V Chernomordik

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Quantification of optical properties of a breast tumor using random walk theory
    Victor Chernomordik
    National Institutes of Health, National Institute of Child Health and Development, Bethesda, Maryland, USA
    J Biomed Opt 7:80-7. 2002
  2. ncbi request reprint Depth dependence of the analytical expression for the width of the point spread function (spatial resolution) in time-resolved transillumination
    V Chernomordik
    National Institute of Child Health and Development, National Institutes of Health, Bldg 12A, Rm 2041, 9000 Rockville Pike, Bethesda, MD 20892 5626, USA
    J Biomed Opt 6:441-5. 2001
  3. ncbi request reprint Analytical calculation of the mean time spent by photons inside an absorptive inclusion embedded in a highly scattering medium
    Victor Chernomordik
    National Institutes of Health, National Institute of Child Health and Development, Bldg 12A, Rm 2041, 9000 Rockville Pike, Bethesda, Maryland 20892 5626, USA
    J Biomed Opt 7:486-92. 2002
  4. doi request reprint Use of scaling relations to extract intrinsic fluorescence lifetime of targets embedded in turbid media
    Victor Chernomordik
    National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    J Biomed Opt 13:024025. 2008
  5. ncbi request reprint Photon migration in turbid media with anisotropic optical properties
    Olga K Dudko
    Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA
    Phys Med Biol 49:3979-89. 2004
  6. ncbi request reprint Three-dimensional localization of fluorescent masses deeply embedded in tissue
    A Eidsath
    ORS DBEPS, National Institutes of Health, Bethesda, MD 20892, USA
    Phys Med Biol 47:4079-92. 2002
  7. pmc Using in-vivo fluorescence imaging in personalized cancer diagnostics and therapy, an image and treat paradigm
    Y Ardeshirpour
    NIH National Institute of Child Health and Human Development, 9 Memorial Dr, Bethesda, MD 20892, USA
    Technol Cancer Res Treat 10:549-60. 2011
  8. ncbi request reprint Tissue characterization by quantitative optical imaging methods
    Amir H Gandjbakhche
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Technol Cancer Res Treat 2:537-51. 2003
  9. ncbi request reprint Noninvasive Multimodality Imaging Techniques to Assess Kaposi's Sarcoma
    Amir Gandjbakhche
    Lab of Integrative and Medical Biophysics, National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Bethesda, MD 20892, USA Email
    Conf Proc IEEE Eng Med Biol Soc 1:694-6. 2005
  10. ncbi request reprint Using quantitative imaging techniques to assess vascularity in AIDS-related Kaposi's sarcoma
    Abby Vogel
    Laboratory of Integrative and Medical Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Conf Proc IEEE Eng Med Biol Soc 1:232-5. 2006

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Quantification of optical properties of a breast tumor using random walk theory
    Victor Chernomordik
    National Institutes of Health, National Institute of Child Health and Development, Bethesda, Maryland, USA
    J Biomed Opt 7:80-7. 2002
    ..The tumors showed increased absorption and scattering. From the absorption coefficients at both wavelengths blood oxygen saturation was estimated for the tumors and the surrounding tissue...
  2. ncbi request reprint Depth dependence of the analytical expression for the width of the point spread function (spatial resolution) in time-resolved transillumination
    V Chernomordik
    National Institute of Child Health and Development, National Institutes of Health, Bldg 12A, Rm 2041, 9000 Rockville Pike, Bethesda, MD 20892 5626, USA
    J Biomed Opt 6:441-5. 2001
    ..This PSF width determines spatial resolution of the time-resolved imaging and is widely discussed in the literature...
  3. ncbi request reprint Analytical calculation of the mean time spent by photons inside an absorptive inclusion embedded in a highly scattering medium
    Victor Chernomordik
    National Institutes of Health, National Institute of Child Health and Development, Bldg 12A, Rm 2041, 9000 Rockville Pike, Bethesda, Maryland 20892 5626, USA
    J Biomed Opt 7:486-92. 2002
    ....
  4. doi request reprint Use of scaling relations to extract intrinsic fluorescence lifetime of targets embedded in turbid media
    Victor Chernomordik
    National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    J Biomed Opt 13:024025. 2008
    ..The suggested algorithm is a promising tool for diagnostic fluorescence, since lifetime can be a sensitive indicator of the fluorophore environment...
  5. ncbi request reprint Photon migration in turbid media with anisotropic optical properties
    Olga K Dudko
    Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA
    Phys Med Biol 49:3979-89. 2004
    ..The mathematical development is based on a diffusion picture, in which the bounding plane is regarded as being totally absorbing so that all photons reaching the surface contribute to the reflectance...
  6. ncbi request reprint Three-dimensional localization of fluorescent masses deeply embedded in tissue
    A Eidsath
    ORS DBEPS, National Institutes of Health, Bethesda, MD 20892, USA
    Phys Med Biol 47:4079-92. 2002
    ....
  7. pmc Using in-vivo fluorescence imaging in personalized cancer diagnostics and therapy, an image and treat paradigm
    Y Ardeshirpour
    NIH National Institute of Child Health and Human Development, 9 Memorial Dr, Bethesda, MD 20892, USA
    Technol Cancer Res Treat 10:549-60. 2011
    ..Transition of these techniques from the bench to bedside is the ultimate goal of our project. Similar approaches can be used potentially for characterization of other cancer related cell biomarkers...
  8. ncbi request reprint Tissue characterization by quantitative optical imaging methods
    Amir H Gandjbakhche
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Technol Cancer Res Treat 2:537-51. 2003
    ..Additionally, we have developed a method which uses time-resolved data and capitalizes on probe lifetime sensitivity to metabolic parameters such as pH and temperature to obtain functional information from the tumor site...
  9. ncbi request reprint Noninvasive Multimodality Imaging Techniques to Assess Kaposi's Sarcoma
    Amir Gandjbakhche
    Lab of Integrative and Medical Biophysics, National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Bethesda, MD 20892, USA Email
    Conf Proc IEEE Eng Med Biol Soc 1:694-6. 2005
    ..The techniques are objective, easy to perform, and appear to be very sensitive in assessing improvement in the lesions upon administration of therapy...
  10. ncbi request reprint Using quantitative imaging techniques to assess vascularity in AIDS-related Kaposi's sarcoma
    Abby Vogel
    Laboratory of Integrative and Medical Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Conf Proc IEEE Eng Med Biol Soc 1:232-5. 2006
    ..These three techniques are objective, easy to perform, and appear to be very sensitive in assessing changes in the lesions upon administration of therapy...
  11. ncbi request reprint Choice of data types in time resolved fluorescence enhanced diffuse optical tomography
    Jason Riley
    Laboratory of Integrative and Medical Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Building 9, Bethesda, Maryland 20892, USA
    Med Phys 34:4890-900. 2007
    ..We conclude that while the local data types may be more expensive to generate in the general case, they do offer clear advantages over the standard global data types...
  12. pmc Direct curvature correction for noncontact imaging modalities applied to multispectral imaging
    Jana M Kainerstorfer
    National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Section on Analytical and Functional Biophotonics PPITS SAFB, Bethesda, Maryland 20892, USA
    J Biomed Opt 15:046013. 2010
    ..2%. Finally, diffuse multispectral images are acquired on forearms in vivo. We demonstrate the enhancement in image quality on intensity images, and consequently on reconstruction results of blood volume and oxygenation distributions...
  13. pmc Fluorescence lifetime imaging system for in vivo studies
    Moinuddin Hassan
    Laboratory of Integrative and Medical Biophysics, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA
    Mol Imaging 6:229-36. 2007
    ..Three-dimensional mapping of the fluorescence lifetime indicates lower lifetime values in superficial breast cancer tumors in mice...
  14. ncbi request reprint Real time in vivo non-invasive optical imaging using near-infrared fluorescent quantum dots
    Nicole Y Morgan
    National Institutes of Health, Bethesda, MD 20892, USA
    Acad Radiol 12:313-23. 2005
    ..For this purpose, the development of novel contrast agents with near-infrared (NIR) fluorescence is especially important. We report on the use of NIR semiconductor nanocrystals in deep-tissue in vivo optical imaging...
  15. ncbi request reprint Functional optical detection based on pH dependent fluorescence lifetime
    Israel Gannot
    Lasers and Optics in Medicine Laboratory, Department of Biomedical Engineering, Faculty of Engineering Tel Aviv University, Tel Aviv 69978, Israel
    Lasers Surg Med 35:342-8. 2004
    ..g., tissue), that was able to extract an original lifetime fluorescence signal from time-of-flight intensity distributions, measured in vivo from a deeply embedded live organ for further analysis...
  16. pmc Principal component model of multispectral data for near real-time skin chromophore mapping
    Jana M Kainerstorfer
    National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Section on Analytical and Functional Biophotonics PPITS SAFB, Bethesda, Maryland 20892, USA
    J Biomed Opt 15:046007. 2010
    ..We demonstrate that PCA applied to multispectral images gives near equivalent results for skin chromophore mapping and quantification with the advantage of being three orders of magnitude faster than the reconstruction algorithm...
  17. ncbi request reprint Differential oblique angle spectroscopy of the oral epithelium
    David Hattery
    National Institutes of Health, National Institute of Child Health and Human Development, Laboratory of Integrative and Medical Biophysics, Building 9, Room B1E11, Bethesda, Maryland 20892 0924, USA
    J Biomed Opt 9:951-60. 2004
    ..We believe that this new method will perform well on patients with diverse tissue optical characteristics and therefore be of practical clinical value for quantifying epithelial thickness in vivo...
  18. pmc Quantitative analysis of Her2 receptor expression in vivo by near-infrared optical imaging
    Victor Chernomordik
    Program on Pediatric Imaging and Tissue Sciences, Section on Analytical and Functional Biophotonics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Mol Imaging 9:192-200. 2010
    ..This work shows that optical imaging, combined with mathematical modeling, allows noninvasive monitoring of HER2 expression in vivo...
  19. pmc Mean time-of-flight of photons in transillumination measurements of optically anisotropic tissue with an inclusion
    Olga K Dudko
    Mathematical and Statistical Computing Laboratory, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA
    Phys Med Biol 51:4719-33. 2006
    ....
  20. ncbi request reprint Intensity profiles of linearly polarized light backscattered from skin and tissue-like phantoms
    Alexander Sviridov
    National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 0924, USA
    J Biomed Opt 10:14012. 2005
    ..5 to 2.5 mm from the entry point. The polarized videoreflectometry of the skin may be a useful tool to assess skin fibrosis resulting from radiation treatment...
  21. pmc Affibody molecules for in vivo characterization of HER2-positive tumors by near-infrared imaging
    Sang Bong Lee
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA
    Clin Cancer Res 14:3840-9. 2008
    ..The goal is to provide probes that will minimally interfere with the studied system, that is, whose binding does not interfere with the binding of the therapeutic agents and whose effect on the target cells is minimal...
  22. ncbi request reprint Enhancement of hidden structures of early skin fibrosis using polarization degree patterns and Pearson correlation analysis
    Alexander P Sviridov
    National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biomed Opt 10:051706. 2005
    ..In addition, Pearson correlation analysis provides information about skin structural size and directionality...
  23. ncbi request reprint Analytical solutions for time-resolved fluorescence lifetime imaging in a turbid medium such as tissue
    D Hattery
    Laboratory of Integrative and Medical Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Opt Soc Am A Opt Image Sci Vis 18:1523-30. 2001
    ..Additionally, the solution has been compared with the exact, numerically solved solution. Thus the presented solution forms the basis for practical lifetime imaging in turbid media such as tissue...
  24. ncbi request reprint Use of small-angle neutron scattering to study tubulin polymers
    Dan L Sackett
    Laboratory of Integrative and Medical Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biomacromolecules 4:461-7. 2003
    ..5 at pD > or = approximately 7.0 to ca. 14 at pD approximately 6.0. Such structural change indicates that analysis of microtubule solutions based on H(2)O/D(2)O contrast variation must be performed with caution, especially at lower pH/pD...
  25. doi request reprint Spatial distribution of VEGF isoforms and chemotactic signals in the vicinity of a tumor
    Alexander R Small
    Laboratory of Integrative and Medical Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Theor Biol 252:593-607. 2008
    ....
  26. ncbi request reprint Monte Carlo simulations of increased/decreased scattering inclusions inside a turbid slab
    Leonardo Dagdug
    Departamento de Fisica, Universidad Autonoma Metropolitana Iztapalapa, Mexico DF
    Phys Med Biol 50:5573-81. 2005
    ..In the case of positive perturbations the time delay is found to be proportional to the square of the size of the inclusion while for negative perturbations the time delay is a linear function of its volume...
  27. ncbi request reprint Experimental evaluation of an anisotropic scattering model of a slab geometry
    Jeremy C Hebden
    Department of Medical Physics and Bioengineering, University College London, London WC1E 6JA, UK
    Opt Lett 29:2518-20. 2004
    ..It is shown that a single set of optical parameters is sufficient to model the experimental measurements acquired across all three orientations of the cube...
  28. ncbi request reprint Quantitative optical imaging of the pharmacokinetics of fluorescent-specific antibodies to tumor markers through tissuelike turbid media
    Israel Gannot
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Opt Lett 29:742-4. 2004
    ..We illustrate application of a new tool, based on the random-walk theory in turbid media, for extracting the pharmacokinetics of these fluorescent antibodies by data deconvolution, excluding the effect of upper turbid tissue layers...
  29. ncbi request reprint In vivo quantitative three-dimensional localization of tumor labeled with exogenous specific fluorescence markers
    Israel Gannot
    Biomedical Engineering Department, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Appl Opt 42:3073-80. 2003
    ..The simulations were performed with agarose-based gel slabs applied to the tongue as tissuelike phantoms. Reconstructed fluorophore locations agree well with the actual values...
  30. ncbi request reprint Visualization of biological texture using correlation coefficient images
    Alexander P Sviridov
    J Biomed Opt 11:060504. 2006
    ..As an example, the subsurface texture of a demineralized tooth sample is enhanced from a noisy polarized light image...