D T Chen

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Enrolling decisionally impaired adults in clinical research
    Donna T Chen
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    Med Care 40:V20-9. 2002
  2. ncbi request reprint Ethical aspects of research into the etiology of autism
    Donna T Chen
    Office of Clinical Director, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Ment Retard Dev Disabil Res Rev 9:48-53. 2003
  3. pmc Ethical and methodological issues in pedigree stroke research
    B B Worrall
    Departments of Neurology and Health Evaluation Sciences, University of Virginia, Charlottesville, USA
    Stroke 32:1242-9. 2001
  4. ncbi request reprint Clinical research and the physician-patient relationship
    Donna T Chen
    Department of Clinical Bioethics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    Ann Intern Med 138:669-72. 2003
  5. pmc The impact of privacy protections on recruitment in a multicenter stroke genetics study
    D T Chen
    Department of Health Evaluation Sciences, University of Virginia, Charlottesville, USA
    Neurology 64:721-4. 2005
  6. ncbi request reprint Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder
    D T Chen
    Human Genetics Branch, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Mol Psychiatry 18:195-205. 2013
  7. pmc Stroke genetic research and adults with impaired decision-making capacity: a survey of IRB and investigator practices
    Donna T Chen
    Department of Neurology, Center for Biomedical Ethics and Humanities, University of Virginia, Charlottesville, VA 22908, USA
    Stroke 39:2732-5. 2008
  8. ncbi request reprint Practice-based clinical research and ethical decision making--Part II: deciding whether to host a particular research study in your practice
    Donna T Chen
    Department of Public Health Sciences, University of Virginia, Charlottesville, 22908, USA
    Semin Neurol 26:140-7. 2006
  9. ncbi request reprint Research with stored biological samples: what do research participants want?
    Donna T Chen
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, and National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Intern Med 165:652-5. 2005
  10. ncbi request reprint National recommendations for enhancing the conduct of ethical health research with human participants in post-disaster situations
    Bowen Chung
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Ethn Dis 18:378-83. 2008

Detail Information

Publications16

  1. ncbi request reprint Enrolling decisionally impaired adults in clinical research
    Donna T Chen
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    Med Care 40:V20-9. 2002
    ....
  2. ncbi request reprint Ethical aspects of research into the etiology of autism
    Donna T Chen
    Office of Clinical Director, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Ment Retard Dev Disabil Res Rev 9:48-53. 2003
    ....
  3. pmc Ethical and methodological issues in pedigree stroke research
    B B Worrall
    Departments of Neurology and Health Evaluation Sciences, University of Virginia, Charlottesville, USA
    Stroke 32:1242-9. 2001
    ..Building consensus on acceptable research practices in this field is vital to the success of multicentered collaborations...
  4. ncbi request reprint Clinical research and the physician-patient relationship
    Donna T Chen
    Department of Clinical Bioethics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    Ann Intern Med 138:669-72. 2003
    ..In addition, we suggest how preparation for advising patients about clinical research participation can be incorporated into the medical education process...
  5. pmc The impact of privacy protections on recruitment in a multicenter stroke genetics study
    D T Chen
    Department of Health Evaluation Sciences, University of Virginia, Charlottesville, USA
    Neurology 64:721-4. 2005
    ..The sibling response rate was 30.6%, for a pedigree response rate of 58%. Of the siblings who replied, 96% authorized further contact. Median time from proband enrollment to pedigree DNA banking, which required 3+ probands, was 134 days...
  6. ncbi request reprint Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder
    D T Chen
    Human Genetics Branch, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Mol Psychiatry 18:195-205. 2013
    ..Further studies are needed to replicate these findings and may potentially lead to identification of functional variants. Sample size will remain a limiting factor in the discovery of common alleles associated with BD...
  7. pmc Stroke genetic research and adults with impaired decision-making capacity: a survey of IRB and investigator practices
    Donna T Chen
    Department of Neurology, Center for Biomedical Ethics and Humanities, University of Virginia, Charlottesville, VA 22908, USA
    Stroke 39:2732-5. 2008
    ..This study was conducted to obtain data on how investigators and IRBs handle surrogate authorization to enroll probands into a genetic study where some may lack capacity because of ischemic stroke...
  8. ncbi request reprint Practice-based clinical research and ethical decision making--Part II: deciding whether to host a particular research study in your practice
    Donna T Chen
    Department of Public Health Sciences, University of Virginia, Charlottesville, 22908, USA
    Semin Neurol 26:140-7. 2006
    ....
  9. ncbi request reprint Research with stored biological samples: what do research participants want?
    Donna T Chen
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, and National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Intern Med 165:652-5. 2005
    ..Many believe consent for each future use is required to respect individuals. Others worry this approach may block important research...
  10. ncbi request reprint National recommendations for enhancing the conduct of ethical health research with human participants in post-disaster situations
    Bowen Chung
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Ethn Dis 18:378-83. 2008
    ....
  11. ncbi request reprint Tools for tomorrow's health care system: a systems-informed mental model, moral imagination, and physicians' professionalism
    Donna T Chen
    Center for Biomedical Ethics and Humanities, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia 22908, USA
    Acad Med 83:723-32. 2008
    ....
  12. pmc Impact of restricting enrollment in stroke genetics research to adults able to provide informed consent
    Donna T Chen
    Department of Public Health Sciences, University of Virginia Center for Biomedical Ethics, University of Virginia, Charlottesville, VA, USA
    Stroke 39:831-7. 2008
    ..The purpose of this study was to assess differences in stroke cohort characteristics between those who provided informed consent and those whose enrollment was authorized by surrogate decision makers...
  13. ncbi request reprint Practice-based clinical research and ethical decision making--Part I: deciding whether to incorporate practice-based research into your clinical practice
    Donna T Chen
    Department of Public Health Sciences, University of Virginia, Charlottesville, 22908, USA
    Semin Neurol 26:131-9. 2006
    ..In this and the following article, we offer two practical frameworks to aid physicians contemplating adding clinical research to their everyday practice of medicine...
  14. ncbi request reprint Curricular approaches to research ethics training for psychiatric investigators
    Donna T Chen
    Department of Clinical Bioethics, National Institute of Mental Health, Warren G Magnuson Clinical Center, National Institutes of Health, MD 20892 1156, Bethesda, MD 20892, USA
    Psychopharmacology (Berl) 171:112-9. 2003
    ..Investigators in training who are physicians have the additional challenge of developing identities as investigators that sometimes conflict with their identities as physicians...
  15. pmc A survey of the SWISS researchers on the impact of sibling privacy protections on pedigree recruitment
    Bradford B Worrall
    Department of Neurology, University of Virginia, Charlottesville, VA, USA
    Neuroepidemiology 25:32-41. 2005
    ..A substantial minority of researchers (37%) said the strategy impeded enrollment, and 44% said it was overly burdensome to probands...
  16. ncbi request reprint Should thrombolysis be given to a stroke patient refusing therapy due to profound anosognosia?
    Bradford B Worrall
    Neurology 65:500; author reply 500. 2005