Wanjun Chen

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint CD4+CD25+ T regulatory cells and TGF-beta in mucosal immune system: the good and the bad
    Wanjun Chen
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Med Chem 14:2245-9. 2007
  2. pmc TGF-beta1 on osteoimmunology and the bone component cells
    Shimpei Kasagi
    Mucosal Immunology Section, NIDCR, NIH, Bethesda, MD, USA
    Cell Biosci 3:4. 2013
  3. ncbi request reprint TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu
    W Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 14:715-25. 2001
  4. pmc TGF-beta and 'adaptive' Foxp3(+) regulatory T cells
    Wanjun Chen
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Cell Biol 2:30-6. 2010
  5. pmc Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    Wanjun Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1875-86. 2003
  6. pmc Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome
    Sylvain Perruche
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 183:953-61. 2009
  7. pmc Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β
    Joanne E Konkel
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:312-9. 2011
  8. pmc Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseases
    Sharon M Wahl
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Disease, National Institutes of Health, Bethesda, Maryland, USA
    Arthritis Res Ther 7:62-8. 2005
  9. pmc Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 467:967-71. 2010
  10. pmc Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway
    Yansong Bian
    Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4330, USA
    Cancer Res 69:5918-26. 2009

Collaborators

Detail Information

Publications36

  1. ncbi request reprint CD4+CD25+ T regulatory cells and TGF-beta in mucosal immune system: the good and the bad
    Wanjun Chen
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Med Chem 14:2245-9. 2007
    ..In this article, we attempt to discuss both beneficial and detrimental effects of TGF-beta and Tregs on oral tolerance, mucosal inflammation and autoimmunity, colon cancer and HIV infection in the gut...
  2. pmc TGF-beta1 on osteoimmunology and the bone component cells
    Shimpei Kasagi
    Mucosal Immunology Section, NIDCR, NIH, Bethesda, MD, USA
    Cell Biosci 3:4. 2013
    ....
  3. ncbi request reprint TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu
    W Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 14:715-25. 2001
    ..These findings broaden the potential mechanisms whereby induction of immune tolerance or deficiency occurs through T cell deletion...
  4. pmc TGF-beta and 'adaptive' Foxp3(+) regulatory T cells
    Wanjun Chen
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Cell Biol 2:30-6. 2010
    ..In this short article, we will highlight the key findings and recent progress in the field, discuss the molecular mechanisms underlying the TGF-beta-mediated induction of Foxp3, and attempt to outline the challenges ahead...
  5. pmc Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    Wanjun Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1875-86. 2003
    ..Finally, in a murine asthma model, coadministration of these TGF-beta-induced suppressor T cells prevented house dust mite-induced allergic pathogenesis in lungs...
  6. pmc Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome
    Sylvain Perruche
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 183:953-61. 2009
    ..The study may also provide a novel molecular mechanism explaining the early death in TGF-beta1(-/-) mice...
  7. pmc Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β
    Joanne E Konkel
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:312-9. 2011
    ..Our data demonstrate a previously unrecognized role for TGF-β in the development of TCRαβ+CD8αα+ IELs and the expression of CD8α in T cells...
  8. pmc Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseases
    Sharon M Wahl
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Disease, National Institutes of Health, Bethesda, Maryland, USA
    Arthritis Res Ther 7:62-8. 2005
    ....
  9. pmc Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 467:967-71. 2010
    ..These data indicate an alternative mode for T(H)17 differentiation. Consistent with genetic data linking IL23R with autoimmunity, our findings re-emphasize the importance of IL-23 and therefore may have therapeutic implications...
  10. pmc Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway
    Yansong Bian
    Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4330, USA
    Cancer Res 69:5918-26. 2009
    ..Our results revealed the critical role of the TGF-beta signaling pathway and its cross-talk with the PI3K/Akt pathway in suppressing head and neck carcinogenesis...
  11. ncbi request reprint Dendritic cells and (CD4+)CD25+ T regulatory cells: crosstalk between two professionals in immunity versus tolerance
    Wanjun Chen
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Heath, 30, Bethesda, MD 20892, USA
    Front Biosci 11:1360-70. 2006
    ..This review focuses on the recent development in our understanding of DCs and (CD4+)CD25+ T regs in immune tolerance, with transforming growth factor-beta (TGF-beta) serving as a potential link between these two professionals...
  12. pmc Mutation of inhibitory helix-loop-helix protein Id3 causes γδ T-cell lymphoma in mice
    Jun Li
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    Blood 116:5615-21. 2010
    ..Our model will provide a tool for studying the molecular mechanisms and development of human γδ T-cell lymphoma...
  13. doi request reprint CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells
    Sylvain Perruche
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research NIDCR, US National Institutes of Health NIH, 30 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Med 14:528-35. 2008
    ..Thus, CD3-specific antibody-induced immune tolerance is associated with TGF-beta production in phagocytes involved in clearing apoptotic T cells, which suggests that apoptosis is linked to active suppression in immune tolerance...
  14. ncbi request reprint Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands
    Seshagiri R Nandula
    National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 56:1798-805. 2007
    ..The aim of this study was to delineate the precise function of TGFbeta signaling in salivary gland inflammation...
  15. ncbi request reprint Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4+CD25+ Tregs from thymic CD4+CD25- single positive T cells
    Yongzhong Liu
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20895, USA
    Transplantation 82:953-64. 2006
    ..However, the detailed pathway(s) by which Tregs are developed remain a mystery. CD28-/- mice have profound decrease in Tregs, but the underlying molecular events remain largely undefined...
  16. pmc Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3
    Takashi Maruyama
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:86-95. 2011
    ..Therefore, a network of factors acts in a TGF-β-dependent manner to control Foxp3 expression and inhibit the development of T(H)17 cells...
  17. doi request reprint A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells
    Yongzhong Liu
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:632-40. 2008
    ..Thus, transforming growth factor-beta signaling is critical to the thymic development of natural CD4+CD25+Foxp3+ T(reg) cells...
  18. ncbi request reprint TGF-beta: receptors, signaling pathways and autoimmunity
    Wanjun Chen
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    Curr Dir Autoimmun 5:62-91. 2002
  19. ncbi request reprint TGF-beta: how tolerant can it be?
    Sharon M Wahl
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
    Immunol Res 28:167-79. 2003
    ..Central to several of these pathways is transforming growth factor-beta (TGF-beta), a potent immunoregulatory cytokine that contributes to the function and generation of regulatory T cells...
  20. pmc PARP-1 regulates expression of TGF-β receptors in T cells
    Pin Zhang
    Mucosal Immunology Section, Oral Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD
    Blood 122:2224-32. 2013
    ..Importantly, inhibition of PARP-1 also enhanced expression of TβRs in human CD4(+) T cells. Thus, PARP-1 regulates TβR expression and TGF-β signaling in T cells. ..
  21. pmc Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy?
    Sylvain Perruche
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Convent Drive, Bethesda, MD 20892, USA
    Arthritis Res Ther 11:R104. 2009
    ..Therefore we evaluated the potential of apoptotic cell injection to influence the course of inflammation in SCW-induced arthritis in rats...
  22. ncbi request reprint TGF-beta: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression
    Wanjun Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, NIDCR, NIH, Room 332, Building 30, Bethesda, MD 20892 4352, USA
    Cytokine Growth Factor Rev 14:85-9. 2003
    ..Collectively, multiple previously unconnected puzzle pieces are beginning to be linked into a more coherent, albeit incomplete picture of CD4(+)CD25(+) T cell-mediated suppression...
  23. pmc Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence
    Masaki Terabe
    Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1741-52. 2003
    ....
  24. pmc The molecular mechanisms of Foxp3 gene regulation
    Takashi Maruyama
    Mucosal Immunology Section, OIIB, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    Semin Immunol 23:418-23. 2011
    ..Here we review the recent progress in understanding the complex molecular events that drive Foxp3 gene expression and allow functional regulatory T cells to develop...
  25. ncbi request reprint TGF-beta: the perpetrator of immune suppression by regulatory T cells and suicidal T cells
    Sharon M Wahl
    NIDCR, NIH, Building 30, Rm 320, 30 Convent Drive, MSC4352, Bethesda, MD 20892 4352, USA
    J Leukoc Biol 76:15-24. 2004
    ....
  26. pmc Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells
    Shoba Amarnath
    Mucosal Immunology Unit, OIIB, NIDCR, NIH, Bethesda, MD 20895, USA
    Retrovirology 4:57. 2007
    ..We also explored the effects of TGF-beta on HIV-1 infection mediated induction of human Tregs since recent evidence has suggested that HIV-1 infection may also impact the generation of Tregs in infected patients...
  27. ncbi request reprint Regulatory T cells and transcription factors: gatekeepers in allergic inflammation
    Sharon M Wahl
    Building 30, Room 320, 30 Convent Drive, MSC 4352, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4352, USA
    Curr Opin Immunol 16:768-74. 2004
    ..Continued unraveling of the pathways underlying the development of deleterious immune responses and their control will guide new avenues of investigation and intervention...
  28. pmc PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3
    Pin Zhang
    Mucosal Immunology Unit, OIIB, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, United States of America
    PLoS ONE 8:e71590. 2013
    ..Thus, our data reveal a role for PARP-1 in controlling the function of Tregs through modulation of the stable expression of Foxp3. ..
  29. pmc Balancing acts: the role of TGF-β in the mucosal immune system
    Joanne E Konkel
    Mucosal Immunology Section, OIIB, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20982, USA
    Trends Mol Med 17:668-76. 2011
    ..In this review, we discuss the role of TGF-β in the generation and functioning of gut lymphocyte populations. We highlight recent findings, summarize controversies, outline remaining questions and provide our personal perspectives...
  30. pmc Dual roles of immune cells and their factors in cancer development and progression
    Brian F Zamarron
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Biol Sci 7:651-8. 2011
    ....
  31. ncbi request reprint Mesenchymal stem cell-organized bone marrow elements: an alternative hematopoietic progenitor resource
    Yasuo Miura
    National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland
    Stem Cells 24:2428-36. 2006
    ..These results indicate that the BMMSC-organized BM niche system represents a unique hematopoietic progenitor resource possessing potential clinical value...
  32. ncbi request reprint Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis
    Karin List
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA
    Oncogene 21:3765-79. 2002
    ..This study demonstrates that Matriptase/MT-SP1 has pleiotropic functions in the development of the epidermis, hair follicles, and cellular immune system...
  33. pmc Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions
    Lynn Vitale-Cross
    Molecular Carcinogenesis Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892, USA
    Cancer Prev Res (Phila) 5:562-73. 2012
    ..Collectively, our data underscore the potential clinical benefits of using metformin as a targeted chemopreventive agent in the control of HNSCC development and progression...
  34. doi request reprint Regulatory ripples
    Yasmine Belkaid
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 11:1077-8. 2010
    ..Data now show that interleukin 35, an immunomodulatory cytokine secreted by regulatory T cells, and interleukin 10 induce so-called 'iTR35 cells', which may have an important role in the phenomenon of infectious tolerance...
  35. pmc CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation
    Driss Ehirchiou
    Center for Vascular and Inflammatory Diseases, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Exp Med 204:1519-24. 2007
    ..Together, we conclude that CD11b facilitates oral tolerance by suppressing Th17 immune differentiation...
  36. pmc Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents
    Takayoshi Yamaza
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, California, United States of America
    PLoS ONE 3:e2615. 2008
    ....