C Chiang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland 20892, USA
    Nature 383:407-13. 1996
  2. ncbi Mediolateral patterning of somites: multiple axial signals, including Sonic hedgehog, regulate Nkx-3.1 expression
    L Kos
    Laboratory of Mammalian Genes and Development, NICHD, NIH, Bethesda, MD 20892, USA
    Mech Dev 70:25-34. 1998
  3. ncbi Essential role for Sonic hedgehog during hair follicle morphogenesis
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Dev Biol 205:1-9. 1999
  4. ncbi Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop
    V Knezevic
    Laboratory of Pathology, NCI, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    Development 124:4523-36. 1997
  5. ncbi Expression of murine Lhx5 suggests a role in specifying the forebrain
    H Z Sheng
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Dyn 208:266-77. 1997
  6. ncbi Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: a study with knockout mice
    J H Pak
    Endocrinology and Reproduction Research Branch and Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:11232-7. 2000
  7. ncbi Induction of midbrain dopaminergic neurons by Sonic hedgehog
    M Hynes
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    Neuron 15:35-44. 1995
  8. ncbi Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3
    Y Litingtung
    Department of Cell Biology, Vanderbilt University Medical Center, B2120 MCN, Nashville, Tennessee 37232, USA
    Nat Neurosci 3:979-85. 2000
  9. ncbi Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function
    C Chiang
    Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Dev Biol 236:421-35. 2001
  10. ncbi Anorectal malformations caused by defects in sonic hedgehog signaling
    R Mo
    Program in Developmental Biology, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 159:765-74. 2001

Collaborators

  • W Shawlot
  • J Li
  • S Mackem
  • H Z Sheng
  • S Bertuzzi
  • W Gaffield
  • Wanguo Liu
  • Hong Zhang
  • Y Litingtung
  • Y Ohkubo
  • R Mo
  • J H Pak
  • H Westphal
  • A G Borycki
  • A Pierani
  • L Kos
  • K A Mahon
  • V Knezevic
  • T M Jessell
  • P A Beachy
  • D T Chang
  • J L R Rubenstein
  • P C Kim
  • J Zhang
  • C C Hui
  • J H Kim
  • K P Huang
  • K G Reymann
  • J A Porter
  • F L Huang
  • H Roelink
  • D Balschun
  • M Hynes
  • C P Emerson
  • S Tajbakhsh
  • S Brenner-Morton
  • B Brunk
  • M Buckingham
  • L Lei
  • R De Santo
  • U Huffstadt
  • K Schughart
  • A Rosenthal
  • M Tessier-Lavigne
  • D Chang
  • Y Tanabe
  • J F Fallon
  • A Lopez
  • R Zhao
  • M F Seldin
  • D P von Kessler
  • B K Simandl

Detail Information

Publications19

  1. ncbi Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland 20892, USA
    Nature 383:407-13. 1996
    ..Defects in all tissues extend beyond the normal sites of Shh transcription, confirming the proposed role of Shh proteins as an extracellular signal required for the tissue-organizing properties of several vertebrate patterning centres...
  2. ncbi Mediolateral patterning of somites: multiple axial signals, including Sonic hedgehog, regulate Nkx-3.1 expression
    L Kos
    Laboratory of Mammalian Genes and Development, NICHD, NIH, Bethesda, MD 20892, USA
    Mech Dev 70:25-34. 1998
    ....
  3. ncbi Essential role for Sonic hedgehog during hair follicle morphogenesis
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Dev Biol 205:1-9. 1999
    ..Our findings reveal an essential role for Shh during hair follicle morphogenesis, where it is required for normal advancement beyond the hair germ stage of development...
  4. ncbi Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop
    V Knezevic
    Laboratory of Pathology, NCI, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    Development 124:4523-36. 1997
    ..Together these results suggest that certain 5' Hoxd genes directly amplify the posterior Shh polarizing signal in a reinforcing positive feedback loop during limb bud outgrowth...
  5. ncbi Expression of murine Lhx5 suggests a role in specifying the forebrain
    H Z Sheng
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Dyn 208:266-77. 1997
    ..5 of gestation. The early, persistent, and dynamic expression of Lhx5 suggests a regulatory function in forebrain formation...
  6. ncbi Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: a study with knockout mice
    J H Pak
    Endocrinology and Reproduction Research Branch and Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:11232-7. 2000
    ..These results indicate a central role of Ng in the regulation of CaMKII activity with decisive influences on synaptic plasticity and spatial learning...
  7. ncbi Induction of midbrain dopaminergic neurons by Sonic hedgehog
    M Hynes
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    Neuron 15:35-44. 1995
    ..Our results also provide the basis for a potential cell transplantation therapy for Parkinson's disease...
  8. ncbi Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3
    Y Litingtung
    Department of Cell Biology, Vanderbilt University Medical Center, B2120 MCN, Nashville, Tennessee 37232, USA
    Nat Neurosci 3:979-85. 2000
    ..Differences between rostral and caudal regions suggest that other signaling molecules-in addition to Shh-may be involved in specifying ventral fates, particularly in the caudal region of the spinal cord...
  9. ncbi Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function
    C Chiang
    Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Dev Biol 236:421-35. 2001
    ..According to this model, the limb bud signaling centers, including the zone of polarizing activity (ZPA) acting through Shh, are required to elaborate upon the axial information provided by the native limb field prepattern...
  10. ncbi Anorectal malformations caused by defects in sonic hedgehog signaling
    R Mo
    Program in Developmental Biology, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 159:765-74. 2001
    ....
  11. ncbi Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles
    Y Ohkubo
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, 401 Parnassus, P O Box 0984, San Francisco, CA 94143 0984, USA
    Neuroscience 111:1-17. 2002
    ....
  12. ncbi Sonic hedgehog controls epaxial muscle determination through Myf5 activation
    A G Borycki
    Department of Cell Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Development 126:4053-63. 1999
    ....
  13. ncbi A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord
    A Pierani
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 97:903-15. 1999
    ..Retinoids appear to mediate this parallel pathway. These findings reveal an unanticipated Shh-independent signaling pathway that controls progenitor cell identity and interneuron diversity in the ventral spinal cord...
  14. ncbi Sonic hedgehog is essential to foregut development
    Y Litingtung
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Nat Genet 20:58-61. 1998
    ..These results indicate that Shh is required for the growth and differentiation of the oesophagus, trachea and lung, and suggest that mutations in SHH and its signalling components may be involved in foregut defects in humans...
  15. ncbi Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
    H Roelink
    Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
    Cell 81:445-55. 1995
    ....
  16. ncbi Products, genetic linkage and limb patterning activity of a murine hedgehog gene
    D T Chang
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205
    Development 120:3339-53. 1994
    ..The significance of Hhg-1 genetic linkage, patterning activity and proteolytic processing in Drosophila and chick embryos is discussed...
  17. ncbi Sonic hedgehog regulates otic capsule chondrogenesis and inner ear development in the mouse embryo
    W Liu
    Department of Otolaryngology, Albert Einstein College of Medicine, Bronx, NY, USA
    Dev Biol 248:240-50. 2002
    ..Our results support a role for Shh as a regulator of otic capsule formation and inner ear development during mammalian embryogenesis...
  18. ncbi Control of Drosophila tracheal branching by the novel homeodomain gene unplugged, a regulatory target for genes of the bithorax complex
    C Chiang
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Development 121:3901-12. 1995
    ....
  19. ncbi Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila
    C Chiang
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Mech Dev 47:225-39. 1994
    ..All of these data combine to suggest a role for tlr in interactions between cells at critical boundaries during development...