Chi Chao Chan

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Loss of heterozygosity for the NF2 gene in retinal and optic nerve lesions of patients with neurofibromatosis 2
    Chi Chao Chan
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Pathol 198:14-20. 2002
  2. ncbi Therapeutic applications of antiflammin peptides in experimental ocular inflammation
    C C Chan
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 10N103, Bethesda, MD 20892 1857, USA
    Ann N Y Acad Sci 923:141-6. 2000
  3. ncbi Intraocular lymphoma
    Chi Chao Chan
    Laboratory of Immunology National Eye Institute, National Institutes of Health, Building 10 Room 10N103, 10 Center Drive, Bethesda, MD 20892 1857, USA
    Curr Opin Ophthalmol 13:411-8. 2002
  4. ncbi Recombinant adenovirus encoding gp100 modulates experimental melanin-protein induced uveitis (EMIU)
    C C Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1858, USA
    J Autoimmun 11:111-8. 1998
  5. ncbi Translocation of chromosomes 11 and 22 in choroidal metastatic Ewing sarcoma detected by fluorescent in situ hybridization
    C C Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Am J Ophthalmol 127:226-8. 1999
  6. ncbi Apoptosis in patients with posterior uveitis
    C C Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Arch Ophthalmol 115:1559-67. 1997
  7. ncbi Interphotoreceptor retinoid-binding protein (IRBP)-deficient C57BL/6 mice have enhanced immunological and immunopathogenic responses to IRBP and an altered recognition of IRBP epitopes
    Dody Avichezer
    Laboratory of Immunology, Section of Immunoregulation, National Institutes of Health, 10 Center Drive, 10 10N222, Bethesda, MD 20892 1857, USA
    J Autoimmun 21:185-94. 2003
  8. ncbi Altered chemokine profile associated with exacerbated autoimmune pathology under conditions of genetic interferon-gamma deficiency
    Shao Bo Su
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 48:4616-25. 2007
  9. ncbi Differentially expressed genes in MHC-compatible rat strains that are susceptible or resistant to experimental autoimmune uveitis
    Mary J Mattapallil
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 49:1957-70. 2008
  10. ncbi Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: initial encounter with autoantigen defines disease phenotype
    Jun Tang
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 178:5578-87. 2007

Collaborators

Detail Information

Publications152 found, 100 shown here

  1. ncbi Loss of heterozygosity for the NF2 gene in retinal and optic nerve lesions of patients with neurofibromatosis 2
    Chi Chao Chan
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Pathol 198:14-20. 2002
    ..Merlin was not expressed in the retina, optic nerve, or iris lesions. These results suggest that inactivation of the NF2 gene is associated with the formation of a variety of retinal and optic nerve lesions in NF2 patients...
  2. ncbi Therapeutic applications of antiflammin peptides in experimental ocular inflammation
    C C Chan
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 10N103, Bethesda, MD 20892 1857, USA
    Ann N Y Acad Sci 923:141-6. 2000
    ....
  3. ncbi Intraocular lymphoma
    Chi Chao Chan
    Laboratory of Immunology National Eye Institute, National Institutes of Health, Building 10 Room 10N103, 10 Center Drive, Bethesda, MD 20892 1857, USA
    Curr Opin Ophthalmol 13:411-8. 2002
    ..Compared with PIOL, metastatic systemic lymphomas have a much lower prevalence, better prognosis, and are less likely to create a diagnostic dilemma...
  4. ncbi Recombinant adenovirus encoding gp100 modulates experimental melanin-protein induced uveitis (EMIU)
    C C Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1858, USA
    J Autoimmun 11:111-8. 1998
    ..No abnormalities developed in rats which received Ad2CMV-gp100 or Ad2CMV-LacZ alone. Therefore, Ad2CMV-gp100 injection prevents the development of EMIU, at least in part, through cytokine regulation...
  5. ncbi Translocation of chromosomes 11 and 22 in choroidal metastatic Ewing sarcoma detected by fluorescent in situ hybridization
    C C Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Am J Ophthalmol 127:226-8. 1999
    ..To describe a patient with metastasis of Ewing sarcoma to the choroid and the molecular genetics of the tumor...
  6. ncbi Apoptosis in patients with posterior uveitis
    C C Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Arch Ophthalmol 115:1559-67. 1997
    ..Apoptosis plays a part in the pathogenesis of autoimmune diseases...
  7. ncbi Interphotoreceptor retinoid-binding protein (IRBP)-deficient C57BL/6 mice have enhanced immunological and immunopathogenic responses to IRBP and an altered recognition of IRBP epitopes
    Dody Avichezer
    Laboratory of Immunology, Section of Immunoregulation, National Institutes of Health, 10 Center Drive, 10 10N222, Bethesda, MD 20892 1857, USA
    J Autoimmun 21:185-94. 2003
    ..Furthermore, endogenous expression of IRBP is directly responsible for lowering the threshold of susceptibility to uveitic disease...
  8. ncbi Altered chemokine profile associated with exacerbated autoimmune pathology under conditions of genetic interferon-gamma deficiency
    Shao Bo Su
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 48:4616-25. 2007
    ..The present study was conducted to explore the differential expression of chemokine(s) likely to account for the distinct inflammatory cell composition in uveitic eyes of WT and GKO mice...
  9. ncbi Differentially expressed genes in MHC-compatible rat strains that are susceptible or resistant to experimental autoimmune uveitis
    Mary J Mattapallil
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 49:1957-70. 2008
    ..The primary objective of this study was to identify the non-MHC genes involved in the pathogenesis of EAU, to identify potential drug targets and possibly to target their protein products for immunotherapy...
  10. ncbi Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: initial encounter with autoantigen defines disease phenotype
    Jun Tang
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 178:5578-87. 2007
    ..These findings may shed new light on the complex biology and the heterogeneous nature of human uveitis, and provide an alternative model for uveitic diseases of immune origin...
  11. ncbi The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration
    Jingsheng Tuo
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    FASEB J 18:1297-9. 2004
    ..Our data suggest that a decrease, caused by sequence variation and/or lower CX3CR1 expression, in CX3CR1-induced cellular activities could contribute to AMD development...
  12. ncbi Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due to reduced T cell priming and inhibition of disease effector mechanisms
    Rajeev K Agarwal
    The Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 180:5423-9. 2008
    ....
  13. ncbi Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity
    Rafael S Grajewski
    Laboratory of Immunology, National Eye Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:851-6. 2006
    ..Our data also provide the first evidence that generation of specific T reg cells to a native autoantigen in a mouse with a diverse T cell repertoire requires a cognate interaction...
  14. ncbi Repertoire analysis and new pathogenic epitopes of IRBP in C57BL/6 (H-2b) and B10.RIII (H-2r) mice
    Lizette M Cortes
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 49:1946-56. 2008
    ..The purpose of this study was to identify and characterize additional uveitogenic epitopes in B10.RIII and C57BL/6 mice and to compare epitope recognition in wild-type versus IRBP-deficient mice on both backgrounds...
  15. ncbi Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration
    Jingsheng Tuo
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 48:3827-36. 2007
    ..Loss-of-function single-nucleotide polymorphisms within CX3CR1 are also found to be associated with AMD. The authors generated Ccl2(-/-)/Cx3cr1(-/-) mice to establish a more characteristic and reproducible AMD model...
  16. ncbi An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms
    Dody Avichezer
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1665-76. 2003
    ..Thus, uveitis-susceptible individuals display a detectable and functionally significant tolerance to their target antigen, in which central mechanisms play a prominent role...
  17. ncbi Effect of sex hormones on experimental autoimmune uveoretinitis (EAU)
    Ronald R Buggage
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Immunol Invest 32:259-73. 2003
    ..We evaluated the effect of estrogen, progesterone, and testosterone in autoimmune uveoretinitis (EAU), a rodent model of human ocular autoimmune disease...
  18. ncbi The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice
    Xiaoguang Cao
    Immunopathology Section, Laboratory of Immunology National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Exp Eye Res 91:15-25. 2010
    ..However, quercetin (25 mg/kg/day) does not improve the retinal AMD-like lesions in the Ccl2(-/-)/Cx3cr1(-/-) mice, likely due to its insufficient suppression of the inflammatory and apoptosis pathways in the eye...
  19. ncbi Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category
    Dror Luger
    Laboratory of Immunology, National Eye Institute NEI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 205:799-810. 2008
    ..These data also raise the possibility that the nonredundant requirement for IL-23 in EAU may extend beyond its role in promoting the Th17 effector response and help provide a balance in the current Th1 versus Th17 paradigm...
  20. ncbi Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition
    Jingsheng Tuo
    Division of Epidemiology and Clinical Research, and Ophthalmic Genetics and Visual Function Branch, Section on Ophthalmic Molecular Genetics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:9256-61. 2006
    ..The strong AMD predisposition conferred by the ERCC6 and CFH SNPs may result from biological epistasis, because ERCC6 functions in universal transcription as a component of RNA pol I transcription complex...
  21. ncbi Constancy of ERp29 expression in cultured retinal pigment epithelial cells in the Ccl2/Cx3cr1 deficient mouse model of age-related macular degeneration
    Varun Verma
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Curr Eye Res 33:701-7. 2008
    ....
  22. ncbi Ccl2/Cx3cr1-deficient mice: an animal model for age-related macular degeneration
    Chi Chao Chan
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892 1857, USA
    Ophthalmic Res 40:124-8. 2008
    ..Senescent Ccl2-/- mice develop cardinal features of human age-related macular degeneration (AMD). Loss-of-function single-nucleotide polymorphisms within CX3CR1 are associated with AMD...
  23. ncbi An apolipoprotein E variant may protect against age-related macular degeneration through cytokine regulation
    Christine M Bojanowski
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Environ Mol Mutagen 47:594-602. 2006
    ..These results further confirm the association between ApoE112R and a decreased risk of AMD development. The underlying mechanisms may involve differential regulation of both CCL2 and VEGF by the ApoE isoforms...
  24. ncbi Immunological protein expression profile in Ccl2/Cx3cr1 deficient mice with lesions similar to age-related macular degeneration
    Robert J Ross
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892, USA
    Exp Eye Res 86:675-83. 2008
    ..Moreover, since human AMD patients show similar immunopathological profiles, these results support the Ccl2(-/-)/Cx3cr1(-/-) as a suitable model for human AMD...
  25. ncbi Hydrodynamic vaccination with DNA encoding an immunologically privileged retinal antigen protects from autoimmunity through induction of regulatory T cells
    Phyllis B Silver
    Laboratory of Immunology, National Eye Institute, National Institutes of Health Bethesda, MD 20892 1857, USA
    J Immunol 179:5146-58. 2007
    ..DNA vaccination may offer a new approach to Ag-specific therapy of uveitis...
  26. ncbi Complement deposits on ocular tissues adjacent to sites of inflammation
    Vanessa Montalvo
    Laboratory of Immunology, National Eye Institute, NIH, Bethesda, Maryland 20892 1857, USA
    Curr Eye Res 32:917-22. 2007
    ..The complement system plays important roles in a variety of chronic ocular diseases such as age-related macular degeneration. Here we examined the deposition of complement components in mouse eyes damaged by various mechanisms...
  27. ncbi A unique pattern of up- and down-regulation of chemokine receptor CXCR3 on inflammation-inducing Th1 cells
    Jun Chen
    National Eye Institute, NIH, Bethesda, MD 20892, USA
    Eur J Immunol 34:2885-94. 2004
    ....
  28. ncbi CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells
    Paul A Antony
    Division of Surgery, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:2591-601. 2005
    ..These findings reveal that Th cells can help break tolerance to a persisting self-Ag and treat established tumors through an IL-2-dependent mechanism, but requires simultaneous absence of naturally occurring T(reg) cells to be effective...
  29. ncbi Both Th1 and Th17 are immunopathogenic but differ in other key biological activities
    Catherine A Cox
    Laboratory of Immunology, National Eye Institute, National Institute of Health, Bethesda, MD 20892, USA
    J Immunol 180:7414-22. 2008
    ..These data reveal that Th1 and Th17 cells differ in several key biological activities influencing migration and pathogenic behavior during inflammatory disease...
  30. ncbi Murine model of primary intraocular lymphoma
    Chi Chao Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Invest Ophthalmol Vis Sci 46:415-9. 2005
    ..The current study was conducted to develop a new experimental model for PIOL...
  31. ncbi The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples
    Robert J Ross
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Invest Ophthalmol Vis Sci 48:1128-32. 2007
    ..S. clinic-based case-control studies...
  32. ncbi Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity
    Shao Bo Su
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:6303-10. 2005
    ..In contrast, signaling through the IL-1R plays a necessary and nonredundant role in EAU and can by itself account for the lack of EAU development in MyD88 mice...
  33. ncbi Serum inflammatory markers in diabetic retinopathy
    Annal D Meleth
    Howard Hughes Medical Institute, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 46:4295-301. 2005
    ..To evaluate the association of serum factors with the severity of diabetic retinopathy and to assess their presence in retinal tissue obtained at autopsy...
  34. ncbi Constitutive and cytokine-induced GITR ligand expression on human retinal pigment epithelium and photoreceptors
    Ben J Kim
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 45:3170-6. 2004
    ..The current study was conducted to examine the expression of glucocorticoid-induced TNF-related receptor ligand (GITRL) and its regulation by ocular tissue...
  35. ncbi Evidence for enhanced tissue factor expression in age-related macular degeneration
    Youngeun Cho
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Lab Invest 91:519-26. 2011
    ..These results indicate that upregulated TF expression may be associated with AMD, and inflammatory and oxidative stress may contribute to TF expression in AMD eyes...
  36. ncbi Naloxone ameliorates retinal lesions in Ccl2/Cx3cr1 double-deficient mice via modulation of microglia
    DeFen Shen
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 52:2897-904. 2011
    ..The authors evaluated the effects of naloxone on Ccl2(-/-)/Cx3cr1(-/-) (DKO) mice, a murine model of age-related macular degeneration (AMD)...
  37. ncbi Survival of donor epithelial cells after limbal stem cell transplantation
    Ali R Djalilian
    National Eye Institute, National Institutes of Health, Building 10, Room 10N112, 10 Center Drive, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 46:803-7. 2005
    ..To determine the long-term fate of donor epithelial cells after limbal allograft transplantation...
  38. ncbi Cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma: a new cause of uveitis
    Michael R Robinson
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1863, USA
    J Immunother 27:478-9. 2004
    ..This suggests that CTLA-4 is an important regulatory molecule for maintenance of tolerance to melanosomal antigens and prevention of uveitis...
  39. ncbi MCP-1 expression in endotoxin-induced uveitis
    Nadine Tuaillon
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bldg 10 Room 10 N 103, 10 Center Drive, Bethesda, MD 20892 1857, USA
    Invest Ophthalmol Vis Sci 43:1493-8. 2002
    ....
  40. ncbi Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells
    Mary J Mattapallil
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 187:1977-85. 2011
    ....
  41. ncbi Copy number variations in candidate genes in neovascular age-related macular degeneration
    Melissa M Liu
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Invest Ophthalmol Vis Sci 52:3129-35. 2011
    ..Copy number variation (CNV), or variation in the number of copies of a particular segment of DNA, may also contribute to AMD pathogenesis. This study evaluated CNVs in candidate genes that have been reported to be linked to AMD...
  42. ncbi Detection of the bcl-2 t(14;18) translocation and proto-oncogene expression in primary intraocular lymphoma
    Dana J Wallace
    Laboratory of Immunology, Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20895 1857, USA, and Department of Ophthalmology, Tokyo Medical and Dental University, Japan
    Invest Ophthalmol Vis Sci 47:2750-6. 2006
    ..This study examined the expression of the bcl-2 t(14;18) translocation, the bcl-10 gene, and high expression of bcl-6 mRNA in PIOL cells...
  43. ncbi Expression of stem cells markers in ocular hemangioblastoma associated with von Hippel-Lindau (VHL) disease
    Chi Chao Chan
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Mol Vis 11:697-704. 2005
    ..To better understand the histogenesis of ocular hemangioblastomas associated with von Hippel-Lindau (VHL) disease...
  44. ncbi Human HtrA1 in the archived eyes with age-related macular degeneration
    Chi Chao Chan
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Trans Am Ophthalmol Soc 105:92-7; discussion 97-8. 2007
    ..The SNP is located in the regulatory region and increases production of HtrA1 protein. This study investigates HtrA1 expression and SNP genotypes in archived ocular slides with AMD...
  45. ncbi Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses
    Rafael S Grajewski
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:4791-7. 2008
    ..These data suggest that pharmacological activation of iNKT cells protects from EAU at least in part by a mechanism involving innate production of IFN-gamma and a consequent dampening of the Th1 as well as the Th17 effector responses...
  46. ncbi Autoreactive memory CD4+ T lymphocytes that mediate chronic uveitis reside in the bone marrow through STAT3-dependent mechanisms
    Hyun Mee Oh
    Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 187:3338-46. 2011
    ....
  47. ncbi LX211 (voclosporin) suppresses experimental uveitis and inhibits human T cells
    Matthew A Cunningham
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 50:249-55. 2009
    ..To test the therapeutic effectiveness of voclosporin against experimental autoimmune uveoretinitis (EAU) in rats and to evaluate its effect on human T cells...
  48. ncbi IL-10 -1082 SNP and IL-10 in primary CNS and vitreoretinal lymphomas
    Hema L Ramkumar
    Immunopathology Section, Laboratory of Immunology National Institutes of Health, 10 Center Drive, 10 10 N103, NIH NEI, Bethesda, MD, 20892 1857, USA
    Graefes Arch Clin Exp Ophthalmol 250:1541-8. 2012
    ..PDCD4 is a tumor suppressor gene and upstream regulator of IL-10. This study examined the correlation between the IL-10 SNP, PDCD4 mRNA expression, and IL-10 expression (at transcript and protein levels) in these lymphoma cells...
  49. ncbi Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model
    Jingsheng Tuo
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    J Neuroinflammation 9:59. 2012
    ..In this study, we evaluated the effect of an intravitreous injection of recombinant TSG-6 on the retinal lesions of Ccl2-/-/Cx3cr1-/- mice...
  50. ncbi Suppressor of cytokine signaling-1 (SOCS1) inhibits lymphocyte recruitment into the retina and protects SOCS1 transgenic rats and mice from ocular inflammation
    Cheng Rong Yu
    Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 52:6978-86. 2011
    ..The purpose of this study was to investigate the role of SOCS1 in intraocular inflammatory diseases (uveitis) and whether SOCS1 expression is defective in patients with ocular inflammatory diseases...
  51. ncbi Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinal autoimmunity by inducing type 2 and regulatory T cells
    Lizette M Cortes
    Laboratory of Immunoregulation, National Eye Institute, National Institute of Health, 10 Center Drive, 10 10N222, Bethesda, MD 20893 1857, USA
    J Leukoc Biol 84:577-85. 2008
    ..Thus, IPA pretreatment prevents induction of EAU by skewing the response to a subsequent uveitogenic challenge with the native peptide to a nonpathogenic phenotype, as well as by eliciting transferable regulatory cells...
  52. ncbi Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration
    Xiaoyan Ding
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 50:4957-66. 2009
    ....
  53. ncbi Expression of chemokine receptors, CXCR4 and CXCR5, and chemokines, BLC and SDF-1, in the eyes of patients with primary intraocular lymphoma
    Chi Chao Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bldg 10, Rm 10N103, 90 Center Drive, Bethesda, MD 20892 1857, USA
    Ophthalmology 110:421-6. 2003
    ..We investigated the expression of these chemokine/chemokine receptors in eyes with primary intraocular B-cell lymphoma (PIOL)...
  54. ncbi Endotoxin-induced uveitis in cyclooxygenase-2-deficient mice
    Jingsheng Tuo
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 45:2306-13. 2004
    ..The purpose of this study was to delineate the role of COX-2 in acute ocular inflammation...
  55. ncbi Analysis of ocular hypopigmentation in Rab38cht/cht mice
    Brian P Brooks
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 48:3905-13. 2007
    ..To characterize the ocular phenotype resulting from mutation of Rab38, a candidate gene for Hermansky-Pudlak syndrome...
  56. ncbi Toll-like receptor polymorphisms and age-related macular degeneration: replication in three case-control samples
    Youngeun Cho
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 50:5614-8. 2009
    ..S. clinic-based case-control study samples and one Australian population-based study sample) were used to further assess the association of the polymorphisms rs3775291 in TLR3 and rs4986790 in TLR4 with AMD...
  57. ncbi Inflammatory cytokine and chemokine expression in sympathetic ophthalmia: a pilot study
    Emiko Furusato
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Washington, DC, USA
    Histol Histopathol 26:1145-51. 2011
    ..Our data indicate for the first time that M1 macrophages are the predominant inflammatory cells within granulomas and DFN of SO. We further observed high levels of IL-17 within granulomas and the presence of Th1 and M1 cells...
  58. ncbi The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples
    Jingsheng Tuo
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Ophthalmology 115:1891-8. 2008
    ..To assess the association and combined effect on the risk of age-related macular degeneration (AMD) by the HtrA1 and complement factor H (CFH) polymorphisms, smoking, and serum cholesterol...
  59. ncbi A case of rapid progression and vision loss in a patient with primary intraocular lymphoma
    Amit Sangave
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Ocul Immunol Inflamm 18:99-100. 2010
    ..To describe an atypical case of primary intraocular lymphoma (PIOL) with rapid progression leading to vision loss and death...
  60. ncbi Ocular clusterin expression in von Hippel-Lindau disease
    Min Zhou
    National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Mol Vis 13:2129-36. 2007
    ..Decreased clusterin secretion has been reported in renal cell carcinoma associated with VHL disease. The purpose of this study was to investigate ocular clusterin expression in VHL disease...
  61. ncbi Analysis of Hemicentin-1, hOgg1, and E-selectin single nucleotide polymorphisms in age-related macular degeneration
    Christine M Bojanowski
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Trans Am Ophthalmol Soc 103:37-44; discussion 44-5. 2005
    ..This study investigates the Hemicentin-1 (an extracellular matrix protein) Q5345R, hOgg1 (DNA repair gene) S326C, and E-selectin (an adhesion molecule) S149R SNPs in association with AMD...
  62. ncbi A double-masked, randomized study to investigate the safety and efficacy of daclizumab to treat the ocular complications related to Behçet's disease
    Ronald R Buggage
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Ocul Immunol Inflamm 15:63-70. 2007
    ..To investigate the safety and efficacy of daclizumab (Zenapax, humanized anti-Tac, HAT) in controlling the ocular manifestations of Behçet's disease...
  63. ncbi Rapid vision loss associated with fludarabine administration
    Rachel J Bishop
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Retina 30:1272-7. 2010
    ..The purpose of this study was to report the clinical and pathologic findings of three cases of rapid vision loss associated with fludarabine toxicity...
  64. ncbi IL-4 and IL-10 are both required for the induction of oral tolerance
    L V Rizzo
    Laboratory of Immunology, National Eye Institute, and Department of Immunology Instituto de Ciêancias Biomédicas, Sao Paulo, Brazil
    J Immunol 162:2613-22. 1999
    ..These data also underscore the fact that oral tolerance, manifested as suppression of proliferation and IL-2 production, is not synonymous with protection from disease...
  65. ncbi Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis
    T K Tarrant
    Laboratory of Immunology, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 189:219-30. 1999
    ....
  66. ncbi Ocular manifestations of trichothiodystrophy
    Brian P Brooks
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ophthalmology 118:2335-42. 2011
    ..Many TTD patients have a defect in known DNA repair genes. This report systematically evaluates the ocular manifestations of the largest-to-date cohort of TTD patients and xeroderma pigmentosum (XP)/TTD patients...
  67. ncbi 25-Gauge transconjunctival sutureless vitrectomy for the diagnosis of intraocular lymphoma
    Steven Yeh
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Building 10, 10N 112, 10 Center Drive, Bethesda, MD 20892, USA
    Br J Ophthalmol 94:633-8. 2010
    ..The availability of expert ophthalmic pathological consultation, flow cytometry, cytokine evaluation and gene rearrangement studies were essential to the diagnosis...
  68. ncbi Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis
    T K Tarrant
    Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, MD 20892, USA
    J Immunol 161:122-7. 1998
    ..Lastly, the diminished ability of primed wt lymphocytes to induce EAU in 12KO mice indicates a role for endogenous IL-12 in the efferent phase of disease expression that is distinct from its role during Ag priming...
  69. ncbi Fas and Fas ligand expressed on cells of the immune system, not on the target tissue, control induction of experimental autoimmune uveitis
    J L Wahlsten
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 165:5480-6. 2000
    ..These results indicate that normal expression of Fas and of FasL on cells of the immune system is important for EAU expression. Unexpectedly, neither lack of Fas nor lack of FasL on the ocular tissues affected expression of EAU...
  70. ncbi A suppressive oligodeoxynucleotide inhibits ocular inflammation
    C Fujimoto
    Laboratories of Immunology, National Eye Institute, NIH, Bethesda, MD 20892 1857, USA
    Clin Exp Immunol 156:528-34. 2009
    ..These findings suggest that suppressive ODN affects both afferent and efferent limbs of the immunopathogenic process and may be of use in the treatment of autoimmune ocular inflammation...
  71. ncbi Mouse models of experimental autoimmune uveitis
    Rachel R Caspi
    Laboratory of Immunology, NEI, NIH, Bethesda, MD 20892 1857, USA
    Ophthalmic Res 40:169-74. 2008
    ..The current overview will summarize the salient features of the experimental autoimmune uveitis model and discuss its mechanisms...
  72. ncbi Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers
    Andrea Boni
    Clinical Research Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 112:4746-54. 2008
    ..Taken together, these data indicate that the use of tumor-specific allogeneic CD8(+) T cells or CD4(+) can result in significant antitumor effects in the absence of measurable GVHD...
  73. ncbi Transgenic expression of an immunologically privileged retinal antigen extraocularly enhances self tolerance and abrogates susceptibility to autoimmune uveitis
    H Xu
    NEI NIH, Bethesda, USA
    Eur J Immunol 30:272-8. 2000
    ..The same level of expression is, however, insufficient to tolerize wild-type effector T cells in the periphery...
  74. ncbi Mice deficient in inducible nitric oxide synthase are susceptible to experimental autoimmune uveoretinitis
    P B Silver
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 40:1280-4. 1999
    ..The present study addresses the question whether inducible nitric oxide synthase (iNOS), and consequently the ability to upregulate NO, is required to effect the pathogenesis of experimental autoimmune uveoretinitis (EAU) in mice...
  75. ncbi gamma Interferon expression disrupts lens and retinal differentiation in transgenic mice
    C E Egwuagu
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892
    Dev Biol 166:557-68. 1994
    ....
  76. ncbi Involvement of apoptosis and interferon-gamma in murine toxoplasmosis
    D F Shen
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-1857, USA
    Invest Ophthalmol Vis Sci 42:2031-6. 2001
    ..Multiple factors are likely to be involved in the pathogenesis of ocular toxoplasmosis...
  77. ncbi Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats
    S H Sun
    Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD 20892, USA
    Int Immunol 11:529-34. 1999
    ..Further analysis of these genomic regions may lead to identification of the susceptibility genes and to characterization of their function...
  78. ncbi Molecular pathology of eyes with von Hippel-Lindau (VHL) Disease: a review
    Chi Chao Chan
    National Eye Institute, National Institutes of Health, Bethesda 20892 1857, USA
    Retina 27:1-7. 2007
    ..von Hippel-Lindau Disease (VHL) is an autosomal dominant inherited systemic cancer syndrome. Recently, many advances have contributed to the understanding of VHL pathophysiology...
  79. ncbi Eyelid myxoma in Carney complex without PRKAR1A allelic loss
    Ekaterini T Tsilou
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, 10 Center Drive, MSC 1860, Bldg 10 Room 10N226, Bethesda, MD 20892, USA
    Am J Med Genet A 130:395-7. 2004
    ..578delTG. Immunohistochemical studies confirmed the diagnosis of myxoma. Loss of heterozygosity was not present, suggesting that haploinsufficiency alone was responsible for tumorigenesis of this eyelid lesion...
  80. ncbi The first Western-style hospital in China
    Chi Chao Chan
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Arch Ophthalmol 129:791-7. 2011
    ..The first Western-style hospital in China has survived and thrived; it is now one of the most prestigious ophthalmic institutes in the world...
  81. ncbi Ocular pathology of uncommon hematologic malignancies: a case series
    James E Head
    Immunopathology Section, National Institutes of Health, Bethesda, MD, USA
    J Med Case Reports 1:158. 2007
    ..Here we present cases of these two relatively rare hematologic malignancies demonstrating clinical and subclinical ocular involvement...
  82. ncbi Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration
    Robert B Nussenblatt
    The National Eye Institute, Laboratory of Immunology, NIH, Building 10, 10 Center Drive, Bethesda, MD, USA
    J Autoimmun 21:283-93. 2003
    ..These studies suggest that anti-IL-2 receptor blockade could be useful in the treatment of Th1-mediated autoimmune conditions...
  83. ncbi Couching for cataract in China
    Chi Chao Chan
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Surv Ophthalmol 55:393-8. 2010
    ..This procedure is gradually fading away in China. The use of jin pi shu reflects the history, culture, and political transformation of China...
  84. ncbi Mutations in KCNJ13 cause autosomal-dominant snowflake vitreoretinal degeneration
    J Fielding Hejtmancik
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, MD 20892, USA
    Am J Hum Genet 82:174-80. 2008
    ..These results indicate that the KCNJ13 R162W mutation can cause SVD and further show that vitreoretinal degeneration can arise through mutations in genes whose products are not structural components of the vitreous...
  85. ncbi Tumor-specific Th17-polarized cells eradicate large established melanoma
    Pawel Muranski
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Mark O Hatfield Clinical Research Center, Bethesda, MD 20892, USA
    Blood 112:362-73. 2008
    ..This principle should be considered in designing clinical trials involving adoptive transfer-based immunotherapy of human malignancies...
  86. ncbi Primary intraocular lymphoma
    Lisa J Faia
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Arch Pathol Lab Med 133:1228-32. 2009
    ..Flow cytometry, immunohistochemistry, cytokine analysis, and gene rearrangements also aid in the diagnosis. Local and systemic treatments, such as chemotherapy and radiation, are employed, although the relapse rate remains high...
  87. ncbi The future of primary intraocular lymphoma (retinal lymphoma)
    Chi Chao Chan
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20895, USA
    Ocul Immunol Inflamm 17:375-9. 2009
    ..While most of this technology already exists, much work still needs to be done to make translational therapy a reality for PIOL patients in the future...
  88. ncbi Common genetic determinants of uveitis shared with other autoimmune disorders
    Mary J Mattapallil
    Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD 20892, USA
    J Immunol 180:6751-9. 2008
    ..Our results suggest that uveitis shares some of the pathogenic mechanisms associated with other autoimmune diseases, and lends support to the "common gene, common pathway" hypothesis for autoimmune disorders...
  89. ncbi [Ocular manifestations in HIV/AIDS]
    Chi Chao Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Zhonghua Yan Ke Za Zhi 41:563-71. 2005
    ....
  90. ncbi Molecular biomarkers for the diagnosis of primary vitreoretinal lymphoma
    Yujuan Wang
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA E Mails Y W D S V M W
    Int J Mol Sci 12:5684-97. 2011
    ..Moreover, the molecular data corresponded well with the clinical course of the diseases. The sensitivity and specificity of these molecular biomarkers for the diagnosis of PVRL are higher than 95%...
  91. ncbi Corneal pseudomembrane from acute inflammatory response and fibrin formation to acute myeloid leukemic infiltrate
    Shree K Kurup
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Ophthalmol 139:921-3. 2005
    ..To describe an unusual ocular manifestation of a patient with acute myeloid leukemia (AML)...
  92. ncbi X-linked anhidrotic ectodermal dysplasia disruption yields a mouse model for ocular surface disease and resultant blindness
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Am J Pathol 167:89-95. 2005
    ..This can be further tested in Tabby and Tabby-EDA transgenic mice, which provide unique models of severe ocular surface disease...
  93. ncbi International Central Nervous System and Ocular Lymphoma Workshop: recommendations for the future
    Robert B Nussenblatt
    Laboratory of Immunology, National Eye Institute, NIH, 10 Center Drive, Building 10, Room 10S219, Bethesda, MD, 20892, USA
    Ocul Immunol Inflamm 14:139-44. 2006
    ..To bring together multidisciplinary experts to discuss primary central nervous system lymphoma (PCNSL) and primary intraocular lymphoma (PIOL)...
  94. ncbi Hypocellular scar formation or aberrant fibrosis induced by an intrastromal corneal ring: a case report
    Xiaoguang Cao
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    J Med Case Reports 5:398. 2011
    ..abstract:..
  95. ncbi Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: dose-dependent effects on ERG and retinal histology
    Ronald A Bush
    Department of Ophthalmology and Visual Science, Kellogg Eye Center, University of Michigan, Ann Arbor, USA
    Invest Ophthalmol Vis Sci 45:2420-30. 2004
    ..ERG and histologic changes were investigated in normal rabbits after intravitreal implantation of encapsulated cell technology (ECT) devices releasing ciliary neurotrophic factor (CNTF)...
  96. ncbi Republished review: Gene therapy for ocular diseases
    Melissa M Liu
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bldg 10, Rm 10N103, NIH NEI, Bethesda, MD 20895 1857, USA
    Postgrad Med J 87:487-95. 2011
    ..These methodological advancements are critical for the implementation of additional gene-based therapies for human ocular diseases in the near future...
  97. ncbi Human cytomegalovirus induced cyclooxygenase-2 in human retinal pigment epithelial cells augments viral replication through a prostaglandin pathway
    John J Hooks
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Microbes Infect 8:2236-44. 2006
    ..The induction of COX-2 and PGE during retinal CMV infection may augment virus replication and alter a variety of retinal physiological responses...
  98. ncbi Intraocular lymphoma: update on diagnosis and management
    Chi Chao Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Control 11:285-95. 2004
    ..The incidence of this previously rare condition has increased dramatically. Given its nonspecific presentation and aggressive course, PIOL provides a diagnostic and therapeutic challenge...
  99. ncbi Diagnosis and management of primary intraocular lymphoma
    Grace A Levy-Clarke
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 10N112, Bethesda, MD 20892, USA
    Hematol Oncol Clin North Am 19:739-49, viii. 2005
    ..The treatment of PIOL is difficult because of its high recurrence rate and refractory nature. The objective for the future is to improve diagnostic techniques and therapeutic success while minimizing ocular toxicities...
  100. ncbi Gene therapy for ocular diseases
    Melissa M Liu
    Immunopathology Section, Laboratory of Immunology, NIH NEI, Bethesda, MD 20895 1857, USA
    Br J Ophthalmol 95:604-12. 2011
    ..These methodological advancements are critical for the implementation of additional gene-based therapies for human ocular diseases in the near future...
  101. ncbi Primary intraocular lymphoma with a low interleukin 10 to interleukin 6 ratio and heterogeneous IgH gene rearrangement
    R R Buggage
    Laboratory of Immunology and the Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Arch Ophthalmol 117:1239-42. 1999
    ..0. The detection of IgH gene rearrangement heterogeneity in the tumor cells by polymerase chain reaction, a high tumor mitotic figure rate, and the rapid onset of multiple brain lesions suggest an aggressive malignant neoplasm...