently regulates canonical Wnt and Notch signalling by modulating LEF1 and Notch protein turnover, respectively...
  19. ncbi request reprint bHLH transcription factor Her5 links patterning to regional inhibition of neurogenesis at the midbrain-hindbrain boundary
    Andrea Geling
    Zebrafish Neurogenetics Junior Research Group, Institute of Virology, Technical University Munich, Trogerstrasse 4b, D 81675 Munich, Germany
    Development 130:1591-604. 2003
    ..Her5 appears as a partially redundant component of this inhibitory process that helps translate early axial patterning information into a distinct spatiotemporal pattern of neurogenesis and cell proliferation within the MH domain...
  20. ncbi request reprint Notch signaling can regulate endoderm formation in zebrafish
    Yutaka Kikuchi
    Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya, Japan
    Dev Dyn 229:756-62. 2004
    ..Altogether, these results suggest that Notch signaling plays a role in the formation of the endoderm, possibly in its segregation from the mesoderm...
  21. ncbi request reprint Mind bomb 1 is essential for generating functional Notch ligands to activate Notch
    Bon Kyoung Koo
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, 790 784, South Korea
    Development 132:3459-70. 2005
    ..Our results show that Mib1 is an essential regulator, but not a potentiator, for generating functional Notch ligands to activate Notch signaling...
  22. pmc Jagged-mediated Notch signaling maintains proliferating neural progenitors and regulates cell diversity in the ventral spinal cord
    Sang Yeob Yeo
    Department of Genetic Engineering, Kyungpook National University, 1370 san Kyuk dong, Buk Gu, Daegu 702 701, Republic of Korea
    Proc Natl Acad Sci U S A 104:5913-8. 2007
    ....