Research Topics
Genomes and Genes | Chris CheadleSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
PubMatrix: a tool for multiplex literature miningKevin G Becker
Gene Expression and Genomics Unit, National Institutes of Health, Baltimore, MD, USA
BMC Bioinformatics 4:61. 2003..PubMatrix is a web-based tool that allows simple text based mining of the NCBI literature search service PubMed using any two lists of keywords terms, resulting in a frequency matrix of term co-occurrence...
Application of z-score transformation to Affymetrix dataChris Cheadle
Cellular Biochemistry Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Appl Bioinformatics 2:209-17. 2003..Z-score transformation provides a useful tool for comparisons between experiments and between laboratories that use the Affymetrix platform...- Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stabilityChris Cheadle
Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
BMC Genomics 6:75. 2005..One reason for this difficulty may result from the intricate convergence of both transcriptional and mRNA turnover events which, together, directly influence steady-state mRNA levels... - Stability regulation of mRNA and the control of gene expressionChris Cheadle
Cellular Biochemistry Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Ann N Y Acad Sci 1058:196-204. 2005..It is proposed that the regulation of mRNA stability in response to external stimuli contributes significantly to observed changes in gene expression as measured by high throughput systems... - A genomic-scale view of the cAMP response element-enhancer decoy: a tumor target-based genetic toolYee Sook Cho
Cellular Biochemistry Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:15626-31. 2002..The CRE-decoy ODN, therefore, may serve as a target-based genetic tool to treat cancer and other diseases in which CRE-directed transcription is abnormally used... - Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutationsMadson Q Almeida
Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1 3330, 10 Center Drive, MSC1103, Bethesda, Maryland 20892, USA
J Clin Endocrinol Metab 97:E687-93. 2012.... - Protein kinase A isozyme switching: eliciting differential cAMP signaling and tumor reversionCatherine L Neary
Cellular Biochemistry Section, Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1750, USA
Oncogene 23:8847-56. 2004..Differential expression of PKA R subunits may therefore serve as a tumor-target-based gene therapy for PC3M prostate and other cancers... - Integrated genomic analysis of nodular tissue in macronodular adrenocortical hyperplasia: progression of tumorigenesis in a disorder associated with multiple benign lesionsMadson Q Almeida
Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Endocrinol Metab 96:E728-38. 2011..Massive macronodular adrenocortical disease or ACTH-independent macronodular adrenal hyperplasia (AIMAH) is a clinically and genetically heterogeneous disorder... - Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitorsMadson Q Almeida
PDEGEN, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Hum Mol Genet 20:165-75. 2011.... - Differentially expressed genes in MHC-compatible rat strains that are susceptible or resistant to experimental autoimmune uveitisMary J Mattapallil
Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
Invest Ophthalmol Vis Sci 49:1957-70. 2008..The primary objective of this study was to identify the non-MHC genes involved in the pathogenesis of EAU, to identify potential drug targets and possibly to target their protein products for immunotherapy... - Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signalingMadson Q Almeida
Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice KennedyShriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Hum Mol Genet 19:1387-98. 2010.... - Dissecting the circuitry of protein kinase A and cAMP signaling in cancer genesis: antisense, microarray, gene overexpression, and transcription factor decoyYoon S Cho-Chung
Cellular Biochemistry Section, BRL, CCR, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1750, USA
Ann N Y Acad Sci 968:22-36. 2002..Thus, a complex circuitry of cAMP signaling comprises cAMP growth regulatory function, and deregulation of the effector molecule by this circuitry may underlie cancer genesis and tumor progression... - Analysis of microarray data using Z score transformationChris Cheadle
DNA Array Unit, Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21221, USA
J Mol Diagn 5:73-81. 2003..The results provided by these methods can be as rigorous and are no more arbitrary than other test methods, and, in addition, they have the advantage that they can be easily adapted to standard spreadsheet programs... - Role of the RNA-binding protein tristetraprolin in glucocorticoid-mediated gene regulationFaoud T Ishmael
Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, MD 21224, USA
J Immunol 180:8342-53. 2008..These results reveal a strong and previously unrecognized contribution of PTR to the anti-inflammatory action of GCs and point at TTP as a key factor mediating this process through a complex mechanism of action... - The local and systemic inflammatory transcriptome after acute kidney injuryDmitry N Grigoryev
Division of Allergy and Clinical Immunology, 5501 Hopkins Bayview Circle, JHAAC 3A 62, Baltimore, Maryland, 21224, USA
J Am Soc Nephrol 19:547-58. 2008..Functional genomic analysis identified potential mediators that connect local and systemic inflammation, suggesting that this type of analysis may be a useful discovery tool for novel biomarkers and therapeutic drug development... - Ischemic acute kidney injury induces a distant organ functional and genomic response distinguishable from bilateral nephrectomyHeitham T Hassoun
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Am J Physiol Renal Physiol 293:F30-40. 2007..Further investigation using this lung molecular signature induced by kidney IRI will provide mechanistic insights and new therapies for critically ill patients with AKI... - A rapid method for microarray cross platform comparisons using gene expression signaturesChris Cheadle
Genomics Core, Division of Allergy and Clinical Immunology, School of Medicine, Johns Hopkins University, Mason Lord Bldg, Center Tower, Rm 664, 5200 Eastern Avenue, Baltimore, MD 21224, USA
Mol Cell Probes 21:35-46. 2007.... - von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arraysStefanie Galban
Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
Mol Cell Biol 23:2316-28. 2003..Our findings uncover a novel function for the pVHL tumor suppressor protein as regulator of protein translation... - Development of a highly specialized cDNA array for the study and diagnosis of epithelial ovarian cancerG Peter Sawiris
Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging/NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Cancer Res 62:2923-8. 2002.... - AF5, a CNS cell line immortalized with an N-terminal fragment of SV40 large T: growth, differentiation, genetic stability, and gene expressionM E Truckenmiller
Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
Exp Neurol 175:318-37. 2002..These data suggest that the AF5 cell line may be useful as an in vitro model system for studies of neural differentiation... - DSCR1(Adapt78) modulates expression of SOD1Gennady Ermak
Ethel Percy Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA
FASEB J 18:62-9. 2004..These data also have importance for our understanding of Down's syndrome, Alzheimer's disease, and other human pathologies...