Francesco S Celi

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine
    Francesco S Celi
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, CRC, room 6 3940, 10 Center Drive, MSC 1613, Bethesda, Maryland 20892 1613, USA
    J Clin Endocrinol Metab 96:3466-74. 2011
  2. pmc The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients
    Francesco S Celi
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, CRC, RM 6 3940, 10 Center Drive, MSC 1613, Bethesda, MD 20892 1613, USA
    Clin Endocrinol (Oxf) 72:709-15. 2010
  3. pmc Minimal changes in environmental temperature result in a significant increase in energy expenditure and changes in the hormonal homeostasis in healthy adults
    Francesco S Celi
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1613, USA
    Eur J Endocrinol 163:863-72. 2010
  4. pmc The role of type 1 and type 2 5'-deiodinase in the pathophysiology of the 3,5,3'-triiodothyronine toxicosis of McCune-Albright syndrome
    Francesco S Celi
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Clinical Research Center, room 6 3940, 10 Center Drive MSC 1613, Bethesda, MD 20892 1613, USA
    J Clin Endocrinol Metab 93:2383-9. 2008
  5. pmc The dynamic pituitary response to escalating-dose TRH stimulation test in hypothyroid patients treated with liothyronine or levothyroxine replacement therapy
    Sahzene Yavuz
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1613, USA
    J Clin Endocrinol Metab 98:E862-6. 2013
  6. pmc Brown fat activation mediates cold-induced thermogenesis in adult humans in response to a mild decrease in ambient temperature
    Kong Y Chen
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1613, USA
    J Clin Endocrinol Metab 98:E1218-23. 2013
  7. pmc The -258A/G (SNP rs12885300) polymorphism of the human type 2 deiodinase gene is associated with a shift in the pattern of secretion of thyroid hormones following a TRH-induced acute rise in TSH
    Maya Y Peltsverger
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Eur J Endocrinol 166:839-45. 2012
  8. pmc An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell-specific over-expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary-selective resistance to thyroid hormone
    Anna Teresa Alberobello
    Diabetes, Endocrinology, and Obesity Branch, NIDDK NIH Bethesda, Maryland, USA
    J Transl Med 9:144. 2011
  9. pmc Moderate weight loss is sufficient to affect thyroid hormone homeostasis and inhibit its peripheral conversion
    Ritesh V Agnihothri
    1 Diabetes, Endocrinology, and Obesity Branch, National Institutes of Health, Bethesda, Maryland
    Thyroid 24:19-26. 2014
  10. ncbi request reprint The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish
    Daniela Mentuccia
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1613, USA
    Thyroid 15:1223-7. 2005

Collaborators

Detail Information

Publications22

  1. pmc Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine
    Francesco S Celi
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, CRC, room 6 3940, 10 Center Drive, MSC 1613, Bethesda, Maryland 20892 1613, USA
    J Clin Endocrinol Metab 96:3466-74. 2011
    ..Previous combination L-T(4)/liothyronine (L-T(3)) therapy trials focused on quality-of-life endpoints, and limited information is available on the effects on other measures of thyroid hormone action...
  2. pmc The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients
    Francesco S Celi
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, CRC, RM 6 3940, 10 Center Drive, MSC 1613, Bethesda, MD 20892 1613, USA
    Clin Endocrinol (Oxf) 72:709-15. 2010
    ..Presently, only limited data are available on the L-T3 for L-T4 therapeutic substitution. Objective To characterize the pharmcodynamic equivalence of L-T3 and L-T4...
  3. pmc Minimal changes in environmental temperature result in a significant increase in energy expenditure and changes in the hormonal homeostasis in healthy adults
    Francesco S Celi
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1613, USA
    Eur J Endocrinol 163:863-72. 2010
    ..Adaptive thermogenesis is a major component of EE in rodents, but little is known on the effects of exposure of humans to mild and sustainable reduction in environmental temperature...
  4. pmc The role of type 1 and type 2 5'-deiodinase in the pathophysiology of the 3,5,3'-triiodothyronine toxicosis of McCune-Albright syndrome
    Francesco S Celi
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Clinical Research Center, room 6 3940, 10 Center Drive MSC 1613, Bethesda, MD 20892 1613, USA
    J Clin Endocrinol Metab 93:2383-9. 2008
    ..McCune-Albright syndrome (MAS) is caused by mutations in GNAS (most often R201C or R201H) leading to constitutive cAMP signaling and multiple endocrine dysfunctions, including morphological and functional thyroid involvement...
  5. pmc The dynamic pituitary response to escalating-dose TRH stimulation test in hypothyroid patients treated with liothyronine or levothyroxine replacement therapy
    Sahzene Yavuz
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1613, USA
    J Clin Endocrinol Metab 98:E862-6. 2013
    ....
  6. pmc Brown fat activation mediates cold-induced thermogenesis in adult humans in response to a mild decrease in ambient temperature
    Kong Y Chen
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1613, USA
    J Clin Endocrinol Metab 98:E1218-23. 2013
    ..The contribution of brown adipose tissue (BAT) to the energy balance in humans exposed to sustainable cold has not been completely established, partially because of measurement limitations of both BAT activity and energy expenditure (EE)...
  7. pmc The -258A/G (SNP rs12885300) polymorphism of the human type 2 deiodinase gene is associated with a shift in the pattern of secretion of thyroid hormones following a TRH-induced acute rise in TSH
    Maya Y Peltsverger
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Eur J Endocrinol 166:839-45. 2012
    ....
  8. pmc An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell-specific over-expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary-selective resistance to thyroid hormone
    Anna Teresa Alberobello
    Diabetes, Endocrinology, and Obesity Branch, NIDDK NIH Bethesda, Maryland, USA
    J Transl Med 9:144. 2011
    ..We thus hypothesized that polymorphisms in the human homologous region could modulate the pituitary expression of the mutated gene contributing to the clinical presentation of RTH...
  9. pmc Moderate weight loss is sufficient to affect thyroid hormone homeostasis and inhibit its peripheral conversion
    Ritesh V Agnihothri
    1 Diabetes, Endocrinology, and Obesity Branch, National Institutes of Health, Bethesda, Maryland
    Thyroid 24:19-26. 2014
    ....
  10. ncbi request reprint The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish
    Daniela Mentuccia
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1613, USA
    Thyroid 15:1223-7. 2005
    ..These findings could be secondary to a different genetic background or to environmental factors specific for this population...
  11. ncbi request reprint Functional characterization of the 258 A/G (D2-ORFa-Gly3Asp) human type-2 deiodinase polymorphism: a naturally occurring variant increases the enzymatic activity by removing a putative repressor site in the 5' UTR of the gene
    Giuseppe Coppotelli
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Thyroid 16:625-32. 2006
    ..The aim of this study was to characterize the gene variant in vitro...
  12. pmc Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis
    Paul Lee
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Clinical Research Center, 10 Center Drive, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 98:E98-102. 2013
    ..In humans, the effects of cold exposure on circulating FGF21 levels are unknown...
  13. pmc Thyroid hormone induced brown adipose tissue and amelioration of diabetes in a patient with extreme insulin resistance
    Monica C Skarulis
    Clinical Endocrine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892 1613, USA
    J Clin Endocrinol Metab 95:256-62. 2010
    ..Factors leading to increased BAT are of great interest for its potential role in the treatment of diabetes and obesity...
  14. pmc Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice
    Susanne Neumann
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:12471-6. 2009
    ..Thus, we discovered a small molecule that activates human TSHR in vitro, is orally active in mice, and could be a lead for development of drugs to use in place of recombinant human TSH in patients with thyroid cancer...
  15. ncbi request reprint Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans
    Paul Lee
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 19:302-9. 2014
    ..Irisin-mediated muscle-adipose crosstalk may represent a thermogenic, cold-activated endocrine axis that is exploitable in obesity therapeutics development. ..
  16. pmc Expression of benign and malignant thyroid tissue in ovarian teratomas and the importance of multimodal management as illustrated by a BRAF-positive follicular variant of papillary thyroid cancer
    Erin F Wolff
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Diabetes, Digestive, and Kidney Diseases, NIH, Bethesda, MD 20892 1613, USA
    Thyroid 20:981-7. 2010
    ..Here we review this topic and illustrate major features by presenting multimodal management of a patient with BRAF-positive disseminated follicular thyroid cancer arising in an ovarian teratoma...
  17. ncbi request reprint Cabozantinib-induced thyroid dysfunction: a review of two ongoing trials for metastatic bladder cancer and sarcoma
    Sahzene Yavuz
    1 National Institute of Diabetes and Digestive and Kidney Diseases, Diabetes, Endocrine, and Obesity Branch, National Institutes of Health, Bethesda, Maryland
    Thyroid 24:1223-31. 2014
    ..Early detection and characterization of cabozantinib-associated thyroid dysfunction and close follow-up are essential to provide adequate management of this common adverse event. ..
  18. pmc Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia
    Jean B Regard
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:20101-6. 2011
    ..Our data suggest that activated Gα proteins are playing physiologically significant roles during both skeletal development and disease by modulating Wnt/β-catenin signaling strength...
  19. ncbi request reprint Two cases of thyroid storm-associated cholestatic jaundice
    Kristen Hull
    Division of Endocrinology, Diabetes and Nutrition, The University of Maryland School of Medicine, Baltimore, Maryland, USA
    Endocr Pract 13:476-80. 2007
    ..To describe the association of the rare and serious complication of jaundice with severe thyrotoxicosis, a potentially lethal endocrine disorder...
  20. ncbi request reprint Increased oxidative metabolism in the Li-Fraumeni syndrome
    Ping Yuan Wang
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 368:1027-32. 2013
    ..These results suggest that p53 regulates bioenergetic homeostasis in humans. (Funded by the National Heart, Lung, and Blood Institute and the National Institutes of Health; ClinicalTrials.gov number, NCT00406445.)...
  21. ncbi request reprint Thyroid disease in patients with McCune-Albright syndrome
    Valentina Congedo
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health Bethesda, Maryland 20892, USA
    Pediatr Endocrinol Rev 4:429-33. 2007
    ..Although thyroid cancer has been described in two cases of MAS, the prevalence of malignancy does not appear to be high. The therapeutic options in MAS involvement of the thyroid gland include thionamides, 131Iodine and surgery...
  22. pmc Multigenic control of thyroid hormone functions in the nervous system
    Jacques Nunez
    National Institutes of Health, NIDDK, Clinical Endocrinology Branch, Bethesda, MD 20892 1772, USA
    Mol Cell Endocrinol 287:1-12. 2008
    ..Overall, TH coordinates this variety of events in both central and sensory systems to promote the function of the nervous system as a complete entity...