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Genomes and Genes | Wanjun ChenSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
CD4+CD25+ T regulatory cells and TGF-beta in mucosal immune system: the good and the badWanjun Chen
Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Curr Med Chem 14:2245-9. 2007..In this article, we attempt to discuss both beneficial and detrimental effects of TGF-beta and Tregs on oral tolerance, mucosal inflammation and autoimmunity, colon cancer and HIV infection in the gut...
TGF-beta1 on osteoimmunology and the bone component cellsShimpei Kasagi
Mucosal Immunology Section, NIDCR, NIH, Bethesda, MD, USA
Cell Biosci 3:4. 2013....- TGF-beta and 'adaptive' Foxp3(+) regulatory T cellsWanjun Chen
Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Mol Cell Biol 2:30-6. 2010..In this short article, we will highlight the key findings and recent progress in the field, discuss the molecular mechanisms underlying the TGF-beta-mediated induction of Foxp3, and attempt to outline the challenges ahead... - TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieuW Chen
Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 14:715-25. 2001..These findings broaden the potential mechanisms whereby induction of immune tolerance or deficiency occurs through T cell deletion... - Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3Wanjun Chen
Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 198:1875-86. 2003..Finally, in a murine asthma model, coadministration of these TGF-beta-induced suppressor T cells prevented house dust mite-induced allergic pathogenesis in lungs... - Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndromeSylvain Perruche
Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 183:953-61. 2009..The study may also provide a novel molecular mechanism explaining the early death in TGF-beta1(-/-) mice... - Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-βJoanne E Konkel
Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
Nat Immunol 12:312-9. 2011..Our data demonstrate a previously unrecognized role for TGF-β in the development of TCRαβ+CD8αα+ IELs and the expression of CD8α in T cells... - Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseasesSharon M Wahl
Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Disease, National Institutes of Health, Bethesda, Maryland, USA
Arthritis Res Ther 7:62-8. 2005.... - Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathwayYansong Bian
Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4330, USA
Cancer Res 69:5918-26. 2009..Our results revealed the critical role of the TGF-beta signaling pathway and its cross-talk with the PI3K/Akt pathway in suppressing head and neck carcinogenesis... - Generation of pathogenic T(H)17 cells in the absence of TGF-β signallingKamran Ghoreschi
Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 467:967-71. 2010..These data indicate an alternative mode for T(H)17 differentiation. Consistent with genetic data linking IL23R with autoimmunity, our findings re-emphasize the importance of IL-23 and therefore may have therapeutic implications... - Dendritic cells and (CD4+)CD25+ T regulatory cells: crosstalk between two professionals in immunity versus toleranceWanjun Chen
Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Heath, 30, Bethesda, MD 20892, USA
Front Biosci 11:1360-70. 2006..This review focuses on the recent development in our understanding of DCs and (CD4+)CD25+ T regs in immune tolerance, with transforming growth factor-beta (TGF-beta) serving as a potential link between these two professionals... 
CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cellsSylvain Perruche
Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research NIDCR, US National Institutes of Health NIH, 30 Convent Drive, Bethesda, Maryland 20892, USA
Nat Med 14:528-35. 2008..Thus, CD3-specific antibody-induced immune tolerance is associated with TGF-beta production in phagocytes involved in clearing apoptotic T cells, which suggests that apoptosis is linked to active suppression in immune tolerance...- Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glandsSeshagiri R Nandula
National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
Arthritis Rheum 56:1798-805. 2007..The aim of this study was to delineate the precise function of TGFbeta signaling in salivary gland inflammation... - Mutation of inhibitory helix-loop-helix protein Id3 causes γδ T-cell lymphoma in miceJun Li
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
Blood 116:5615-21. 2010..Our model will provide a tool for studying the molecular mechanisms and development of human γδ T-cell lymphoma... - Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4+CD25+ Tregs from thymic CD4+CD25- single positive T cellsYongzhong Liu
Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20895, USA
Transplantation 82:953-64. 2006..CONCLUSIONS: TGF-beta and TCR co-stimulation converts thymic CD4+CD25+ T cells into CD4+CD25+ Tregs by inducing Foxp3, and the contribution of CD28 stimulation to this process is mainly through maintaining survival of the induced Tregs... - TGF-beta: receptors, signaling pathways and autoimmunityWanjun Chen
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
Curr Dir Autoimmun 5:62-91. 2002 - Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3Takashi Maruyama
Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institutes of Health, Bethesda, Maryland, USA
Nat Immunol 12:86-95. 2011..Therefore, a network of factors acts in a TGF-β-dependent manner to control Foxp3 expression and inhibit the development of T(H)17 cells... - TGF-beta: how tolerant can it be?Sharon M Wahl
Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
Immunol Res 28:167-79. 2003..Central to several of these pathways is transforming growth factor-beta (TGF-beta), a potent immunoregulatory cytokine that contributes to the function and generation of regulatory T cells... - A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cellsYongzhong Liu
Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 9:632-40. 2008..Thus, transforming growth factor-beta signaling is critical to the thymic development of natural CD4+CD25+Foxp3+ T(reg) cells... - Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy?Sylvain Perruche
Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Convent Drive, Bethesda, MD 20892, USA
Arthritis Res Ther 11:R104. 2009..Therefore we evaluated the potential of apoptotic cell injection to influence the course of inflammation in SCW-induced arthritis in rats... - Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrenceMasaki Terabe
Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 198:1741-52. 2003.... - TGF-beta: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppressionWanjun Chen
Cellular Immunology Section, Oral Infection and Immunity Branch, NIDCR, NIH, Room 332, Building 30, Bethesda, MD 20892-4352, USA
Cytokine Growth Factor Rev 14:85-9. 2003..Collectively, multiple previously unconnected puzzle pieces are beginning to be linked into a more coherent, albeit incomplete picture of CD4(+)CD25(+) T cell-mediated suppression... - The molecular mechanisms of Foxp3 gene regulationTakashi Maruyama
Mucosal Immunology Section, OIIB, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
Semin Immunol 23:418-23. 2011..Here we review the recent progress in understanding the complex molecular events that drive Foxp3 gene expression and allow functional regulatory T cells to develop... - TGF-beta: the perpetrator of immune suppression by regulatory T cells and suicidal T cellsSharon M Wahl
NIDCR, NIH, Building 30, Rm 320, 30 Convent Drive, MSC4352, Bethesda, MD 20892 4352, USA
J Leukoc Biol 76:15-24. 2004.... - Regulatory T cells and transcription factors: gatekeepers in allergic inflammationSharon M Wahl
Building 30, Room 320, 30 Convent Drive, MSC 4352, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4352, USA
Curr Opin Immunol 16:768-74. 2004..Continued unraveling of the pathways underlying the development of deleterious immune responses and their control will guide new avenues of investigation and intervention... - Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cellsShoba Amarnath
Mucosal Immunology Unit, OIIB, NIDCR, NIH, Bethesda, MD 20895, USA
Retrovirology 4:57. 2007..We also explored the effects of TGF-beta on HIV-1 infection mediated induction of human Tregs since recent evidence has suggested that HIV-1 infection may also impact the generation of Tregs in infected patients... - Balancing acts: the role of TGF-β in the mucosal immune systemJoanne E Konkel
Mucosal Immunology Section, OIIB, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20982, USA
Trends Mol Med 17:668-76. 2011..In this review, we discuss the role of TGF-β in the generation and functioning of gut lymphocyte populations. We highlight recent findings, summarize controversies, outline remaining questions and provide our personal perspectives... - Mesenchymal stem cell-organized bone marrow elements: an alternative hematopoietic progenitor resourceYasuo Miura
National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland
Stem Cells 24:2428-36. 2006..These results indicate that the BMMSC-organized BM niche system represents a unique hematopoietic progenitor resource possessing potential clinical value... - Dual roles of immune cells and their factors in cancer development and progressionBrian F Zamarron
Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Int J Biol Sci 7:651-8. 2011.... - Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasisKarin List
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA
Oncogene 21:3765-79. 2002..This study demonstrates that Matriptase/MT-SP1 has pleiotropic functions in the development of the epidermis, hair follicles, and cellular immune system... - Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesionsLynn Vitale-Cross
Molecular Carcinogenesis Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892, USA
Cancer Prev Res (Phila) 5:562-73. 2012..Collectively, our data underscore the potential clinical benefits of using metformin as a targeted chemopreventive agent in the control of HNSCC development and progression... - Regulatory ripplesYasmine Belkaid
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Nat Immunol 11:1077-8. 2010..Data now show that interleukin 35, an immunomodulatory cytokine secreted by regulatory T cells, and interleukin 10 induce so-called 'iTR35 cells', which may have an important role in the phenomenon of infectious tolerance... - CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiationDriss Ehirchiou
Center for Vascular and Inflammatory Diseases, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Exp Med 204:1519-24. 2007..Together, we conclude that CD11b facilitates oral tolerance by suppressing Th17 immune differentiation... - Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodentsTakayoshi Yamaza
Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, California, United States of America
PLoS ONE 3:e2615. 2008....