E Chew

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Screening options for diabetic retinopathy
    Emily Y Chew
    Division of Epidemiology and Clinical Research, National Eye Institute National Institutes of Health, Bethesda, Maryland 20892 1204, USA
    Curr Opin Ophthalmol 17:519-22. 2006
  2. pmc The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples
    Robert J Ross
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Invest Ophthalmol Vis Sci 48:1128-32. 2007
  3. pmc Age-related macular degeneration-clinical review and genetics update
    R Ratnapriya
    Neurobiology Neurodegeneration and Repair Laboratory, National Institutes of Health, Bethesda, MD, USA
    Clin Genet 84:160-6. 2013
  4. ncbi request reprint Randomized trial of the ForeseeHome monitoring device for early detection of neovascular age-related macular degeneration. The HOme Monitoring of the Eye (HOME) study design - HOME Study report number 1
    Emily Y Chew
    National Eye Institute, Bethesda, MD, USA Electronic address
    Contemp Clin Trials 37:294-300. 2014
  5. doi request reprint Randomized trial of a home monitoring system for early detection of choroidal neovascularization home monitoring of the Eye (HOME) study
    Emily Y Chew
    Clinical Trials Branch, National Eye Institute National Institutes of Health, Bethesda, Maryland Electronic address
    Ophthalmology 121:535-44. 2014
  6. pmc Long-term effects of vitamins C and E, β-carotene, and zinc on age-related macular degeneration: AREDS report no. 35
    Emily Y Chew
    Division of Epidemiology and Clinical Applications, National Eye Institute National Institutes of Health, Bethesda, Maryland 20892 1204, USA
    Ophthalmology 120:1604-11.e4. 2013
  7. pmc The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1)
    Emily Y Chew
    Division of Epidemiology and Clinical Applications, National Eye Institute National Institutes of Health, Bethesda, Maryland, USA
    Ophthalmology 119:2282-9. 2012
  8. pmc Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration
    Baoying Liu
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 9:1-12. 2011
  9. pmc Preliminary assessment of celecoxib and microdiode pulse laser treatment of diabetic macular edema
    Emily Y Chew
    Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1204, USA
    Retina 30:459-67. 2010
  10. ncbi request reprint Clinical course of macular holes: the Eye Disease Case-Control Study
    E Y Chew
    Division of Biometry and Epidemiology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 2510, USA
    Arch Ophthalmol 117:242-6. 1999

Detail Information

Publications77

  1. ncbi request reprint Screening options for diabetic retinopathy
    Emily Y Chew
    Division of Epidemiology and Clinical Research, National Eye Institute National Institutes of Health, Bethesda, Maryland 20892 1204, USA
    Curr Opin Ophthalmol 17:519-22. 2006
    ..This update is particularly timely because the incidence of diabetes is rising rapidly and the number of patients with vision-threatening diabetic retinopathy is increasing...
  2. pmc The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples
    Robert J Ross
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Invest Ophthalmol Vis Sci 48:1128-32. 2007
    ..S. clinic-based case-control studies...
  3. pmc Age-related macular degeneration-clinical review and genetics update
    R Ratnapriya
    Neurobiology Neurodegeneration and Repair Laboratory, National Institutes of Health, Bethesda, MD, USA
    Clin Genet 84:160-6. 2013
    ..Finally, we discuss the recent advancement in genetics and genomics and the future prospective of personalized medicine in AMD patients. ..
  4. ncbi request reprint Randomized trial of the ForeseeHome monitoring device for early detection of neovascular age-related macular degeneration. The HOme Monitoring of the Eye (HOME) study design - HOME Study report number 1
    Emily Y Chew
    National Eye Institute, Bethesda, MD, USA Electronic address
    Contemp Clin Trials 37:294-300. 2014
    ....
  5. doi request reprint Randomized trial of a home monitoring system for early detection of choroidal neovascularization home monitoring of the Eye (HOME) study
    Emily Y Chew
    Clinical Trials Branch, National Eye Institute National Institutes of Health, Bethesda, Maryland Electronic address
    Ophthalmology 121:535-44. 2014
    ..The main predictor of treatment outcome from anti-vascular endothelial growth factor (VEGF) agents is the visual acuity at the time of CNV treatment...
  6. pmc Long-term effects of vitamins C and E, β-carotene, and zinc on age-related macular degeneration: AREDS report no. 35
    Emily Y Chew
    Division of Epidemiology and Clinical Applications, National Eye Institute National Institutes of Health, Bethesda, Maryland 20892 1204, USA
    Ophthalmology 120:1604-11.e4. 2013
    ..To describe the long-term effects (10 years) of the Age-Related Eye Disease Study (AREDS) formulation of high-dose antioxidants and zinc supplement on progression of age-related macular degeneration (AMD)...
  7. pmc The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1)
    Emily Y Chew
    Division of Epidemiology and Clinical Applications, National Eye Institute National Institutes of Health, Bethesda, Maryland, USA
    Ophthalmology 119:2282-9. 2012
    ..The study also assesses the reduction in zinc and the omission of β-carotene from original AREDS formulation...
  8. pmc Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration
    Baoying Liu
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 9:1-12. 2011
    ..Elevated levels of complement activating molecules including complement component 5a (C5a) have been found in the serum of AMD patients. Our aim is to study whether C5a can impact human T cells and its implication in AMD...
  9. pmc Preliminary assessment of celecoxib and microdiode pulse laser treatment of diabetic macular edema
    Emily Y Chew
    Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1204, USA
    Retina 30:459-67. 2010
    ..The purpose of this study was to evaluate combined antiinflammatory therapy and laser approaches for treating patients with diabetic macular edema...
  10. ncbi request reprint Clinical course of macular holes: the Eye Disease Case-Control Study
    E Y Chew
    Division of Biometry and Epidemiology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 2510, USA
    Arch Ophthalmol 117:242-6. 1999
    ..To describe the clinical course of affected and unaffected eyes in patients with idiopathic macular holes...
  11. ncbi request reprint Rationale, design, and methods of the Action to Control Cardiovascular Risk in Diabetes Eye Study (ACCORD-EYE)
    Emily Y Chew
    Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1204, USA
    Am J Cardiol 99:103i-111i. 2007
    ..These data will provide valuable information regarding the effects of medical treatment on the prevention and progression of DR...
  12. pmc Diabetic retinopathy: should this patient receive laser treatment? Overview
    E Chew
    Br J Ophthalmol 88:436-7. 2004
  13. pmc Diabetic retinopathy: should this patient receive laser treatment?
    E Y Chew
    Br J Ophthalmol 88:433. 2004
  14. ncbi request reprint Results after lens extraction in patients with diabetic retinopathy: early treatment diabetic retinopathy study report number 25
    E Y Chew
    Division of Biometry and Epidemiology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 2510, USA
    Arch Ophthalmol 117:1600-6. 1999
    ..To assess the visual results after surgical lens removal in patients with diabetic retinopathy...
  15. ncbi request reprint Intravitreal anti-vascular endothelial growth factor therapy with pegaptanib for advanced von Hippel-Lindau disease of the retina
    Sam S Dahr
    Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Retina 27:150-8. 2007
    ....
  16. pmc Intravitreal ranibizumab therapy for retinal capillary hemangioblastoma related to von Hippel-Lindau disease
    Wai T Wong
    Office of Scientific Director, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Ophthalmology 115:1957-64. 2008
    ..To evaluate the effect of intravitreal ranibizumab on retinal capillary hemangioblastomas (RCHs) associated with von Hippel-Lindau (VHL) disease that are not amenable or responsive to standard therapy...
  17. ncbi request reprint von Hippel-Lindau disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1414, USA
    Lancet 361:2059-67. 2003
    ..We present an overview of the clinical aspects, management, and treatment options for von Hippel-Lindau disease...
  18. ncbi request reprint Infantile cataract in the collaborative perinatal project: prevalence and risk factors
    John Paul SanGiovanni
    Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bldg 31, Room 6A52, 31 Center Dr, MSC 2510, Bethesda, MD 20892 2510, USA
    Arch Ophthalmol 120:1559-65. 2002
    ..To estimate the prevalence of 4 categories of infantile cataract in subjects surviving the neonatal period in a US cohort, and to investigate risk factors for isolated infantile cataract...
  19. ncbi request reprint Histopathology and regression of retinal hard exudates in diabetic retinopathy after reduction of elevated serum lipid levels
    Michael Cusick
    Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ophthalmology 110:2126-33. 2003
    ..To describe a regression of retinal hard exudates in 2 patients with diabetic maculopathy, and to report immunohistologic findings reflecting lipid deposition in the retina...
  20. pmc Molecular pathology of eyes with von Hippel-Lindau (VHL) Disease: a review
    Chi Chao Chan
    National Eye Institute, National Institutes of Health, Bethesda 20892 1857, USA
    Retina 27:1-7. 2007
    ..von Hippel-Lindau Disease (VHL) is an autosomal dominant inherited systemic cancer syndrome. Recently, many advances have contributed to the understanding of VHL pathophysiology...
  21. pmc Ocular clusterin expression in von Hippel-Lindau disease
    Min Zhou
    National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Mol Vis 13:2129-36. 2007
    ..Decreased clusterin secretion has been reported in renal cell carcinoma associated with VHL disease. The purpose of this study was to investigate ocular clusterin expression in VHL disease...
  22. pmc Expression of stem cells markers in ocular hemangioblastoma associated with von Hippel-Lindau (VHL) disease
    Chi Chao Chan
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Mol Vis 11:697-704. 2005
    ..To better understand the histogenesis of ocular hemangioblastomas associated with von Hippel-Lindau (VHL) disease...
  23. pmc Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration
    Anand Swaroop
    Neurobiology Neurodegeneration and Repair Laboratory N NRL, National Eye Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Annu Rev Genomics Hum Genet 10:19-43. 2009
    ..We also attempt to integrate available genetic and biochemical data with cellular pathways involved in aging to formulate an integrated model of AMD pathogenesis...
  24. ncbi request reprint The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina
    John Paul SanGiovanni
    Division of Epidemiology and Clinical Research, National Eye Insitute, National Institutes of Health, 31 Center Drive, Building 31, Room 6A52, MSC 2510, Bethesda, MD 20892 2510, USA
    Prog Retin Eye Res 24:87-138. 2005
    ..Our general conclusion is that there is consistent evidence to suggest that omega-3 LCPUFAs may act in a protective role against ischemia-, light-, oxygen-, inflammatory-, and age-associated pathology of the vascular and neural retina...
  25. pmc Treatment of geographic atrophy by the topical administration of OT-551: results of a phase II clinical trial
    Wai T Wong
    Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 51:6131-9. 2010
    ..To investigate the safety and preliminary efficacy of OT-551, a disubstituted hydroxylamine with antioxidant properties, for the treatment of geographic atrophy (GA), the advanced atrophic form of age-related macular degeneration (AMD)...
  26. pmc Evaluation of the age-related eye disease study clinical lens grading system AREDS report No. 31
    Emily Y Chew
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20850 1707, USA
    Ophthalmology 117:2112-9.e3. 2010
    ..To examine the grading (interrater) reliability of the Age-Related Eye Disease Study (AREDS) Clinical Lens Grading System (ARLNS)...
  27. pmc Fundus autofluorescence in type 2 idiopathic macular telangiectasia: correlation with optical coherence tomography and microperimetry
    Wai T Wong
    Office of the Scientific Director, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Ophthalmol 148:573-83. 2009
    ....
  28. ncbi request reprint Dose-ranging study of lutein supplementation in persons aged 60 years or older
    Julie M Rosenthal
    Clinical Trials Branch, Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Invest Ophthalmol Vis Sci 47:5227-33. 2006
    ..To examine the dose-response relationship between oral lutein supplementation and serum lutein concentrations in persons aged 60 years and older, with or without age-related macular degeneration (AMD)...
  29. pmc Evaluation of time domain and spectral domain optical coherence tomography in the measurement of diabetic macular edema
    Farzin Forooghian
    Division of Epidemiology and Clinical Research, National Eye Institute, National Institutesof Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 49:4290-6. 2008
    ..Dublin, CA), in the context of diabetic macular edema (DME)...
  30. doi request reprint Clinical course of retrobulbar hemangioblastomas in von Hippel-Lindau disease
    Catherine B Meyerle
    National Eye Institute, Bethesda, Maryland 20892, USA
    Ophthalmology 115:1382-9. 2008
    ..To report clinical findings of rare retrobulbar optic nerve hemangioblastomas associated with von Hippel-Lindau disease (VHL)...
  31. doi request reprint Oral supplementation of lutein/zeaxanthin and omega-3 long chain polyunsaturated fatty acids in persons aged 60 years or older, with or without AMD
    Lynn L Huang
    Clinical Trials Branch, Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Invest Ophthalmol Vis Sci 49:3864-9. 2008
    ..The purpose of the study was to examine the effect of oral supplementation of omega-3 LCPUFA on changes in serum levels of lutein/zeaxanthin during supplementation in persons 60 years of age and older, with or without AMD...
  32. pmc The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23
    John Paul SanGiovanni
    National Eye Institute, Bethesda, Maryland, USA
    Arch Ophthalmol 126:1274-9. 2008
    ..To examine the association of dietary omega-3 long-chain polyunsaturated fatty acid and fish intake with incident neovascular age-related macular degeneration (AMD) and central geographic atrophy (CGA)...
  33. pmc Visual acuity outcomes after cataract surgery in patients with age-related macular degeneration: age-related eye disease study report no. 27
    Farzin Forooghian
    Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute National Institutes of Health, Bethesda, Maryland 20892 1204, USA
    Ophthalmology 116:2093-100. 2009
    ..To evaluate visual acuity outcomes after cataract surgery in patients with varying degrees of age-related macular degeneration (AMD)...
  34. pmc Relationship between photoreceptor outer segment length and visual acuity in diabetic macular edema
    Farzin Forooghian
    Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Retina 30:63-70. 2010
    ....
  35. ncbi request reprint Effects of aldose reductase inhibitors and galactose withdrawal on fluorescein angiographic lesions in galactose-fed dogs
    Michael Cusick
    National Eye Institute, National Institutes of Health, and Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, MD 20892, USA
    Arch Ophthalmol 121:1745-51. 2003
    ....
  36. pmc Clinical characterization of retinal capillary hemangioblastomas in a large population of patients with von Hippel-Lindau disease
    Wai T Wong
    Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1204, USA
    Ophthalmology 115:181-8. 2008
    ....
  37. pmc The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration
    Jingsheng Tuo
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    FASEB J 18:1297-9. 2004
    ..Our data suggest that a decrease, caused by sequence variation and/or lower CX3CR1 expression, in CX3CR1-induced cellular activities could contribute to AMD development...
  38. ncbi request reprint Central visual function and the NEI-VFQ-25 near and distance activities subscale scores in people with type 1 and 2 diabetes
    Michael Cusick
    Division of Epidemiology and Clinical Research, National Eye Institute NIH, Building 10, 10 Center Drive, Bethesda, MD 20892 1204, USA
    Am J Ophthalmol 139:1042-50. 2005
    ..To investigate relationships between clinical measures of central visual function and NEI-VFQ-25 Near and Distance Activities subscales in patients with diabetic retinopathy...
  39. ncbi request reprint Associations of mortality and diabetes complications in patients with type 1 and type 2 diabetes: early treatment diabetic retinopathy study report no. 27
    Michael Cusick
    National Eye Institute, National Institutes of Health, Building 10, CRC, Rm 3 2531, 10 Center Dr, MSC 1204, Bethesda, MD 20892, USA
    Diabetes Care 28:617-25. 2005
    ..Diabetes is a leading cause of morbidity and mortality. The purpose of this study is to assess the associations between diabetes complications and mortality in the Early Treatment Diabetic Retinopathy Study (ETDRS)...
  40. pmc Genotype-phenotype correlation in von Hippel-Lindau disease with retinal angiomatosis
    Wai T Wong
    Division of Epidemiology and Clinical Research, Office of the Scientific Director, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Ophthalmol 125:239-45. 2007
    ....
  41. ncbi request reprint The long-term effects of laser photocoagulation treatment in patients with diabetic retinopathy: the early treatment diabetic retinopathy follow-up study
    Emily Y Chew
    National Eye Institute National Institutes of Health, Division of Epidemiology and Clinical Research, Bethesda, Maryland 20892 2510, USA
    Ophthalmology 110:1683-9. 2003
    ..To evaluate the long-term natural history and effects of laser photocoagulation treatment in patients with diabetic retinopathy...
  42. pmc An apolipoprotein E variant may protect against age-related macular degeneration through cytokine regulation
    Christine M Bojanowski
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Environ Mol Mutagen 47:594-602. 2006
    ..These results further confirm the association between ApoE112R and a decreased risk of AMD development. The underlying mechanisms may involve differential regulation of both CCL2 and VEGF by the ApoE isoforms...
  43. pmc Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition
    Jingsheng Tuo
    Division of Epidemiology and Clinical Research, and Ophthalmic Genetics and Visual Function Branch, Section on Ophthalmic Molecular Genetics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:9256-61. 2006
    ..The strong AMD predisposition conferred by the ERCC6 and CFH SNPs may result from biological epistasis, because ERCC6 functions in universal transcription as a component of RNA pol I transcription complex...
  44. pmc {omega}-3 Long-chain polyunsaturated fatty acid intake and 12-y incidence of neovascular age-related macular degeneration and central geographic atrophy: AREDS report 30, a prospective cohort study from the Age-Related Eye Disease Study
    John Paul SanGiovanni
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1204, USA
    Am J Clin Nutr 90:1601-7. 2009
    ..omega-3 (n-3) Long-chain polyunsaturated fatty acids (LCPUFAs) affect processes implicated in vascular and neural retinal pathogenesis and thus may influence the risk of developing age-related macular degeneration (AMD)...
  45. pmc The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples
    Jingsheng Tuo
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Ophthalmology 115:1891-8. 2008
    ..To assess the association and combined effect on the risk of age-related macular degeneration (AMD) by the HtrA1 and complement factor H (CFH) polymorphisms, smoking, and serum cholesterol...
  46. pmc Fundus autofluorescence changes in cytomegalovirus retinitis
    Steven Yeh
    National Eye Institute National Institutes of Health, Bethesda, MD, USA
    Retina 30:42-50. 2010
    ..The purpose of this study was to describe fundus autofluorescence imaging features of cytomegalovirus (CMV) retinitis and to correlate fundus autofluorescence features with clinical activity...
  47. pmc Age-related macular degeneration
    Hanna R Coleman
    Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Lancet 372:1835-45. 2008
    ....
  48. pmc Tachyphylaxis after intravitreal bevacizumab for exudative age-related macular degeneration
    Farzin Forooghian
    Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Retina 29:723-31. 2009
    ..To describe tachyphylaxis to intravitreal bevacizumab (IVB) in patients with exudative age-related macular degeneration (AMD)...
  49. pmc Retinal vascular proliferation as an ocular manifestation of von Hippel-Lindau disease
    Wai T Wong
    Office of Scientific Director, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Ophthalmol 126:637-43. 2008
    ..To describe the features, natural history, and management of an unusual manifestation of ocular von Hippel-Lindau disease in the form of fine vascular proliferation...
  50. pmc Von Hippel-Lindau gene deletion and expression of hypoxia-inducible factor and ubiquitin in optic nerve hemangioma
    Chi Chao Chan
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Trans Am Ophthalmol Soc 102:75-9; discussion 79-81. 2004
    ..The VHL protein-associated complex is a primary ubiquitin ligase for the ubiquitination of hypoxia-inducible factor (HIF). This study examines VHL and ubiquitin expression in optic nerve hemangiomas and juxtapapillary angiomas...
  51. pmc Nutritional supplements for age-related macular degeneration
    Nupura Krishnadev
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Curr Opin Ophthalmol 21:184-9. 2010
    ..This review describes the current literature on the role of nutritional supplementation in primary and secondary prevention of AMD...
  52. ncbi request reprint Risk factors for renal replacement therapy in the Early Treatment Diabetic Retinopathy Study (ETDRS), Early Treatment Diabetic Retinopathy Study Report No. 26
    Michael Cusick
    National Eye Institute National Institutes of Health, Bethesda, Maryland 20892 2510, USA
    Kidney Int 66:1173-9. 2004
    ..Diabetes is a leading cause of end-stage renal disease (ESRD). The purpose of this study is to assess the risk factors for renal replacement therapy (RRT) in the Early Treatment Diabetic Retinopathy Study (ETDRS)...
  53. pmc Fundus autofluorescence imaging of the white dot syndromes
    Steven Yeh
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Ophthalmol 128:46-56. 2010
    ..To characterize the fundus autofluorescence (FAF) findings in patients with white dot syndromes (WDSs)...
  54. ncbi request reprint Serum inflammatory markers in diabetic retinopathy
    Annal D Meleth
    Howard Hughes Medical Institute, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 46:4295-301. 2005
    ..To evaluate the association of serum factors with the severity of diabetic retinopathy and to assess their presence in retinal tissue obtained at autopsy...
  55. pmc Natural history of drusenoid pigment epithelial detachment in age-related macular degeneration: Age-Related Eye Disease Study Report No. 28
    Catherine Cukras
    Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Ophthalmology 117:489-99. 2010
    ..To describe the natural history of eyes with drusenoid pigment epithelial detachments (DPEDs) associated with age-related macular degeneration (AMD)...
  56. pmc Risk of advanced age-related macular degeneration after cataract surgery in the Age-Related Eye Disease Study: AREDS report 25
    Emily Y Chew
    National Eye Institute, Bethesda, Maryland, USA
    Ophthalmology 116:297-303. 2009
    ..To assess the risk of advanced age-related macular degeneration (AMD) developing after cataract surgery...
  57. pmc Alterations in the intraocular cytokine milieu after intravitreal bevacizumab
    Farzin Forooghian
    Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1204, USA
    Invest Ophthalmol Vis Sci 51:2388-92. 2010
    ..The etiology of these complications remains unclear. The purpose of this study was to characterize changes in the intraocular levels of inflammatory cytokines after IVB as a possible explanation for these complications...
  58. pmc Analysis of Hemicentin-1, hOgg1, and E-selectin single nucleotide polymorphisms in age-related macular degeneration
    Christine M Bojanowski
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Trans Am Ophthalmol Soc 103:37-44; discussion 44-5. 2005
    ..This study investigates the Hemicentin-1 (an extracellular matrix protein) Q5345R, hOgg1 (DNA repair gene) S326C, and E-selectin (an adhesion molecule) S149R SNPs in association with AMD...
  59. ncbi request reprint Epidemiology of diabetic retinopathy
    Emily Y Chew
    Division of Epidemiology and Clinical Research, National Eye Institute National Institutes of Health, MSC 2510, Bethesda, MD 20892 2510, USA
    Hosp Med 64:396-9. 2003
    ..Patients with diabetes should be vigorously treated for these modifiable risk factors to prevent the development and progression of diabetic retinopathy...
  60. pmc Toll-like receptor polymorphisms and age-related macular degeneration: replication in three case-control samples
    Youngeun Cho
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 50:5614-8. 2009
    ..S. clinic-based case-control study samples and one Australian population-based study sample) were used to further assess the association of the polymorphisms rs3775291 in TLR3 and rs4986790 in TLR4 with AMD...
  61. ncbi request reprint The relationship of dietary lipid intake and age-related macular degeneration in a case-control study: AREDS Report No. 20
    John Paul SanGiovanni
    AREDS Coordinating Center, The EMMES Corporation, 401 N Washington Street, Rockville, MD 20850, USA
    Arch Ophthalmol 125:671-9. 2007
    ..To evaluate the association of lipid intake with baseline severity of age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS)...
  62. pmc Retinal thickness on Stratus optical coherence tomography in people with diabetes and minimal or no diabetic retinopathy
    Neil M Bressler
    Jaeb Center for Health Research, Tampa, FL 33647, USA
    Am J Ophthalmol 145:894-901. 2008
    ....
  63. pmc National Eye Institute Visual Function Questionnaire in the Age-Related Eye Disease Study (AREDS): AREDS Report No. 10
    Traci E Clemons
    AREDS Coordinating Center, The EMMES Corporation, 401 N Washington Street, Suite 700, Rockville, MD 20850 1707, USA
    Arch Ophthalmol 121:211-7. 2003
    ....
  64. pmc Beta carotene supplementation and age-related maculopathy in a randomized trial of US physicians
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Arch Ophthalmol 125:333-9. 2007
    ..To test whether beta carotene supplementation affects the incidence of age-related maculopathy (ARM) in a large-scale randomized trial...
  65. ncbi request reprint A simplified diabetic retinopathy scale
    Emily Y Chew
    Ophthalmology 110:1675-6. 2003
  66. ncbi request reprint Retinal precursors and the development of geographic atrophy in age-related macular degeneration
    Michael L Klein
    Devers Eye Institute, Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon, USA
    Ophthalmology 115:1026-31. 2008
    ..To determine specific retinal precursor lesions and sequence of events preceding the onset of geographic atrophy (GA) in eyes with age-related macular degeneration (AMD)...
  67. pmc A simplified severity scale for age-related macular degeneration: AREDS Report No. 18
    Frederick L Ferris
    AREDS Coordinating Center, The EMMES Corporation, Rockville, MD 20850 1707, USA
    Arch Ophthalmol 123:1570-4. 2005
    ..To develop a simplified clinical scale defining risk categories for development of advanced age-related macular degeneration (AMD)...
  68. ncbi request reprint The effect of lutein and zeaxanthin supplementation on metabolites of these carotenoids in the serum of persons aged 60 or older
    Frederick Khachik
    Department of Chemistry and Biochemistry, Joint Institute for Food Safety and Applied Nutrition JIFSAN, University of Maryland, College Park, MD 20742 2021, USA
    Invest Ophthalmol Vis Sci 47:5234-42. 2006
    ..To determine whether supplementation with lutein can interact with the serum levels of other dietary carotenoids, retinol, and alpha-tocopherol...
  69. pmc Ocular von Hippel-Lindau disease: clinical update and emerging treatments
    Wai T Wong
    Office of Scientific Director, USA
    Curr Opin Ophthalmol 19:213-7. 2008
    ..von Hippel-Lindau disease is an inherited, multisystemic cancer syndrome often involving the retina. This review will provide an update for the clinical characterization and treatment of ocular von Hippel-Lindau disease...
  70. ncbi request reprint Vitamin E and age-related cataract in a randomized trial of women
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmology 115:822-829.e1. 2008
    ..To investigate whether vitamin E supplementation decreases the risk of age-related cataract in women...
  71. ncbi request reprint The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22
    John Paul SanGiovanni
    The EMMES Corporation, 401 N Washington St, Ste 700, Rockville, MD 20850 1707, USA
    Arch Ophthalmol 125:1225-32. 2007
    ..To evaluate the relationship of dietary carotenoids, vitamin A, alpha-tocopherol, and vitamin C with prevalent age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS)...
  72. pmc Complement factor H polymorphism in age-related macular degeneration
    Robert J Klein
    Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 308:385-9. 2005
    ..This polymorphism is in a region of CFH that binds heparin and C-reactive protein. The CFH gene is located on chromosome 1 in a region repeatedly linked to AMD in family-based studies...
  73. pmc A severity scale for diabetic macular edema developed from ETDRS data
    Ronald E Gangnon
    Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin 53711 1068, USA
    Invest Ophthalmol Vis Sci 49:5041-7. 2008
    ..To develop a severity scale for diabetic macular edema (DME) and to assess relationships between severity and duration of DME and visual acuity (VA)...
  74. pmc The National Eye Institute Visual Function Questionnaire in the Macular Telangiectasia (MacTel) Project
    Traci E Clemons
    The EMMES Corporation, Rockville, Maryland 20850 1707, USA
    Invest Ophthalmol Vis Sci 49:4340-6. 2008
    ....
  75. ncbi request reprint Vitamin E and the age-related eye disease study supplementation for age-related macular degeneration
    Emily Y Chew
    Arch Ophthalmol 123:395-6. 2005
  76. pmc Heritability of the severity of diabetic retinopathy: the FIND-Eye study
    Nedal H Arar
    Family Investigation of Nephropathy and Diabetes FIND Genetic Analysis and Data Coordinating Center, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    Invest Ophthalmol Vis Sci 49:3839-45. 2008
    ....
  77. ncbi request reprint Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis
    Kip M Connor
    Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Med 13:868-73. 2007
    ..Supplementing omega-3-PUFA intake may be of benefit in preventing retinopathy...