Chi Chao Chan


Affiliation: National Institutes of Health
Country: USA


  1. Chan C, Rubenstein J, Coupland S, Davis J, Harbour J, Johnston P, et al. Primary vitreoretinal lymphoma: a report from an International Primary Central Nervous System Lymphoma Collaborative Group symposium. Oncologist. 2011;16:1589-99 pubmed publisher
    ..Because of the disease rarity, international, multicenter, collaborative efforts are required to better understand the biology and pathogenesis of PVRL as well as to define both diagnostic markers and optimal therapies. ..
  2. Wang H, Shepard M, Zhang C, Dong L, Walker D, Guedez L, et al. Deletion of the von Hippel-Lindau Gene in Hemangioblasts Causes Hemangioblastoma-like Lesions in Murine Retina. Cancer Res. 2018;78:1266-1274 pubmed publisher
    ..i>Cancer Res; 78(5); 1266-74. ©2018 AACR. ..
  3. Tuo J, Wang Y, Cheng R, Li Y, Chen M, Qiu F, et al. Wnt signaling in age-related macular degeneration: human macular tissue and mouse model. J Transl Med. 2015;13:330 pubmed publisher
  4. Chan C. Couching for cataract in China. Surv Ophthalmol. 2010;55:393-8 pubmed publisher
    ..This procedure is gradually fading away in China. The use of jin pi shu reflects the history, culture, and political transformation of China. ..
  5. Chen S, Chew E, Chan C. Pathology characteristics of ocular von Hippel-Lindau disease with neovascularization of the iris and cornea: a case report. J Med Case Rep. 2015;9:66 pubmed publisher
    ..The present case is unusual because of the co-existing neovascularization in the iris and cornea, which may have led to corneal perforation and vision loss. ..
  6. Chan C, Sen H. Current concepts in diagnosing and managing primary vitreoretinal (intraocular) lymphoma. Discov Med. 2013;15:93-100 pubmed
    ..A professional team of medical experts in ophthalmology, oncology (particularly neuro-oncology), and pathology is essential for optimizing patient management. ..
  7. Tuo J, Shen D, Yang H, Chan C. Distinct microRNA-155 expression in the vitreous of patients with primary vitreoretinal lymphoma and uveitis. Am J Ophthalmol. 2014;157:728-34 pubmed publisher
    ..Primary vitreoretinal B-cell lymphoma and uveitis might be characterized by distinct microRNA signatures. Quantification of ocular microRNA-155 might be helpful in the differential diagnosis of these 2 diseases. ..
  8. Chan C, Ardeljan D. Molecular pathology of macrophages and interleukin-17 in age-related macular degeneration. Adv Exp Med Biol. 2014;801:193-8 pubmed publisher
    ..Targeting of these specific inflammatory pathways and molecules at appropriate times should be explored and may become promising novel adjunct agents to AMD therapy. ..
  9. Chan C, Collins A, Chew E. Molecular pathology of eyes with von Hippel-Lindau (VHL) Disease: a review. Retina. 2007;27:1-7 pubmed
    ..Targeting these proteins and ischemic factors, not VEGF alone, may be a potential therapeutic approach for VHL-associated ocular hemangioblastomas. ..

More Information


  1. Chan C, Fisson S, Bodaghi B. The future of primary intraocular lymphoma (retinal lymphoma). Ocul Immunol Inflamm. 2009;17:375-9 pubmed publisher
    ..While most of this technology already exists, much work still needs to be done to make translational therapy a reality for PIOL patients in the future. ..
  2. Chan C, Liu M, Tsai J. The first Western-style hospital in China. Arch Ophthalmol. 2011;129:791-7 pubmed publisher
    ..The first Western-style hospital in China has survived and thrived; it is now one of the most prestigious ophthalmic institutes in the world. ..
  3. Chan C, Wallace D. Intraocular lymphoma: update on diagnosis and management. Cancer Control. 2004;11:285-95 pubmed
    ..Future studies are required to determine the role of radiotherapy and optimal local and systemic chemotherapeutic regimens. ..
  4. Ouyang H, Goldberg J, Chen S, Xu G, Li W, Zhang K, et al. Ocular Stem Cell Research from Basic Science to Clinical Application: A Report from Zhongshan Ophthalmic Center Ocular Stem Cell Symposium. Int J Mol Sci. 2016;17:415 pubmed publisher
    ..The recent Zhongshan Ophthalmic Center Ocular Stem Cell Symposium discussed the potential applications of various stem cell types in stem cell-based therapies, drug discoveries and tissue engineering for treating ocular diseases. ..
  5. Wang Y, Hanus J, Abu Asab M, Shen D, Ogilvy A, Ou J, et al. NLRP3 Upregulation in Retinal Pigment Epithelium in Age-Related Macular Degeneration. Int J Mol Sci. 2016;17: pubmed publisher
    ..The data suggest that the NLRP3 inflammasome may contribute in AMD pathogenesis. ..
  6. Chan C, Ross R, Shen D, Ding X, Majumdar Z, Bojanowski C, et al. Ccl2/Cx3cr1-deficient mice: an animal model for age-related macular degeneration. Ophthalmic Res. 2008;40:124-8 pubmed publisher
    ..Decreased ERp29 was found in the retina of DKO mice. A broad spectrum of AMD pathologies with early onset and high penetrance in these mice implicate certain chemokines, A2E and endoplasmic reticulum proteins in AMD pathogenesis. ..
  7. Chan C, Chew E, Shen D, Hackett J, Zhuang Z. Expression of stem cells markers in ocular hemangioblastoma associated with von Hippel-Lindau (VHL) disease. Mol Vis. 2005;11:697-704 pubmed
    ..To better understand the histogenesis of ocular hemangioblastomas associated with von Hippel-Lindau (VHL) disease...
  8. Chan C, Tuo J, Bojanowski C, Csaky K, Green W. Detection of CX3CR1 single nucleotide polymorphism and expression on archived eyes with age-related macular degeneration. Histol Histopathol. 2005;20:857-63 pubmed publisher
    ..Our data suggest that the M280 allele, a SNP resulting in aberrant CX3CR1 and CX3CL1 interaction, as well as lowered expression of macular CX3CR1, may contribute to the development of AMD. ..
  9. Chan C, Smith J, Shen D, Ursea R, LeHoang P, Grossniklaus H. Helicobacter pylori (H. pylori) molecular signature in conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma. Histol Histopathol. 2004;19:1219-26 pubmed publisher
    ..These data suggest that H. pylori may play a role in conjunctival MALT lymphoma...