Marta Catalfamo

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells
    Marta Catalfamo
    Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation and Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:19851-6. 2008
  2. doi request reprint CD4 and CD8 T cell immune activation during chronic HIV infection: roles of homeostasis, HIV, type I IFN, and IL-7
    Marta Catalfamo
    Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 186:2106-16. 2011
  3. pmc TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4+CD25+ T cells
    Marta Catalfamo
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1360, USA
    Immunology 125:70-9. 2008
  4. pmc Acquisition of antigen presentasome (APS), an MHC/costimulatory complex, is a checkpoint of memory T-cell homeostasis
    Sven Mostbock
    The Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 109:2488-95. 2007
  5. pmc Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
    Jung Hyun Park
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 11:257-64. 2010
  6. pmc Enhanced effector function of CD8(+) T cells from healthy controls and HIV-infected patients occurs through thrombin activation of protease-activated receptor 1
    Amanda Hurley
    CMRS Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1360, USA
    J Infect Dis 207:638-50. 2013
  7. pmc Noninvasive in vivo imaging of CD4 cells in simian-human immunodeficiency virus (SHIV)-infected nonhuman primates
    Michele Di Mascio
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20817, USA
    Blood 114:328-37. 2009
  8. pmc IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells
    Kebin Liu
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 99:6192-7. 2002
  9. pmc The role of cytokines in the pathogenesis and treatment of HIV infection
    Marta Catalfamo
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1360, United States
    Cytokine Growth Factor Rev 23:207-14. 2012
  10. pmc Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis
    Bibiana Bielekova
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:5941-6. 2006

Collaborators

Detail Information

Publications19

  1. pmc HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells
    Marta Catalfamo
    Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation and Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:19851-6. 2008
    ..Taken together these data demonstrate that at least two different pathways lead to immune activation of T cells in patients with HIV infection and these pathways differentially influence CD4 and CD8 T cell subsets...
  2. doi request reprint CD4 and CD8 T cell immune activation during chronic HIV infection: roles of homeostasis, HIV, type I IFN, and IL-7
    Marta Catalfamo
    Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 186:2106-16. 2011
    ..CD4 T cell subsets also showed enhanced STAT1 phosphorylation in response to exogenous IL-7...
  3. pmc TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4+CD25+ T cells
    Marta Catalfamo
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1360, USA
    Immunology 125:70-9. 2008
    ..These results demonstrate that fast delivery of mediators by the regulated secretory pathway in CD4+ T cells can be used to perform other functions that are not involved in cytotoxic function but that can influence/regulate other cells...
  4. pmc Acquisition of antigen presentasome (APS), an MHC/costimulatory complex, is a checkpoint of memory T-cell homeostasis
    Sven Mostbock
    The Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 109:2488-95. 2007
    ..The acquisition of APS by memory T cells might be an important checkpoint leading to the clonal deletion of the majority of effector T cells, possibly allowing the surviving cells to become long-term memory cells by default...
  5. pmc Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
    Jung Hyun Park
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 11:257-64. 2010
    ....
  6. pmc Enhanced effector function of CD8(+) T cells from healthy controls and HIV-infected patients occurs through thrombin activation of protease-activated receptor 1
    Amanda Hurley
    CMRS Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1360, USA
    J Infect Dis 207:638-50. 2013
    ..These findings suggest that thrombin mediates cross-talk between the coagulation system and the adaptive immune system at sites of vascular injury through increased T-cell motility and production of proinflammatory cytokines...
  7. pmc Noninvasive in vivo imaging of CD4 cells in simian-human immunodeficiency virus (SHIV)-infected nonhuman primates
    Michele Di Mascio
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20817, USA
    Blood 114:328-37. 2009
    ..These data provide an estimate for the total number of lymphocytes in the body as being between 1.9 and 2.9 x 10(12) and suggest that the partition between peripheral blood and lymphoid tissue is between 0.3% and 0.5%...
  8. pmc IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells
    Kebin Liu
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 99:6192-7. 2002
    ..Thus, IL-15 acts not only as a crucial growth factor but also as an antigen-independent activator of effector functions for CD8(+) memory T cells...
  9. pmc The role of cytokines in the pathogenesis and treatment of HIV infection
    Marta Catalfamo
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1360, United States
    Cytokine Growth Factor Rev 23:207-14. 2012
    ..This review discusses the cytokine mediated pathways of immune activation of the CD4 and CD8 T cell pools during HIV infection...
  10. pmc Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis
    Bibiana Bielekova
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:5941-6. 2006
    ..This immunoregulation has potential importance for the treatment of autoimmune diseases and transplant rejection and toward modification of tumor immunity...
  11. ncbi request reprint Amplification of the lytic potential of effector/memory CD8+ cells by vector-based enhancement of ICAM-1 (CD54) in target cells: implications for intratumoral vaccine therapy
    Dale C Slavin-Chiorini
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Cancer Gene Ther 11:665-80. 2004
    ..These studies thus support the concept of intratumoral vaccination employing vectors expressing costimulatory molecules...
  12. ncbi request reprint CD8+ effector cells
    Pierre A Henkart
    National Institutes of Health, Bethesda, Maryland 20892 1360, USA
    Adv Immunol 83:233-52. 2004
  13. pmc Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8(+) T-cell response
    Monchou Fann
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Blood 108:3363-70. 2006
    ..Together, these findings suggest that differential gene expression mediated at least in part by histone H3K9 hyperacetylation may be responsible for the rapid and robust memory CD8(+) T-cell response...
  14. ncbi request reprint Chronic active Epstein-Barr virus infection associated with mutations in perforin that impair its maturation
    Harutaka Katano
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 103:1244-52. 2004
    ..Mutations in the perforin gene are associated with some cases of CAEBV with hemophagocytic lymphohistiocytosis...
  15. ncbi request reprint Human CD8+ T cells store RANTES in a unique secretory compartment and release it rapidly after TcR stimulation
    Marta Catalfamo
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 20:219-30. 2004
    ..These results show that CD8+ T cells have two distinct TcR-regulated secretory compartments characterized by different mobilization kinetics, effector molecules, and biological function...
  16. ncbi request reprint IL-15 is a growth factor and an activator of CD8 memory T cells
    Nan Ping Weng
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 975:46-56. 2002
    ..These findings indicate that IL-15 is not only a growth factor but also an antigen-independent activator for CD8 memory T cells...
  17. pmc Imaging of lytic granule exocytosis in CD8+ cytotoxic T lymphocytes reveals a modified form of full fusion
    Jose A Martina
    Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Heath, Bethesda, MD 20892 8017, USA
    Cell Immunol 271:267-79. 2011
    ..Finally, the diffusion properties upon release of the three cargos examined put an upper limit on the size of the macromolecular complex of granzyme and serglycin that is presented to the target cell...
  18. ncbi request reprint Perforin and the granule exocytosis cytotoxicity pathway
    Marta Catalfamo
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 4B36, 9000 Rockville Pike, Bethesda, MD 20892 1360, USA
    Curr Opin Immunol 15:522-7. 2003
    ..Selfprotection of cytotoxic lymphocytes after degranulation can be explained by surface expression of the granule protease cathepsin B, as shown by suicidal degranulation in the presence of specific inhibitors...
  19. pmc Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation
    Kithiganahalli N Balaji
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Bethesda, MD 20892, USA
    J Exp Med 196:493-503. 2002
    ..These experiments support a model in which granule-derived surface cathepsin B provides self-protection for degranulating cytotoxic lymphocytes...