Research Topics
Genomes and Genes | Keqiang ChenSummaryAffiliation: National Cancer Institute Country: USA Publications
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Publications
Toll-like receptors in inflammation, infection and cancerKeqiang Chen
Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
Int Immunopharmacol 7:1271-85. 2007..We hope to provide new insight into the pathogenesis and progression of diseases and more importantly, into the potential for TLRs as targets of therapeutics...- CD40/CD40L dyad in the inflammatory and immune responses in the central nervous systemKeqiang Chen
School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 201101, China
Cell Mol Immunol 3:163-9. 2006..Thus, both molecules serve as amplifiers of pro-inflammatory and immune responses in the CNS and constitute important molecular targets for therapeutic intervention of diseases... - Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptideKeqiang Chen
Laboratory of Molecular Immunoregulation, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
J Biol Chem 281:3651-9. 2006..Our results demonstrated a potentially important role for TLR2 in microglial cells of promoting cell responses to chemoattractants produced in lesions of inflammatory and neurodegenerative diseases in the brain... 
Interleukin 10 and TNFalpha synergistically enhance the expression of the G protein-coupled formylpeptide receptor 2 in microgliaPablo Iribarren
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Neurobiol Dis 27:90-8. 2007..Our results suggest that IL-10 may affect the pathogenic process of AD by up-regulating mFPR2 and thus favoring the recognition and internalization of Abeta(42) by activated microglial cells...
Cooperation between NOD2 and Toll-like receptor 2 ligands in the up-regulation of mouse mFPR2, a G-protein-coupled Abeta42 peptide receptor, in microglial cellsKeqiang Chen
School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, China
J Leukoc Biol 83:1467-75. 2008..Our results suggest that TLR2 and NOD2 cooperate to up-regulate the expression of mFPR2 and therefore, may actively participate in the pathogenic processes of brain inflammation and neurodegenerative diseases...- Induction of the formyl peptide receptor 2 in microglia by IFN-gamma and synergy with CD40 ligandKeqiang Chen
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
J Immunol 178:1759-66. 2007.... - A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responsesKeqiang Chen
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Maryland, USA
J Immunol 184:3331-5. 2010..This study reveals a critical role for mFPR2 in the progression of allergic airway inflammation and immune responses... - Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiationJian Huang
Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Carcinogenesis 30:348-55. 2009..These results indicate that increased methylation of p53 gene retains human glioblastoma cells at a more poorly differentiated phase associated with the aberrant expression of FPR as a tumor-promoting cell surface receptor... - Synergy of TRIF-dependent TLR3 and MyD88-dependent TLR7 in up-regulating expression of mouse FPR2, a promiscuous G-protein-coupled receptor, in microglial cellsKeqiang Chen
School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, PR China
J Neuroimmunol 213:69-77. 2009..Our results indicated that RNA virus infection may actively participate in the pathogenic processes of brain inflammation and neurodegenerative diseases by TLR3- and TLR7-mediated TRIF-dependent and MyD88-dependent signaling pathways... - IL-4 inhibits the expression of mouse formyl peptide receptor 2, a receptor for amyloid beta1-42, in TNF-alpha-activated microgliaPablo Iribarren
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702, USA
J Immunol 175:6100-6. 2005.... - G-protein coupled chemoattractant receptors and cancerJian Huang
Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Front Biosci 13:3352-63. 2008..The diverse properties of GPCRs in the progression of malignant tumors have attracted intense interest in their potential as novel anti-tumor pharmacological targets... - The active contribution of Toll-like receptors to allergic airway inflammationKeqiang Chen
Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, United States
Int Immunopharmacol 11:1391-8. 2011..Therefore, understanding the complex regulatory roles of TLRs in the pathogenesis of allergic airway inflammation should facilitate the development of preventive and therapeutic measures for asthmatic patients... - Annexin 1 released by necrotic human glioblastoma cells stimulates tumor cell growth through the formyl peptide receptor 1Yan Yang
Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland College of Marine Life Sciences, Ocean University of China, Qingdao, China
Am J Pathol 179:1504-12. 2011..Our study implicates Anx A1 as a major component in necrotic tumor cell-derived stimulants of the growth of glioblastoma via the activation of FPR1... - Receptor "hijacking" by malignant glioma cells: a tactic for tumor progressionJian Huang
Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Building 560, Room 31 76, Frederick, MD 21702 1201, USA
Cancer Lett 267:254-61. 2008..Thus, FPR hijacked by human glioblastoma cells exploits the function of EGFR to promote rapid tumor progression... - Transactivation of the epidermal growth factor receptor by formylpeptide receptor exacerbates the malignant behavior of human glioblastoma cellsJian Huang
Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Science Applications International Corporation Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702 1201, USA
Cancer Res 67:5906-13. 2007..Thus, targeting both receptors may yield antiglioblastoma agents superior to those targeting one of them... - The essential role of phosphoinositide 3-kinases (PI3Ks) in regulating pro-inflammatory responses and the progression of cancerKeqiang Chen
School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 201101, China
Cell Mol Immunol 2:241-52. 2005..The aim of this review is to outline current understandings of the PI3K family, mechanism of their activation, their role in inflammatory responses and the development of malignant tumors... - Cell surface receptor FPR2 promotes antitumor host defense by limiting M2 polarization of macrophagesYing Liu
Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center of Cancer Research, National Cancer Institute Frederick, NIH, Frederick, Maryland 21702, USA
Cancer Res 73:550-60. 2013..These results suggest that Fpr2 plays an important role in host defense against implanted LLC by sustaining macrophages in an M1 phenotype with more potent antitumor activities... - Chemoattractant receptors as pharmacological targets for elimination of glioma stem-like cellsXiao hong Yao
Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Int Immunopharmacol 11:1961-6. 2011.... - CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein- coupled receptor mFPR2Pablo Iribarren
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702 1201, USA
FASEB J 19:2032-4. 2005..Our results suggest that TLR9 may play an important role in promoting microglial recognition of Abeta42, thus affecting the pathogenic process of AD... - Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenesMingyong Liu
Department of Spine Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Sci Rep 2:786. 2012..Thus, Fprs are essential sentinels to guide the first wave of neutrophil infiltration in the liver of Listeria-infected mice for effective elimination of the invading pathogen...