Byron Caughey

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays
    Jason M Wilham
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, Hamilton, Montana, United States of America
    PLoS Pathog 6:e1001217. 2010
  2. doi request reprint Prions and the potential transmissibility of protein misfolding diseases
    Allison Kraus
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 email
    Annu Rev Microbiol 67:543-64. 2013
  3. pmc Cyclic tetrapyrrole sulfonation, metals, and oligomerization in antiprion activity
    Winslow S Caughey
    Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th St, Hamilton, MT 59840, USA
    Antimicrob Agents Chemother 51:3887-94. 2007
  4. ncbi request reprint Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders
    Byron Caughey
    NIAID, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    Annu Rev Neurosci 26:267-98. 2003
  5. pmc Transmission and adaptation of chronic wasting disease to hamsters and transgenic mice: evidence for strains
    Gregory J Raymond
    Laboratory of Persistent Viral Diseases, Rocky Mountain Veterinary Branch, NIAID, NIH, Rocky Mountain Labs, 903 S 4th St, Hamilton, MT 59840, USA
    J Virol 81:4305-14. 2007
  6. pmc Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC
    Sarah Vascellari
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    PLoS ONE 7:e48969. 2012
  7. doi request reprint Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking
    Ryuichiro Atarashi
    Laboratory of Persistent Viral Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, 903 S 4th St, Hamilton, Montana 59840, USA
    Nat Methods 5:211-2. 2008
  8. pmc Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease
    Gregory J Raymond
    Laboratory of Persistent Viral Diseases, NIAID, NIH, Rocky Mountain Labs, 903 S 4th St, Hamilton, MT 59840, USA
    J Virol 80:596-604. 2006
  9. ncbi request reprint Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein
    Ryuichiro Atarashi
    Laboratory of Persistent Viral Diseases, National Institutes of Health, 903 S 4th Street, Hamilton, Montana 59840, USA
    Nat Methods 4:645-50. 2007
  10. ncbi request reprint Searching for anti-prion compounds: cell-based high-throughput in vitro assays and animal testing strategies
    David A Kocisko
    Laboratory of Persisten Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Methods Enzymol 412:223-34. 2006

Collaborators

Detail Information

Publications58

  1. pmc Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays
    Jason M Wilham
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, Hamilton, Montana, United States of America
    PLoS Pathog 6:e1001217. 2010
    ..In principle, end-point dilution quantitation can be applied to many types of prion and amyloid seeding assays. End point dilution RT-QuIC provides a sensitive, rapid, quantitative, and high throughput assay of prion seeding activity...
  2. doi request reprint Prions and the potential transmissibility of protein misfolding diseases
    Allison Kraus
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 email
    Annu Rev Microbiol 67:543-64. 2013
    ..These findings raise concerns that various protein misfolding diseases might have spreading, prion-like etiologies that contribute to pathogenesis or prevalence. ..
  3. pmc Cyclic tetrapyrrole sulfonation, metals, and oligomerization in antiprion activity
    Winslow S Caughey
    Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th St, Hamilton, MT 59840, USA
    Antimicrob Agents Chemother 51:3887-94. 2007
    ..Similar comparisons of iron- and manganese-bound porphyrin sulfonates confirmed that stacking ability correlates with anti-TSE activity among cyclic tetrapyrroles...
  4. ncbi request reprint Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders
    Byron Caughey
    NIAID, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    Annu Rev Neurosci 26:267-98. 2003
    ..This review focuses on recent experimental studies aimed at identification and characterization of the neurotoxic protein aggregates...
  5. pmc Transmission and adaptation of chronic wasting disease to hamsters and transgenic mice: evidence for strains
    Gregory J Raymond
    Laboratory of Persistent Viral Diseases, Rocky Mountain Veterinary Branch, NIAID, NIH, Rocky Mountain Labs, 903 S 4th St, Hamilton, MT 59840, USA
    J Virol 81:4305-14. 2007
    ....
  6. pmc Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC
    Sarah Vascellari
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    PLoS ONE 7:e48969. 2012
    ..Overall, we conclude that these new mouse-adapted prion seeding assays detect diverse types of PrP(Sc)...
  7. doi request reprint Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking
    Ryuichiro Atarashi
    Laboratory of Persistent Viral Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, 903 S 4th St, Hamilton, Montana 59840, USA
    Nat Methods 5:211-2. 2008
  8. pmc Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease
    Gregory J Raymond
    Laboratory of Persistent Viral Diseases, NIAID, NIH, Rocky Mountain Labs, 903 S 4th St, Hamilton, MT 59840, USA
    J Virol 80:596-604. 2006
    ..This demonstrates the utility of these cells in a rapid in vitro screening assay for PrP(CWD) inhibitors and suggests that these compounds have potential to be active against CWD in vivo...
  9. ncbi request reprint Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein
    Ryuichiro Atarashi
    Laboratory of Persistent Viral Diseases, National Institutes of Health, 903 S 4th Street, Hamilton, Montana 59840, USA
    Nat Methods 4:645-50. 2007
    ..This method should facilitate the development of rapid, ultrasensitive prion assays and diagnostic tests, in addition to aiding fundamental studies of structure and mechanism of PrPSc formation...
  10. ncbi request reprint Searching for anti-prion compounds: cell-based high-throughput in vitro assays and animal testing strategies
    David A Kocisko
    Laboratory of Persisten Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Methods Enzymol 412:223-34. 2006
    ..Methods for in vivo testing of compounds for anti-scrapie activity in transgenic mice, a much more lengthy and expensive process, are also discussed...
  11. pmc Potent antiscrapie activities of degenerate phosphorothioate oligonucleotides
    David A Kocisko
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Antimicrob Agents Chemother 50:1034-44. 2006
    ..With these antiscrapie activities and their much lower anticoagulant activities than that of pentosan polysulfate, degenerate PS-ONs are attractive new compounds for the treatment of TSEs...
  12. pmc Structure of the flexible amino-terminal domain of prion protein bound to a sulfated glycan
    Lara M Taubner
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Mol Biol 395:475-90. 2010
    ..These data may in part explain how sulfated glycans modulate PrP conformational conversions and oligomerizations...
  13. pmc Human variant Creutzfeldt-Jakob disease and sheep scrapie PrP(res) detection using seeded conversion of recombinant prion protein
    Christina D Orru
    Laboratory of Persistent Viral Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, 903 S 4th St, Hamilton, MT 59840, USA
    Protein Eng Des Sel 22:515-21. 2009
    ..This new method enables the relatively rapid and sensitive detection of human CJD and sheep scrapie PrP(res) and may facilitate the development of practical preclinical diagnostic and high-throughput interference tests...
  14. pmc Prion shedding from olfactory neurons into nasal secretions
    Richard A Bessen
    Veterinary Molecular Biology, Montana State University, Bozeman, Montana, United States of America
    PLoS Pathog 6:e1000837. 2010
    ....
  15. pmc Time course of prion seeding activity in cerebrospinal fluid of scrapie-infected hamsters after intratongue and intracerebral inoculations
    Christina D Orru
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Clin Microbiol 50:1464-6. 2012
    ..However, after intratongue inoculation, activity first appeared in CSF with the onset of clinical signs, well after higher-level accumulation of seeding activity in brain...
  16. pmc Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes
    Gerald S Baron
    Laboratory of Persistent Viral Diseases, NIAID, NIH, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA
    EMBO J 21:1031-40. 2002
    ....
  17. pmc Accelerated shedding of prions following damage to the olfactory epithelium
    Richard A Bessen
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, USA
    J Virol 86:1777-88. 2012
    ..This mechanism of prion shedding from the olfactory mucosa could contribute to prion transmission...
  18. doi request reprint New generation QuIC assays for prion seeding activity
    Christina D Orru
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    Prion 6:147-52. 2012
    ....
  19. doi request reprint Prion seeded conversion and amplification assays
    Christina D Orru
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Top Curr Chem 305:121-33. 2011
    ..This chapter will provide an overview of such reactions and the practical and fundamental consequences of their development...
  20. doi request reprint Ultrastructures and strain comparison of under-glycosylated scrapie prion fibrils
    Valerie L Sim
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, United States
    Neurobiol Aging 30:2031-42. 2009
    ..These measurements of the amyloid core of scrapie fibrils should aid development of models of prion structure and strain determination...
  21. pmc Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra
    Gerald S Baron
    Laboratory of Persistent Viral Diseases, Research Technology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Biochemistry 50:4479-90. 2011
    ..Our IR data provide evidence that similar core structures also comprise wild-type PrP(res)...
  22. ncbi request reprint Hemin interactions and alterations of the subcellular localization of prion protein
    Kil S Lee
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 282:36525-33. 2007
    ..These hemin-PrPC interactions suggest that PrPC may participate in hemin homeostasis, sensing, and/or uptake and that hemin might affect PrPC functions...
  23. ncbi request reprint Prion proteins meet protein quality control
    Derek E Dimcheff
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases NIH, Hamilton, MT 59840, USA
    Trends Cell Biol 13:337-40. 2003
    ..These findings are discussed in the light of other studies linking proteasome inhibition and neurodegeneration...
  24. pmc A porphyrin increases survival time of mice after intracerebral prion infection
    David A Kocisko
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S 4th Street, Hamilton, MT 59840, USA
    Antimicrob Agents Chemother 50:759-61. 2006
    ..Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times...
  25. pmc Prion disease blood test using immunoprecipitation and improved quaking-induced conversion
    Christina D Orru
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    MBio 2:e00078-11. 2011
    ..This combined assay, which we call "enhanced QuIC" (eQuIC), markedly improves prospects for routine detection of low levels of prions in tissues, fluids, or environmental samples...
  26. ncbi request reprint Identification of prion inhibitors by a fluorescence-polarization-based competitive binding assay
    David A Kocisko
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Anal Biochem 363:154-6. 2007
  27. pmc Enhanced antiscrapie effect using combination drug treatment
    David A Kocisko
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Antimicrob Agents Chemother 50:3447-9. 2006
    ..Combination therapy may therefore be more effective for treatment of transmissible spongiform encephalopathies and other protein-misfolding diseases...
  28. ncbi request reprint Anchorless prion protein results in infectious amyloid disease without clinical scrapie
    Bruce Chesebro
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA
    Science 308:1435-9. 2005
    ..In contrast, combined expression of anchorless and wild-type PrP produced accelerated clinical scrapie. Thus, the PrP GPI anchor may play a role in the pathogenesis of prion diseases...
  29. ncbi request reprint Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells
    Ana Cristina Magalhães
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Neurosci 25:5207-16. 2005
    ..These experiments visualize and characterize the initial steps associated with prion infection and transport within neuronal cells...
  30. ncbi request reprint A solid-phase assay for identification of modulators of prion protein interactions
    Laura Maxson
    Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th St, Hamilton, MT 59840, USA
    Anal Biochem 323:54-64. 2003
    ....
  31. pmc Mefloquine, an antimalaria drug with antiprion activity in vitro, lacks activity in vivo
    David A Kocisko
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Virol 80:1044-6. 2006
    ..While most anti-scrapie agent compounds inhibit PrP-res formation in vitro, many PrP-res inhibitors have no activity in vivo. This underscores the importance of testing promising candidates in vivo...
  32. pmc Are cheetahs on the run from prion-like amyloidosis?
    Byron Caughey
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 598940, USA
    Proc Natl Acad Sci U S A 105:7113-4. 2008
  33. ncbi request reprint Comparison of protease-resistant prion protein inhibitors in cell cultures infected with two strains of mouse and sheep scrapie
    David A Kocisko
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Neurosci Lett 388:106-11. 2005
    ..These results identify new inhibitors of murine and ovine PrP-res formation and reinforce the idea that compounds effective against PrP-res from one species or strain cannot be assumed to be active against others...
  34. ncbi request reprint Biomedicine. A view from the top--prion diseases from 10,000 feet
    Suzette A Priola
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    Science 300:917-9. 2003
  35. pmc Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions
    Byron Caughey
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Annu Rev Biochem 78:177-204. 2009
    ....
  36. pmc Recent advances in prion chemotherapeutics
    Valerie L Sim
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Infect Disord Drug Targets 9:81-91. 2009
    ..Importantly, there is evidence that combining compounds may provide synergistic responses. This review provides an update on current testing methods, therapeutic targets, and promising candidates for chemical-based therapy...
  37. ncbi request reprint Prion protein conversions: insight into mechanisms, TSE transmission barriers and strains
    Byron Caughey
    NIAID Rocky Mountain Laboratories, NIH, Hamilton, Montana 59840, USA
    Br Med Bull 66:109-20. 2003
    ..Such in vitro conversion systems have yielded insights into the molecular mechanisms of TSE disease and are being exploited as screens for anti-TSE drugs and as bases for diagnostic tests...
  38. ncbi request reprint Evaluation of new cell culture inhibitors of protease-resistant prion protein against scrapie infection in mice
    David A Kocisko
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Gen Virol 85:2479-83. 2004
    ..These results highlight the need to assess TSE inhibitors active in cell culture against TSE infections in vivo prior to testing these compounds in humans and livestock...
  39. pmc Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res
    Gerald S Baron
    Rocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, NIAID, NIH, Hamilton, MT 59840, USA
    J Virol 80:2106-17. 2006
    ..Our observations provide evidence that infection of cells is aided by the association of PrP-res with membranes and/or other microsomal constituents...
  40. ncbi request reprint Fractionation of prion protein aggregates by asymmetrical flow field-flow fractionation
    Jay R Silveira
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana 59840, USA
    Methods Enzymol 412:21-33. 2006
    ..This flexibility, coupled with the ability to produce fast, high-resolution separations, makes FFF a potentially valuable tool in the field of amyloid research...
  41. ncbi request reprint Prions and their partners in crime
    Byron Caughey
    National Institute of Allergy and Infectious Disease, National Institutes of Health, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, Montana 59840, USA
    Nature 443:803-10. 2006
    ....
  42. pmc The most infectious prion protein particles
    Jay R Silveira
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Nature 437:257-61. 2005
    ..These results suggest that non-fibrillar particles, with masses equivalent to 14-28 PrP molecules, are the most efficient initiators of TSE disease...
  43. pmc Prion strain-dependent differences in conversion of mutant prion proteins in cell culture
    Ryuichiro Atarashi
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 853 8523, Japan
    J Virol 80:7854-62. 2006
    ..These results show that two strains with the same PrP sequence but different conformations have differing abilities to convert the same mutated PrP(C)...
  44. ncbi request reprint Effect of glycosylphosphatidylinositol anchor-dependent and -independent prion protein association with model raft membranes on conversion to the protease-resistant isoform
    Gerald S Baron
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 278:14883-92. 2003
    ..Thus, of the two forms of raft membrane association by PrP-sen, only the GPI anchor-directed form resists conversion induced by exogenous PrP-res...
  45. ncbi request reprint The role of helix 1 aspartates and salt bridges in the stability and conversion of prion protein
    Jonathan O Speare
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 278:12522-9. 2003
    ....
  46. ncbi request reprint Subclinical scrapie infection in a resistant species: persistence, replication, and adaptation of infectivity during four passages
    Richard Race
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, 903 S Fourth Street, Hamilton, MT 59840, USA
    J Infect Dis 186:S166-70. 2002
    ..In some cases infectivity similar to the original 263K hamster scrapie strain was found after 2 or 3 serial mouse passages totaling 1200-1550 days...
  47. pmc Reaction of complement factors varies with prion strains in vitro and in vivo
    Rie Hasebe
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, MT 59840, USA
    Virology 423:205-13. 2012
    ..These results indicate that the reactivity of complement factors differs between prion strains both in vitro and in vivo...
  48. pmc New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products
    David A Kocisko
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 77:10288-94. 2003
    ..The fact that many are either approved human drugs or edible natural products should facilitate their use in animal testing and clinical trials...
  49. pmc A simplified recipe for prions
    Kil Sun Lee
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 104:9551-2. 2007
  50. pmc Inhibition of protease-resistant prion protein accumulation in vitro by curcumin
    Byron Caughey
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    J Virol 77:5499-502. 2003
    ..Nonetheless, other studies have shown that curcumin is nontoxic and can penetrate the brain, properties that give curcumin advantages over inhibitors previously identified as potential prophylactic and/or therapeutic anti-TSE compounds...
  51. ncbi request reprint Structural insights into the interaction between prion protein and nucleic acid
    Luis Mauricio T R Lima
    Faculdade de Farmacia, Universidade Federal do Rio de Janeiro, 21941 590 Rio de Janeiro, RJ Brazil
    Biochemistry 45:9180-7. 2006
    ..This visualization of the complex provides insight into how oligonucleotides bind to PrP and opens new avenues to the design of compounds against prion diseases...
  52. ncbi request reprint Intramolecular versus intermolecular disulfide bonds in prion proteins
    Ervin Welker
    Baker Laboratory of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853 1301, USA
    J Biol Chem 277:33477-81. 2002
    ....
  53. ncbi request reprint Molecular heterosis of prion protein beta-oligomers. A potential mechanism of human resistance to disease
    Abdessamad Tahiri-Alaoui
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 281:34171-8. 2006
    ..It may be that this example of molecular heterosis in vitro provides the basis for maintenance of the polymorphism in the population and that beta-oligomers represent a form of PrP sequestered from pathogenic amyloid formation in vivo...
  54. ncbi request reprint Structural properties of prion protein protofibrils and fibrils: an experimental assessment of atomic models
    Mari L DeMarco
    Department of Medicinal Chemistry, Biomolecular Structure and Design Program, University of Washington, Seattle, Washington 98195 7610, USA
    Biochemistry 45:15573-82. 2006
    ..Both the improved characterization of prion aggregates and the existing atomic models can be used to devise further experiments to better elucidate the misfolding pathway and the structure of prion protofibrils...
  55. ncbi request reprint Prion diseases: a nucleic-acid accomplice?
    Byron Caughey
    Nature 425:673-4. 2003
  56. ncbi request reprint Probing for prions: recognizing misfolded PrP
    Byron Caughey
    Nat Med 9:819-20. 2003
  57. ncbi request reprint Cell death and autophagy in prion diseases (transmissible spongiform encephalopathies)
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Czechosłowacka Str 8 10, PL 92 216 Lodz, Poland
    Folia Neuropathol 46:1-25. 2008
    ..On the basis of ultrastructural studies, we suggest that autophagy may play a major role in transmissible spongiform encephalopathies and may even participate in the formation of spongiform change...
  58. ncbi request reprint Prion diseases--close to effective therapy?
    Neil R Cashman
    Centre for Research in Neurodegenerative Diseases, University of Toronto, 6 Queen s Park Crescent West, Toronto, Ontario M553H2, Canada
    Nat Rev Drug Discov 3:874-84. 2004
    ..The lessons learned in treating prion disease will almost certainly have an impact on other diseases that are characterized by the pathological accumulation of misfolded proteins...