Research Topics
| Francesco S CeliSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
The Dynamic Pituitary Response to Escalating-Dose TRH Stimulation Test in Hypothyroid Patients Treated With Liothyronine or Levothyroxine Replacement TherapySahzene Yavuz
MD, MHSC, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Clinical Research Center, room 6 3940, 10 Center Drive, Bethesda, MD 20892 1613
J Clin Endocrinol Metab 98:E862-6. 2013..Furthermore, the data suggest that lower doses of TRH might provide clinically relevant information of thyrotroph function, particularly when investigating partial pituitary insufficiency states...
Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxineFrancesco S Celi
Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, CRC, room 6 3940, 10 Center Drive, MSC 1613, Bethesda, Maryland 20892 1613, USA
J Clin Endocrinol Metab 96:3466-74. 2011..Previous combination L-T(4)/liothyronine (L-T(3)) therapy trials focused on quality-of-life endpoints, and limited information is available on the effects on other measures of thyroid hormone action...- The role of type 1 and type 2 5'-deiodinase in the pathophysiology of the 3,5,3'-triiodothyronine toxicosis of McCune-Albright syndromeFrancesco S Celi
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Clinical Research Center, room 6 3940, 10 Center Drive MSC 1613, Bethesda, MD 20892 1613, USA
J Clin Endocrinol Metab 93:2383-9. 2008..McCune-Albright syndrome (MAS) is caused by mutations in GNAS (most often R201C or R201H) leading to constitutive cAMP signaling and multiple endocrine dysfunctions, including morphological and functional thyroid involvement... - Minimal changes in environmental temperature result in a significant increase in energy expenditure and changes in the hormonal homeostasis in healthy adultsFrancesco S Celi
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1613, USA
Eur J Endocrinol 163:863-72. 2010..Adaptive thermogenesis is a major component of EE in rodents, but little is known on the effects of exposure of humans to mild and sustainable reduction in environmental temperature... - The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patientsFrancesco S Celi
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, CRC, RM 6 3940, 10 Center Drive, MSC 1613, Bethesda, MD 20892 1613, USA
Clin Endocrinol (Oxf) 72:709-15. 2010..Presently, only limited data are available on the L-T3 for L-T4 therapeutic substitution. Objective To characterize the pharmcodynamic equivalence of L-T3 and L-T4... - The -258A/G (SNP rs12885300) polymorphism of the human type 2 deiodinase gene is associated with a shift in the pattern of secretion of thyroid hormones following a TRH-induced acute rise in TSHMaya Y Peltsverger
Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
Eur J Endocrinol 166:839-45. 2012.... - An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell-specific over-expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary-selective resistance to thyroid hormoneAnna Teresa Alberobello
Diabetes, Endocrinology, and Obesity Branch, NIDDK NIH Bethesda, Maryland, USA
J Transl Med 9:144. 2011..We thus hypothesized that polymorphisms in the human homologous region could modulate the pituitary expression of the mutated gene contributing to the clinical presentation of RTH... 
The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of AmishDaniela Mentuccia
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1613, USA
Thyroid 15:1223-7. 2005..These findings could be secondary to a different genetic background or to environmental factors specific for this population...- Functional characterization of the 258 A/G (D2-ORFa-Gly3Asp) human type-2 deiodinase polymorphism: a naturally occurring variant increases the enzymatic activity by removing a putative repressor site in the 5' UTR of the geneGiuseppe Coppotelli
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Thyroid 16:625-32. 2006..The aim of this study was to characterize the gene variant in vitro... - Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesisPaul Lee
Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Clinical Research Center, 10 Center Drive, Bethesda, Maryland 20892, USA
J Clin Endocrinol Metab 98:E98-102. 2013..In humans, the effects of cold exposure on circulating FGF21 levels are unknown... - Thyroid hormone induced brown adipose tissue and amelioration of diabetes in a patient with extreme insulin resistanceMonica C Skarulis
Clinical Endocrine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892 1613, USA
J Clin Endocrinol Metab 95:256-62. 2010..Factors leading to increased BAT are of great interest for its potential role in the treatment of diabetes and obesity... - Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and miceSusanne Neumann
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:12471-6. 2009..Thus, we discovered a small molecule that activates human TSHR in vitro, is orally active in mice, and could be a lead for development of drugs to use in place of recombinant human TSH in patients with thyroid cancer... - Expression of benign and malignant thyroid tissue in ovarian teratomas and the importance of multimodal management as illustrated by a BRAF-positive follicular variant of papillary thyroid cancerErin F Wolff
Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Diabetes, Digestive, and Kidney Diseases, NIH, Bethesda, MD 20892 1613, USA
Thyroid 20:981-7. 2010..Here we review this topic and illustrate major features by presenting multimodal management of a patient with BRAF-positive disseminated follicular thyroid cancer arising in an ovarian teratoma... - Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasiaJean B Regard
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 108:20101-6. 2011..Our data suggest that activated Gα proteins are playing physiologically significant roles during both skeletal development and disease by modulating Wnt/β-catenin signaling strength... - Two cases of thyroid storm-associated cholestatic jaundiceKristen Hull
Division of Endocrinology, Diabetes and Nutrition, The University of Maryland School of Medicine, Baltimore, Maryland, USA
Endocr Pract 13:476-80. 2007..To describe the association of the rare and serious complication of jaundice with severe thyrotoxicosis, a potentially lethal endocrine disorder... - Increased oxidative metabolism in the Li-Fraumeni syndromePing Yuan Wang
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
N Engl J Med 368:1027-32. 2013..These results suggest that p53 regulates bioenergetic homeostasis in humans. (Funded by the National Heart, Lung, and Blood Institute and the National Institutes of Health; ClinicalTrials.gov number, NCT00406445.)... - Thyroid disease in patients with McCune-Albright syndromeValentina Congedo
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health Bethesda, Maryland 20892, USA
Pediatr Endocrinol Rev 4:429-33. 2007..Although thyroid cancer has been described in two cases of MAS, the prevalence of malignancy does not appear to be high. The therapeutic options in MAS involvement of the thyroid gland include thionamides, 131Iodine and surgery... - Multigenic control of thyroid hormone functions in the nervous systemJacques Nunez
National Institutes of Health, NIDDK, Clinical Endocrinology Branch, Bethesda, MD 20892 1772, USA
Mol Cell Endocrinol 287:1-12. 2008..Overall, TH coordinates this variety of events in both central and sensory systems to promote the function of the nervous system as a complete entity...