Chi Chao Chan
Affiliation: National Institutes of Health
- Chan C, Fisson S, Bodaghi B. The future of primary intraocular lymphoma (retinal lymphoma). Ocul Immunol Inflamm. 2009;17:375-9 pubmed publisher..While most of this technology already exists, much work still needs to be done to make translational therapy a reality for PIOL patients in the future. ..
- Chan C, Liu M, Tsai J. The first Western-style hospital in China. Arch Ophthalmol. 2011;129:791-7 pubmed publisher..The first Western-style hospital in China has survived and thrived; it is now one of the most prestigious ophthalmic institutes in the world. ..
- Chan C, Wallace D. Intraocular lymphoma: update on diagnosis and management. Cancer Control. 2004;11:285-95 pubmed..Future studies are required to determine the role of radiotherapy and optimal local and systemic chemotherapeutic regimens. ..
- Ouyang H, Goldberg J, Chen S, Xu G, Li W, Zhang K, et al. Ocular Stem Cell Research from Basic Science to Clinical Application: A Report from Zhongshan Ophthalmic Center Ocular Stem Cell Symposium. Int J Mol Sci. 2016;17:415 pubmed publisher..The recent Zhongshan Ophthalmic Center Ocular Stem Cell Symposium discussed the potential applications of various stem cell types in stem cell-based therapies, drug discoveries and tissue engineering for treating ocular diseases. ..
- Wang Y, Hanus J, Abu Asab M, Shen D, Ogilvy A, Ou J, et al. NLRP3 Upregulation in Retinal Pigment Epithelium in Age-Related Macular Degeneration. Int J Mol Sci. 2016;17: pubmed publisher..The data suggest that the NLRP3 inflammasome may contribute in AMD pathogenesis. ..
- Chan C, Ross R, Shen D, Ding X, Majumdar Z, Bojanowski C, et al. Ccl2/Cx3cr1-deficient mice: an animal model for age-related macular degeneration. Ophthalmic Res. 2008;40:124-8 pubmed publisher..Decreased ERp29 was found in the retina of DKO mice. A broad spectrum of AMD pathologies with early onset and high penetrance in these mice implicate certain chemokines, A2E and endoplasmic reticulum proteins in AMD pathogenesis. ..
- Chan C, Chew E, Shen D, Hackett J, Zhuang Z. Expression of stem cells markers in ocular hemangioblastoma associated with von Hippel-Lindau (VHL) disease. Mol Vis. 2005;11:697-704 pubmed..To better understand the histogenesis of ocular hemangioblastomas associated with von Hippel-Lindau (VHL) disease...
- Chan C, Tuo J, Bojanowski C, Csaky K, Green W. Detection of CX3CR1 single nucleotide polymorphism and expression on archived eyes with age-related macular degeneration. Histol Histopathol. 2005;20:857-63 pubmed publisher..Our data suggest that the M280 allele, a SNP resulting in aberrant CX3CR1 and CX3CL1 interaction, as well as lowered expression of macular CX3CR1, may contribute to the development of AMD. ..
- Chan C, Smith J, Shen D, Ursea R, LeHoang P, Grossniklaus H. Helicobacter pylori (H. pylori) molecular signature in conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma. Histol Histopathol. 2004;19:1219-26 pubmed publisher..These data suggest that H. pylori may play a role in conjunctival MALT lymphoma...