Zhi Chen

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Distinct regulation of interleukin-17 in human T helper lymphocytes
    Zhi Chen
    National Institute of Arthritis and Musculoskeletal and Skin Diseases and National Human Genome Research Institute, NIH, Bethesda, Maryland 20892 1820, USA
    Arthritis Rheum 56:2936-46. 2007
  2. doi request reprint Th17 cells: a new fate for differentiating helper T cells
    Zhi Chen
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, Musculoskeletal and Skin Diseases, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Res 41:87-102. 2008
  3. pmc New complexities in helper T cell fate determination and the implications for autoimmune diseases
    Hiroaki Takatori
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mod Rheumatol 18:533-41. 2008
  4. ncbi request reprint Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    Arian Laurence
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 26:371-81. 2007
  5. ncbi request reprint Regulation of IL-17 production in human lymphocytes
    Zhi Chen
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Cytokine 41:71-8. 2008
  6. pmc Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation
    Zhi Chen
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Semin Immunol 19:400-8. 2007
  7. pmc Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
    Zhi Chen
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:8137-42. 2006
  8. ncbi request reprint Large-scale differential display analysis of T helper cell differentiation
    Pekka Ojala
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Finland
    Electrophoresis 28:903-17. 2007

Collaborators

Detail Information

Publications8

  1. pmc Distinct regulation of interleukin-17 in human T helper lymphocytes
    Zhi Chen
    National Institute of Arthritis and Musculoskeletal and Skin Diseases and National Human Genome Research Institute, NIH, Bethesda, Maryland 20892 1820, USA
    Arthritis Rheum 56:2936-46. 2007
    ..The present study was undertaken to assess the effects on naive human CD4+ T cells of cytokines known to promote murine Th17 cells...
  2. doi request reprint Th17 cells: a new fate for differentiating helper T cells
    Zhi Chen
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, Musculoskeletal and Skin Diseases, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Res 41:87-102. 2008
    ..Selectively targeting the Th17 lineage may be beneficial for the treatment of inflammatory and autoimmune diseases...
  3. pmc New complexities in helper T cell fate determination and the implications for autoimmune diseases
    Hiroaki Takatori
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mod Rheumatol 18:533-41. 2008
    ..Selectively targeting Tregs and Th17 cells are likely to be important strategies in the treatment of inflammatory and autoimmune diseases in humans...
  4. ncbi request reprint Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    Arian Laurence
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 26:371-81. 2007
    ..We conclude that in addition to the promotion of activation-induced cell death of lymphocytes and the generation of Treg cells, inhibition of Th17 polarization appears to be an important function of IL-2...
  5. ncbi request reprint Regulation of IL-17 production in human lymphocytes
    Zhi Chen
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Cytokine 41:71-8. 2008
    ..Targeting the production and action of this cytokine is also likely to be beneficial therapeutically for autoinflammatory and autoimmune diseases...
  6. pmc Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation
    Zhi Chen
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Semin Immunol 19:400-8. 2007
    ..Precisely how cytokines produced by this lineage are selectively expressed and selectively extinguished through epigenetic modifications is an area of great importance, but considerable uncertainty...
  7. pmc Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
    Zhi Chen
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:8137-42. 2006
    ..We conclude that Socs3 is an essential negative regulator of IL-23 signaling, inhibition of which constrains the generation of Th17 differentiation...
  8. ncbi request reprint Large-scale differential display analysis of T helper cell differentiation
    Pekka Ojala
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Finland
    Electrophoresis 28:903-17. 2007
    ..Using this method, we demonstrate the effect of activation and genotype. In addition, agreement of our real experimental data to the theoretical basis of DD, as well as issues in anchoring primer selectivity, are studied...