Jean Celli

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The francisella intracellular life cycle: toward molecular mechanisms of intracellular survival and proliferation
    Audrey Chong
    Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health Hamilton, MT, USA
    Front Microbiol 1:138. 2010
  2. pmc Low dose vaccination with attenuated Francisella tularensis strain SchuS4 mutants protects against tularemia independent of the route of vaccination
    Dedeke Rockx-Brouwer
    Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories National Institute of Allergy and Infectious Diseases National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 7:e37752. 2012
  3. pmc LRSAM1, an E3 Ubiquitin ligase with a sense for bacteria
    Jean Celli
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Cell Host Microbe 12:735-6. 2012
  4. doi Of microbes and membranes: pathogenic subversion of host cell processes
    Jean Celli
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Cell Host Microbe 4:514-8. 2008
  5. pmc Brucella coopts the small GTPase Sar1 for intracellular replication
    Jean Celli
    Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique Université delaMéditerranée, 13288 Marseille Cedex 09, France
    Proc Natl Acad Sci U S A 102:1673-8. 2005
  6. ncbi Surviving inside a macrophage: the many ways of Brucella
    Jean Celli
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton MT 59840, USA
    Res Microbiol 157:93-8. 2006
  7. pmc Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathway
    Audrey Chong
    Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    Autophagy 8:1342-56. 2012
  8. doi Brucella intracellular replication requires trafficking through the late endosomal/lysosomal compartment
    Tregei Starr
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Traffic 9:678-94. 2008
  9. pmc The early phagosomal stage of Francisella tularensis determines optimal phagosomal escape and Francisella pathogenicity island protein expression
    Audrey Chong
    National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 76:5488-99. 2008
  10. pmc Brucella modulates secretory trafficking via multiple type IV secretion effector proteins
    Sebenzile Myeni
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    PLoS Pathog 9:e1003556. 2013

Collaborators

Detail Information

Publications26

  1. pmc The francisella intracellular life cycle: toward molecular mechanisms of intracellular survival and proliferation
    Audrey Chong
    Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health Hamilton, MT, USA
    Front Microbiol 1:138. 2010
    ....
  2. pmc Low dose vaccination with attenuated Francisella tularensis strain SchuS4 mutants protects against tularemia independent of the route of vaccination
    Dedeke Rockx-Brouwer
    Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories National Institute of Allergy and Infectious Diseases National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 7:e37752. 2012
    ..Together our data provides proof of principle that low dose attenuated vaccines may be a viable goal in development of novel vaccines directed against tularemia...
  3. pmc LRSAM1, an E3 Ubiquitin ligase with a sense for bacteria
    Jean Celli
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Cell Host Microbe 12:735-6. 2012
    ..Huett et al. (2012) show that the LRR- and RING-domain-containing E3 ubiquitin ligase LRSAM1 recognizes various bacteria and generates a ubiquitin signal that initiates the autophagic cascade...
  4. doi Of microbes and membranes: pathogenic subversion of host cell processes
    Jean Celli
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Cell Host Microbe 4:514-8. 2008
    ..Work presented at this meeting highlighted how pathogens exploit host cell membrane processes to their advantage and also revealed fundamental signaling and trafficking mechanisms of eukaryotic cells...
  5. pmc Brucella coopts the small GTPase Sar1 for intracellular replication
    Jean Celli
    Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique Université delaMéditerranée, 13288 Marseille Cedex 09, France
    Proc Natl Acad Sci U S A 102:1673-8. 2005
    ..These results assign an essential role for Sar1 in pathogenesis of an intracellular bacterium...
  6. ncbi Surviving inside a macrophage: the many ways of Brucella
    Jean Celli
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton MT 59840, USA
    Res Microbiol 157:93-8. 2006
    ..This review focuses on how this pathogen uses multiple strategies to circumvent macrophage defense mechanisms and generate an organelle permissive for replication...
  7. pmc Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathway
    Audrey Chong
    Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    Autophagy 8:1342-56. 2012
    ....
  8. doi Brucella intracellular replication requires trafficking through the late endosomal/lysosomal compartment
    Tregei Starr
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Traffic 9:678-94. 2008
    ..Taken together, these results demonstrate that BCVs traffic along the endocytic pathway and fuse with lysosomes, and such fusion events are required for further maturation of BCVs into an ER-derived replicative organelle...
  9. pmc The early phagosomal stage of Francisella tularensis determines optimal phagosomal escape and Francisella pathogenicity island protein expression
    Audrey Chong
    National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 76:5488-99. 2008
    ..Altogether, these results demonstrate that early phagosomal maturation is required for optimal phagosomal escape and that the early FCP provides cues other than intravacuolar pH that determine intracellular induction of FPI proteins...
  10. pmc Brucella modulates secretory trafficking via multiple type IV secretion effector proteins
    Sebenzile Myeni
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    PLoS Pathog 9:e1003556. 2013
    ..Taken together, these findings demonstrate that Brucella modulates secretory trafficking via multiple T4SS effector proteins that likely act coordinately to promote Brucella pathogenesis...
  11. pmc Intracellular biology and virulence determinants of Francisella tularensis revealed by transcriptional profiling inside macrophages
    Tara D Wehrly
    Tularemia Pathogenesis Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Cell Microbiol 11:1128-50. 2009
    ....
  12. pmc Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replication
    Claire Checroun
    Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South Fourth Street, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 103:14578-83. 2006
    ..Taken together, our results demonstrate that, via autophagy, F. tularensis reenters the endocytic pathway after cytoplasmic replication, a process thus far undescribed for intracellular pathogens...
  13. pmc Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle
    Tregei Starr
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Cell Host Microbe 11:33-45. 2012
    ....
  14. pmc Restricted cytosolic growth of Francisella tularensis subsp. tularensis by IFN-gamma activation of macrophages
    Jessica A Edwards
    Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Microbiology 156:327-39. 2010
    ..Hence, IFN-gamma induces phagocyte NADPH oxidase Phox- and inducible nitric oxide synthase (iNOS)-independent cytosolic effector mechanisms that restrict growth of virulent Francisella in macrophages...
  15. pmc Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum
    Jean Celli
    Centre d Immunologie INSERM CNRS Université Mediterranée de Marseille Luminy, 13288 Marseille Cedex 09, France
    J Exp Med 198:545-56. 2003
    ..Moreover, we assign an intracellular function to the VirB system, as being required for late maturation events necessary for the biogenesis of an ER-derived replicative organelle...
  16. pmc Mechanisms of Francisella tularensis intracellular pathogenesis
    Jean Celli
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MO 59840, USA
    Cold Spring Harb Perspect Med 3:a010314. 2013
    ..Here, we review the intracellular life cycle of Francisella and highlight key genetic determinants and/or pathways that contribute to the survival and proliferation of this bacterium within host cells...
  17. pmc Acid phosphatases do not contribute to the pathogenesis of type A Francisella tularensis
    Robert Child
    Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    Infect Immun 78:59-67. 2010
    ..Hence, the acid phosphatases AcpA, AcpB, and AcpC do not contribute to intracellular pathogenesis and do not play a major role in the virulence of type A Francisella strains...
  18. ncbi Organelle robbery: Brucella interactions with the endoplasmic reticulum
    Jean Celli
    Centre d Immunologie INSERM CNRS Université de la Mediterranée de Marseille Luminy, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Curr Opin Microbiol 7:93-7. 2004
    ..A major virulence factor, the VirB type IV secretion system, is required for sustained interactions and fusion with the host endoplasmic reticulum...
  19. pmc Phagocytic receptors dictate phagosomal escape and intracellular proliferation of Francisella tularensis
    Henriette Geier
    Tularemia Pathogenesis Section, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 79:2204-14. 2011
    ..Taken together, these results demonstrate that opsonophagocytic receptors alter the intracellular fate of Francisella by delivering bacteria through phagocytic pathways that restrict phagosomal escape and intracellular proliferation...
  20. ncbi Intracellular localization of Brucella abortus and Francisella tularensis in primary murine macrophages
    Jean Celli
    Tularemia Pathogenesis Section, Laboratory of Parasites, Rocky Mountain Laboratoties, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    Methods Mol Biol 431:133-45. 2008
    ..In addition, we describe an assay to assess the integrity of Francisella-containing phagosomes and bacterial release into the macrophage cytoplasm, which is a hallmark of Francisella intracellular pathogenesis...
  21. pmc Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia
    Leigh A Knodler
    Laboratory of Intracellular Parasites and Research Technologies Branch, Microscopy Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 107:17733-8. 2010
    ....
  22. pmc Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4
    Jennifer C Chase
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 303 S 4th St Hamilton, MT 59840, USA
    Infect Immun 77:180-95. 2009
    ..This suggests that immune dysregulation by F. tularensis operates on a broader and more comprehensive scale than previously appreciated...
  23. pmc Eating the strangers within: host control of intracellular bacteria via xenophagy
    Leigh A Knodler
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Cell Microbiol 13:1319-27. 2011
    ..Here we review recent advances in our molecular understanding of these processes, and in how bacteria have adapted to avoid xenophagy or even take advantage of this innate immune process...
  24. pmc Host-microbe interaction systems biology: lifecycle transcriptomics and comparative genomics
    Daniel E Sturdevant
    Genomics Unit, Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA
    Future Microbiol 5:205-19. 2010
    ..Together, microarray and comparative genomic technologies will continue to advance our understanding of pathogen evolution and assist in combating human infectious disease...
  25. pmc Construction and characterization of an attenuated purine auxotroph in a Francisella tularensis live vaccine strain
    Roger Pechous
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Infect Immun 74:4452-61. 2006
    ..Collectively, these results suggest that F. tularensis mutants deleted in the purMCD biosynthetic locus exhibit characteristics that may warrant further investigation of their use as potential live vaccine candidates...
  26. ncbi Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems
    Leigh A Knodler
    Biotechnology Laboratory, Room 237, 6174 University Blvd, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
    Mol Microbiol 43:1089-103. 2002
    ..Thus, we demonstrate a functional and regulatory cross-talk between three chromosomal PAIs, SPI-1, SPI-2 and SPI-5, which has significant implications for the evolution and role of PAIs in bacterial pathogenesis...