J A Chalela

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Rising statin use and effect on ischemic stroke outcome
    Sung Sug Yoon
    Stroke Neuroscience Unit, NINDS NIH, Bethesda, MD 20892, USA
    BMC Med 2:4. 2004
  2. ncbi request reprint Magnetic resonance imaging in the evaluation of intracranial hemorrhage
    Julio A Chalela
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Expert Rev Neurother 4:267-73. 2004
  3. ncbi request reprint Reversal of perfusion and diffusion abnormalities after intravenous thrombolysis for a lacunar infarction
    Julio A Chalela
    National Institutes of Health, National Institute of Neurological Disorders and Stroke, Section on Stroke Diagnostics and Therapeutics, 10 Center Drive, Room B1D733, MSC 1063, Bethesda, MD 20892 4129, USA
    J Neuroimaging 13:152-4. 2003
  4. ncbi request reprint Multiple cerebral microbleeds: MRI marker of a diffuse hemorrhage-prone state
    Julio A Chalela
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Room B1D733, MSC 1063, Bethesda, MD 20892 1063, USA
    J Neuroimaging 14:54-7. 2004
  5. ncbi request reprint Continuous arterial spin labeling perfusion magnetic resonance imaging findings in postpartum vasculopathy
    J A Chalela
    Department of Neurology, Hospital of the University of Pennsylvania, USA
    J Neuroimaging 11:444-6. 2001
  6. ncbi request reprint Acute stroke patients are being underfed: a nitrogen balance study
    Julio A Chalela
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neurocrit Care 1:331-4. 2004
  7. ncbi request reprint Induced hypertension improves cerebral blood flow in acute ischemic stroke
    Julio A Chalela
    Stroke Diagnostics and Therapeutics Section, NINDS NIH, 10 Center Dr, Room B1D733, MSC 1063, Bethesda, MD 20892, USA
    Neurology 64:1979. 2005
  8. ncbi request reprint Safety of intra-arterial thrombolysis in the postoperative period
    J A Chalela
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Stroke 32:1365-9. 2001
  9. ncbi request reprint MRI identification of early white matter injury in anoxic-ischemic encephalopathy
    J A Chalela
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neurology 56:481-5. 2001
  10. ncbi request reprint Early magnetic resonance imaging findings in patients receiving tissue plasminogen activator predict outcome: Insights into the pathophysiology of acute stroke in the thrombolysis era
    Julio A Chalela
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Ann Neurol 55:105-12. 2004

Detail Information

Publications34

  1. pmc Rising statin use and effect on ischemic stroke outcome
    Sung Sug Yoon
    Stroke Neuroscience Unit, NINDS NIH, Bethesda, MD 20892, USA
    BMC Med 2:4. 2004
    ..The aim of this study was to determine if patients taking statins before hospital admission for stroke had an improved clinical outcome...
  2. ncbi request reprint Magnetic resonance imaging in the evaluation of intracranial hemorrhage
    Julio A Chalela
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Expert Rev Neurother 4:267-73. 2004
    ..In the era of acute stroke intervention, magnetic resonance imaging offers significant advantages over computed tomography...
  3. ncbi request reprint Reversal of perfusion and diffusion abnormalities after intravenous thrombolysis for a lacunar infarction
    Julio A Chalela
    National Institutes of Health, National Institute of Neurological Disorders and Stroke, Section on Stroke Diagnostics and Therapeutics, 10 Center Drive, Room B1D733, MSC 1063, Bethesda, MD 20892 4129, USA
    J Neuroimaging 13:152-4. 2003
    ..This case suggests that perfusion and diffusion MRI may be informative in patients with lacunar infarction who are candidates for thrombolysis...
  4. ncbi request reprint Multiple cerebral microbleeds: MRI marker of a diffuse hemorrhage-prone state
    Julio A Chalela
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Room B1D733, MSC 1063, Bethesda, MD 20892 1063, USA
    J Neuroimaging 14:54-7. 2004
    ..Recent reports have indicated that cerebral microbleeds (CMBs) detected on gradient-echo (GRF) magnetic resonance imaging may be a risk factor for therapy related intracranial hemorrhages (ICHs)...
  5. ncbi request reprint Continuous arterial spin labeling perfusion magnetic resonance imaging findings in postpartum vasculopathy
    J A Chalela
    Department of Neurology, Hospital of the University of Pennsylvania, USA
    J Neuroimaging 11:444-6. 2001
    ..Although angiography often reveals diffuse arterial narrowing, the CBF values encountered in this study do not support a state of generalized or focal oligoemia. Vasomotor tone may change intermittently in patients with PPV...
  6. ncbi request reprint Acute stroke patients are being underfed: a nitrogen balance study
    Julio A Chalela
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neurocrit Care 1:331-4. 2004
    ..We sought to assess nitrogen balance in patients with acute stroke and to determine the variables associated with negative nitrogen balance...
  7. ncbi request reprint Induced hypertension improves cerebral blood flow in acute ischemic stroke
    Julio A Chalela
    Stroke Diagnostics and Therapeutics Section, NINDS NIH, 10 Center Dr, Room B1D733, MSC 1063, Bethesda, MD 20892, USA
    Neurology 64:1979. 2005
  8. ncbi request reprint Safety of intra-arterial thrombolysis in the postoperative period
    J A Chalela
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Stroke 32:1365-9. 2001
    ..However, IAT may increase the risk of surgical bleeding. We sought to determine the safety of postoperative IAT...
  9. ncbi request reprint MRI identification of early white matter injury in anoxic-ischemic encephalopathy
    J A Chalela
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neurology 56:481-5. 2001
    ..The authors describe the MRI findings in seven patients with AIE who demonstrate early preferential involvement of the white matter...
  10. ncbi request reprint Early magnetic resonance imaging findings in patients receiving tissue plasminogen activator predict outcome: Insights into the pathophysiology of acute stroke in the thrombolysis era
    Julio A Chalela
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Ann Neurol 55:105-12. 2004
    ..We propose MTT lesion volume decrease more than 30% 2 hours after tPA as an early marker of long-term clinical benefit of thrombolytic therapy...
  11. ncbi request reprint Safety of air medical transportation after tissue plasminogen activator administration in acute ischemic stroke
    J A Chalela
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Stroke 30:2366-8. 1999
    ..The safety of AMT of patients with AIS after or during administration of tPA has not been examined...
  12. ncbi request reprint Reliability and validity of estimating the NIH stroke scale score from medical records
    S E Kasner
    Department of Neurology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Stroke 30:1534-7. 1999
    ..Recently, retrospective observational studies have estimated NIHSS scores from medical records for quantitative outcome analysis. The reliability and validity of estimation based on chart review has not been determined...
  13. ncbi request reprint Predictors of fatal brain edema in massive hemispheric ischemic stroke
    S E Kasner
    University of Pennsylvania, Department of Neurology, Philadelphia, PA, USA
    Stroke 32:2117-23. 2001
    ..Prior studies suggested that early nausea/vomiting and major hypodensity on baseline computed tomography (CT) were predictive of herniation...
  14. ncbi request reprint Aphemia: an isolated disorder of articulation
    R J Fox
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Clin Neurol Neurosurg 103:123-6. 2001
    ..This case suggests that aphemia can occur as an isolated articulation deficit without language involvement or more widespread bulbar apraxia, and may be a severe form of apraxia of speech...
  15. ncbi request reprint Early and late recurrence of ischemic lesion on MRI: evidence for a prolonged stroke-prone state?
    D W Kang
    Stroke Branch, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1063, USA
    Neurology 63:2261-5. 2004
    ....
  16. ncbi request reprint The association between neurological deficit in acute ischemic stroke and mean transit time: comparison of four different perfusion MRI algorithms
    Peter D Schellinger
    Section on Stroke Diagnostics and Therapeutics, NINDS, NIH, Bethesda, MD 20892, USA
    Neuroradiology 48:69-77. 2006
    ..Larger sample sizes which allow comparison between imaging and clinical outcomes are needed to refine the choice of best perfusion parameter in pMRI...
  17. ncbi request reprint CT-NIHSS mismatch does not correlate with MRI diffusion-perfusion mismatch
    Steven R Messe
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Stroke 38:2079-84. 2007
    ..However, MRI has limited availability in many hospitals. We investigated whether mismatch between the Alberta Stroke Program Early CT Score (ASPECTS) and the NIH Stroke Scale (NIHSS) correlates with MRI diffusion-perfusion mismatch...
  18. pmc The safety and efficacy of thrombolysis for strokes after cardiac catheterization
    Pooja Khatri
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267 0525, USA
    J Am Coll Cardiol 51:906-11. 2008
    ..The purpose of this study was to systematically compare clinical outcomes of patients treated with thrombolysis with those without treatment in a multi-year, multicenter cohort of strokes after cardiac catheterization...
  19. ncbi request reprint MRI screening before standard tissue plasminogen activator therapy is feasible and safe
    Dong Wha Kang
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892 1063, USA
    Stroke 36:1939-43. 2005
    ..We hypothesized that times to treatment and outcomes in a stroke center with immediate MRI access and interpretation would not differ from those of the typical clinical practice...
  20. pmc Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison
    Julio A Chalela
    Medical University of South Carolina, Charleston, SC, USA
    Lancet 369:293-8. 2007
    ..We aimed to prospectively compare CT and MRI for emergency diagnosis of acute stroke...
  21. ncbi request reprint Diagnostic and prognostic value of early MR Imaging vessel signs in hyperacute stroke patients imaged <3 hours and treated with recombinant tissue plasminogen activator
    Peter D Schellinger
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    AJNR Am J Neuroradiol 26:618-24. 2005
    ..We assessed the diagnostic and prognostic strength of early MR imaging vessel signs in AIS patients treated with intravenous thrombolysis (IVT) within 3 hours of the onset of symptoms...
  22. ncbi request reprint Early ischemic lesion recurrence within a week after acute ischemic stroke
    Dong Wha Kang
    Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1063, USA
    Ann Neurol 54:66-74. 2003
    ..026). These results may indicate a prolonged state of increased ischemic risk over the first week and suggest DWI as a possible surrogate measure for recurrent stroke...
  23. ncbi request reprint Association of ischemic lesion patterns on early diffusion-weighted imaging with TOAST stroke subtypes
    Dong Wha Kang
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1063, USA
    Arch Neurol 60:1730-4. 2003
    ..Different topographic patterns in patients who experience an acute ischemic stroke may be related to specific stroke causes...
  24. ncbi request reprint Update on stroke
    Julio A Chalela
    Section on Stroke Diagnosis and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Opin Neurol 17:447-51. 2004
    ..This review highlights some advances in the areas of epidemiology, therapy, and imaging of acute stroke...
  25. ncbi request reprint Comparison of MRI and CT for detection of acute intracerebral hemorrhage
    Chelsea S Kidwell
    UCLA Stroke Center, Los Angeles, Calif, USA
    JAMA 292:1823-30. 2004
    ..However, the accuracy of MRI relative to CT for the detection of hyperacute intracerebral hemorrhage has not been demonstrated...
  26. ncbi request reprint Early blood-brain barrier disruption in human focal brain ischemia
    Lawrence L Latour
    Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20878, USA
    Ann Neurol 56:468-77. 2004
    ....
  27. ncbi request reprint Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial
    Scott E Kasner
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Stroke 33:130-4. 2002
    ..Elevated core body temperature (CBT), even if mild, may exacerbate neuronal injury and worsen outcome, whereas hypothermia is potentially neuroprotective. The antipyretic effects of acetaminophen were hypothesized to reduce CBT...
  28. ncbi request reprint Intraventricular nicardipine for refractory cerebral vasospasm after subarachnoid hemorrhage
    Kelly Goodson
    Department of Neurosciences, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
    Neurocrit Care 8:247-52. 2008
    ..We report our clinical experience with intraventricular nicardipine for refractory vasospasm in eight patients in whom conventional therapies were ineffective, contraindicated, or technically not feasible...
  29. ncbi request reprint Modified National Institutes of Health Stroke Scale can be estimated from medical records
    Scott E Kasner
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Stroke 34:568-70. 2003
    ..We aimed to determine whether the mNIHSS could be accurately abstracted from medical records to facilitate retrospective research...
  30. ncbi request reprint Stroke in the tropics
    Joao Gomes
    Neuroscience Critical Care Department, Johns Hopkins University Hospital, Baltimore, Maryland 20892, USA
    Semin Neurol 25:290-9. 2005
    ..Our current knowledge of stroke in the tropics is limited by the financial restrictions existing in such regions limiting health care delivery and epidemiological research...
  31. ncbi request reprint Cerebellar hemorrhage caused by remote neurological surgery
    Julio A Chalela
    Department of Neurosurgery, Medical University of South Carolina, Charleston, SC 29425, USA
    Neurocrit Care 5:30-4. 2006
    ..Intracranial hemorrhage usually occurs as a complication of hypertension, coagulopathy, or trauma. In rare instances, remote cerebellar hemorrhage (RCH) may complicate supratentorial or spinal surgery...
  32. ncbi request reprint Pseudo-subarachnoid hemorrhage: report of three cases and review of the literature
    Brett Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Neurocrit Care 1:371-4. 2004
    ..In contrast to prior reports, all three of our patients had a favorable outcome...
  33. ncbi request reprint Myocardial injury in acute stroke: a troponin I study
    Julio A Chalela
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neurocrit Care 1:343-6. 2004
    ..We sought to describe the findings in a cohort of patients who had an acute stroke in whom Troponin I (TI) was sampled to determine the presence of associated myocardial damage...
  34. doi request reprint The role of mechanical ventilation in acute brain injury
    Robert D Stevens
    Division of Neurosciences Critical Care, Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Neurol Clin 26:543-63, x. 2008
    ..Recent research has begun to clarify key questions regarding the pathophysiology and management of MV in critically ill neurological patients...