Po Chuen Chan

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Tumor induction in F344/N rats and B6C3F1 mice following inhalation exposure to ethylbenzene
    P C Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Lett 99:23-32. 1998
  2. ncbi Induction of thyroid and liver tumors by chronic exposure to 2-methylimidazole in F344/N rats and B6C3F1 mice
    P C Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Arch Toxicol 82:399-412. 2008
  3. ncbi Ginkgo biloba leave extract: biological, medicinal, and toxicological effects
    Po Chuen Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 25:211-44. 2007
  4. ncbi Toxicity and carcinogenicity studies of 4-methylimidazole in F344/N rats and B6C3F1 mice
    P C Chan
    Toxicology Operation Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Arch Toxicol 82:45-53. 2008
  5. ncbi Induction of thyroid lesions in 14-week toxicity studies of 2 and 4-methylimidazole in Fischer 344/N rats and B6C3F1 mice
    Po Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Arch Toxicol 80:169-80. 2006
  6. ncbi Toxicity and carcinogenicity of riddelliine in rats and mice
    Po C Chan
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709 9998, USA
    Toxicol Lett 144:295-311. 2003
  7. ncbi Forestomach tumor induction by 2,4-hexadienal in F344N rats and B6C3F1 mice
    Po C Chan
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Arch Toxicol 77:511-20. 2003
  8. ncbi Two-year toxicity and carcinogenicity studies of Panax ginseng in Fischer 344 rats and B6C3F1 mice
    Po Chuen Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Chin Med 39:779-88. 2011
  9. ncbi Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract
    Natasha P Clayton
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Exp Toxicol Pathol 58:223-36. 2007
  10. ncbi Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene
    Hue Hua L Hong
    1 Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:720-6. 2008

Detail Information

Publications12

  1. ncbi Tumor induction in F344/N rats and B6C3F1 mice following inhalation exposure to ethylbenzene
    P C Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Lett 99:23-32. 1998
    ..Ethylbenzene is carcinogenic inducing neoplasms in kidneys and testes in Fischer rats and in lungs in male and liver in female B6C3F1 mice...
  2. ncbi Induction of thyroid and liver tumors by chronic exposure to 2-methylimidazole in F344/N rats and B6C3F1 mice
    P C Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Arch Toxicol 82:399-412. 2008
    ..Under these experimental conditions, carcinogenic activity of 2MI was demonstrated in male and female rats and mice...
  3. ncbi Ginkgo biloba leave extract: biological, medicinal, and toxicological effects
    Po Chuen Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 25:211-44. 2007
    ..Safety evaluation of Ginkgo biloba leave extract is being conducted by the U.S. National Toxicology Program...
  4. ncbi Toxicity and carcinogenicity studies of 4-methylimidazole in F344/N rats and B6C3F1 mice
    P C Chan
    Toxicology Operation Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Arch Toxicol 82:45-53. 2008
    ..4MI is carcinogenic inducing alveolar/bronchiolar adenoma and carcinoma in male and female mice. 4MI may also induce mononuclear cell leukemia in female rats...
  5. ncbi Induction of thyroid lesions in 14-week toxicity studies of 2 and 4-methylimidazole in Fischer 344/N rats and B6C3F1 mice
    Po Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Arch Toxicol 80:169-80. 2006
    ..Our studies demonstrated that, in rats and mice, 2MI induces thyroid hyperplasia and hypertrophy, and both 2MI and 4MI induce anemia; 2MI induces thyroid follicular-cell adenoma in male rats...
  6. ncbi Toxicity and carcinogenicity of riddelliine in rats and mice
    Po C Chan
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709 9998, USA
    Toxicol Lett 144:295-311. 2003
    ..These studies demonstrate toxicity and carcinogenicity of riddelliine in rats and mice, and a dose-response relationship in female rats and male mice under the experimental conditions employed...
  7. ncbi Forestomach tumor induction by 2,4-hexadienal in F344N rats and B6C3F1 mice
    Po C Chan
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Arch Toxicol 77:511-20. 2003
    ..Mechanistic studies indicated that the forestomach carcinogenesis in rats and mice may be due to depletion of glutathione as a result of oxidative stress induced by 2,4-Hx...
  8. ncbi Two-year toxicity and carcinogenicity studies of Panax ginseng in Fischer 344 rats and B6C3F1 mice
    Po Chuen Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Chin Med 39:779-88. 2011
    ..In this paper, we reported the results of NTP chronic toxicity and tumorigenicity bioassay. It shows that, under these experimental conditions, Panax ginseng is not toxic or tumorigenic...
  9. ncbi Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract
    Natasha P Clayton
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Exp Toxicol Pathol 58:223-36. 2007
    ..Kava-induced hepatic functional changes in the F344 rat might be relevant to human clinical cases of hepatotoxicity following exposure...
  10. ncbi Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene
    Hue Hua L Hong
    1 Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:720-6. 2008
    ..The pattern of mutations identified in the lung tumors suggests that DNA damage and genomic instability may be contributing factors to the mutation profile and development of lung cancer in mice exposed to cumene...
  11. ncbi Glutathione S-transferase pi expression in forestomach carcinogenesis process induced by gavage-administered 2,4-hexadienal in the F344 rat
    A Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Arch Toxicol 75:618-24. 2001
    ....
  12. ncbi Toxicity of kava kava
    Peter P Fu
    National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 26:89-112. 2008
    ..At present toxicological evaluation of kava extract is being conducted by the NTP. The present review focuses on the recent findings on kava toxicity and the mechanisms by which kava induces hepatotoxicity...