B Chesebro

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoring
    Bruce Chesebro
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, United States of America
    PLoS Pathog 6:e1000800. 2010
  2. ncbi Grand ideas floating freely. Conference on the new prion biology: basic science, diagnosis and therapy
    Bruce Chesebro
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, MT 59840, USA
    EMBO Rep 3:1123-6. 2002
  3. ncbi Scrapie pathogenesis in brain and retina: effects of prion protein expression in neurons and astrocytes
    Bruce Chesebro
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana 59840, USA
    J Neurovirol 11:476-80. 2005
  4. ncbi Host genes conferring resistance to a central nervous system disease induced by a polytropic recombinant Friend murine retrovirus
    R S Buller
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
    J Virol 64:493-8. 1990
  5. ncbi Analyses of frequency of infection, specific infectivity, and prion protein biosynthesis in scrapie-infected neuroblastoma cell clones
    R E Race
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
    J Virol 62:2845-9. 1988
  6. ncbi Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier
    D A Kocisko
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergies and Infectious Diseases, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 92:3923-7. 1995
  7. ncbi Detection of prion protein mRNA in normal and scrapie-infected tissues and cell lines
    B Caughey
    National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840
    J Gen Virol 69:711-6. 1988
  8. ncbi Fine mapping of the friend retrovirus resistance gene, Rfv3, on mouse chromosome 15
    H J Super
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 73:7848-52. 1999
  9. ncbi Introduction to the transmissible spongiform encephalopathies or prion diseases
    Bruce Chesebro
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    Br Med Bull 66:1-20. 2003
  10. ncbi Major histocompatibility complex class I gene controls the generation of gamma interferon-producing CD4(+) and CD8(+) T cells important for recovery from friend retrovirus-induced leukemia
    K E Peterson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 74:5363-7. 2000

Collaborators

Detail Information

Publications59

  1. ncbi Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoring
    Bruce Chesebro
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, United States of America
    PLoS Pathog 6:e1000800. 2010
    ..These findings were similar to certain human familial prion diseases as well as to non-prion human neurodegenerative diseases, such as Alzheimer's disease...
  2. ncbi Grand ideas floating freely. Conference on the new prion biology: basic science, diagnosis and therapy
    Bruce Chesebro
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, MT 59840, USA
    EMBO Rep 3:1123-6. 2002
  3. ncbi Scrapie pathogenesis in brain and retina: effects of prion protein expression in neurons and astrocytes
    Bruce Chesebro
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana 59840, USA
    J Neurovirol 11:476-80. 2005
    ..Surprisingly damage to neurons in brain and retina appeared to require different prion protein-expressing cells, suggesting that different pathogenic mechanisms operate in these two neuronal tissues...
  4. ncbi Host genes conferring resistance to a central nervous system disease induced by a polytropic recombinant Friend murine retrovirus
    R S Buller
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
    J Virol 64:493-8. 1990
    ..The mechanism of action of the second gene was less clear, but it appeared to be associated with development of an antiviral antibody response...
  5. ncbi Analyses of frequency of infection, specific infectivity, and prion protein biosynthesis in scrapie-infected neuroblastoma cell clones
    R E Race
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
    J Virol 62:2845-9. 1988
    ..No PK-resistant PrP was found in infected or uninfected cultures, although the PK-sensitive PrP was readily detected. These results suggested that PK-resistant PrP may not be an essential component of the infectious scrapie agent...
  6. ncbi Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier
    D A Kocisko
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergies and Infectious Diseases, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 92:3923-7. 1995
    ..This specificity may be the molecular basis for the barriers to interspecies transmission of scrapie and other transmissible spongiform encephalopathies in vivo...
  7. ncbi Detection of prion protein mRNA in normal and scrapie-infected tissues and cell lines
    B Caughey
    National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840
    J Gen Virol 69:711-6. 1988
    ..In contrast, no PrP mRNA was detected in two mouse myeloid cell lines and one T cell lymphoma. These results provide evidence that PrP is a protein common to numerous, but not all, cell types besides those of the brain...
  8. ncbi Fine mapping of the friend retrovirus resistance gene, Rfv3, on mouse chromosome 15
    H J Super
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 73:7848-52. 1999
    ..This localization of Rfv3 to a region of less than 1 cM now makes it feasible to attempt the cloning of Rfv3 by physical methods...
  9. ncbi Introduction to the transmissible spongiform encephalopathies or prion diseases
    Bruce Chesebro
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    Br Med Bull 66:1-20. 2003
    ..Such information should open up new approaches to both diagnosis and therapy...
  10. ncbi Major histocompatibility complex class I gene controls the generation of gamma interferon-producing CD4(+) and CD8(+) T cells important for recovery from friend retrovirus-induced leukemia
    K E Peterson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 74:5363-7. 2000
    ..Furthermore, the influence of MHC class I genotype on the generation of both IFN-gamma-producing CD4(+) and CD8(+) T cells helps explain the major impact of the H-2D gene on recovery from FV disease...
  11. ncbi In vitro expression in eukaryotic cells of a prion protein gene cloned from scrapie-infected mouse brain
    B Caughey
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840
    Proc Natl Acad Sci U S A 85:4657-61. 1988
    ..Thus, either PrP is not the transmissible agent of scrapie or the expressed PrP requires additional modification to be infectious...
  12. ncbi Prion protein biosynthesis in scrapie-infected and uninfected neuroblastoma cells
    B Caughey
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840
    J Virol 63:175-81. 1989
    ..Once on the cell surface, the major PrP forms had half-lives of 3 to 6 h. No differences in PrP biosynthesis were observed between the scrapie-infected versus uninfected neuroblastoma cells...
  13. ncbi Methods for studying prion protein (PrP) metabolism and the formation of protease-resistant PrP in cell culture and cell-free systems. An update
    B Caughey
    NIH Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    Mol Biotechnol 13:45-55. 1999
    ..These studies have shed light on the mechanism of PrP-res formation and suggest molecular bases for TSE species barrier effects and agent strain propagation...
  14. ncbi Two separate envelope regions influence induction of brain disease by a polytropic murine retrovirus (FMCF98)
    K J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA Kim
    J Virol 70:4825-8. 1996
    ....
  15. ncbi Neurologic disease induced by polytropic murine retroviruses: neurovirulence determined by efficiency of spread to microglial cells
    S J Robertson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 71:5287-94. 1997
    ....
  16. ncbi Requirement for CD4(+) T cells in the Friend murine retrovirus neutralizing antibody response: evidence for functional T cells in genetic low-recovery mice
    H J Super
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 72:9400-3. 1998
    ..These studies revealed the first evidence for a functional T-cell response following FV infection in these low-recovery mice and showed that CD4(+) T-helper cells are required for the Rfv-3-controlled FV antibody response...
  17. ncbi High-frequency cell surface expression of a foreign protein in murine hematopoietic stem cells using a new retroviral vector
    D B Tumas
    Laboratories of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, MT 59840, USA
    Blood 87:509-17. 1996
    ..The multilineage, high-frequency expression observed suggests that pSFF may be useful in gene therapy directed at hematopoietic stem cells and their differentiated progeny...
  18. ncbi Abnormal properties of prion protein with insertional mutations in different cell types
    S A Priola
    Laboratory of Persistent Viral Diseases, NIAID, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    J Biol Chem 273:11980-5. 1998
    ..However, these abnormal molecules were at least 1000-fold less protease-resistant than bona fide PrP-res derived from TSE-infected brain tissue, and they showed no increased ability to form PrP-res in a cell-free system...
  19. ncbi Analysis of protein levels of 24 cytokines in scrapie agent-infected brain and glial cell cultures from mice differing in prion protein expression levels
    Déborah Tribouillard-Tanvier
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Virol 83:11244-53. 2009
    ....
  20. ncbi Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes
    Gerald S Baron
    Laboratory of Persistent Viral Diseases, NIAID, NIH, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA
    EMBO J 21:1031-40. 2002
    ....
  21. ncbi Differences in cytokine and chemokine responses during neurological disease induced by polytropic murine retroviruses Map to separate regions of the viral envelope gene
    K E Peterson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 75:2848-56. 2001
    ..In contrast, disease associated with the central region of the Fr98 env gene showed no upregulation of cytokines or chemokines and thus did not require increased expression of these genes for disease induction...
  22. ncbi Immunity to retroviral infection: the Friend virus model
    K J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 94:7811-6. 1997
    ..In vivo depletion experiments demonstrate different requirements for CD8(+) T cells depending on the vaccine used. The implications of these studies for human retroviral diseases are discussed...
  23. ncbi Mapping of independent V3 envelope determinants of human immunodeficiency virus type 1 macrophage tropism and syncytium formation in lymphocytes
    B Chesebro
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    J Virol 70:9055-9. 1996
    ....
  24. ncbi Comparative sequence analysis, in vitro expression and biosynthesis of mouse PrP
    B Caughey
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840
    Prog Clin Biol Res 317:619-36. 1989
    ..No scrapie-associated modifications of PrP biosynthesis were observed, and, none of the metabolically labeled PrP observed in either scrapie-infected normal cells was resistant to proteinase K...
  25. ncbi Neurovirulence of polytropic murine retrovirus is influenced by two separate regions on opposite sides of the envelope protein receptor binding domain
    Karin E Peterson
    Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Skip Bertman Dr, Baton Rouge, Louisiana 708031, USA
    J Virol 82:8906-10. 2008
    ..Further studies indicated a role for these residues in virus replication in the CNS, although the residues did not affect viral entry...
  26. ncbi Prion protein expression differences in microglia and astroglia influence scrapie-induced neurodegeneration in the retina and brain of transgenic mice
    Lisa Kercher
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, 903 S 4th Street, Hamilton, MT 59840, USA
    J Virol 81:10340-51. 2007
    ..Thus, retinal and brain microglia appeared to differ in their requirements for activation, suggesting that different activation pathways occur in the two tissues...
  27. ncbi Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions
    Byron Caughey
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Annu Rev Biochem 78:177-204. 2009
    ....
  28. ncbi Differences in scrapie-induced pathology of the retina and brain in transgenic mice that express hamster prion protein in neurons, astrocytes, or multiple cell types
    Lisa Kercher
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Am J Pathol 165:2055-67. 2004
    ....
  29. ncbi Biomedicine. A fresh look at BSE
    Bruce Chesebro
    Laboratory of Persistent Virus Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA
    Science 305:1918-21. 2004
  30. ncbi Prion protein on astrocytes or in extracellular fluid impedes neurodegeneration induced by truncated prion protein
    Brent Race
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840 USA
    Exp Neurol 217:347-52. 2009
    ....
  31. ncbi Flexible N-terminal region of prion protein influences conformation of protease-resistant prion protein isoforms associated with cross-species scrapie infection in vivo and in vitro
    Victoria A Lawson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 279:13689-95. 2004
    ..Thus, by its effects on PrP-res conformation, the flexible N-terminal region of PrP seemed to influence TSE pathogenesis and cross-species TSE transmission...
  32. ncbi Anchorless prion protein results in infectious amyloid disease without clinical scrapie
    Bruce Chesebro
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA
    Science 308:1435-9. 2005
    ..In contrast, combined expression of anchorless and wild-type PrP produced accelerated clinical scrapie. Thus, the PrP GPI anchor may play a role in the pathogenesis of prion diseases...
  33. ncbi Biomedicine. A view from the top--prion diseases from 10,000 feet
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    Science 300:917-9. 2003
  34. ncbi Long-term subclinical carrier state precedes scrapie replication and adaptation in a resistant species: analogies to bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease in humans
    R Race
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    J Virol 75:10106-12. 2001
    ....
  35. ncbi Analysis of linkage between scrapie incubation period and the prion protein gene in mice
    R E Race
    National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840
    J Gen Virol 71:493-7. 1990
    ..Therefore, although these phenotypes are certainly linked in I/LnJ and P/J mice, it is possible that PrP and incubation period are controlled by separate genes...
  36. ncbi Subclinical scrapie infection in a resistant species: persistence, replication, and adaptation of infectivity during four passages
    Richard Race
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, 903 S. Fourth Street, Hamilton, MT 59840, USA
    J Infect Dis 186:S166-70. 2002
    ..In some cases infectivity similar to the original 263K hamster scrapie strain was found after 2 or 3 serial mouse passages totaling 1200-1550 days...
  37. ncbi Susceptibilities of nonhuman primates to chronic wasting disease
    Brent Race
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    Emerg Infect Dis 15:1366-76. 2009
    ..Thus, these 2 species differed in susceptibility to CWD. Because humans are evolutionarily closer to macaques than to squirrel monkeys, they may also be resistant to CWD...
  38. ncbi Novel role of CD8(+) T cells and major histocompatibility complex class I genes in the generation of protective CD4(+) Th1 responses during retrovirus infection in mice
    Karin E Peterson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 76:7942-8. 2002
    ..The ability of MHC class I genes to facilitate CD4(+) Th1 development could also be considerable evolutionary advantage by allowing a wider variety of MHC genotypes to generate protective immune responses against intracellular pathogens...
  39. ncbi Role of Erk1/2 activation in prion disease pathogenesis: absence of CCR1 leads to increased Erk1/2 activation and accelerated disease progression
    Rachel A LaCasse
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, United States
    J Neuroimmunol 196:16-26. 2008
    ..In both mouse strains activation of the Erk1/2 pathway may lead to astrocyte dysfunction resulting in neurodegeneration...
  40. ncbi Spontaneous recovery from Friend retrovirus-induced leukemia. Mapping of the Rfv-2 gene in the Q/TL region of mouse MHC
    M Miyazawa
    Laboratory of Persistent Viral Diseases, National Institutes of Health, National Institute of Allergy and Infections Diseases, Hamilton, MT 59840
    J Immunol 148:1964-7. 1992
    ....
  41. ncbi Detection of prion infectivity in fat tissues of scrapie-infected mice
    Brent Race
    Laboratory of Persistent Virus Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS Pathog 4:e1000232. 2008
    ..Since high amounts of ruminant fat are consumed by humans and also incorporated into animal feed, fat-containing tissues may pose a previously unappreciated hazard for spread of prion infection...
  42. ncbi Resistance to chronic wasting disease in transgenic mice expressing a naturally occurring allelic variant of deer prion protein
    Kimberly Meade White
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases NIH, 903 South Fourth Street, Hamilton, MT 59840, USA
    J Virol 81:4533-9. 2007
    ....
  43. ncbi MCP-1 and CCR2 contribute to non-lymphocyte-mediated brain disease induced by Fr98 polytropic retrovirus infection in mice: role for astrocytes in retroviral neuropathogenesis
    Karin E Peterson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease NIH, 903 S 4th Street, Hamilton, MT 59840, USA
    J Virol 78:6449-58. 2004
    ....
  44. ncbi N-terminal truncation of prion protein affects both formation and conformation of abnormal protease-resistant prion protein generated in vitro
    V A Lawson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 276:35265-71. 2001
    ..Thus, regions within the flexible N-terminal tail of PrP influenced interactions required for both generating and disrupting PrP-res formation...
  45. ncbi Chromosome mapping of Rfv3, a host resistance gene to Friend murine retrovirus
    K J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
    J Virol 69:2617-20. 1995
    ..Potential candidate genes for Rfv3 are several genes expressed in cells of the immune system and previously mapped to the same region, including a T-cell antigen gene, Ly6, and three cytokine receptor genes, IL2rb, IL3rb1, and IL3rb2...
  46. ncbi Prion infectivity in fat of deer with chronic wasting disease
    Brent Race
    Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    J Virol 83:9608-10. 2009
    ..Deer fat devoid of muscle contained low levels of CWD infectivity and might be a risk factor for prion infection of other species...
  47. ncbi Levels of abnormal prion protein in deer and elk with chronic wasting disease
    Brent L Race
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    Emerg Infect Dis 13:824-30. 2007
    ....
  48. ncbi Crucial role for prion protein membrane anchoring in the neuroinvasion and neural spread of prion infection
    Mikael Klingeborn
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    J Virol 85:1484-94. 2011
    ..Thus, anchored PrP was an essential component for the rapid neural spread and CNS neuroinvasion of prion infection...
  49. ncbi Complete nucleotide sequence of Friend murine leukemia virus, strain FB29
    S Perryman
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840
    Nucleic Acids Res 19:6950. 1991
  50. ncbi Detailed mapping of the Rfv-1 gene that influences spontaneous recovery from Friend retrovirus-induced leukaemia
    M Miyazawa
    Laboratory of Persistent Viral Diseases, National Institutes of Health, National Institute of Allergy and Infections Diseases, Hamilton, MT
    Eur J Immunogenet 19:159-64. 1992
    ..The results suggest that an increase in the expression of Db may lead to more effective stimulation of FV-specific CTL...
  51. ncbi Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection
    Mario L Santiago
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Science 321:1343-6. 2008
    ..The link between Apobec3 and neutralizing antibody responses highlights an Apobec3-dependent mechanism of host protection that might extend to HIV and other human retroviral infections...
  52. ncbi Increased proinflammatory cytokine and chemokine responses and microglial infection following inoculation with neural stem cells infected with polytropic murine retroviruses
    Karin E Peterson
    Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Skip Bertman Dr, Baton Rouge, LA 70803, USA
    Virology 354:143-53. 2006
    ..As polytropic and ecotropic viruses utilize different receptors for entry, these receptors may play a critical role in the induction of these innate immune responses in the brain...
  53. ncbi Prion-induced amyloid heart disease with high blood infectivity in transgenic mice
    Matthew J Trifilo
    Viral-Immunobiology Laboratory, Departments of Molecular and Integrative Neurosciences and Infectology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 313:94-7. 2006
    ..The titer of infectious scrapie in blood plasma exceeded 10(7) 50% infectious doses per milliliter. The hearts of these transgenic mice contained PrPres-positive amyloid deposits that led to myocardial stiffness and cardiac disease...
  54. ncbi Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion
    Michael B A Oldstone
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:4357-63. 2002
    ....
  55. ncbi Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons
    Jose R Criado
    Department of Neuropharmacology TPC 10, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neurobiol Dis 19:255-65. 2005
    ....
  56. ncbi Scrapie-specific neuronal lesions are independent of neuronal PrP expression
    Martin Jeffrey
    Veterinary Laboratories Agency, Lasswade Laboratory, Pentlands Science Park, Penicuik, Midlothian, Scotland
    Ann Neurol 55:781-92. 2004
    ....
  57. ncbi Gene expression alterations in brains of mice infected with three strains of scrapie
    Pamela J Skinner
    Department of Veterinary and Biomedical Sciences, University of Minnesota, USA
    BMC Genomics 7:114. 2006
    ..Three strains of mouse scrapie that show striking differences in neuropathology were studied: ME7, 22L, and Chandler/RML...
  58. ncbi Separate sequences in a murine retroviral envelope protein mediate neuropathogenesis by complementary mechanisms with differing requirements for tumor necrosis factor alpha
    Karin E Peterson
    Department of Pathobiological Sciences, School of Veterinary Medicine, Skip Bertman Dr, Louisiana State University, Baton Rouge, LA 70803, USA
    J Virol 78:13104-12. 2004
    ..These results provide new insights into the multifactorial mechanisms involved in retrovirus-induced neurodegeneration and may also have analogies to other types of neurodegeneration...
  59. ncbi Human immunodeficiency virus type 1 envelope-mediated neuronal death: uncoupling of viral replication and neurotoxicity
    Kunyan Zhang
    Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    J Virol 77:6899-912. 2003
    ..These findings underscore the importance of HIV-1 envelope protein expression in neurotoxic pathways associated with HIV-induced brain disease and highlight the envelope as a target for neuroprotective therapeutic interventions...