Nilanjan Chatterjee

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Bethesda, Maryland, 20892 7238, USA
    BMC Cancer 4:9. 2004
  2. ncbi Adjustment for competing risk in kin-cohort estimation
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Genet Epidemiol 25:303-13. 2003
  3. ncbi Case-control and case-only designs with genotype and family history data: estimating relative risk, residual familial aggregation, and cumulative risk
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6210 Executive Boulevard, Rockville, Maryland 20852, USA
    Biometrics 62:36-48. 2006
  4. ncbi Risk of non-Hodgkin's lymphoma and family history of lymphatic, hematologic, and other cancers
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 13:1415-21. 2004
  5. ncbi Exploiting gene-environment independence in family-based case-control studies: increased power for detecting associations, interactions and joint effects
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland 20852, USA
    Genet Epidemiol 28:138-56. 2005
  6. ncbi Invited commentary: efficient testing of gene-environment interaction
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Am J Epidemiol 169:231-3; discussion 234-5. 2009
  7. ncbi Validation studies: bias, efficiency, and exposure assessment
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Epidemiology 13:503-6. 2002
  8. ncbi Powerful multilocus tests of genetic association in the presence of gene-gene and gene-environment interactions
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Am J Hum Genet 79:1002-16. 2006
  9. ncbi A semiparametric pseudo-score method for analysis of two-phase studies with continuous phase-I covariates
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
    Lifetime Data Anal 13:607-22. 2007
  10. ncbi A bivariate cure-mixture approach for modeling familial association in diseases
    N Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Biometrics 57:779-86. 2001

Detail Information

Publications120 found, 100 shown here

  1. ncbi Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Bethesda, Maryland, 20892 7238, USA
    BMC Cancer 4:9. 2004
    ..Thus, 19 single nucleotide polymorphisms (SNPs) in eight genes involved in base excision repair (XRCC1, APEX, POLD1), BRCA1 protein interaction (BRIP1, ZNF350, BRCA2), and growth regulation (TGFss1, IGFBP3) were evaluated...
  2. ncbi Adjustment for competing risk in kin-cohort estimation
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Genet Epidemiol 25:303-13. 2003
    ..We also evaluate the performance of the proposed estimation method, based on simulated data that were generated following the setup of the Washington Ashkenazi Study...
  3. ncbi Case-control and case-only designs with genotype and family history data: estimating relative risk, residual familial aggregation, and cumulative risk
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6210 Executive Boulevard, Rockville, Maryland 20852, USA
    Biometrics 62:36-48. 2006
    ..We illustrate the proposed methodologies by estimating the risk of breast cancer from BRCA1/2 mutations using data from the Washington Ashkenazi Study...
  4. ncbi Risk of non-Hodgkin's lymphoma and family history of lymphatic, hematologic, and other cancers
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 13:1415-21. 2004
    ..An elevated risk of developing non-Hodgkin's lymphoma (NHL) has been associated with a family history of NHL and several other malignancies, but the magnitude of risks and mechanisms are uncertain...
  5. ncbi Exploiting gene-environment independence in family-based case-control studies: increased power for detecting associations, interactions and joint effects
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland 20852, USA
    Genet Epidemiol 28:138-56. 2005
    ..These comparisons reveal important design implications. Extensions of the methodologies for dealing with complex family studies are also discussed...
  6. ncbi Invited commentary: efficient testing of gene-environment interaction
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Am J Epidemiol 169:231-3; discussion 234-5. 2009
    ..The development of new approaches to testing for interaction is an example of methodological progress leading to practical advantages...
  7. ncbi Validation studies: bias, efficiency, and exposure assessment
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Epidemiology 13:503-6. 2002
  8. ncbi Powerful multilocus tests of genetic association in the presence of gene-gene and gene-environment interactions
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Am J Hum Genet 79:1002-16. 2006
    ....
  9. ncbi A semiparametric pseudo-score method for analysis of two-phase studies with continuous phase-I covariates
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
    Lifetime Data Anal 13:607-22. 2007
    ..Advantage of the proposed smoothing approach over alternative methods that use discretized phase-I covariate information is illustrated using two-phase data simulated within the National Wilms Tumor Study (NWTS)...
  10. ncbi A bivariate cure-mixture approach for modeling familial association in diseases
    N Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Biometrics 57:779-86. 2001
    ..We apply the methodology to breast cancer using the kinship data from the Washington Ashkenazi Study. We also discuss potential applications of the proposed method in the area of cure modeling...
  11. ncbi Association and aggregation analysis using kin-cohort designs with applications to genotype and family history data from the Washington Ashkenazi Study
    N Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Genet Epidemiol 21:123-38. 2001
    ..We find that positive history of a single first-degree relative significantly increases risk of the non-carriers (RR = 2.0, 95% CI = 1.6-2.6) but has little or no effect on the carriers...
  12. ncbi A marginal likelihood approach for estimating penetrance from kin-cohort designs
    N Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
    Biometrics 57:245-52. 2001
    ..We study the trade-off between robustness and efficiency using simulation experiments. The method is illustrated by analysis of the data from the Washington Ashkenazi Study...
  13. ncbi Apportioning causes, targeting populations and predicting risks: population attributable fractions
    Nilanjan Chatterjee
    Biostatistics Branch, Epidemiology and Biostatistics Program, National Cancer Institute, NIH, DHHS, USA
    Eur J Epidemiol 18:933-5. 2003
  14. ncbi Genetic variation in the nucleotide excision repair pathway and bladder cancer risk
    Montserrat Garcia-Closas
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Room 7076, 6120 Executive Boulevard, MSC 7234, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 15:536-42. 2006
    ..A detailed characterization of genetic variation in key NER genes is warranted and might ultimately help identify multiple susceptibility variants that could be responsible for substantial joint increases in risk...
  15. ncbi A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma
    Maria Teresa Landi
    Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Hum Genet 85:679-91. 2009
    ..In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma...
  16. ncbi C-reactive protein and risk of lung cancer
    Anil K Chaturvedi
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Rockville, MD 20852, USA
    J Clin Oncol 28:2719-26. 2010
    ..We investigated the association of circulating high-sensitivity C-reactive protein (CRP, an inflammation biomarker) and CRP single nucleotide polymorphisms (SNPs) with prospective lung cancer risk...
  17. ncbi Cigarette smoking, N-acetyltransferase genes and the risk of advanced colorectal adenoma
    Roxana Moslehi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd, EPS 8047, Rockville, MD 20852 USA
    Pharmacogenomics 7:819-29. 2006
    ..Our interest is in the polymorphisms within the NAT1 and NAT2 genes that influence the tobacco-colorectal tumor relationship by impacting on the metabolic activation and detoxification of tobacco smoke-derived carcinogens...
  18. ncbi Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:306-11. 2006
    ....
  19. ncbi Transforming growth factor beta 1 (TGFB1) gene polymorphisms and risk of advanced colorectal adenoma
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 28:1965-70. 2007
    ..No associations were observed for polymorphisms at codons 25 and 263. In conclusion, variants that enhance TGFB1 production may be associated with an increased risk of advanced colorectal adenoma...
  20. ncbi A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis...
  21. ncbi Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 18:1259-70. 2009
    ..Replication of our findings and further study to identify functional SNPs are warranted...
  22. ncbi Genetic variation in catechol-O-methyltransferase (COMT) and obesity in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 5104, MSC 7234, Rockville, MD 20852, USA
    Hum Genet 122:41-9. 2007
    ..Our results support a need for comprehensive evaluation of COMT variations and their functional relevance as COMT may be an important molecular target to evaluate for new treatments regarding obesity...
  23. ncbi Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression
    Melissa Rotunno
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e5652. 2009
    ..Our findings emphasize the necessity of post-GWAS fine mapping and SNP functional assessment to further elucidate cancer risk associations...
  24. ncbi Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Br J Haematol 151:239-44. 2010
    ..These results support the hypothesis that common genetic polymorphisms in human DNA repair genes may modify the risk of NHL...
  25. ncbi Genetic variation in innate immunity and inflammation pathways associated with lung cancer risk
    Meredith S Shiels
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
    Cancer 118:5630-6. 2012
    ....
  26. ncbi Association of genetic variants in the calcium-sensing receptor with risk of colorectal adenoma
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
    Cancer Epidemiol Biomarkers Prev 13:2181-6. 2004
    ..We assessed the associations between CASR gene variants and risk for colorectal adenoma, a cancer precursor. We further investigated gene-diet interactions between the CASR variants and calcium intake on adenoma risk...
  27. ncbi Pathway analysis by adaptive combination of P-values
    Kai Yu
    Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland 20892, USA
    Genet Epidemiol 33:700-9. 2009
    ..We also illustrate the advantage of the proposed methods using a study of the association between the nicotinic receptor pathway and cigarette smoking behaviors...
  28. ncbi Using cases to strengthen inference on the association between single nucleotide polymorphisms and a secondary phenotype in genome-wide association studies
    Huilin Li
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, Bethesda, Maryland, USA
    Genet Epidemiol 34:427-33. 2010
    ....
  29. ncbi Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma
    Joanne S Colt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
    Blood 113:1899-905. 2009
    ..This shows that the relation between organochlorine exposure and NHL risk may be modified by particular variants in immune genes and provides one of the first examples of a potential gene-environment interaction for NHL...
  30. ncbi Potential excess mortality in BRCA1/2 mutation carriers beyond breast, ovarian, prostate, and pancreatic cancers, and melanoma
    Phuong L Mai
    Clinical Genetic Branch, National Cancer Institute, Rockville, Maryland, United States of America
    PLoS ONE 4:e4812. 2009
    ..Further, possible effect of BRCA mutations on non-cancer mortality risk has not been examined...
  31. ncbi Estimation of effect size distribution from genome-wide association studies and implications for future discoveries
    Ju Hyun Park
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland, USA
    Nat Genet 42:570-5. 2010
    ..However, for BPC cancers, which have modest familial aggregation, our analysis suggests that risk models based on common variants alone will have modest discriminatory power (63.5% area under curve), even with new discoveries...
  32. ncbi Likelihood ratio test for detecting gene (G)-environment (E) interactions under an additive risk model exploiting G-E independence for case-control data
    Summer S Han
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
    Am J Epidemiol 176:1060-7. 2012
    ..5-fold. The authors illustrate their method by applying it to data from a bladder cancer study...
  33. ncbi SLC6A3 and body mass index in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
    Elizabeth M Azzato
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland, USA
    BMC Med Genet 10:9. 2009
    ....
  34. ncbi Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility
    Hong Lou
    Laboratory of Experimental Immunology, Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 106:7933-8. 2009
    ..Further investigation is warranted to determine whether rs10993994 alone or in combination with additional variants contributes to prostate cancer susceptibility...
  35. ncbi Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS Genet 3:e29. 2007
    ..In conclusion, this large-scale evaluation of candidate cancer genes has identified common genetic variants in the regulatory regions of VEGF that could be associated with bladder cancer risk...
  36. ncbi Etiologic heterogeneity among non-Hodgkin lymphoma subtypes
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Rockville, MD, USA
    Blood 112:5150-60. 2008
    ....
  37. ncbi Common gene variants in the tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma risk
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America
    PLoS ONE 4:e5360. 2009
    ..We hypothesized that the TNF and NF-kappaB pathways are important for NHL and that gene variations across the pathways may alter NHL risk...
  38. ncbi Serum vitamin D concentration and prostate cancer risk: a nested case-control study
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Bethesda, MD 20892, USA
    J Natl Cancer Inst 100:796-804. 2008
    ....
  39. ncbi Nitric oxide synthase gene polymorphisms and prostate cancer risk
    Kyoung Mu Lee
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 30:621-5. 2009
    ..61, 1.18-2.19; P(interaction) = 0.01). Our results suggest that NOS gene polymorphisms are genetic susceptibility factors for aggressive prostate cancer...
  40. ncbi A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 41:579-84. 2009
    ..1 (rs999737; P = 1.74 x 10(-7)) localizes to RAD51L1, a gene in the homologous recombination DNA repair pathway. We also confirmed associations with loci on chromosomes 2q35, 5p12, 5q11.2, 8q24, 10q26 and 16q12.1...
  41. ncbi Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Carcinogenesis 30:769-76. 2009
    ..Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status...
  42. ncbi Common genetic variants and central adiposity among Asian-Indians
    Steven C Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
    Obesity (Silver Spring) 20:1902-8. 2012
    ....
  43. ncbi Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk
    Yi Ping Fu
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:4974-9. 2012
    ....
  44. ncbi Multi-center feasibility study evaluating recruitment, variability in risk factors and biomarkers for a diet and cancer cohort in India
    Rashmi Sinha
    National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    BMC Public Health 11:405. 2011
    ..The aim of this feasibility study was to evaluate whether a diet-focused cohort study of cancer could be established in India, providing insight into potentially unique diet and lifestyle exposures...
  45. ncbi Risk of subsequent endometrial carcinoma associated with endometrial intraepithelial neoplasia classification of endometrial biopsies
    James V Lacey
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852 7234, USA
    Cancer 113:2073-81. 2008
    ..The authors estimated progression risk associated with EIN among endometrial biopsies in a nested case-control study of EH progression...
  46. ncbi Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
    Cancer Epidemiol Biomarkers Prev 19:1349-55. 2010
    ..2, showed a promising association with PrCa overall (P=2.14x10(-6)), with a suggestion of stronger association with aggressive disease (P=1.2x10(-7))...
  47. ncbi Endogenous sex hormones and the risk of prostate cancer: a prospective study
    Jocelyn M Weiss
    Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD, USA
    Int J Cancer 122:2345-50. 2008
    ..T:SHBG ratio was related to risk in this older population of men, but the significance of this ratio in steroidal biology is unclear. (c) 2008 Wiley-Liss, Inc...
  48. ncbi A partially linear tree-based regression model for multivariate outcomes
    Kai Yu
    Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland 20892, USA
    Biometrics 66:89-96. 2010
    ..The proposed method is general enough to be used for the assessment of the joint effect of a set of multiple risk factors on a multivariate outcome in other biomedical research settings...
  49. ncbi Identification of a new prostate cancer susceptibility locus on chromosome 8q24
    Meredith Yeager
    Core Genotyping Facility, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland, USA
    Nat Genet 41:1055-7. 2009
    ..3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24...
  50. ncbi The association of telomere length and genetic variation in telomere biology genes
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Hum Mutat 31:1050-8. 2010
    ..The combination of limited diversity and evolutionary conservation suggest that these genes may be under selective pressure. More work is needed to explore the role of genetic variants in telomere length regulation...
  51. ncbi A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
    Carcinogenesis 30:275-81. 2009
    ..No associations with TLR4 variants were observed. This pooled analysis provides strong evidence that variation in the TLR10-TLR1-TLR6 region is associated with NHL risk and suggests that TLR2 variants may influence susceptibility to MZL...
  52. ncbi Large-scale fine mapping of the HNF1B locus and prostate cancer risk
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Hum Mol Genet 20:3322-9. 2011
    ..This study demonstrates a complex relationship between variants in the HNF1B region and prostate cancer risk. Further studies are needed to investigate the biological basis of the association of variants in 17q12 with prostate cancer...
  53. ncbi Variant in sex hormone-binding globulin gene and the risk of prostate cancer
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7240, USA
    Cancer Epidemiol Biomarkers Prev 16:165-8. 2007
    ..34; 95% confidence interval, 1.10-1.63; P = 0.0007). This study suggests that genetic variation in SHBG may influence prostate cancer susceptibility...
  54. ncbi A haplotype-based test of association using data from cohort and nested case-control epidemiologic studies
    Jinbo Chen
    Biostatistics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Hum Hered 58:18-29. 2004
    ..Utilizing simulated data in the context of two genomic regions GPX1 and GPX3, we evaluate the validity of the proposed test for small sample sizes and study its power in the presence and absence of missing genotype data...
  55. ncbi Supplemental and dietary vitamin E, beta-carotene, and vitamin C intakes and prostate cancer risk
    Victoria A Kirsh
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    J Natl Cancer Inst 98:245-54. 2006
    ..However, vitamin E supplementation in male smokers and beta-carotene supplementation in men with low dietary beta-carotene intakes were associated with reduced risk of this disease...
  56. ncbi Common genetic variants in proinflammatory and other immunoregulatory genes and risk for non-Hodgkin lymphoma
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20892 7234, USA
    Cancer Res 66:9771-80. 2006
    ..Our results require replication but potentially provide important clues for investigating common genetic variants as susceptibility factors and in disease outcomes, treatment responses, and immunotherapy targets...
  57. ncbi Assessing disease risk in genome-wide association studies using family history
    Arpita Ghosh
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Epidemiology 23:616-22. 2012
    ....
  58. ncbi A cross-sectional investigation of regional patterns of diet and cardio-metabolic risk in India
    Carrie R Daniel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
    Nutr J 10:12. 2011
    ..The role of diet in India's rapidly progressing chronic disease epidemic is unclear; moreover, diet may vary considerably across North-South regions...
  59. ncbi On a supplemented case-control design
    Ruth M Pfeiffer
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8030, Bethesda, Maryland 20892 7244, USA
    Biometrics 61:584-90. 2005
    ....
  60. ncbi Multiple loci identified in a genome-wide association study of prostate cancer
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nat Genet 40:310-5. 2008
    ..Our findings point to multiple loci with moderate effects associated with susceptibility to prostate cancer that, taken together, in the future may predict high risk in select individuals...
  61. ncbi Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer
    Charles C Chung
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute NIH, 8717 Grovemont Circle, Bethesda, MD 20892, USA
    Hum Mol Genet 20:2869-78. 2011
    ..We estimate that at least 63 common variants should be considered in future studies designed to investigate the biological basis of the multiple association signals...
  62. ncbi Pathway analysis of breast cancer genome-wide association study highlights three pathways and one canonical signaling cascade
    Idan Menashe
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD20852 7244, USA
    Cancer Res 70:4453-9. 2010
    ..0051, FDR = 0.07). These results suggest that genetic alterations associated with these three pathways and one canonical signaling cascade may contribute to breast cancer susceptibility...
  63. ncbi Insulin resistance-related genes and advanced left-sided colorectal adenoma
    Marc J Gunter
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 16:703-8. 2007
    ....
  64. ncbi NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20852 7234, USA
    Lancet 366:649-59. 2005
    ..Associations between polymorphisms in other NAT and GST genes and bladder-cancer risk have been inconsistent...
  65. ncbi CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenoma
    Lifang Hou
    Department of Human and Health Services, Division of Cancer Epidemiology and Genetics, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Carcinogenesis 26:1122-8. 2005
    ..002). In summary, joint carriage of CYP1A1 Val(462) and NQO1 Ser(187) alleles, particularly in smokers, was related to colorectal adenoma risk, with a propensity for formation of multiple lesions...
  66. ncbi A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Pharmacogenet Genomics 21:231-6. 2011
    ..Further studies are required to determine the functional implications of rs1495741 and the structure and evolution of the haplotype on which it resides...
  67. ncbi RNASEL Arg462Gln polymorphism and prostate cancer in PLCO
    Sarah E Daugherty
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Prostate 67:849-54. 2007
    ..The relationship of this variant to sporadic prostate cancer remains uncertain...
  68. ncbi Dairy products, calcium intake, and risk of prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:2623-30. 2007
    ..Furthermore, we found no relationship between calcium intake and circulating vitamin D...
  69. ncbi A prospective study of lycopene and tomato product intake and risk of prostate cancer
    Victoria A Kirsh
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:92-8. 2006
    ..Evidence for protective associations in subjects with a family history of prostate cancer requires further corroboration...
  70. ncbi A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33
    Hemang Parikh
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Gaithersburg, MD 20877, USA
    Hum Genet 127:91-9. 2010
    ....
  71. ncbi Using principal components of genetic variation for robust and powerful detection of gene-gene interactions in case-control and case-only studies
    Samsiddhi Bhattacharjee
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Am J Hum Genet 86:331-42. 2010
    ....
  72. ncbi High serum selenium and reduced risk of advanced colorectal adenoma in a colorectal cancer early detection program
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 15:315-20. 2006
    ..Although substantial evidence suggests that smoking is a strong effect modifier for other antioxidative nutrients, little is known about smoking-selenium interactions in colorectal tumors...
  73. ncbi Fat, fiber, fruits, vegetables, and risk of colorectal adenomas
    Aleyamma Mathew
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Int J Cancer 108:287-92. 2004
    ..Increased intake of dietary fiber was associated with a moderately decreased risk of adenomas...
  74. ncbi The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Aging Cell 8:405-13. 2009
    ..However, correlations of telomere length with healthy lifestyles were noted, suggesting the role of these factors in telomere biology maintenance and potentially impacting overall health status...
  75. ncbi Vitamin D receptor polymorphisms and renal cancer risk in Central and Eastern Europe
    S Karami
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA karamis mail nih gov
    J Toxicol Environ Health A 71:367-72. 2008
    ..60; 95% CI: 0.33-1.1; P trend = 0.05). Genotype associations with these subgroups were not modified when dietary sources of vitamin D or calcium were considered. Additional studies of genetic variation in the VDR gene are warranted...
  76. ncbi Breast cancer risk in Ashkenazi BRCA1/2 mutation carriers: effects of reproductive history
    Patricia Hartge
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7246, USA
    Epidemiology 13:255-61. 2002
    ..Younger age at first birth and greater parity generally reduce the risk of developing breast cancer, but whether this reduced risk holds in women with a mutation in the BRCA1 or BRCA2 gene is unknown...
  77. ncbi IGF-1 and IGFBP-3: Risk of prostate cancer among men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
    Jocelyn M Weiss
    Division of Cancer Epidemiology and Genetics, NCI NIH, Bethesda, MD, USA
    Int J Cancer 121:2267-73. 2007
    ..11-7.08). In summary, our large prospective study showed no overall association between the insulin-like growth factor axis and prostate cancer risk, however, IGFmr was related to risk for aggressive prostate cancer in obese men...
  78. ncbi Genome-wide and candidate gene association study of cigarette smoking behaviors
    Neil Caporaso
    Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland, United States of America
    PLoS ONE 4:e4653. 2009
    ..4x10(-5)), our analysis provides independent replication of the association between the chr15q25.1 region and smoking intensity and data for multiple other loci associated with smoking behavior that merit further follow-up...
  79. ncbi Variation in breast cancer hormone receptor and HER2 levels by etiologic factors: a population-based analysis
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    Int J Cancer 121:1079-85. 2007
    ..07) for low PR and HER2 expression vs. OR = 1.78 (95% CI = 1.25-2.55) for high expression (p-heterogeneity = 0.001). PR and HER2 levels in breast cancer vary by BMI, suggesting a heterogeneous etiology for tumors related to these markers...
  80. ncbi GSTM1, GSTT1, and GSTP1 polymorphisms and risk of advanced colorectal adenoma
    Lee E Moore
    National Cancer Institute, 6120 Executive Boulevard, EPS 7034, Bethesda, MD 20892 7240, USA
    Cancer Epidemiol Biomarkers Prev 14:1823-7. 2005
    ..These findings only became apparent using a newly developed assay able to distinguish heterozygous from wild-type individuals. Our data provide evidence that phenotypic differences between these two groups exist...
  81. ncbi Joint effect of genes and environment distorted by selection biases: implications for hospital-based case-control studies
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892-7244, USA
    Cancer Epidemiol Biomarkers Prev 11:885-9. 2002
    ..This formulation extends to the general problem of distortion of joint effects from selection biases or confounding...
  82. ncbi Predictors of sustained smoking cessation: a prospective analysis of chronic smokers from the alpha-tocopherol Beta-carotene cancer prevention study
    Erik M Augustson
    National Cancer Institute, DCCPS TCRB, EPN 4039B, 6130 Executive Blvd, MSC 7337, Bethesda, MD 20892 7337, USA
    Am J Public Health 98:549-55. 2008
    ..Using a nested case-control design, we explored the association between ability to sustain cessation over an extended period and demographic, smoking, medical, and behavioral variables...
  83. ncbi The HER2 I655V polymorphism and breast cancer risk in Ashkenazim
    Joni L Rutter
    Laboratory of Population Genetics, Center for Cancer Research, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Epidemiology 14:694-700. 2003
    ..CONCLUSION These analyses suggest that the HER2 valine allele might be associated with increased risk of breast cancer, especially in young women and in women with a family history of the disease...
  84. ncbi Efficient p-value evaluation for resampling-based tests
    Kai Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    Biostatistics 12:582-93. 2011
    ..We demonstrate the application of the new method by applying it to a large-scale genetic association study of prostate cancer...
  85. ncbi Dietary fibre and colorectal adenoma in a colorectal cancer early detection programme
    Ulrike Peters
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, DHHS, MD 20892 7273, USA
    Lancet 361:1491-5. 2003
    ..Although dietary fibre has been reported to have no association with colorectal adenoma and cancer, in some studies this topic remains controversial...
  86. ncbi PTEN expression in endometrial biopsies as a marker of progression to endometrial carcinoma
    James V Lacey
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    Cancer Res 68:6014-20. 2008
    ..Loss of PTEN expression in endometrial biopsies was neither associated with nor a sensitive and specific marker of subsequent progression to endometrial carcinoma...
  87. ncbi Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway
    H Dean Hosgood
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 29:1938-43. 2008
    ..These results should be viewed as exploratory until they are replicated in a larger study...
  88. ncbi Estimating age-specific breast cancer risks: a descriptive tool to identify age interactions
    William F Anderson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Executive Plaza South 8070, 6120 Executive Plaza Blvd, Rockville, MD 20892 7242, USA
    Cancer Causes Control 18:439-47. 2007
    ..Clarifying age-specific female breast cancer risks and interactions may provide important etiologic clues...
  89. ncbi Hepatitis C virus infection and non-Hodgkin lymphoma: results of the NCI-SEER multi-center case-control study
    Eric A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
    Int J Cancer 111:76-80. 2004
    ..Our study demonstrates an association between HCV infection and NHL in the United States. HCV infection may be a cause of NHL...
  90. ncbi Chlamydia pneumoniae infection and risk for lung cancer
    Anil K Chaturvedi
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 19:1498-505. 2010
    ....
  91. ncbi Hepatitis C virus load and survival among injection drug users in the United States
    Michie Hisada
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Hepatology 42:1446-52. 2005
    ..98, 95% CI: 0.48-2.88). Non-black patients were at increased risk for ESLD death (RH(adj)= 2.76, 95% CI: 1.49-10.09). In conclusion, HCV RNA level is a predictor of ESLD death among persons with chronic HCV infection...
  92. ncbi Reproducibility of biopsy diagnoses of endometrial hyperplasia: evidence supporting a simplified classification
    Mark E Sherman
    Cancer Epidemiology and Genetics, The National Cancer Institute, 6120 Executive Blvd, Room 5028, Rockville, MD 20892 7374, USA
    Int J Gynecol Pathol 27:318-25. 2008
    ..Identifying which categories in the World Health Organization classification of endometrial hyperplasia contribute to suboptimal reproducibility is clinically important...
  93. ncbi Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Blood 114:264-7. 2009
    ..It is noteworthy that genetic variants in CASP8 were associated with risk of all major NHL subtypes. Our findings suggest that genetic variation in caspases may play an important role in lymphomagenesis...
  94. ncbi Measurement of spices and seasonings in India: opportunities for cancer epidemiology and prevention
    Leah M Ferrucci
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Asian Pac J Cancer Prev 11:1621-9. 2010
    ....
  95. ncbi Reproductive risk factors for endometrial cancer among Polish women
    L A Brinton
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Suite 550, Rockville, MD 20852 7234, USA
    Br J Cancer 96:1450-6. 2007
    ..Alternative explanations for reproductive effects should be sought, including alterations in endogenous hormones...
  96. ncbi Endometrial carcinoma risk among women diagnosed with endometrial hyperplasia: the 34-year experience in a large health plan
    J V Lacey
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
    Br J Cancer 98:45-53. 2008
    ..9) were substantially lower and only slightly higher than the progression risk for DPEM. The higher progression risks for AH could foster management guidelines based on markedly different progression risks for atypical vs non-atypical EH...
  97. ncbi Human epidermal growth factor receptor-2 and estrogen receptor expression, a demonstration project using the residual tissue repository of the Surveillance, Epidemiology, and End Results (SEER) program
    W F Anderson
    NIH NCI DCEG, EPS Room 8036, 6120 Executive Blvd, Bethesda, MD 20852, USA
    Breast Cancer Res Treat 113:189-96. 2009
    ..To validate the utility of the RTR for supplementing SEER's central database, we assessed human epidermal growth factor receptor-2 (HER2) and estrogen receptor expression (ER) in a demonstration project...
  98. ncbi Tumor variants by hormone receptor expression in white patients with node-negative breast cancer from the surveillance, epidemiology, and end results database
    W F Anderson
    Division of Cancer Prevention, Office of Special Population Research, and Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7161, USA
    J Clin Oncol 19:18-27. 2001
    ..Determining whether hormone receptor expression represents one or more breast cancer phenotypes would have important paradigmatic and practical implications...
  99. ncbi Established breast cancer risk factors by clinically important tumour characteristics
    M Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Rockville, MD 20852 7234, USA
    Br J Cancer 95:123-9. 2006
    ..In conclusion, these data support distinctive risk factor relationships by tumour characteristics of prognostic relevance. These findings might be useful in developing targeted prevention efforts...
  100. ncbi Poliovirus vaccination during pregnancy, maternal seroconversion to simian virus 40, and risk of childhood cancer
    E A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    Am J Epidemiol 160:306-16. 2004
    ..The authors conclude that an increased cancer risk in CPP children whose mothers received pre-1963 poliovirus vaccine was unlikely to have been due to SV40 infection transmitted from mothers to their children...
  101. ncbi Methods for testing familial aggregation of diseases in population-based samples: application to Hodgkin lymphoma in Swedish registry data
    R M Pfeiffer
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd, Bethesda, MD, 20892 7244, USA
    Ann Hum Genet 68:498-508. 2004
    ..We compare these methods in analysis of familial aggregation of HL and also present simulations to compare survival analyses with analyses of binary outcome data...