Aiwu Cheng

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines
    Aiwu Cheng
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    Nat Commun 3:1250. 2012
  2. pmc Mitochondria and neuroplasticity
    Aiwu Cheng
    Laboratory of Neurosciences, National Institute of Aging Intramural Research Program, Baltimore, MD 21224, U S A
    ASN Neuro 2:e00045. 2010
  3. pmc TLR2 activation inhibits embryonic neural progenitor cell proliferation
    Eitan Okun
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurochem 114:462-74. 2010
  4. ncbi request reprint Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stress
    Sic L Chan
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Biol Chem 279:28733-43. 2004
  5. pmc Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis
    Eitan Okun
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 107:15625-30. 2010
  6. pmc Monoamine oxidases regulate telencephalic neural progenitors in late embryonic and early postnatal development
    Aiwu Cheng
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 30:10752-62. 2010
  7. pmc Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation
    Justin D Lathia
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 28:13978-84. 2008
  8. pmc Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death
    Thiruma V Arumugam
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:14104-9. 2007
  9. pmc Mitochondrial superoxide production negatively regulates neural progenitor proliferation and cerebral cortical development
    Yan Hou
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Stem Cells 30:2535-47. 2012
  10. pmc Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
    Sung Chun Tang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:13798-803. 2007

Collaborators

Detail Information

Publications38

  1. pmc Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines
    Aiwu Cheng
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    Nat Commun 3:1250. 2012
    ..Our findings suggest that proliferator-activated receptor γ co-activator-1α and mitochondrial biogenesis have important roles in the formation and maintenance of hippocampal dendritic spines and synapses...
  2. pmc Mitochondria and neuroplasticity
    Aiwu Cheng
    Laboratory of Neurosciences, National Institute of Aging Intramural Research Program, Baltimore, MD 21224, U S A
    ASN Neuro 2:e00045. 2010
    ..Disturbances in mitochondrial functions and signalling may play roles in impaired neuroplasticity and neuronal degeneration in Alzheimer's disease, Parkinson's disease, psychiatric disorders and stroke...
  3. pmc TLR2 activation inhibits embryonic neural progenitor cell proliferation
    Eitan Okun
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurochem 114:462-74. 2010
    ..TLR2-mediated inhibition of NPC proliferation may therefore be a mechanism by which infection, ischemia, and inflammation adversely affect brain development...
  4. ncbi request reprint Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stress
    Sic L Chan
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Biol Chem 279:28733-43. 2004
    ..By stabilizing ER Ca(2+) homeostasis and mitochondrial functions, Herp serves a neuroprotective function under conditions of ER stress...
  5. pmc Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis
    Eitan Okun
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 107:15625-30. 2010
    ..Our findings reveal previously undescribed roles for TLR3 as a suppressor of hippocampal cellular plasticity and memory retention...
  6. pmc Monoamine oxidases regulate telencephalic neural progenitors in late embryonic and early postnatal development
    Aiwu Cheng
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 30:10752-62. 2010
    ..Our findings reveal novel roles for MAOs and serotonin in the regulation of IPC proliferation in the developing brain...
  7. pmc Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation
    Justin D Lathia
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 28:13978-84. 2008
    ..Our findings reveal a novel role for TLR3 in the negative regulation of NPC proliferation in the developing brain...
  8. pmc Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death
    Thiruma V Arumugam
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:14104-9. 2007
    ..Our data suggest a major role for complement-mediated cell death in ischemic brain injury and the prospect of using IVIG in relatively low doses as an interventional therapy for stroke...
  9. pmc Mitochondrial superoxide production negatively regulates neural progenitor proliferation and cerebral cortical development
    Yan Hou
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Stem Cells 30:2535-47. 2012
    ..Taken together, our findings suggest that mitochondrial SO flashes negatively regulate NPC self-renewal in the developing cerebral cortex...
  10. pmc Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
    Sung Chun Tang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:13798-803. 2007
    ..Our findings establish a proapoptotic signaling pathway for TLR2 and -4 in neurons that may render them vulnerable to ischemic death...
  11. ncbi request reprint Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage
    Aiwu Cheng
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 27:3722-33. 2007
    ....
  12. pmc Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease
    Dong Gyu Jo
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    Neurobiol Aging 31:917-25. 2010
    ..Our findings suggest that gamma-secretase mediates oxidative stress-induced expression of BACE1 resulting in excessive Abeta production in AD...
  13. ncbi request reprint Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death
    Aiwu Cheng
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 27:1519-28. 2007
    ..Thus, pancortin-2 is a mediator of ischemia-induced apoptosis of neurons in the adult cerebral cortex and functions in a novel mitochondrial/actin-associated protein complex that sequesters Bcl-xL...
  14. ncbi request reprint Gap junctional communication is required to maintain mouse cortical neural progenitor cells in a proliferative state
    Aiwu Cheng
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Dev Biol 272:203-16. 2004
    ..In addition to promoting their proliferation, gap junctions are required for the survival of NPCs. Gap junctional communication is therefore both necessary and sufficient to maintain NPCs in a self-renewing state...
  15. pmc Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal
    Sung Chun Tang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Exp Neurol 213:114-21. 2008
    ..Our findings suggest that TLR4 signaling increases the vulnerability of neurons to Abeta and oxidative stress in AD, and identify TLR4 as a potential therapeutic target for AD...
  16. ncbi request reprint Truncated tyrosine kinase B brain-derived neurotrophic factor receptor directs cortical neural stem cells to a glial cell fate by a novel signaling mechanism
    Aiwu Cheng
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurochem 100:1515-30. 2007
    ..Our findings suggest a mechanism by which a single factor (BDNF) regulates the production of the two major cell types in the mammalian cerebral cortex...
  17. pmc Age and energy intake interact to modify cell stress pathways and stroke outcome
    Thiruma V Arumugam
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Ann Neurol 67:41-52. 2010
    ..We therefore determined the interactions of age and energy intake on the outcome of ischemic brain injury, and elucidated the underlying mechanisms...
  18. pmc Permeability transition pore-mediated mitochondrial superoxide flashes regulate cortical neural progenitor differentiation
    Yan Hou
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America
    PLoS ONE 8:e76721. 2013
    ..Conversely, manipulations that increase superoxide flash frequency accelerate neuronal differentiation. Our findings reveal a regulatory role for mitochondrial superoxide flashes, mediated by mPTP opening, in neuronal differentiation. ..
  19. pmc Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats
    Ruiqian Wan
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
    J Nutr Biochem 21:413-7. 2010
    ..Because recent studies have shown that adiponectin can protect the heart against ischemic injury, our findings suggest a potential role for adiponectin as a mediator of the cardioprotective effect of IF...
  20. ncbi request reprint Membrane properties of rat embryonic multipotent neural stem cells
    Jingli Cai
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Neurochem 88:212-26. 2004
    ..Overall, our results show that fetal NSCs exhibit a unique signature that can be used to determine their location and assess their ability to respond to their environment...
  21. pmc Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells
    Seema Gulyani
    Neurology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Neurol 215:236-42. 2009
    ..In conclusion, the A(2A)R is increased across different iron-insufficient conditions. The relation between A(2A)R and cellular iron status may be an important pathway by which adenosine may alter the function of the dopaminergic system...
  22. doi request reprint Notch: from neural development to neurological disorders
    Justin D Lathia
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    J Neurochem 107:1471-81. 2008
    ..Studies of animal models suggest the potential of agents that target notch signaling as therapeutic interventions for several different CNS disorders...
  23. pmc Permeability transition pore-mediated mitochondrial superoxide flashes mediate an early inhibitory effect of amyloid beta1-42 on neural progenitor cell proliferation
    Yan Hou
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA
    Neurobiol Aging 35:975-89. 2014
    ..If Aβ inhibits NPC proliferation in the brains of AD patients by a similar mechanism, then interventions that inhibit mPTP-mediated superoxide flashes would be expected to protect NPCs against the adverse effects of Aβ. ..
  24. ncbi request reprint The PTEN phosphatase is essential for long-term depression of hippocampal synapses
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuromolecular Med 8:329-36. 2006
    ..These findings demonstrate a pivotal role for PTEN in LTD, and suggest that alterations in PTEN could have an impact on learning and memory processes...
  25. doi request reprint Telomere neurobiology
    Mark P Mattson
    National Institute on Aging NIH, Baltimore, MD, USA
    Methods Mol Biol 438:185-96. 2008
    ....
  26. ncbi request reprint Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke
    Thiruma V Arumugam
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Nat Med 12:621-3. 2006
    ..These findings suggest that Notch signaling may be a therapeutic target for treatment of stroke and related neurodegenerative conditions...
  27. ncbi request reprint Concurrent generation of subplate and cortical plate neurons in developing trisomy 16 mouse cortex
    Aiwu Cheng
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Dev Neurosci 26:255-65. 2004
    ..Indeed, using lipophilic membrane tracers to label axonal projections, we found very little thalamocortical innervation of the Ts16 SP at an age when there is extensive innervation of the euploid SP...
  28. pmc Superoxide flashes in single mitochondria
    Wang Wang
    Laboratories of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Cell 134:279-90. 2008
    ..We propose that superoxide flashes could serve as a valuable biomarker for a wide variety of oxidative stress-related diseases...
  29. ncbi request reprint Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain
    Aiwu Cheng
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Dev Biol 258:319-33. 2003
    ....
  30. pmc Mitochondria in neuroplasticity and neurological disorders
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Neuron 60:748-66. 2008
    ..Advances in understanding the molecular and cell biology of mitochondria are leading to novel approaches for the prevention and treatment of neurological disorders...
  31. pmc Clathrin assembly proteins AP180 and CALM in the embryonic rat brain
    Catherine M Schwartz
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Comp Neurol 518:3803-18. 2010
    ..These results identify the developmental stage of AP180 and CALM expression and suggest that each protein has distinct functions in neural development...
  32. ncbi request reprint Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations
    Ollivier Milhavet
    Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Neurochem 83:673-81. 2002
    ..An abnormality in the translational regulation of Gadd153 may sensitize cells to the detrimental effects of ER stress and contribute to the pathogenic actions of PS1 mutations in FAD...
  33. ncbi request reprint Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats
    Donald E Mager
    Laboratory of Neurosciences, National Institute on Aging, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    FASEB J 20:631-7. 2006
    ..These results suggest an additional cardiovascular benefit of DR that merits further studies of this potential effect in humans...
  34. ncbi request reprint Calmodulin mediates brain-derived neurotrophic factor cell survival signaling upstream of Akt kinase in embryonic neocortical neurons
    Aiwu Cheng
    Laboratories of Neurosciences and Cardiovascular Science, Gerontology Research Center, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 278:7591-9. 2003
    ..In addition, our findings show that the C-terminal Ca(2+)-binding sites are critical for calmodulin-mediated cell survival signaling...
  35. ncbi request reprint Neurohormetic phytochemicals: Low-dose toxins that induce adaptive neuronal stress responses
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Trends Neurosci 29:632-9. 2006
    ..Thus, as we discuss in this review, highly conserved longevity and survival pathways in neurons are the targets of many phytochemicals...
  36. ncbi request reprint Neuroprotective and neurorestorative signal transduction mechanisms in brain aging: modification by genes, diet and behavior
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center 4F01, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurobiol Aging 23:695-705. 2002
    ..The recent application of modem methods of molecular and cellular biology to the problem of brain aging is revealing a remarkable capacity within brain cells for adaptation to aging and resistance to disease...
  37. pmc The N-terminal 24 amino acids of the p55 gamma regulatory subunit of phosphoinositide 3-kinase binds Rb and induces cell cycle arrest
    Xianmin Xia
    Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201, USA
    Mol Cell Biol 23:1717-25. 2003
    ..These data demonstrate for the first time an association of p55gamma with Rb and show that modification of this association can lead to cell cycle arrest...
  38. ncbi request reprint Compatibility of Gd-DTPA perfusion and histologic studies of the brain
    Richard G Spencer
    Nuclear Magnetic Resonance Unit, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    Magn Reson Imaging 24:27-31. 2006
    ..D.=131.2+/-28.4; n=3) as compared to nontreated specimens (116.2+/-34.7; n=3, P=.7). Therefore, Gd-DTPA may be applied as a microMRI contrast agent in formalin-fixed brain tissue prior to histologic studies...