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Genomes and Genes | Jean CelliSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
LRSAM1, an E3 Ubiquitin ligase with a sense for bacteriaJean Celli
Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Cell Host Microbe 12:735-6. 2012..Huett et al. (2012) show that the LRR- and RING-domain-containing E3 ubiquitin ligase LRSAM1 recognizes various bacteria and generates a ubiquitin signal that initiates the autophagic cascade...- Of microbes and membranes: pathogenic subversion of host cell processesJean Celli
Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Cell Host Microbe 4:514-8. 2008..Work presented at this meeting highlighted how pathogens exploit host cell membrane processes to their advantage and also revealed fundamental signaling and trafficking mechanisms of eukaryotic cells... 
Brucella coopts the small GTPase Sar1 for intracellular replicationJean Celli
Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique Université delaMéditerranée, 13288 Marseille Cedex 09, France
Proc Natl Acad Sci U S A 102:1673-8. 2005..These results assign an essential role for Sar1 in pathogenesis of an intracellular bacterium...
Surviving inside a macrophage: the many ways of BrucellaJean Celli
Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton MT 59840, USA
Res Microbiol 157:93-8. 2006..This review focuses on how this pathogen uses multiple strategies to circumvent macrophage defense mechanisms and generate an organelle permissive for replication...- Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathwayAudrey Chong
Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
Autophagy 8:1342-56. 2012.... - Brucella intracellular replication requires trafficking through the late endosomal/lysosomal compartmentTregei Starr
Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Traffic 9:678-94. 2008..Taken together, these results demonstrate that BCVs traffic along the endocytic pathway and fuse with lysosomes, and such fusion events are required for further maturation of BCVs into an ER-derived replicative organelle... - The early phagosomal stage of Francisella tularensis determines optimal phagosomal escape and Francisella pathogenicity island protein expressionAudrey Chong
National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA
Infect Immun 76:5488-99. 2008..Altogether, these results demonstrate that early phagosomal maturation is required for optimal phagosomal escape and that the early FCP provides cues other than intravacuolar pH that determine intracellular induction of FPI proteins... - Low dose vaccination with attenuated Francisella tularensis strain SchuS4 mutants protects against tularemia independent of the route of vaccinationDedeke Rockx-Brouwer
Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories National Institute of Allergy and Infectious Diseases National Institutes of Health, Hamilton, Montana, United States of America
PLoS ONE 7:e37752. 2012..Together our data provides proof of principle that low dose attenuated vaccines may be a viable goal in development of novel vaccines directed against tularemia... - Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycleTregei Starr
Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Cell Host Microbe 11:33-45. 2012.... - Intracellular biology and virulence determinants of Francisella tularensis revealed by transcriptional profiling inside macrophagesTara D Wehrly
Tularemia Pathogenesis Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Cell Microbiol 11:1128-50. 2009.... - Restricted cytosolic growth of Francisella tularensis subsp. tularensis by IFN-gamma activation of macrophagesJessica A Edwards
Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Microbiology 156:327-39. 2010..Hence, IFN-gamma induces phagocyte NADPH oxidase Phox- and inducible nitric oxide synthase (iNOS)-independent cytosolic effector mechanisms that restrict growth of virulent Francisella in macrophages... 
Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulumJean Celli
, 13288 Marseille Cedex 09, France
J Exp Med 198:545-56. 2003..Moreover, we assign an intracellular function to the VirB system, as being required for late maturation events necessary for the biogenesis of an ER-derived replicative organelle...- Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replicationClaire Checroun
Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South Fourth Street, Hamilton, MT 59840, USA
Proc Natl Acad Sci U S A 103:14578-83. 2006..Taken together, our results demonstrate that, via autophagy, F. tularensis reenters the endocytic pathway after cytoplasmic replication, a process thus far undescribed for intracellular pathogens... - Acid phosphatases do not contribute to the pathogenesis of type A Francisella tularensisRobert Child
Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
Infect Immun 78:59-67. 2010..Hence, the acid phosphatases AcpA, AcpB, and AcpC do not contribute to intracellular pathogenesis and do not play a major role in the virulence of type A Francisella strains... - Phagocytic receptors dictate phagosomal escape and intracellular proliferation of Francisella tularensisHenriette Geier
Tularemia Pathogenesis Section, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA
Infect Immun 79:2204-14. 2011..Taken together, these results demonstrate that opsonophagocytic receptors alter the intracellular fate of Francisella by delivering bacteria through phagocytic pathways that restrict phagosomal escape and intracellular proliferation... - Intracellular localization of Brucella abortus and Francisella tularensis in primary murine macrophagesJean Celli
Tularemia Pathogenesis Section, Laboratory of Parasites, Rocky Mountain Laboratoties, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
Methods Mol Biol 431:133-45. 2008..In addition, we describe an assay to assess the integrity of Francisella-containing phagosomes and bacterial release into the macrophage cytoplasm, which is a hallmark of Francisella intracellular pathogenesis... - Organelle robbery: Brucella interactions with the endoplasmic reticulumJean Celli
, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
Curr Opin Microbiol 7:93-7. 2004..A major virulence factor, the VirB type IV secretion system, is required for sustained interactions and fusion with the host endoplasmic reticulum... - Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epitheliaLeigh A Knodler
Laboratory of Intracellular Parasites and Research Technologies Branch, Microscopy Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Proc Natl Acad Sci U S A 107:17733-8. 2010.... - Eating the strangers within: host control of intracellular bacteria via xenophagyLeigh A Knodler
Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Cell Microbiol 13:1319-27. 2011..Here we review recent advances in our molecular understanding of these processes, and in how bacteria have adapted to avoid xenophagy or even take advantage of this innate immune process... - The francisella intracellular life cycle: toward molecular mechanisms of intracellular survival and proliferationAudrey Chong
Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health Hamilton, MT, USA
Front Microbiol 1:138. 2010.... - Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4Jennifer C Chase
Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 303 S 4th St Hamilton, MT 59840, USA
Infect Immun 77:180-95. 2009..This suggests that immune dysregulation by F. tularensis operates on a broader and more comprehensive scale than previously appreciated... - Host-microbe interaction systems biology: lifecycle transcriptomics and comparative genomicsDaniel E Sturdevant
Genomics Unit, Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA
Future Microbiol 5:205-19. 2010..Together, microarray and comparative genomic technologies will continue to advance our understanding of pathogen evolution and assist in combating human infectious disease... - Construction and characterization of an attenuated purine auxotroph in a Francisella tularensis live vaccine strainRoger Pechous
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Infect Immun 74:4452-61. 2006..Collectively, these results suggest that F. tularensis mutants deleted in the purMCD biosynthetic locus exhibit characteristics that may warrant further investigation of their use as potential live vaccine candidates... - Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systemsLeigh A Knodler
Biotechnology Laboratory, Room 237, 6174 University Blvd, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
Mol Microbiol 43:1089-103. 2002..Thus, we demonstrate a functional and regulatory cross-talk between three chromosomal PAIs, SPI-1, SPI-2 and SPI-5, which has significant implications for the evolution and role of PAIs in bacterial pathogenesis...