Research Topics
Genomes and Genes | Marta CatalfamoSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cellsMarta Catalfamo
Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation and Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 105:19851-6. 2008..Taken together these data demonstrate that at least two different pathways lead to immune activation of T cells in patients with HIV infection and these pathways differentially influence CD4 and CD8 T cell subsets...
CD4 and CD8 T cell immune activation during chronic HIV infection: roles of homeostasis, HIV, type I IFN, and IL-7Marta Catalfamo
Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 186:2106-16. 2011..CD4 T cell subsets also showed enhanced STAT1 phosphorylation in response to exogenous IL-7...- TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4+CD25+ T cellsMarta Catalfamo
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1360, USA
Immunology 125:70-9. 2008..These results demonstrate that fast delivery of mediators by the regulated secretory pathway in CD4+ T cells can be used to perform other functions that are not involved in cytotoxic function but that can influence/regulate other cells... - Acquisition of antigen presentasome (APS), an MHC/costimulatory complex, is a checkpoint of memory T-cell homeostasisSven Mostbock
The Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 109:2488-95. 2007..The acquisition of APS by memory T cells might be an important checkpoint leading to the clonal deletion of the majority of effector T cells, possibly allowing the surviving cells to become long-term memory cells by default... - Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cellsJung Hyun Park
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Nat Immunol 11:257-64. 2010.... - Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8(+) T-cell responseMonchou Fann
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Blood 108:3363-70. 2006..Together, these findings suggest that differential gene expression mediated at least in part by histone H3K9 hyperacetylation may be responsible for the rapid and robust memory CD8(+) T-cell response... - Noninvasive in vivo imaging of CD4 cells in simian-human immunodeficiency virus (SHIV)-infected nonhuman primatesMichele Di Mascio
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20817, USA
Blood 114:328-37. 2009..These data provide an estimate for the total number of lymphocytes in the body as being between 1.9 and 2.9 x 10(12) and suggest that the partition between peripheral blood and lymphoid tissue is between 0.3% and 0.5%... - IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cellsKebin Liu
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 99:6192-7. 2002..Thus, IL-15 acts not only as a crucial growth factor but also as an antigen-independent activator of effector functions for CD8(+) memory T cells... - The role of cytokines in the pathogenesis and treatment of HIV infectionMarta Catalfamo
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1360, United States
Cytokine Growth Factor Rev 23:207-14. 2012..This review discusses the cytokine mediated pathways of immune activation of the CD4 and CD8 T cell pools during HIV infection... - Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosisBibiana Bielekova
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 103:5941-6. 2006..This immunoregulation has potential importance for the treatment of autoimmune diseases and transplant rejection and toward modification of tumor immunity... 
CD8+ effector cellsPierre A Henkart
National Institutes of Health, Bethesda, Maryland 20892-1360, USA
Adv Immunol 83:233-52. 2004- Amplification of the lytic potential of effector/memory CD8+ cells by vector-based enhancement of ICAM-1 (CD54) in target cells: implications for intratumoral vaccine therapyDale C Slavin-Chiorini
Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Cancer Gene Ther 11:665-80. 2004..These studies thus support the concept of intratumoral vaccination employing vectors expressing costimulatory molecules... - Human CD8+ T cells store RANTES in a unique secretory compartment and release it rapidly after TcR stimulationMarta Catalfamo
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 20:219-30. 2004..These results show that CD8+ T cells have two distinct TcR-regulated secretory compartments characterized by different mobilization kinetics, effector molecules, and biological function... - Chronic active Epstein-Barr virus infection associated with mutations in perforin that impair its maturationHarutaka Katano
Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 103:1244-52. 2004..Mutations in the perforin gene are associated with some cases of CAEBV with hemophagocytic lymphohistiocytosis... - IL-15 is a growth factor and an activator of CD8 memory T cellsNan Ping Weng
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Ann N Y Acad Sci 975:46-56. 2002..These findings indicate that IL-15 is not only a growth factor but also an antigen-independent activator for CD8 memory T cells... - Imaging of lytic granule exocytosis in CD8+ cytotoxic T lymphocytes reveals a modified form of full fusionJose A Martina
Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Heath, Bethesda, MD 20892 8017, USA
Cell Immunol 271:267-79. 2011..Finally, the diffusion properties upon release of the three cargos examined put an upper limit on the size of the macromolecular complex of granzyme and serglycin that is presented to the target cell... - Perforin and the granule exocytosis cytotoxicity pathwayMarta Catalfamo
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 4B36, 9000 Rockville Pike, Bethesda, MD 20892-1360, USA
Curr Opin Immunol 15:522-7. 2003..Selfprotection of cytotoxic lymphocytes after degranulation can be explained by surface expression of the granule protease cathepsin B, as shown by suicidal degranulation in the presence of specific inhibitors... - Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulationKithiganahalli N Balaji
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Bethesda, MD 20892, USA
J Exp Med 196:493-503. 2002..These experiments support a model in which granule-derived surface cathepsin B provides self-protection for degranulating cytotoxic lymphocytes...