Dennis S Charney

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi National Depressive and Manic-Depressive Association consensus statement on the use of placebo in clinical trials of mood disorders
    Dennis S Charney
    Division of Intramural Research Programs, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 59:262-70. 2002
  2. ncbi Life stress, genes, and depression: multiple pathways lead to increased risk and new opportunities for intervention
    Dennis S Charney
    Mood and Anxiety Disorders Research Program, National Institute of Mental Health, 15K North Drive, Room 101, MSC 2670, Bethesda, MD 20892 2670, USA
    Sci STKE 2004:re5. 2004
  3. ncbi Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress
    Dennis S Charney
    Mood and Anxiety Disorders Program, NIMH, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 161:195-216. 2004
  4. ncbi Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder
    Erin B McClure
    Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:97-106. 2007
  5. ncbi Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder
    Dara M Cannon
    Molecular Imaging Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 62:870-7. 2007
  6. pmc Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression
    Allison C Nugent
    National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD 20892 1030, USA
    Eur Neuropsychopharmacol 23:822-9. 2013
  7. ncbi Deficits in social cognition and response flexibility in pediatric bipolar disorder
    Erin B McClure
    Mood and Anxiety Disorders Program, NIMH, 15K North Dr, Room 102, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 162:1644-51. 2005
  8. ncbi Increased amygdala activity during successful memory encoding in adolescent major depressive disorder: An FMRI study
    Roxann Roberson-Nay
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland, USA
    Biol Psychiatry 60:966-73. 2006
  9. ncbi Pramipexole for bipolar II depression: a placebo-controlled proof of concept study
    Carlos A Zarate
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institute of Health, Department of Human and Health Services, Bethesda, Maryland, USA
    Biol Psychiatry 56:54-60. 2004
  10. ncbi Attention bias to threat in maltreated children: implications for vulnerability to stress-related psychopathology
    Daniel S Pine
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramurral Research Program, Bethesda, MD 20817 2670, USA
    Am J Psychiatry 162:291-6. 2005

Collaborators

Detail Information

Publications93

  1. ncbi National Depressive and Manic-Depressive Association consensus statement on the use of placebo in clinical trials of mood disorders
    Dennis S Charney
    Division of Intramural Research Programs, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 59:262-70. 2002
    ..Research is needed on the ethical conduct of studies to limit risks of medication-free intervals and facilitate poststudy treatment. Patients must fully understand the risks and lack of individualized treatment involved in research...
  2. ncbi Life stress, genes, and depression: multiple pathways lead to increased risk and new opportunities for intervention
    Dennis S Charney
    Mood and Anxiety Disorders Research Program, National Institute of Mental Health, 15K North Drive, Room 101, MSC 2670, Bethesda, MD 20892 2670, USA
    Sci STKE 2004:re5. 2004
    ....
  3. ncbi Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress
    Dennis S Charney
    Mood and Anxiety Disorders Program, NIMH, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 161:195-216. 2004
    ..Most research on the effects of severe psychological stress has focused on stress-related psychopathology. Here, the author develops psychobiological models of resilience to extreme stress...
  4. ncbi Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder
    Erin B McClure
    Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:97-106. 2007
    ..However, in pediatric anxiety, no research has examined attention modulation of neural response to threat cues...
  5. ncbi Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder
    Dara M Cannon
    Molecular Imaging Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 62:870-7. 2007
    ....
  6. pmc Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression
    Allison C Nugent
    National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD 20892 1030, USA
    Eur Neuropsychopharmacol 23:822-9. 2013
    ..These findings suggest that 5-HT(1A) receptor binding is abnormally reduced in BD, and this abnormality may particularly involve the postsynaptic 5-HT(1A) receptor system of individuals with a tendency toward cortisol hypersecretion...
  7. ncbi Deficits in social cognition and response flexibility in pediatric bipolar disorder
    Erin B McClure
    Mood and Anxiety Disorders Program, NIMH, 15K North Dr, Room 102, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 162:1644-51. 2005
    ..The purpose of this study was to test the hypothesis that youths with bipolar disorder would perform more poorly than matched healthy comparison subjects on measures of social cognition, motor inhibition, and response flexibility...
  8. ncbi Increased amygdala activity during successful memory encoding in adolescent major depressive disorder: An FMRI study
    Roxann Roberson-Nay
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland, USA
    Biol Psychiatry 60:966-73. 2006
    ..This study tests the hypothesis that adolescent MDD is associated with abnormal amygdala activity during evocative-face viewing...
  9. ncbi Pramipexole for bipolar II depression: a placebo-controlled proof of concept study
    Carlos A Zarate
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institute of Health, Department of Human and Health Services, Bethesda, Maryland, USA
    Biol Psychiatry 56:54-60. 2004
    ..The current study was undertaken as a proof of the concept that dopamine agonists will be effective in patients with bipolar II depression...
  10. ncbi Attention bias to threat in maltreated children: implications for vulnerability to stress-related psychopathology
    Daniel S Pine
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramurral Research Program, Bethesda, MD 20817 2670, USA
    Am J Psychiatry 162:291-6. 2005
    ..They tested the hypothesis that attention bias to threatening facial photographs is associated with maltreatment and PTSD...
  11. ncbi A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression
    Carlos A Zarate
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, and Department of Health and Human Services, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:856-64. 2006
    ..Converging lines of evidence suggest the role of the glutamatergic system in the pathophysiology and treatment of mood disorders...
  12. ncbi Mood-congruent bias in affective go/no-go performance of unmedicated patients with major depressive disorder
    Kristine Erickson
    Mood and Anxiety Disorders Program, National Institute of Mental Health, MD 20814 9692, USA
    Am J Psychiatry 162:2171-3. 2005
    ..This study investigated performance of unmedicated depressed patients on the Affective Go/No-Go Task...
  13. ncbi A double-blind, placebo-controlled study of memantine in the treatment of major depression
    Carlos A Zarate
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Human Health Services, Bethesda, MD, USA
    Am J Psychiatry 163:153-5. 2006
    ..This study was designed to assess possible antidepressant effects of memantine, a selective N-methyl-D-aspartate (NMDA) receptor antagonist in humans...
  14. pmc Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletion
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, NIH, Bethesda, MD 20892 0940, USA
    Neuroimage 43:764-74. 2008
    ..The robust nature of the classification results indicates that much of the variance in metabolic response to ATD is accounted for by genotypic and phenotypic category...
  15. pmc Reward circuitry in resilience to severe trauma: an fMRI investigation of resilient special forces soldiers
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD, 20892, USA
    Psychiatry Res 172:75-7. 2009
    ..Findings in this group of resilient individuals revealed unique patterns of activation during expectation of reward in the subgenual prefrontal cortex and nucleus accumbens area, regions pivotal to reward processes...
  16. ncbi A developmental examination of gender differences in brain engagement during evaluation of threat
    Erin B McClure
    Section on Development and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 55:1047-55. 2004
    ..Recent theoretical models suggest that developmental changes in brain functioning play important roles in the emergence of such gender differences...
  17. pmc Habenula volume in bipolar disorder and major depressive disorder: a high-resolution magnetic resonance imaging study
    Jonathan B Savitz
    Mood and Anxiety Disorders Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 69:336-43. 2011
    ..We conducted the first magnetic resonance imaging analysis of habenula volume in MDD and bipolar disorder (BD)...
  18. ncbi Experience-dependent plasticity for attention to threat: Behavioral and neurophysiological evidence in humans
    Christopher S Monk
    National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 56:607-10. 2004
    ..Examination of plasticity of attention bias with individuals at risk for anxiety disorders may reveal how threatening stimuli come to be categorized differently in this population over time...
  19. ncbi Frontotemporal alterations in pediatric bipolar disorder: results of a voxel-based morphometry study
    Daniel P Dickstein
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:734-41. 2005
    ..While numerous magnetic resonance imaging (MRI) studies have evaluated adults with bipolar disorder (BPD), few have examined MRI changes in children with BPD...
  20. ncbi Emotion recognition deficits in pediatric anxiety disorders: implications for amygdala research
    Josh Easter
    Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892 2670, USA
    J Child Adolesc Psychopharmacol 15:563-70. 2005
    ..This study examines the relationship between face-emotion recognition and anxiety in a sample of children and adolescents participating in a brain-imaging study of amygdala structure and function...
  21. ncbi A neuroimaging method for the study of threat in adolescents
    Christopher S Monk
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Dev Psychobiol 43:359-66. 2003
    ..Those who reported increased fear showed right amygdala activation during the threat condition and left amygdala activation in the safe condition. These procedures offer a promising tool for studying youth with anxiety disorders...
  22. ncbi An open-label trial of the glutamate-modulating agent riluzole in combination with lithium for the treatment of bipolar depression
    Carlos A Zarate
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 57:430-2. 2005
    ..This study was conducted to determine the efficacy and safety of riluzole, a glutamate-modulating agent, in bipolar depression...
  23. ncbi No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder
    Omer Bonne
    Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 162:383-5. 2005
    ..In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD)...
  24. ncbi Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls
    Alexander Neumeister
    Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 61:765-73. 2004
    ....
  25. ncbi Evidence for continuing neuropsychological impairments in depression
    Petra Weiland-Fiedler
    Mood and Anxiety Disorders Program, National Institute of Mental Health, North Drive, Building 15K, Room 200, Bethesda, MD 20892 2670, USA
    J Affect Disord 82:253-8. 2004
    ..The purpose of the present study was to describe the neuropsychological functioning of fully remitted, unmedicated patients with a history of MDD by focusing on tasks related to prefrontal cortex functioning...
  26. ncbi Memory and learning in pediatric bipolar disorder
    Erin B McClure
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 44:461-9. 2005
    ..To test the hypothesis that patients with pediatric bipolar disorder (PBPD) would demonstrate impairment relative to diagnosis-free controls of comparable age, gender, and IQ on measures of memory functioning...
  27. ncbi Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects
    Alexander Neumeister
    Section on Experimental Therapeutics and Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 57:935-7. 2005
    ..Hippocampal volumes obtained from a group of medication-free, remitted subjects with recurrent major depressive disorder (MDD) were compared against corresponding measures from healthy controls...
  28. ncbi Effects of tryptophan depletion on serum levels of brain-derived neurotrophic factor in unmedicated patients with remitted depression and healthy subjects
    Alexander Neumeister
    NIMH Mood and Anxiety Disorders Program, Bethesda, MD, USA
    Am J Psychiatry 162:805-7. 2005
    ....
  29. ncbi Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography
    Dara M Cannon
    Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 60:207-17. 2006
    ..This study used PET and [(11)C]DASB, a radioligand that afforded higher sensitivity and specificity for the 5-HTT than previously available radioligands, to compare 5-HTT binding between BD and control subjects...
  30. pmc Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A
    Mitchel A Kling
    Clinical Neuroendocrinology Branch, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
    Biol Psychiatry 62:309-13. 2007
    ..Elevations of the inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) predict increased CAD risk in populations; few data on these markers exist in MDD, particularly in remitted patients...
  31. pmc Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders
    Karina Blair
    Mood and Anxiety Program, NIMH, NIH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 165:1193-202. 2008
    ..Functional magnetic resonance imaging assessed the neural response to facial expressions in generalized social phobia and generalized anxiety disorder...
  32. ncbi Hydrocortisone impairs hippocampal-dependent trace eyeblink conditioning in post-traumatic stress disorder
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Neuropsychopharmacology 31:182-8. 2006
    ..Patients with PTSD had increased glucocorticoid sensitivity in the focal brain regions mediating trace eyeblink conditioning...
  33. pmc Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial
    Sanjay J Mathew
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Neuropsychopharmacol 13:71-82. 2010
    ..Riluzole did not prevent relapse in the first month following ketamine. Further investigation of relapse prevention strategies post-ketamine is necessary...
  34. ncbi Regulation of cellular plasticity cascades in the pathophysiology and treatment of mood disorders: role of the glutamatergic system
    Carlos A Zarate
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 1003:273-91. 2003
    ....
  35. ncbi Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans
    Alexander Neumeister
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
    Pharmacogenet Genomics 15:143-9. 2005
    ..In-frame deletion of the alpha2C-adrenoreceptor subtype (alpha2CDel322-325) increases the risk of congestive heart failure. Increased delivery of catecholamines to cardiovascular receptors might explain this increased risk...
  36. pmc Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression
    James W Murrough
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biol Psychiatry 74:250-6. 2013
    ..In the current report, we examined the pattern and durability of antidepressant effects of repeated ketamine infusions in a larger sample, inclusive of the original...
  37. ncbi Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 56:101-12. 2004
    ..However, the relationships between depression, hippocampal structure and function, and cortisol levels are unclear and the effects of antidepressant treatment on the measures are not well studied...
  38. ncbi Smaller head of the hippocampus in Gulf War-related posttraumatic stress disorder
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, MAP, 15K North Drive, Room 111, MSC 2670, Bethesda, MD 20892 2670, USA
    Psychiatry Res 139:89-99. 2005
    ....
  39. ncbi Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy
    Omer Bonne
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institute of Health, 15K North Drive, Rm 200, Bethesda, MD 20892 2670, USA
    Neurosci Biobehav Rev 28:65-94. 2004
    ..The implications of this model for the discovery of novel pharmacological approaches to the treatment of severe psychological distress are discussed...
  40. ncbi Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy
    Gregor Hasler
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Biol Psychiatry 58:969-73. 2005
    ..As a result, the current study investigates whether GABA levels in the prefrontal cortex differ between unmedicated subjects with remitted major depressive disorder (rMDD) and healthy control subjects...
  41. doi Unmedicated, remitted patients with major depression have decreased serum immunoglobulin A
    Philip W Gold
    Clinical Neuroendocrinology Branch, NIH NIMH, 10 Center Drive, Bethesda, MD 20892, USA
    Neurosci Lett 520:1-5. 2012
    ..In the light of the fact that IgA serves many immunomodulatory, anti-inflammatory roles, this finding supports the concept that major depressive illness represents a proinflammatory state...
  42. pmc Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: the impact of medication
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, NIH NIMH MAP, Bethesda, MD 20892, USA
    Neuroimage 49:2966-76. 2010
    ..Here we extend these results to the amygdala. We raise the possibility that neuroplastic changes in the amygdala associated with BD are moderated by some mood stabilizing medications...
  43. ncbi An open-label trial of riluzole in patients with treatment-resistant major depression
    Carlos A Zarate
    Laboratory of Molecular Pathophysiology and Experimental Therapeutics and the Pathophysiology Branch, Mood and Anxiety Disorders Program, NIMH, Department of Health and Human Services, NIH, Bethesda, MD 20892, USA
    Am J Psychiatry 161:171-4. 2004
    ..This study was conducted to determine the efficacy and safety of riluzole, a glutamate-modulating agent, in patients with recurrent major depression...
  44. pmc Habenula volume in post-traumatic stress disorder measured with high-resolution MRI
    Jonathan B Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, NIH NIMH, Bethesda, MD, USA
    Biol Mood Anxiety Disord 1:7. 2011
    ..abstract:..
  45. ncbi Discovering endophenotypes for major depression
    Gregor Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
    Neuropsychopharmacology 29:1765-81. 2004
    ....
  46. pmc Cortisol and DHEA-S are associated with startle potentiation during aversive conditioning in humans
    Christian Grillon
    NIMH NIH DHHS, Mood and Anxiety Disorder Program, 15K North Drive, MSC 2670, Bethesda, MD 20892 2670, USA
    Psychopharmacology (Berl) 186:434-41. 2006
    ....
  47. ncbi Adolescent immaturity in attention-related brain engagement to emotional facial expressions
    Christopher S Monk
    Section on Development and Affective Neuroscience and Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuroimage 20:420-8. 2003
    ..These findings suggest that adults show greater modulation of activity in relevant brain structures based on attentional demands, whereas adolescents exhibit greater modulation based on emotional content...
  48. ncbi Irritability in pediatric mania and other childhood psychopathology
    Ellen Leibenluft
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Room 4N 208, MSC 1255, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1008:201-18. 2003
    ..Examples of such paradigms are described, and the pharmacology of irritability is reviewed briefly...
  49. pmc A selective neurokinin-1 receptor antagonist in chronic PTSD: a randomized, double-blind, placebo-controlled, proof-of-concept trial
    Sanjay J Mathew
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Eur Neuropsychopharmacol 21:221-9. 2011
    ..The selective NK(1)R antagonist GR205171 had fewer adverse effects but was not significantly superior to placebo in the short-term treatment of chronic PTSD. (ClinicalTrials.gov Identifier: NCT 00211861, NCT 00383786)...
  50. ncbi Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life
    Dennis S Charney
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 60:664-72. 2003
    ..To review progress made during the past decade in late-life mood disorders and to identify areas of unmet need in health care delivery and research...
  51. pmc Is there anything really novel on the antidepressant horizon?
    James W Murrough
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1230, New York, NY 10029, USA
    Curr Psychiatry Rep 14:643-9. 2012
    ..We review in detail findings regarding the antidepressant effects of the glutamate N-methyl-d-aspartate receptor antagonist ketamine in order to highlight the promise of novel agents as future treatments for major depression...
  52. doi Cognitive dysfunction in depression: neurocircuitry and new therapeutic strategies
    James W Murrough
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Neurobiol Learn Mem 96:553-63. 2011
    ..Finally, we highlight potential new pharmacological and non-pharmacological therapeutic strategies for MDD based on an evolving mechanistic understanding of the disorder...
  53. ncbi Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression
    Husseini K Manji
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, Maryland 20892 4405, USA
    Biol Psychiatry 53:707-42. 2003
    ..The development of novel, nonaminergic-based therapeutics holds much promise for improved treatment of severe, refractory mood disorders...
  54. pmc Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia
    Philip W Gold
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Proc Natl Acad Sci U S A 102:8303-8. 2005
    ..Even mildly-to-moderately depressed melancholic patients had clinically relevant increases in the arterial NE-appearance rate. These findings will not apply to all clinical subtypes of major depression...
  55. doi Novel drugs and therapeutic targets for severe mood disorders
    Sanjay J Mathew
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 33:2080-92. 2008
    ....
  56. ncbi A developmental and neurobiological approach to early trauma research
    Christopher S Monk
    Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Semin Clin Neuropsychiatry 7:137-46. 2002
    ..This approach will help clarify how early traumatic events have the capacity to lead to psychopathology or a healthy outcome...
  57. ncbi Overview of psychiatric disorders and the role of newer antidepressants
    Dennis S Charney
    Mood and Anxiety Disorders Research Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Clin Psychiatry 63:3-9. 2002
  58. ncbi Researching the pathophysiology of pediatric bipolar disorder
    Ellen Leibenluft
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 53:1009-20. 2003
    ..Potential foci for research on the pathophysiology of pediatric BPD include reactivity to standardized positive and negative emotional stimuli, and the interaction between emotion regulation and attentional processes...
  59. ncbi Reduced serotonin type 1A receptor binding in panic disorder
    Alexander Neumeister
    National Institutes of Health, National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, Maryland 20892 2670, USA
    J Neurosci 24:589-91. 2004
    ..These results provide for the first time in vivo evidence for the involvement of 5-HT(1A)Rs in the pathophysiology of PD...
  60. pmc Childhood trauma associated with smaller hippocampal volume in women with major depression
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, 15K North Drive, Room 111, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 159:2072-80. 2002
    ..In this study, the volumes of the hippocampus and of control brain regions were measured in depressed women with and without childhood abuse and in healthy nonabused comparison subjects...
  61. ncbi Effects of the beta-blocker propranolol on cued and contextual fear conditioning in humans
    Christian Grillon
    Mood and Anxiety Disorder Program, NIMH NIH DHHS National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Psychopharmacology (Berl) 175:342-52. 2004
    ..It is possible that fear inhibitory avoidance is more akin to contextual conditioning than to cued fear conditioning, suggesting that context conditioning may be disrupted by beta-adrenergic blockade...
  62. ncbi Research on major depression: strategies and priorities
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892, USA
    JAMA 289:3167-8. 2003
  63. ncbi Defining clinical phenotypes of juvenile mania
    Ellen Leibenluft
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1255, USA
    Am J Psychiatry 160:430-7. 2003
    ..The authors suggest criteria for a range of narrow to broad phenotypes of bipolar disorder in children, differentiated according to the characteristics of the manic or hypomanic episodes, and present methods for validation of the criteria...
  64. ncbi New insights into the role of cortisol and the glucocorticoid receptor in severe depression
    Philip W Gold
    National Institutes of Health, National Institute of Mental Health, Clinical Neuroendocrinology Branch, Intramural Research Program, 20852, Bethesda, MD, USA
    Biol Psychiatry 52:381-5. 2002
  65. ncbi Effects of dexamethasone on declarative memory function in posttraumatic stress disorder
    J Douglas Bremner
    Departments of Psychiatry and Behavioral Sciences and Radiology, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta 30306 GA, USA
    Psychiatry Res 129:1-10. 2004
    ....
  66. ncbi Pindolol augmentation in depressed patients resistant to selective serotonin reuptake inhibitors: a double-blind, randomized, controlled trial
    Edward B Perry
    Department of Psychiatry, VA Connecticut Healthcare System, Psychiatry Service 116A, 950 Campbell Avenue, West Haven, CT 06516, USA
    J Clin Psychiatry 65:238-43. 2004
    ..Here, we report on a double-blind, randomized, controlled 6-week study of pindolol augmentation of selective serotonin reuptake inhibitors (SSRIs) in depressed outpatients resistant to SSRI monotherapy...
  67. ncbi Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia 30306, USA
    Biol Psychiatry 53:879-89. 2003
    ..The purpose of this study was to assess neural correlates of emotionally valenced declarative memory in women with early childhood sexual abuse and PTSD...
  68. ncbi Effects of glucocorticoids on declarative memory function in major depression
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 126 Briarcliff Road, Atlanta, GA 30306, USA
    Biol Psychiatry 55:811-5. 2004
    ..The purpose of this study was to assess the effects of the glucocorticoid, dexamethasone, on verbal declarative memory function in patients with untreated unipolar major depressive disorder (MDD)...
  69. pmc Reduced posterior hippocampal volume in posttraumatic stress disorder
    Omer Bonne
    Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Psychiatry 69:1087-91. 2008
    ..Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously distributed or confined to a certain part of the structure...
  70. ncbi Monoamine depletion in unmedicated depressed subjects
    Robert M Berman
    Abraham Ribicoff Center Clinical Neuroscience Research Unit of the Connecticut Mental Health Center, New Haven, Connecticut, USA
    Biol Psychiatry 51:469-73. 2002
    ..This study assesses the integrated role of these monoamine systems in depressed patients...
  71. ncbi Deficits in hippocampal and anterior cingulate functioning during verbal declarative memory encoding in midlife major depression
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, and Atlanta VA Medical Center, Decatur, GA, USA
    Am J Psychiatry 161:637-45. 2004
    ..The purpose of the present study was to assess hippocampal and prefrontal functioning during performance of a verbal declarative memory task in subjects with midlife major depression...
  72. ncbi An increased capacity for adrenal DHEA release is associated with decreased avoidance and negative mood symptoms in women with PTSD
    Ann M Rasmusson
    Department of Psychiatry, Yale University School of Medicine and VA National Center for PTSD, Clinical Neuroscience Division, VA Boston Healthcare System, West Haven, CT 06516, USA
    Neuropsychopharmacology 29:1546-57. 2004
    ....
  73. ncbi Fighting the psychological war on terrorism
    Matthew J Friedman
    National Center for PTSD, VAM and ROC, White River Junction, Vermont, and Department of Psychiatry, Dartmouth Medical School, Hanover, New Hampshire, USA
    Psychiatry 67:123-36. 2004
  74. ncbi Significance of adolescent neurodevelopment for the neural circuitry of bipolar disorder
    Hilary P Blumberg
    Department of Psychiatry, Yale University School of Medicine, VA Depression Research Center REAP, VA Connecticut Healthcare System 116 A, 950 Campbell Avenue, West Haven, CT 06516, USA
    Ann N Y Acad Sci 1021:376-83. 2004
    ..This potential neurodevelopmental model for BD could have important implications for the recognition of early signs of the disorder and for age-specific treatment strategies...
  75. ncbi Frontotemporal neural systems in bipolar disorder
    Hilary P Blumberg
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Semin Clin Neuropsychiatry 7:243-54. 2002
    ..We suggest that ventral and medial prefrontal and amygdalar abnormalities may play important roles in a subset of BD symptoms and are potential targets for treatments...
  76. ncbi Frontostriatal abnormalities in adolescents with bipolar disorder: preliminary observations from functional MRI
    Hilary P Blumberg
    Department of Psychiatry and Diagnostic Radiology and the Yale Child Study Center, Yale University School of Medicine, New Haven, Conn, 06516, USA
    Am J Psychiatry 160:1345-7. 2003
    ..This study investigated whether the functional abnormalities in prefrontal systems observed in adult bipolar disorder are manifested in adolescents with this illness...
  77. pmc Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
    Arch Gen Psychiatry 65:521-31. 2008
    ..An instructive paradigm for more directly investigating the relationship between catecholaminergic function and depression has involved the mood response to experimental catecholamine depletion (CD)...
  78. ncbi Discovering the neural basis of human social anxiety: a diagnostic and therapeutic imperative
    Dennis S Charney
    Am J Psychiatry 161:1-2. 2004
  79. ncbi Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder
    Christopher S Monk
    Department of Psychology, University of Michigan, 2000 East Hall, 530 Church St, Ann Arbor, MI 48109, USA
    Am J Psychiatry 163:1091-7. 2006
    ....
  80. ncbi Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder
    Hilary P Blumberg
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Arch Gen Psychiatry 60:1201-8. 2003
    ..Appreciation of whether volumetric abnormalities are early features of BD or whether the abnormalities represent neurodegenerative changes associated with illness duration is limited by the paucity of data in juvenile samples...
  81. pmc Alterations in stress reactivity after long-term treatment with paroxetine in women with posttraumatic stress disorder
    Eric Vermetten
    Rudolf Magnus Institute of Neurosciences, Department Psychiatry, University Medical Center, Int mailbox B01206, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Ann N Y Acad Sci 1071:184-202. 2006
    ..These results suggest that successful treatment with SSRI in chronic PTSD is associated with a trend for a decrease in baseline diurnal cortisol and with reduced cortisol reactivity to stress...
  82. ncbi Addition of the alpha2-antagonist yohimbine to fluoxetine: effects on rate of antidepressant response
    Gerard Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 29:1166-71. 2004
    ..The addition of the alpha2-antagonist yohimbine to fluoxetine appears to hasten the antidepressant response. There is also a trend suggesting an increased percentage of responders to the combined treatment at the end of the 6-week trial...
  83. ncbi Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls
    Alexander Neumeister
    Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Arch Gen Psychiatry 63:978-86. 2006
    ....
  84. ncbi Assessment of the hypothalamic-pituitary-adrenal axis over a 24-hour diurnal period and in response to neuroendocrine challenges in women with and without childhood sexual abuse and posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia, USA
    Biol Psychiatry 54:710-8. 2003
    ..We performed a comprehensive assessment of the HPA axis in women with and without a history of early childhood sexual abuse and posttraumatic stress disorder (PTSD)...
  85. pmc Effects of antidepressant treatment on neural correlates of emotional and neutral declarative verbal memory in depression
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States
    J Affect Disord 101:99-111. 2007
    ..The purpose of this study was to examine the effects of treatment with antidepressants on verbal declarative memory in patients with depression...
  86. ncbi Neurobiology of anxiety disorders and implications for treatment
    Amir Garakani
    Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 73:941-9. 2006
    ..Combining these medication approaches with psychotherapies that promote extinction, such as cognitive behavioral therapy (CBT), may offer patients with anxiety disorders a rapid and robust treatment with good durability of effect...
  87. ncbi A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices
    Hilary P Blumberg
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Arch Gen Psychiatry 60:601-9. 2003
    ..We sought to characterize state- and trait-related functional impairment in frontal systems in bipolar disorder...
  88. pmc Recognition of facial emotions among maltreated children with high rates of post-traumatic stress disorder
    Carrie L Masten
    Department of Psychology, University of California, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095, USA
    Child Abuse Negl 32:139-53. 2008
    ..However, research has provided little evidence indicating how high rates of PTSD might relate to maltreated children's processing of emotions...
  89. ncbi Neural correlates of the classic color and emotional stroop in women with abuse-related posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia, USA
    Biol Psychiatry 55:612-20. 2004
    ..Dysfunction of the anterior cingulate/medial prefrontal cortex has been implicated in posttraumatic stress disorder (PTSD). The purpose of this study was to use the Stroop task as a probe of anterior cingulate function in PTSD...
  90. doi Recent advances in the neurobiology of anxiety disorders: implications for novel therapeutics
    Sanjay J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place Box 1217, New York, NY 10029
    Am J Med Genet C Semin Med Genet 148:89-98. 2008
    ..Each of these active areas of research holds promise for expanding and improving evidence-based treatment options for individuals suffering with clinical anxiety...
  91. pmc Hippocampal N-acetylaspartate concentration and response to riluzole in generalized anxiety disorder
    Sanjay J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 63:891-8. 2008
    ....