Ye Che

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Development of small molecules designed to modulate protein-protein interactions
    Ye Che
    Laboratory of Computational Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Comput Aided Mol Des 20:109-30. 2006
  2. ncbi request reprint Engineering metal complexes of chiral pentaazacrowns as privileged reverse-turn scaffolds
    Ye Che
    Laboratory of Computational Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Chem Biol Drug Des 69:99-110. 2007
  3. ncbi request reprint Protein recognition motifs: design of peptidomimetics of helix surfaces
    Ye Che
    Laboratory of Computational Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biopolymers 86:288-97. 2007
  4. ncbi request reprint Impact of cis-proline analogs on peptide conformation
    Ye Che
    Center for Computational Biology and Department of Biochemistry and Molecular Biophysics, Washington University, St Louis, MO 63110, USA
    Biopolymers 81:392-406. 2006
  5. ncbi request reprint Engineering cyclic tetrapeptides containing chimeric amino acids as preferred reverse-turn scaffolds
    Ye Che
    Center for Computational Biology and Department of Biochemistry and Molecular Biophysics, Washington University, St Louis, Missouri 63110, USA
    J Med Chem 49:111-24. 2006
  6. ncbi request reprint Privileged scaffolds targeting reverse-turn and helix recognition
    Ye Che
    Washington University, Center for Computational Biology and Department of Biochemistry and Molecular Biophysics, St Louis, MO 63110, USA
    Expert Opin Ther Targets 12:101-14. 2008
  7. ncbi request reprint Impact of azaproline on Peptide conformation
    Ye Che
    Center for Computational Biology and Department of Biochemistry and Molecular Biophysics, Washington University, St Louis, Missouri 63110, USA
    J Org Chem 69:9030-42. 2004

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Development of small molecules designed to modulate protein-protein interactions
    Ye Che
    Laboratory of Computational Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Comput Aided Mol Des 20:109-30. 2006
    ....
  2. ncbi request reprint Engineering metal complexes of chiral pentaazacrowns as privileged reverse-turn scaffolds
    Ye Che
    Laboratory of Computational Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Chem Biol Drug Des 69:99-110. 2007
    ....
  3. ncbi request reprint Protein recognition motifs: design of peptidomimetics of helix surfaces
    Ye Che
    Laboratory of Computational Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biopolymers 86:288-97. 2007
    ..This change in rotamer orientation complicates mimicry of the helix surface...
  4. ncbi request reprint Impact of cis-proline analogs on peptide conformation
    Ye Che
    Center for Computational Biology and Department of Biochemistry and Molecular Biophysics, Washington University, St Louis, MO 63110, USA
    Biopolymers 81:392-406. 2006
    ..Azaproline and its derivatives are most effective in stabilizing cis-amide bonds without introducing additional steric bulk to compromise receptor interactions...
  5. ncbi request reprint Engineering cyclic tetrapeptides containing chimeric amino acids as preferred reverse-turn scaffolds
    Ye Che
    Center for Computational Biology and Department of Biochemistry and Molecular Biophysics, Washington University, St Louis, Missouri 63110, USA
    J Med Chem 49:111-24. 2006
    ..5 A. Structural diversity of CTP scaffolds could be enhanced by the incorporation of proline analogues, such as azaproline (azPro) or pipecolic (Pip), azapipecolic (azPip), nipecotic (Nip), and isonipecotic (Inp) acids...
  6. ncbi request reprint Privileged scaffolds targeting reverse-turn and helix recognition
    Ye Che
    Washington University, Center for Computational Biology and Department of Biochemistry and Molecular Biophysics, St Louis, MO 63110, USA
    Expert Opin Ther Targets 12:101-14. 2008
    ..Protein-protein interactions dominate molecular recognition in biologic systems. One major challenge for drug discovery arises from the very large surfaces that are characteristic of many protein-protein interactions...
  7. ncbi request reprint Impact of azaproline on Peptide conformation
    Ye Che
    Center for Computational Biology and Department of Biochemistry and Molecular Biophysics, Washington University, St Louis, Missouri 63110, USA
    J Org Chem 69:9030-42. 2004
    ..Such modifications can scan receptors for biological recognition of reverse turns containing cis-amide bonds by the incorporation of type VI beta-turn scaffolds with oriented appended side chains...