Guang Chen

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines
    Tewarit Sarachana
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, 2300 Eye St NW, Washington, DC 20037, USA
    Genome Med 2:23. 2010
  2. pmc Translational research in bipolar disorder: emerging insights from genetically based models
    G Chen
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 15:883-95. 2010
  3. ncbi request reprint The extracellular signal-regulated kinase pathway: an emerging promising target for mood stabilizers
    Guang Chen
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland 20892 3711, USA
    Curr Opin Psychiatry 19:313-23. 2006
  4. ncbi request reprint Lithium treatment attenuates muscarinic M(1) receptor dysfunction
    Thomas K Creson
    Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Bipolar Disord 13:238-49. 2011
  5. pmc Genome-wide gene expression profiling in GluR1 knockout mice: key role of the calcium signaling pathway in glutamatergically mediated hippocampal transmission
    Rulun Zhou
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Neurosci 30:2318-26. 2009
  6. pmc Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers
    Rulun Zhou
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 34:1395-405. 2009
  7. pmc Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia
    Peixiong Yuan
    Biomarker Laboratory, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    J Affect Disord 124:164-9. 2010
  8. pmc The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior
    Jing Du
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20878, USA
    J Neurosci 28:68-79. 2008
  9. pmc Valproate activates the Notch3/c-FLIP signaling cascade: a strategy to attenuate white matter hyperintensities in bipolar disorder in late life?
    Peixiong Yuan
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Bipolar Disord 11:256-69. 2009
  10. doi request reprint The anterior cingulate ERK pathway contributes to regulation of behavioral excitement and hedonic activity
    Thomas K Creson
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 3711, USA
    Bipolar Disord 11:339-50. 2009

Collaborators

Detail Information

Publications44

  1. pmc Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines
    Tewarit Sarachana
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, 2300 Eye St NW, Washington, DC 20037, USA
    Genome Med 2:23. 2010
    ..CONCLUSIONS : Findings from this study strongly suggest that dysregulation of miRNA expression contributes to the observed alterations in gene expression and, in turn, may lead to the pathophysiological conditions underlying autism...
  2. pmc Translational research in bipolar disorder: emerging insights from genetically based models
    G Chen
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 15:883-95. 2010
    ....
  3. ncbi request reprint The extracellular signal-regulated kinase pathway: an emerging promising target for mood stabilizers
    Guang Chen
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland 20892 3711, USA
    Curr Opin Psychiatry 19:313-23. 2006
    ....
  4. ncbi request reprint Lithium treatment attenuates muscarinic M(1) receptor dysfunction
    Thomas K Creson
    Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Bipolar Disord 13:238-49. 2011
    ..We hypothesized that miRNAs regulate M(1) receptor translation, and that disrupted M(1) expression leads to aberrant behaviors and disrupted downstream signaling pathways that are rescued by lithium treatment...
  5. pmc Genome-wide gene expression profiling in GluR1 knockout mice: key role of the calcium signaling pathway in glutamatergically mediated hippocampal transmission
    Rulun Zhou
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Neurosci 30:2318-26. 2009
    ..These findings raise the possibility that calcium signaling and other plasticity molecules may contribute to the hippocampal plasticity and behavioral deficits observed in GluR1 KO mice...
  6. pmc Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers
    Rulun Zhou
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 34:1395-405. 2009
    ..These findings are the first to demonstrate that miRNAs and their predicted effectors are targets for the action of psychotherapeutic drugs...
  7. pmc Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia
    Peixiong Yuan
    Biomarker Laboratory, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    J Affect Disord 124:164-9. 2010
    ..The extent of the possible involvement of this pathway in psychiatric disorders remains unknown, as does its potential utility as a pharmacological target for the future development of novel therapeutics...
  8. pmc The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior
    Jing Du
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20878, USA
    J Neurosci 28:68-79. 2008
    ..These studies provide novel insights into the role of hippocampal GluR1/2 receptors in mediating facets of the manic syndrome and offer avenues for the development of novel therapeutics for these disorders...
  9. pmc Valproate activates the Notch3/c-FLIP signaling cascade: a strategy to attenuate white matter hyperintensities in bipolar disorder in late life?
    Peixiong Yuan
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Bipolar Disord 11:256-69. 2009
    ....
  10. doi request reprint The anterior cingulate ERK pathway contributes to regulation of behavioral excitement and hedonic activity
    Thomas K Creson
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 3711, USA
    Bipolar Disord 11:339-50. 2009
    ..Here we investigated the extent to which perturbation of one of the affected pathways, the ERK pathway, in the ACC influences affective-related behavior...
  11. pmc Acute D-serine treatment produces antidepressant-like effects in rodents
    Oz Malkesman
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Int J Neuropsychopharmacol 15:1135-48. 2012
    ..It is unclear whether D-serine has a convergent influence on downstream synaptic plasticity cascades that may yield a similar therapeutic profile to NMDA antagonists like ketamine...
  12. pmc Evidence for involvement of ERK, PI3K, and RSK in induction of Bcl-2 by valproate
    Thomas K Creson
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, 35 Convent Drive, Bldg 35, Rm 1C 912, Bethesda, MD, 20892 3711, USA
    J Mol Neurosci 37:123-34. 2009
    ....
  13. pmc Involvement of AMPA receptors in the antidepressant-like effects of lithium in the mouse tail suspension test and forced swim test
    Todd D Gould
    Laboratory of Molecular Pathophysiology and Experimental Therapeutics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Neuropharmacology 54:577-87. 2008
    ..Lithium may exert its antidepressant effects in humans through AMPA receptors, thus further supporting a role of targeting AMPA receptors as a therapeutic approach for the treatment of depression...
  14. pmc The female urine sniffing test: a novel approach for assessing reward-seeking behavior in rodents
    Oz Malkesman
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 67:864-71. 2010
    ..We describe a novel approach for monitoring reward-seeking behavior in rodents: sniffing of estrus female urine by male mice, along with number of ultrasonic vocalizations (USVs) emitted during the test...
  15. pmc The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor-mediated endoplasmic reticulum calcium release in subjects with bipolar disorder
    Rodrigo Machado-Vieira
    Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 69:344-52. 2011
    ..Here, we examined the effects of the Bcl-2 gene single nucleotide polymorphism (SNP) rs956572 on intracellular Ca(2+) dynamics in patients with BPD...
  16. pmc BAG1 plays a critical role in regulating recovery from both manic-like and depression-like behavioral impairments
    Sungho Maeng
    Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:8766-71. 2008
    ..These data suggest that BAG1 plays a key role in affective resilience and in regulating recovery from both manic-like and depression-like behavioral impairments...
  17. ncbi request reprint Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis
    Yanlei Hao
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 4405, USA
    J Neurosci 24:6590-9. 2004
    ..This cascade of events provides a potential mechanism whereby mood stabilizers alleviate cerebral morphometric deficits associated with manic-depressive illness...
  18. pmc Generation and behavioral characterization of beta-catenin forebrain-specific conditional knock-out mice
    Todd D Gould
    Laboratory of Molecular Pathophysiology and Experimental Therapeutics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Behav Brain Res 189:117-25. 2008
    ..Alternatively, regulating beta-catenin may modulate drug effects rather than being a model of mood disorder pathophysiology per se...
  19. ncbi request reprint The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers
    Rulun Zhou
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, Maryland 20852, USA
    J Neurosci 25:4493-502. 2005
    ....
  20. pmc Neuronal peroxisome proliferator-activated receptor gamma signaling: regulation by mood-stabilizer valproate
    Martin J Lan
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    J Mol Neurosci 35:225-34. 2008
    ..These biochemical changes may have functional consequences for either valproate's therapeutic mechanism or for its neurological side effects and merit further investigation...
  21. pmc Cellular mechanisms underlying affective resiliency: the role of glucocorticoid receptor- and mitochondrially-mediated plasticity
    Joshua G Hunsberger
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res 1293:76-84. 2009
    ..Further identification of resiliency and susceptibility factors will also be vital. Ultimately, these developments would allow for the treatment of susceptible individuals prior to the development of BPD...
  22. pmc Bax inhibitor 1, a modulator of calcium homeostasis, confers affective resilience
    Joshua G Hunsberger
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Brain Res 1403:19-27. 2011
    ..Together, these data suggest that BI-1, through its actions on calcium homeostasis, may confer affective resiliency in multiple animal models of depression and anhedonia...
  23. pmc The effects of chronic treatment with mood stabilizers on the rat hippocampal post-synaptic density proteome
    Dhaval Nanavati
    Laboratory of Neurotoxicology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1262, USA
    J Neurochem 119:617-29. 2011
    ..Our findings support the hypotheses that BPD is a synaptic disorder and that mood stabilizers modulate the protein signaling complex in the hippocampal post-synaptic density...
  24. pmc Animal models of suicide-trait-related behaviors
    Oz Malkesman
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Pharmacol Sci 30:165-73. 2009
    ..Modeling these relevant traits in animals can help to clarify the impact of SSRIs on these traits, suggesting avenues for reducing suicide risk in this vulnerable population...
  25. ncbi request reprint In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3
    Todd D Gould
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 4405, USA
    Neuropsychopharmacology 29:32-8. 2004
    ..These results strongly suggest that lithium significantly inhibits brain glycogen synthase kinase-3 in vivo at concentrations relevant for the treatment of bipolar disorder...
  26. pmc MicroRNAs in mental health: from biological underpinnings to potential therapies
    Joshua G Hunsberger
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Building 35, 1C912, Bethesda, MD 20892, USA
    Neuromolecular Med 11:173-82. 2009
    ..Clearly, considerable research is required to better determine any therapeutic potential of targeting miRNAs; however, these agents may provide the next generation of effective therapies for psychiatric illnesses...
  27. ncbi request reprint Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors
    Sungho Maeng
    Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Biol Psychiatry 63:349-52. 2008
    ..Understanding the mechanisms underlying the intriguing effects of N-methyl d-aspartate (NMDA) antagonists could lead to novel treatments with a rapid onset of action...
  28. pmc Reverse translational strategies for developing animal models of bipolar disorder
    Oz Malkesman
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Dis Model Mech 2:238-45. 2009
    ..These studies demonstrate that this method is useful, viable and deserves attention in new efforts to generate animal models of BD...
  29. ncbi request reprint Neurotrophic signaling cascades in the pathophysiology and treatment of bipolar disorder
    Galit Shaltiel
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 4405, USA
    Curr Opin Pharmacol 7:22-6. 2007
    ..Further data suggest that agents which directly target neurotrophic signaling cascades may have considerable utility for the treatment of this devastating illness...
  30. ncbi request reprint The role of the extracellular signal-regulated kinase signaling pathway in mood modulation
    Haim Einat
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4405, USA
    J Neurosci 23:7311-6. 2003
    ..These data suggest that the ERK pathway may mediate the antimanic effects of mood stabilizers...
  31. pmc Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans
    Giacomo Salvadore
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:804-7. 2009
    ..We tested the hypothesis that this SNP would modulate gray matter (GM) volume in the limbic-cortical-striatal-pallidal-thalamic circuitry that plays major roles in mood regulation...
  32. ncbi request reprint Neurogenesis and neuroenhancement in the pathophysiology and treatment of bipolar disorder
    Robert J Schloesser
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Research Program National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Int Rev Neurobiol 77:143-78. 2007
  33. pmc The neurotrophic and neuroprotective effects of psychotropic agents
    Joshua Hunsberger
    Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, MD, 20892, USA
    Dialogues Clin Neurosci 11:333-48. 2009
    ....
  34. ncbi request reprint [Possible involvement of protein kinase C in the pathophysiology and treatment of bipolar disorder]
    Haim Einat
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, HHS, Bethesda, USA
    Harefuah 143:420-5, 462. 2004
    ..Therefore, this pathway may be a promising candidate for the development of new, more specific drugs for the disease...
  35. ncbi request reprint Targeting signal transduction pathways in the treatment of mood disorders: recent insights into the relevance of the Wnt pathway
    Todd D Gould
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, HHS, Bethesda, Maryland 20892 3711, USA
    CNS Neurol Disord Drug Targets 6:193-204. 2007
    ..Future directions, aimed at understanding mood disorders and developing more efficacious treatments, are also discussed...
  36. pmc Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents
    Peixiong Yuan
    Biomarker Laboratory, National Institute of Mental Health, Mood and Anxiety Disorders Program, National Institutes of Health, Bethesda, MD 20892, USA
    Pharmacol Biochem Behav 98:349-55. 2011
    ..The results suggest that PDE4 may be a plausible contributor to the sexual pleasure-seeking deficits seen in depressed patients; inhibiting PDE4 may restore these deficits...
  37. pmc Systems biology-defined NF-kappaB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status
    Bin Yan
    Head and Neck Surgery Branch, NIDCD, National Institutes of Health, Bethesda, MD 20892, USA
    Genome Biol 9:R53. 2008
    ..However, how NF-kappaB acts as a key regulatory node to modulate global gene expression, and contributes to the malignant heterogeneity of head and neck cancer, is not well understood...
  38. ncbi request reprint Glutamate-induced over-expression of GAD is down-regulated by acetyl-L-carnitine in rat islet cells
    Yanlei Hao
    Laboratory of Molecular Pathophysiology, NIMH, NIH, Bethesda, Maryland 20892, USA
    Endocr Res 30:107-16. 2004
    ..Meanwhile, it indicates that ALC, an ester of the trimethylated amino acid, can block glutamate-induced over-expression of GAD67, a key beta-cell autoantigen, suggesting a therapeutic potential of ALC in IDDM...
  39. ncbi request reprint Post-mortem interval effects on the phosphorylation of signaling proteins
    Jianling Li
    Laboratory of Molecular Pathophysiology, Wayne State University School of Medicine, Detroit, MI, USA
    Neuropsychopharmacology 28:1017-25. 2003
    ..Thus, it appears that measurements (such as two-dimensional gel electrophoresis and functional assays) that rely on the phosphorylation state of proteins would be extremely sensitive to PMI...
  40. pmc Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha
    Rana K Gupta
    Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 21:756-69. 2007
    ..Together, these results indicate that HNF-4alpha is essential for the physiological expansion of adult beta-cell mass in response to increased metabolic demand...
  41. pmc Clustering of genes into regulons using integrated modeling-COGRIM
    Guang Chen
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genome Biol 8:R4. 2007
    ..In these applications, we demonstrate the ability to predict gene-transcription factor interactions with reduced numbers of false-positive findings and to make predictions beyond what is obtained when single types of data are considered...
  42. ncbi request reprint [Studies on the relationship between the level of cytokine and liver function in patients with clonorchiasis sinensis]
    Lian Shun Cai
    Department of Parasitology, Basic Medical College, Jiamusi University, Jiamusi 154007, China
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 22:54-6. 2004
    ..To explore the relationship between cytokine level and liver function among patients infected with Clonorchis sinensis...
  43. pmc Defining the mammalian CArGome
    Qiang Sun
    Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Genome Res 16:197-207. 2006
    ..We suggest one function of SRF is that of an ancient master regulator of the actin cytoskeleton...
  44. ncbi request reprint Group SCAD regression analysis for microarray time course gene expression data
    LiFeng Wang
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Bioinformatics 23:1486-94. 2007
    ....