Keqiang Chen

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Toll-like receptors in inflammation, infection and cancer
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Int Immunopharmacol 7:1271-85. 2007
  2. ncbi request reprint CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system
    Keqiang Chen
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 201101, China
    Cell Mol Immunol 3:163-9. 2006
  3. ncbi request reprint Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 281:3651-9. 2006
  4. pmc Signal relay by CC chemokine receptor 2 (CCR2) and formylpeptide receptor 2 (Fpr2) in the recruitment of monocyte-derived dendritic cells in allergic airway inflammation
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 288:16262-73. 2013
  5. pmc Interleukin 10 and TNFalpha synergistically enhance the expression of the G protein-coupled formylpeptide receptor 2 in microglia
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Neurobiol Dis 27:90-8. 2007
  6. doi request reprint Cooperation between NOD2 and Toll-like receptor 2 ligands in the up-regulation of mouse mFPR2, a G-protein-coupled Abeta42 peptide receptor, in microglial cells
    Keqiang Chen
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, China
    J Leukoc Biol 83:1467-75. 2008
  7. ncbi request reprint Induction of the formyl peptide receptor 2 in microglia by IFN-gamma and synergy with CD40 ligand
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Immunol 178:1759-66. 2007
  8. doi request reprint A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responses
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Maryland, USA
    J Immunol 184:3331-5. 2010
  9. pmc Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation
    Jian Huang
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Carcinogenesis 30:348-55. 2009
  10. pmc Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
    J Clin Invest 123:1694-704. 2013

Detail Information

Publications24

  1. ncbi request reprint Toll-like receptors in inflammation, infection and cancer
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Int Immunopharmacol 7:1271-85. 2007
    ..We hope to provide new insight into the pathogenesis and progression of diseases and more importantly, into the potential for TLRs as targets of therapeutics...
  2. ncbi request reprint CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system
    Keqiang Chen
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 201101, China
    Cell Mol Immunol 3:163-9. 2006
    ..Thus, both molecules serve as amplifiers of pro-inflammatory and immune responses in the CNS and constitute important molecular targets for therapeutic intervention of diseases...
  3. ncbi request reprint Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 281:3651-9. 2006
    ..Our results demonstrated a potentially important role for TLR2 in microglial cells of promoting cell responses to chemoattractants produced in lesions of inflammatory and neurodegenerative diseases in the brain...
  4. pmc Signal relay by CC chemokine receptor 2 (CCR2) and formylpeptide receptor 2 (Fpr2) in the recruitment of monocyte-derived dendritic cells in allergic airway inflammation
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 288:16262-73. 2013
    ..Our study demonstrates that the interaction of CCR2 and Fpr2 with their endogenous ligands sequentially mediates the trafficking of DCs within the inflamed lung...
  5. pmc Interleukin 10 and TNFalpha synergistically enhance the expression of the G protein-coupled formylpeptide receptor 2 in microglia
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Neurobiol Dis 27:90-8. 2007
    ..Our results suggest that IL-10 may affect the pathogenic process of AD by up-regulating mFPR2 and thus favoring the recognition and internalization of Abeta(42) by activated microglial cells...
  6. doi request reprint Cooperation between NOD2 and Toll-like receptor 2 ligands in the up-regulation of mouse mFPR2, a G-protein-coupled Abeta42 peptide receptor, in microglial cells
    Keqiang Chen
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, China
    J Leukoc Biol 83:1467-75. 2008
    ..Our results suggest that TLR2 and NOD2 cooperate to up-regulate the expression of mFPR2 and therefore, may actively participate in the pathogenic processes of brain inflammation and neurodegenerative diseases...
  7. ncbi request reprint Induction of the formyl peptide receptor 2 in microglia by IFN-gamma and synergy with CD40 ligand
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Immunol 178:1759-66. 2007
    ....
  8. doi request reprint A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responses
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Maryland, USA
    J Immunol 184:3331-5. 2010
    ..This study reveals a critical role for mFPR2 in the progression of allergic airway inflammation and immune responses...
  9. pmc Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation
    Jian Huang
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Carcinogenesis 30:348-55. 2009
    ..These results indicate that increased methylation of p53 gene retains human glioblastoma cells at a more poorly differentiated phase associated with the aberrant expression of FPR as a tumor-promoting cell surface receptor...
  10. pmc Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
    J Clin Invest 123:1694-704. 2013
    ..These results indicate that FPR2 is critical in mediating homeostasis, inflammation, and epithelial repair processes in the colon...
  11. pmc Synergy of TRIF-dependent TLR3 and MyD88-dependent TLR7 in up-regulating expression of mouse FPR2, a promiscuous G-protein-coupled receptor, in microglial cells
    Keqiang Chen
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, PR China
    J Neuroimmunol 213:69-77. 2009
    ..Our results indicated that RNA virus infection may actively participate in the pathogenic processes of brain inflammation and neurodegenerative diseases by TLR3- and TLR7-mediated TRIF-dependent and MyD88-dependent signaling pathways...
  12. ncbi request reprint IL-4 inhibits the expression of mouse formyl peptide receptor 2, a receptor for amyloid beta1-42, in TNF-alpha-activated microglia
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702, USA
    J Immunol 175:6100-6. 2005
    ....
  13. pmc Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells
    Teizo Yoshimura
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
    PLoS ONE 8:e58791. 2013
    ..A greater understanding of the source and role of this chemokine may lead to novel strategies for cancer treatment...
  14. ncbi request reprint G-protein coupled chemoattractant receptors and cancer
    Jian Huang
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Front Biosci 13:3352-63. 2008
    ..The diverse properties of GPCRs in the progression of malignant tumors have attracted intense interest in their potential as novel anti-tumor pharmacological targets...
  15. pmc Formylpeptide receptors mediate rapid neutrophil mobilization to accelerate wound healing
    Mingyong Liu
    Department of Spine Surgery, Daping Hospital, Third Military Medical University, Chongqing, China Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
    PLoS ONE 9:e90613. 2014
    ..Our study thus demonstrates that Fprs are critical for normal healing of the sterile skin wound by mediating the first wave of neutrophil infiltration. ..
  16. pmc Cell surface receptor FPR2 promotes antitumor host defense by limiting M2 polarization of macrophages
    Ying Liu
    Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center of Cancer Research, National Cancer Institute Frederick, NIH, Frederick, Maryland 21702, USA
    Cancer Res 73:550-60. 2013
    ..These results suggest that Fpr2 plays an important role in host defense against implanted LLC by sustaining macrophages in an M1 phenotype with more potent antitumor activities...
  17. doi request reprint The active contribution of Toll-like receptors to allergic airway inflammation
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, United States
    Int Immunopharmacol 11:1391-8. 2011
    ..Therefore, understanding the complex regulatory roles of TLRs in the pathogenesis of allergic airway inflammation should facilitate the development of preventive and therapeutic measures for asthmatic patients...
  18. pmc Annexin 1 released by necrotic human glioblastoma cells stimulates tumor cell growth through the formyl peptide receptor 1
    Yan Yang
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland College of Marine Life Sciences, Ocean University of China, Qingdao, China
    Am J Pathol 179:1504-12. 2011
    ..Our study implicates Anx A1 as a major component in necrotic tumor cell-derived stimulants of the growth of glioblastoma via the activation of FPR1...
  19. ncbi request reprint The essential role of phosphoinositide 3-kinases (PI3Ks) in regulating pro-inflammatory responses and the progression of cancer
    Keqiang Chen
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 201101, China
    Cell Mol Immunol 2:241-52. 2005
    ..The aim of this review is to outline current understandings of the PI3K family, mechanism of their activation, their role in inflammatory responses and the development of malignant tumors...
  20. doi request reprint Receptor "hijacking" by malignant glioma cells: a tactic for tumor progression
    Jian Huang
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Building 560, Room 31 76, Frederick, MD 21702 1201, USA
    Cancer Lett 267:254-61. 2008
    ..Thus, FPR hijacked by human glioblastoma cells exploits the function of EGFR to promote rapid tumor progression...
  21. ncbi request reprint Transactivation of the epidermal growth factor receptor by formylpeptide receptor exacerbates the malignant behavior of human glioblastoma cells
    Jian Huang
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Science Applications International Corporation Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702 1201, USA
    Cancer Res 67:5906-13. 2007
    ..Thus, targeting both receptors may yield antiglioblastoma agents superior to those targeting one of them...
  22. pmc Chemoattractant receptors as pharmacological targets for elimination of glioma stem-like cells
    Xiao hong Yao
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Int Immunopharmacol 11:1961-6. 2011
    ....
  23. ncbi request reprint CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein- coupled receptor mFPR2
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702 1201, USA
    FASEB J 19:2032-4. 2005
    ..Our results suggest that TLR9 may play an important role in promoting microglial recognition of Abeta42, thus affecting the pathogenic process of AD...
  24. pmc Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes
    Mingyong Liu
    Department of Spine Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Sci Rep 2:786. 2012
    ..Thus, Fprs are essential sentinels to guide the first wave of neutrophil infiltration in the liver of Listeria-infected mice for effective elimination of the invading pathogen...