Chi Chao Chan

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint RPE65 is highly uveitogenic in rats
    Don Il Ham
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 10N112, Bethesda, MD 20892 1857, USA
    Invest Ophthalmol Vis Sci 43:2258-63. 2002
  2. pmc Toll-like receptor polymorphisms and age-related macular degeneration: replication in three case-control samples
    Youngeun Cho
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 50:5614-8. 2009
  3. pmc Immunological protein expression profile in Ccl2/Cx3cr1 deficient mice with lesions similar to age-related macular degeneration
    Robert J Ross
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892, USA
    Exp Eye Res 86:675-83. 2008
  4. pmc A double-masked, randomized study to investigate the safety and efficacy of daclizumab to treat the ocular complications related to Behçet's disease
    Ronald R Buggage
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Ocul Immunol Inflamm 15:63-70. 2007
  5. pmc Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition
    Jingsheng Tuo
    Division of Epidemiology and Clinical Research, and Ophthalmic Genetics and Visual Function Branch, Section on Ophthalmic Molecular Genetics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:9256-61. 2006
  6. pmc Evidence for enhanced tissue factor expression in age-related macular degeneration
    Youngeun Cho
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Lab Invest 91:519-26. 2011
  7. pmc Controversial view of a genetically altered mouse model of focal retinal degeneration
    Xi K Chu
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Bioengineered 4:130-5. 2013
  8. pmc Peroxisome proliferator-activated receptor and age-related macular degeneration
    Alexandra A Herzlich
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    PPAR Res 2008:389507. 2008
  9. pmc Ocular manifestations and pathology of adult T-cell leukemia/lymphoma associated with human T-lymphotropic virus type 1
    Melissa M Liu
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Rare Tumors 2:e63. 2010
  10. pmc Autoimmune retinopathy in systemic lupus erythematosus: histopathologic features
    Xiaoguang Cao
    Immunopathology Section, Laboratory of Immunology
    Open Ophthalmol J 3:20-5. 2009

Collaborators

Detail Information

Publications134 found, 100 shown here

  1. ncbi request reprint RPE65 is highly uveitogenic in rats
    Don Il Ham
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 10N112, Bethesda, MD 20892 1857, USA
    Invest Ophthalmol Vis Sci 43:2258-63. 2002
    ..To examine the hypothesis that RPE65, a protein specific to the retinal pigment epithelium, is uveitogenic in rats...
  2. pmc Toll-like receptor polymorphisms and age-related macular degeneration: replication in three case-control samples
    Youngeun Cho
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 50:5614-8. 2009
    ..S. clinic-based case-control study samples and one Australian population-based study sample) were used to further assess the association of the polymorphisms rs3775291 in TLR3 and rs4986790 in TLR4 with AMD...
  3. pmc Immunological protein expression profile in Ccl2/Cx3cr1 deficient mice with lesions similar to age-related macular degeneration
    Robert J Ross
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892, USA
    Exp Eye Res 86:675-83. 2008
    ..Moreover, since human AMD patients show similar immunopathological profiles, these results support the Ccl2(-/-)/Cx3cr1(-/-) as a suitable model for human AMD...
  4. pmc A double-masked, randomized study to investigate the safety and efficacy of daclizumab to treat the ocular complications related to Behçet's disease
    Ronald R Buggage
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Ocul Immunol Inflamm 15:63-70. 2007
    ..To investigate the safety and efficacy of daclizumab (Zenapax, humanized anti-Tac, HAT) in controlling the ocular manifestations of Behçet's disease...
  5. pmc Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition
    Jingsheng Tuo
    Division of Epidemiology and Clinical Research, and Ophthalmic Genetics and Visual Function Branch, Section on Ophthalmic Molecular Genetics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:9256-61. 2006
    ..The strong AMD predisposition conferred by the ERCC6 and CFH SNPs may result from biological epistasis, because ERCC6 functions in universal transcription as a component of RNA pol I transcription complex...
  6. pmc Evidence for enhanced tissue factor expression in age-related macular degeneration
    Youngeun Cho
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Lab Invest 91:519-26. 2011
    ..These results indicate that upregulated TF expression may be associated with AMD, and inflammatory and oxidative stress may contribute to TF expression in AMD eyes...
  7. pmc Controversial view of a genetically altered mouse model of focal retinal degeneration
    Xi K Chu
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Bioengineered 4:130-5. 2013
    ....
  8. pmc Peroxisome proliferator-activated receptor and age-related macular degeneration
    Alexandra A Herzlich
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    PPAR Res 2008:389507. 2008
    ..In addition, PPAR gamma is expressed in RPE, an essential cell in photoreceptor regeneration and vision maintenance. This review summarizes the interactions between PPAR, AMD-related molecules, and AMD-related disease processes...
  9. pmc Ocular manifestations and pathology of adult T-cell leukemia/lymphoma associated with human T-lymphotropic virus type 1
    Melissa M Liu
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Rare Tumors 2:e63. 2010
    ..International collaboration will be needed to better understand the presentation and diagnosis of this rare malignancy...
  10. pmc Autoimmune retinopathy in systemic lupus erythematosus: histopathologic features
    Xiaoguang Cao
    Immunopathology Section, Laboratory of Immunology
    Open Ophthalmol J 3:20-5. 2009
    ..Serum autoantibodies against normal retinal nuclei were detected. These pathological changes represent both known SLE-associated ocular complications as well as possible features of autoimmune retinopathy secondary to SLE...
  11. pmc Pigment epithelium-derived factor reduces apoptosis and pro-inflammatory cytokine gene expression in a murine model of focal retinal degeneration
    Yujuan Wang
    Section of Protein Structure and Function, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, U S A
    ASN Neuro 5:e00126. 2013
    ..Our results establish that PEDF potently stabilizes photoreceptor degeneration via suppression of both apoptotic and inflammatory pathways. The multiple beneficial effects of PEDF represent a novel approach for potential AMD treatment...
  12. ncbi request reprint Molecular pathology of macrophages and interleukin-17 in age-related macular degeneration
    Chi Chao Chan
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, 10 10N103, 20892 1857, Bethesda, MD, USA
    Adv Exp Med Biol 801:193-8. 2014
    ..Targeting of these specific inflammatory pathways and molecules at appropriate times should be explored and may become promising novel adjunct agents to AMD therapy. ..
  13. pmc Genetic mechanisms and age-related macular degeneration: common variants, rare variants, copy number variations, epigenetics, and mitochondrial genetics
    Melissa M Liu
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Hum Genomics 6:13. 2012
    ..The role of these additional mechanisms remains only partly understood, but the importance of their further investigation is clear to elucidate more completely the genetic basis of AMD...
  14. pmc Sympathetic ophthalmia: to the twenty-first century and beyond
    Xi K Chu
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Room 10N103, Bethesda, MD 20892, USA
    J Ophthalmic Inflamm Infect 3:49. 2013
    ....
  15. pmc Current concepts in diagnosing and managing primary vitreoretinal (intraocular) lymphoma
    Chi Chao Chan
    Section on Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Discov Med 15:93-100. 2013
    ..A professional team of medical experts in ophthalmology, oncology (particularly neuro-oncology), and pathology is essential for optimizing patient management...
  16. pmc Autoantibody against transient receptor potential M1 cation channels of retinal ON bipolar cells in paraneoplastic vitelliform retinopathy
    Yujuan Wang
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, NIH NEI, Bethesda, MD 20892 1857, USA
    BMC Ophthalmol 12:56. 2012
    ..This is the first report of anti-transient receptor potential M1 antibody directly against human retinal bipolar dendritic tips in a melanoma patient with paraneoplastic vitelliform retinopathy...
  17. doi request reprint Interview with chi-chao chan
    Chi Chao Chan
    National Eye Institute at National Institutes of Health, 10 Center Drive, 10 10N103, Bethesda, MD 20892 1857, USA
    Future Med Chem 4:2139-40. 2012
    ..Dr Chan spoke to Future Medicinal Chemistry, about the challenges ophthalmic research faces and how the aging population could lead to better drugs. Interview conducted by Isaac Bruce, Commissioning Editor...
  18. ncbi request reprint Application of small molecules/macromolecules in ocular inflammatory diseases
    Baoying Liu
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Antiinflamm Antiallergy Agents Med Chem 11:113-20. 2012
    ..The future direction is to tailor treatments to individual patients in order to provide the safest and most effective therapies for ocular inflammatory diseases...
  19. pmc Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration
    Baoying Liu
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 9:1-12. 2011
    ..Elevated levels of complement activating molecules including complement component 5a (C5a) have been found in the serum of AMD patients. Our aim is to study whether C5a can impact human T cells and its implication in AMD...
  20. pmc A correlation of pregnancy term, disease activity, serum female hormones, and cytokines in uveitis
    C C Chan
    National Eye Institute NIH, Bldg 10, Room 10N103, 10 Center Drive, Bethesda, MD 20892 1857, USA
    Br J Ophthalmol 88:1506-9. 2004
    ..The authors studied ocular inflammation, female hormones, and serum cytokine levels during and after pregnancy...
  21. pmc Ccl2/Cx3cr1-deficient mice: an animal model for age-related macular degeneration
    Chi Chao Chan
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892 1857, USA
    Ophthalmic Res 40:124-8. 2008
    ..Senescent Ccl2-/- mice develop cardinal features of human age-related macular degeneration (AMD). Loss-of-function single-nucleotide polymorphisms within CX3CR1 are associated with AMD...
  22. pmc Intraocular lymphoma: update on diagnosis and management
    Chi Chao Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Control 11:285-95. 2004
    ..The incidence of this previously rare condition has increased dramatically. Given its nonspecific presentation and aggressive course, PIOL provides a diagnostic and therapeutic challenge...
  23. pmc Murine model of primary intraocular lymphoma
    Chi Chao Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Invest Ophthalmol Vis Sci 46:415-9. 2005
    ..The current study was conducted to develop a new experimental model for PIOL...
  24. pmc Molecular pathology of eyes with von Hippel-Lindau (VHL) Disease: a review
    Chi Chao Chan
    National Eye Institute, National Institutes of Health, Bethesda 20892 1857, USA
    Retina 27:1-7. 2007
    ..von Hippel-Lindau Disease (VHL) is an autosomal dominant inherited systemic cancer syndrome. Recently, many advances have contributed to the understanding of VHL pathophysiology...
  25. pmc Ocular pathology of uncommon hematologic malignancies: a case series
    James E Head
    Immunopathology Section, National Institutes of Health, Bethesda, MD, USA
    J Med Case Reports 1:158. 2007
    ..Here we present cases of these two relatively rare hematologic malignancies demonstrating clinical and subclinical ocular involvement...
  26. pmc Detection of CX3CR1 single nucleotide polymorphism and expression on archived eyes with age-related macular degeneration
    C C Chan
    National Eye Institute, National Institutes of Health, Bldg 10, 10 Center Drive, Bethesda, MD 20895, USA
    Histol Histopathol 20:857-63. 2005
    ..Our data suggest that the M280 allele, a SNP resulting in aberrant CX3CR1 and CX3CL1 interaction, as well as lowered expression of macular CX3CR1, may contribute to the development of AMD...
  27. ncbi request reprint [Ocular manifestations in HIV/AIDS]
    Chi Chao Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Zhonghua Yan Ke Za Zhi 41:563-71. 2005
    ....
  28. pmc Expression of stem cells markers in ocular hemangioblastoma associated with von Hippel-Lindau (VHL) disease
    Chi Chao Chan
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Mol Vis 11:697-704. 2005
    ..To better understand the histogenesis of ocular hemangioblastomas associated with von Hippel-Lindau (VHL) disease...
  29. pmc Helicobacter pylori (H. pylori) molecular signature in conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma
    C C Chan
    National Eye Institute NIH, Bethesda, MD 20892 1857, USA
    Histol Histopathol 19:1219-26. 2004
    ..These data suggest that H. pylori may play a role in conjunctival MALT lymphoma...
  30. ncbi request reprint Congenital iridocorneal malformation in Rieger syndrome
    Chi Chao Chan
    NIH NEI, Bethesda, MD 20892 1857, USA
    Arch Ophthalmol 121:582-3. 2003
  31. pmc Primary vitreoretinal lymphoma: a report from an International Primary Central Nervous System Lymphoma Collaborative Group symposium
    Chi Chao Chan
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Oncologist 16:1589-99. 2011
    ..Because of the disease rarity, international, multicenter, collaborative efforts are required to better understand the biology and pathogenesis of PVRL as well as to define both diagnostic markers and optimal therapies...
  32. pmc Hypocellular scar formation or aberrant fibrosis induced by an intrastromal corneal ring: a case report
    Xiaoguang Cao
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    J Med Case Reports 5:398. 2011
    ..abstract:..
  33. pmc The first Western-style hospital in China
    Chi Chao Chan
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Arch Ophthalmol 129:791-7. 2011
    ..The first Western-style hospital in China has survived and thrived; it is now one of the most prestigious ophthalmic institutes in the world...
  34. pmc Couching for cataract in China
    Chi Chao Chan
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Surv Ophthalmol 55:393-8. 2010
    ..This procedure is gradually fading away in China. The use of jin pi shu reflects the history, culture, and political transformation of China...
  35. pmc The future of primary intraocular lymphoma (retinal lymphoma)
    Chi Chao Chan
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20895, USA
    Ocul Immunol Inflamm 17:375-9. 2009
    ..While most of this technology already exists, much work still needs to be done to make translational therapy a reality for PIOL patients in the future...
  36. ncbi request reprint Interphotoreceptor retinoid-binding protein (IRBP)-deficient C57BL/6 mice have enhanced immunological and immunopathogenic responses to IRBP and an altered recognition of IRBP epitopes
    Dody Avichezer
    Laboratory of Immunology, Section of Immunoregulation, National Institutes of Health, 10 Center Drive, 10 10N222, Bethesda, MD 20892 1857, USA
    J Autoimmun 21:185-94. 2003
    ..Furthermore, endogenous expression of IRBP is directly responsible for lowering the threshold of susceptibility to uveitic disease...
  37. pmc Altered chemokine profile associated with exacerbated autoimmune pathology under conditions of genetic interferon-gamma deficiency
    Shao Bo Su
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 48:4616-25. 2007
    ..The present study was conducted to explore the differential expression of chemokine(s) likely to account for the distinct inflammatory cell composition in uveitic eyes of WT and GKO mice...
  38. ncbi request reprint Methimazole protects from experimental autoimmune uveitis (EAU) by inhibiting antigen presenting cell function and reducing antigen priming
    Peng Wang
    Laboratory of Immunology, NEI NIH, 10 Center Drive, Bethesda, MD 20892, USA
    J Leukoc Biol 73:57-64. 2003
    ..We suggest that MMI inhibits EAU at least in part by preventing the recruitment and/or maturation of APC, resulting in reduced generation of Ag-specific T cells...
  39. pmc Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due to reduced T cell priming and inhibition of disease effector mechanisms
    Rajeev K Agarwal
    The Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 180:5423-9. 2008
    ....
  40. pmc The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration
    Jingsheng Tuo
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    FASEB J 18:1297-9. 2004
    ..Our data suggest that a decrease, caused by sequence variation and/or lower CX3CR1 expression, in CX3CR1-induced cellular activities could contribute to AMD development...
  41. ncbi request reprint Suppression of immune-mediated ocular inflammation in mice by interleukin 1 receptor antagonist administration
    Wee Kiak Lim
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Ophthalmol 123:957-63. 2005
    ..To evaluate the effects of an interleukin 1 receptor antagonist (IL-1RA) on the development of immune-mediated ocular inflammation in mice...
  42. ncbi request reprint Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: initial encounter with autoantigen defines disease phenotype
    Jun Tang
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 178:5578-87. 2007
    ..These findings may shed new light on the complex biology and the heterogeneous nature of human uveitis, and provide an alternative model for uveitic diseases of immune origin...
  43. pmc Differentially expressed genes in MHC-compatible rat strains that are susceptible or resistant to experimental autoimmune uveitis
    Mary J Mattapallil
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 49:1957-70. 2008
    ..The primary objective of this study was to identify the non-MHC genes involved in the pathogenesis of EAU, to identify potential drug targets and possibly to target their protein products for immunotherapy...
  44. ncbi request reprint Dissociating the enhancing and inhibitory effects of pertussis toxin on autoimmune disease
    Shao Bo Su
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 171:2314-9. 2003
    ..Our results suggest that PT-B is largely responsible for the disease-enhancing properties of PT...
  45. ncbi request reprint Pertussis toxin is superior to TLR ligands in enhancing pathogenic autoimmunity, targeted at a neo-self antigen, by triggering robust expansion of Th1 cells and their cytokine production
    Chiaki Fujimoto
    Laboratory of Immunology, National Eye Institute, National Institute of Health, Bethesda, MD 20892 1857, USA
    J Immunol 177:6896-903. 2006
    ....
  46. pmc Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration
    Jingsheng Tuo
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 48:3827-36. 2007
    ..Loss-of-function single-nucleotide polymorphisms within CX3CR1 are also found to be associated with AMD. The authors generated Ccl2(-/-)/Cx3cr1(-/-) mice to establish a more characteristic and reproducible AMD model...
  47. pmc Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration
    Xiaoyan Ding
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 50:4957-66. 2009
    ....
  48. pmc Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity
    Rafael S Grajewski
    Laboratory of Immunology, National Eye Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:851-6. 2006
    ..Our data also provide the first evidence that generation of specific T reg cells to a native autoantigen in a mouse with a diverse T cell repertoire requires a cognate interaction...
  49. pmc Repertoire analysis and new pathogenic epitopes of IRBP in C57BL/6 (H-2b) and B10.RIII (H-2r) mice
    Lizette M Cortes
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 49:1946-56. 2008
    ..The purpose of this study was to identify and characterize additional uveitogenic epitopes in B10.RIII and C57BL/6 mice and to compare epitope recognition in wild-type versus IRBP-deficient mice on both backgrounds...
  50. ncbi request reprint Effect of sex hormones on experimental autoimmune uveoretinitis (EAU)
    Ronald R Buggage
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Immunol Invest 32:259-73. 2003
    ..We evaluated the effect of estrogen, progesterone, and testosterone in autoimmune uveoretinitis (EAU), a rodent model of human ocular autoimmune disease...
  51. pmc The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice
    Xiaoguang Cao
    Immunopathology Section, Laboratory of Immunology National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Exp Eye Res 91:15-25. 2010
    ..However, quercetin (25 mg/kg/day) does not improve the retinal AMD-like lesions in the Ccl2(-/-)/Cx3cr1(-/-) mice, likely due to its insufficient suppression of the inflammatory and apoptosis pathways in the eye...
  52. pmc Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category
    Dror Luger
    Laboratory of Immunology, National Eye Institute NEI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 205:799-810. 2008
    ..These data also raise the possibility that the nonredundant requirement for IL-23 in EAU may extend beyond its role in promoting the Th17 effector response and help provide a balance in the current Th1 versus Th17 paradigm...
  53. pmc An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms
    Dody Avichezer
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1665-76. 2003
    ..Thus, uveitis-susceptible individuals display a detectable and functionally significant tolerance to their target antigen, in which central mechanisms play a prominent role...
  54. ncbi request reprint Inflammatory processes triggered by TCR engagement or by local cytokine expression: differences in profiles of gene expression and infiltrating cell populations
    Hiroshi Takase
    Laboratory of Immunology, National Eye Institute, NIH, Building 10, 10 Center Drive, Bethesda, MD 20892 1857, USA
    J Leukoc Biol 80:538-45. 2006
    ....
  55. ncbi request reprint Pertussis toxin alters the innate and the adaptive immune responses in a pertussis-dependent model of autoimmunity
    Rajeev K Agarwal
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, 10 10N222, Bethesda, MD 20892 1857, USA
    J Neuroimmunol 129:133-40. 2002
    ....
  56. ncbi request reprint The level of thymic expression of RPE65 inversely correlates with its capacity to induce experimental autoimmune uveitis (EAU) in different rodent strains
    Don Il Ham
    Laboratory of Immunology, National Eye Institute, National Institute of Health, Bethesda, MD 20892 1857, USA
    Exp Eye Res 83:897-902. 2006
    ....
  57. ncbi request reprint Central immunotolerance in transgenic mice expressing a foreign antigen under control of the rhodopsin promoter
    Don Il Ham
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 45:857-62. 2004
    ..The present study was aimed at analyzing the state of tolerance in Tg mice expressing hen egg lysozyme (HEL) under control of the rhodopsin promoter...
  58. ncbi request reprint Tgf-beta inhibits activation and uveitogenicity of primary but not of fully polarized retinal antigen-specific memory-effector T cells
    Hui Xu
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 44:4805-12. 2003
    ..TGF-beta exerts suppressive effects on immunity, but its potential applications in therapy of ocular autoimmunity have not been widely explored. In the present study, the effects of TGF-beta on uveitogenic T cells were examined...
  59. ncbi request reprint Constitutive and cytokine-induced GITR ligand expression on human retinal pigment epithelium and photoreceptors
    Ben J Kim
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 45:3170-6. 2004
    ..The current study was conducted to examine the expression of glucocorticoid-induced TNF-related receptor ligand (GITRL) and its regulation by ocular tissue...
  60. pmc Constancy of ERp29 expression in cultured retinal pigment epithelial cells in the Ccl2/Cx3cr1 deficient mouse model of age-related macular degeneration
    Varun Verma
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Curr Eye Res 33:701-7. 2008
    ....
  61. ncbi request reprint Induction of ocular inflammation by T-helper lymphocytes type 2
    Stephen J Kim
    Laboratory of Immunology, Laboratory of Molecular and Developmental Biology, National Eye Institute NIH, 10 Center Drive, Room 10N112, Bethesda, MD 20892 1857, USA
    Invest Ophthalmol Vis Sci 43:758-65. 2002
    ..In the present study, the capacity of Th1 and Th2 cells to induce ocular inflammation was examined...
  62. pmc A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice
    Giuseppina Pennesi
    Laboratory of Immunology, National Eye Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    J Clin Invest 111:1171-80. 2003
    ..Thus, EAU in HLA TG mice offers a new model of uveitis that should represent human disease more faithfully than currently existing models...
  63. pmc CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells
    Paul A Antony
    Division of Surgery, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:2591-601. 2005
    ..These findings reveal that Th cells can help break tolerance to a persisting self-Ag and treat established tumors through an IL-2-dependent mechanism, but requires simultaneous absence of naturally occurring T(reg) cells to be effective...
  64. pmc Hydrodynamic vaccination with DNA encoding an immunologically privileged retinal antigen protects from autoimmunity through induction of regulatory T cells
    Phyllis B Silver
    Laboratory of Immunology, National Eye Institute, National Institutes of Health Bethesda, MD 20892 1857, USA
    J Immunol 179:5146-58. 2007
    ..DNA vaccination may offer a new approach to Ag-specific therapy of uveitis...
  65. pmc Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen
    Reiko Horai
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    J Autoimmun 44:21-33. 2013
    ....
  66. pmc Macrophage polarization in the maculae of age-related macular degeneration: a pilot study
    Xiaoguang Cao
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, USA
    Pathol Int 61:528-35. 2011
    ..The number of M2 macrophages was increased compared to M1 macrophages in normal aging eyes. A pathological shift of macrophage polarization may play a potential role in AMD pathogenesis...
  67. pmc Detection of Helicobacter pylori and Chlamydia pneumoniae genes in primary orbital lymphoma
    Chi Chao Chan
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Trans Am Ophthalmol Soc 104:62-70. 2006
    ..We examined the molecular signatures of H pylori and Chlamydia in eight orbital lymphomas...
  68. ncbi request reprint The immunomodulator vasoactive intestinal peptide (VIP) does not affect experimental autoimmune uveitis (EAU) in B10.RIII mice
    Jun Chen
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Ocul Immunol Inflamm 13:13-7. 2005
    ..In this study, we investigated the effects of VIP treatment on the induction of experimental autoimmune uveoretinitis (EAU)...
  69. pmc An apolipoprotein E variant may protect against age-related macular degeneration through cytokine regulation
    Christine M Bojanowski
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Environ Mol Mutagen 47:594-602. 2006
    ..These results further confirm the association between ApoE112R and a decreased risk of AMD development. The underlying mechanisms may involve differential regulation of both CCL2 and VEGF by the ApoE isoforms...
  70. ncbi request reprint Inflammatory mediators in uveitis: differential induction of cytokines and chemokines in Th1- versus Th2-mediated ocular inflammation
    Ellen F Foxman
    National Eye Institute, National Institutes of Health, 10 Center Drive, Building 10, Rm 10N112, Bethesda, MD 20892, USA
    J Immunol 168:2483-92. 2002
    ..These data underscore the multiplicity of mediators that participate in the pathogenesis of eye inflammation and point to upstream cytokines as potential therapeutic targets...
  71. ncbi request reprint Disruption of CD40/CD40-ligand interactions in a retinal autoimmunity model results in protection without tolerance
    Lee M Bagenstose
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:124-30. 2005
    ..Taken together, our data suggest that ongoing CD40/CD40L blockade might be required to maintain a therapeutic effect against uveitis...
  72. ncbi request reprint A unique pattern of up- and down-regulation of chemokine receptor CXCR3 on inflammation-inducing Th1 cells
    Jun Chen
    National Eye Institute, NIH, Bethesda, MD 20892, USA
    Eur J Immunol 34:2885-94. 2004
    ....
  73. pmc Human HtrA1 in the archived eyes with age-related macular degeneration
    Chi Chao Chan
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Trans Am Ophthalmol Soc 105:92-7; discussion 97-8. 2007
    ..The SNP is located in the regulatory region and increases production of HtrA1 protein. This study investigates HtrA1 expression and SNP genotypes in archived ocular slides with AMD...
  74. ncbi request reprint Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity
    Shao Bo Su
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:6303-10. 2005
    ..In contrast, signaling through the IL-1R plays a necessary and nonredundant role in EAU and can by itself account for the lack of EAU development in MyD88 mice...
  75. pmc The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples
    Robert J Ross
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Invest Ophthalmol Vis Sci 48:1128-32. 2007
    ..S. clinic-based case-control studies...
  76. ncbi request reprint Survival of donor epithelial cells after limbal stem cell transplantation
    Ali R Djalilian
    National Eye Institute, National Institutes of Health, Building 10, Room 10N112, 10 Center Drive, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 46:803-7. 2005
    ..To determine the long-term fate of donor epithelial cells after limbal allograft transplantation...
  77. pmc Nutrient supplementation with n3 polyunsaturated fatty acids, lutein, and zeaxanthin decrease A2E accumulation and VEGF expression in the retinas of Ccl2/Cx3cr1-deficient mice on Crb1rd8 background
    Hema L Ramkumar
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    J Nutr 143:1129-35. 2013
    ..Xanthophylls and LCPUFAs have antiinflammatory, neuroprotective, and antiangiogenic properties. Our data provide potential mechanisms by which the AREDS2 formula has a protective effect on retinal lesions in DKO mice. ..
  78. ncbi request reprint Complement deposits on ocular tissues adjacent to sites of inflammation
    Vanessa Montalvo
    Laboratory of Immunology, National Eye Institute, NIH, Bethesda, Maryland 20892 1857, USA
    Curr Eye Res 32:917-22. 2007
    ..The complement system plays important roles in a variety of chronic ocular diseases such as age-related macular degeneration. Here we examined the deposition of complement components in mouse eyes damaged by various mechanisms...
  79. pmc Naloxone ameliorates retinal lesions in Ccl2/Cx3cr1 double-deficient mice via modulation of microglia
    DeFen Shen
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 52:2897-904. 2011
    ..The authors evaluated the effects of naloxone on Ccl2(-/-)/Cx3cr1(-/-) (DKO) mice, a murine model of age-related macular degeneration (AMD)...
  80. ncbi request reprint Serum inflammatory markers in diabetic retinopathy
    Annal D Meleth
    Howard Hughes Medical Institute, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 46:4295-301. 2005
    ..To evaluate the association of serum factors with the severity of diabetic retinopathy and to assess their presence in retinal tissue obtained at autopsy...
  81. ncbi request reprint Cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma: a new cause of uveitis
    Michael R Robinson
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1863, USA
    J Immunother 27:478-9. 2004
    ..This suggests that CTLA-4 is an important regulatory molecule for maintenance of tolerance to melanosomal antigens and prevention of uveitis...
  82. pmc Ocular clusterin expression in von Hippel-Lindau disease
    Min Zhou
    National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Mol Vis 13:2129-36. 2007
    ..Decreased clusterin secretion has been reported in renal cell carcinoma associated with VHL disease. The purpose of this study was to investigate ocular clusterin expression in VHL disease...
  83. pmc Both Th1 and Th17 are immunopathogenic but differ in other key biological activities
    Catherine A Cox
    Laboratory of Immunology, National Eye Institute, National Institute of Health, Bethesda, MD 20892, USA
    J Immunol 180:7414-22. 2008
    ..These data reveal that Th1 and Th17 cells differ in several key biological activities influencing migration and pathogenic behavior during inflammatory disease...
  84. pmc The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples
    Jingsheng Tuo
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Ophthalmology 115:1891-8. 2008
    ..To assess the association and combined effect on the risk of age-related macular degeneration (AMD) by the HtrA1 and complement factor H (CFH) polymorphisms, smoking, and serum cholesterol...
  85. pmc Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses
    Rafael S Grajewski
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:4791-7. 2008
    ..These data suggest that pharmacological activation of iNKT cells protects from EAU at least in part by a mechanism involving innate production of IFN-gamma and a consequent dampening of the Th1 as well as the Th17 effector responses...
  86. pmc Autoreactive memory CD4+ T lymphocytes that mediate chronic uveitis reside in the bone marrow through STAT3-dependent mechanisms
    Hyun Mee Oh
    Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 187:3338-46. 2011
    ....
  87. pmc Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells
    Mary J Mattapallil
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 187:1977-85. 2011
    ....
  88. pmc Copy number variations in candidate genes in neovascular age-related macular degeneration
    Melissa M Liu
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Invest Ophthalmol Vis Sci 52:3129-35. 2011
    ..Copy number variation (CNV), or variation in the number of copies of a particular segment of DNA, may also contribute to AMD pathogenesis. This study evaluated CNVs in candidate genes that have been reported to be linked to AMD...
  89. pmc Detection of the bcl-2 t(14;18) translocation and proto-oncogene expression in primary intraocular lymphoma
    Dana J Wallace
    Laboratory of Immunology, Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20895 1857, USA, and Department of Ophthalmology, Tokyo Medical and Dental University, Japan
    Invest Ophthalmol Vis Sci 47:2750-6. 2006
    ..This study examined the expression of the bcl-2 t(14;18) translocation, the bcl-10 gene, and high expression of bcl-6 mRNA in PIOL cells...
  90. ncbi request reprint MCP-1 expression in endotoxin-induced uveitis
    Nadine Tuaillon
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bldg 10 Room 10 N 103, 10 Center Drive, Bethesda, MD 20892 1857, USA
    Invest Ophthalmol Vis Sci 43:1493-8. 2002
    ....
  91. pmc LX211 (voclosporin) suppresses experimental uveitis and inhibits human T cells
    Matthew A Cunningham
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 50:249-55. 2009
    ..To test the therapeutic effectiveness of voclosporin against experimental autoimmune uveoretinitis (EAU) in rats and to evaluate its effect on human T cells...
  92. pmc Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model
    Jingsheng Tuo
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    J Neuroinflammation 9:59. 2012
    ..In this study, we evaluated the effect of an intravitreous injection of recombinant TSG-6 on the retinal lesions of Ccl2-/-/Cx3cr1-/- mice...
  93. pmc Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinal autoimmunity by inducing type 2 and regulatory T cells
    Lizette M Cortes
    Laboratory of Immunoregulation, National Eye Institute, National Institute of Health, 10 Center Drive, 10 10N222, Bethesda, MD 20893 1857, USA
    J Leukoc Biol 84:577-85. 2008
    ..Thus, IPA pretreatment prevents induction of EAU by skewing the response to a subsequent uveitogenic challenge with the native peptide to a nonpathogenic phenotype, as well as by eliciting transferable regulatory cells...
  94. pmc Suppressor of cytokine signaling-1 (SOCS1) inhibits lymphocyte recruitment into the retina and protects SOCS1 transgenic rats and mice from ocular inflammation
    Cheng Rong Yu
    Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 52:6978-86. 2011
    ..The purpose of this study was to investigate the role of SOCS1 in intraocular inflammatory diseases (uveitis) and whether SOCS1 expression is defective in patients with ocular inflammatory diseases...
  95. ncbi request reprint Expression of chemokine receptors, CXCR4 and CXCR5, and chemokines, BLC and SDF-1, in the eyes of patients with primary intraocular lymphoma
    Chi Chao Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bldg 10, Rm 10N103, 90 Center Drive, Bethesda, MD 20892 1857, USA
    Ophthalmology 110:421-6. 2003
    ..We investigated the expression of these chemokine/chemokine receptors in eyes with primary intraocular B-cell lymphoma (PIOL)...
  96. pmc Analysis of ocular hypopigmentation in Rab38cht/cht mice
    Brian P Brooks
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 48:3905-13. 2007
    ..To characterize the ocular phenotype resulting from mutation of Rab38, a candidate gene for Hermansky-Pudlak syndrome...
  97. pmc Inflammatory cytokine and chemokine expression in sympathetic ophthalmia: a pilot study
    Emiko Furusato
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Washington, DC, USA
    Histol Histopathol 26:1145-51. 2011
    ..Our data indicate for the first time that M1 macrophages are the predominant inflammatory cells within granulomas and DFN of SO. We further observed high levels of IL-17 within granulomas and the presence of Th1 and M1 cells...
  98. pmc Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers
    Andrea Boni
    Clinical Research Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 112:4746-54. 2008
    ..Taken together, these data indicate that the use of tumor-specific allogeneic CD8(+) T cells or CD4(+) can result in significant antitumor effects in the absence of measurable GVHD...