Research Topics
Species | Joseph P CasazzaSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Autocrine production of beta-chemokines protects CMV-Specific CD4 T cells from HIV infectionJoseph P Casazza
Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA
PLoS Pathog 5:e1000646. 2009..These data suggest that CD4+ T cells which produce MIP-1alpha and MIP-1beta bind these chemokines in an autocrine fashion which decreases the risk of in vivo HIV infection...- Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturationJoseph P Casazza
Immunology Laboratory, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID, National Institutes of Health (NIH, Bethesda, MD 20892, USA
J Exp Med 203:2865-77. 2006..Thus, mature CMV-specific CD4+ T cells exhibit distinct functional properties reminiscent of antiviral CD8+ T lymphocytes... - T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesisJason M Brenchley
Human Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 78:1160-8. 2004..These data illuminate the underlying mechanisms that distort T-cell homeostasis in HIV infection... - Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infectionConstantinos Petrovas
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA
J Immunol 183:1120-32. 2009..Thus, our data further support the role of PD-1 as a preapoptotic factor for CD8(+) T cells in HIV infection... - Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infectionChristof Geldmacher
Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 207:2869-81. 2010.... - Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapyJoseph P Casazza
Immunology Laboratory, National Institutes of Health, Bethesda, MD 20892, USA
J Virol 79:3653-63. 2005.... - Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivoJason M Brenchley
Human Virology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA
J Virol 80:6801-9. 2006.... - Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infectionTakuya Yamamoto
National Institutes of Health, Bethesda, MD, USA
Blood 117:4805-15. 2011..Thus, multiple coinhibitory receptors can affect the development of HIV-specific CD8(+) T-cell responses and, by extension, represent potential targets for new immune-based interventions in HIV-infected persons... - PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infectionConstantinos Petrovas
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 203:2281-92. 2006.... 
Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cellsJason M Brenchley
Vaccine Research Center and the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 101:2711-20. 2003..Thus, our studies define a phenotype associated with replicative senescence in HIV-specific CD8(+) T cells, which may have broad implications to other conditions associated with chronic antigenic stimulation...- HIV preferentially infects HIV-specific CD4+ T cellsDaniel C Douek
Vaccine Research Center, NIAID, NIH, Maryland 20892, USA
Nature 417:95-8. 2002..Furthermore, the phenomenon of HIV specifically infecting the very cells that respond to it adds a cautionary note to the practice of structured therapy interruption... - Optimizing peptide matrices for identifying T-cell antigensMelissa L Precopio
Immunology Laboratory, Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
Cytometry A 73:1071-8. 2008..This optimized deconvolution method allows for efficient mapping of T-cell peptide epitopes. It is rapid, powerful, efficient, and unrestricted by HLA type... - A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escapeDaniel C Douek
Department of Experimental Transplantation and Immunology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 168:3099-104. 2002..Thus, CD8(+) T cells comprising multiple TCR clonotypes may expand in vivo in response to individual epitopes, and may increase the ability of the response to recognize virus escape mutants... - Early depletion of Mycobacterium tuberculosis-specific T helper 1 cell responses after HIV-1 infectionChristof Geldmacher
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 198:1590-8. 2008..This study was conducted to better understand the mechanism underlying M. tuberculosis-specific pathogenicity early after onset of HIV infection...