R E Carson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint PET physiological measurements using constant infusion
    R E Carson
    Positron Emission Tomography Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1180, USA
    Nucl Med Biol 27:657-60. 2000
  2. ncbi request reprint Brain uptake of the acid metabolites of F-18-labeled WAY 100635 analogs
    Richard E Carson
    Positrom Emission Tomography Department, W G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 23:249-60. 2003
  3. ncbi request reprint PET evaluation of [(18)F]FCWAY, an analog of the 5-HT(1A) receptor antagonist, WAY-100635
    R E Carson
    Positron Emission Tomography Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Building 10, Room 1C 401, 10 Center Dr, MSC 1180, Bethesda, Maryland 20892 1180, USA
    Nucl Med Biol 27:493-7. 2000
  4. ncbi request reprint Opiate receptor avidity and cerebral blood flow in Alzheimer's disease
    R M Cohen
    Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD 20892 4030, USA
    J Neurol Sci 148:171-80. 1997
  5. ncbi request reprint In vivo muscarinic binding selectivity of (R,S)- and (R,R)-[18F]-fluoromethyl QNB
    D O Kiesewetter
    National Institutes of Health, Positron Emission Tomography Department, Warren G Magnusen Clinical Center, Bethesda, MD 20892 1180, USA
    Bioorg Med Chem 5:1555-67. 1997
  6. ncbi request reprint Opiate receptor avidity is reduced in non-motor impaired MPTP-lesioned rhesus monkeys
    R M Cohen
    Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bldg 36, Room 1A05, 36 Convent Dr MSC 4030, Bethesda, MD 20892 4030, USA
    Brain Res 806:292-6. 1998
  7. ncbi request reprint Opiate receptor avidity is reduced bilaterally in rhesus monkeys unilaterally lesioned with MPTP
    R M Cohen
    Laboratory of Cerebral Metabolism, National Institute of Health, Bethesda, Maryland 20892 4030, USA
    Synapse 33:282-8. 1999
  8. ncbi request reprint PET imaging of 5-HT1A receptor binding in patients with temporal lobe epilepsy
    M T Toczek
    Clinical Epilepsy Section, Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, Warren Grant Magnuson Clinical Center, NIH, Bethesda, MD 20892 1408, USA
    Neurology 60:749-56. 2003
  9. ncbi request reprint In vivo muscarinic binding of 3-(alkylthio)-3-thiadiazolyl tetrahydropyridines
    D O Kiesewetter
    NIH PET Department, Warren G Magnusen Clinical Center, Bethesda, Maryland 20892 1180, USA
    Synapse 31:29-40. 1999
  10. ncbi request reprint Dissociated pattern of activity in visual cortices and their projections during human rapid eye movement sleep
    A R Braun
    Language Section, Voice Speech and Language Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Science 279:91-5. 1998

Collaborators

Detail Information

Publications47

  1. ncbi request reprint PET physiological measurements using constant infusion
    R E Carson
    Positron Emission Tomography Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1180, USA
    Nucl Med Biol 27:657-60. 2000
    ..This paper provides an overview of the tradeoffs in using bolus/infusion methods versus conventional bolus injection for receptor binding studies...
  2. ncbi request reprint Brain uptake of the acid metabolites of F-18-labeled WAY 100635 analogs
    Richard E Carson
    Positrom Emission Tomography Department, W G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 23:249-60. 2003
    ..These results can be used to correct the tissue [ 18F]FCWAY time-activity data for brain uptake of [ 18F]FC using the measured [ 18F]FC input function...
  3. ncbi request reprint PET evaluation of [(18)F]FCWAY, an analog of the 5-HT(1A) receptor antagonist, WAY-100635
    R E Carson
    Positron Emission Tomography Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Building 10, Room 1C 401, 10 Center Dr, MSC 1180, Bethesda, Maryland 20892 1180, USA
    Nucl Med Biol 27:493-7. 2000
    ..Preblocking data showed uniform V of 2-3 mL/mL. These studies demonstrate that [(18)F]FCWAY has very similar kinetic characteristics to [(11)C]WAY-100635...
  4. ncbi request reprint Opiate receptor avidity and cerebral blood flow in Alzheimer's disease
    R M Cohen
    Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD 20892 4030, USA
    J Neurol Sci 148:171-80. 1997
    ....
  5. ncbi request reprint In vivo muscarinic binding selectivity of (R,S)- and (R,R)-[18F]-fluoromethyl QNB
    D O Kiesewetter
    National Institutes of Health, Positron Emission Tomography Department, Warren G Magnusen Clinical Center, Bethesda, MD 20892 1180, USA
    Bioorg Med Chem 5:1555-67. 1997
    ..Displacement with (R)-QNB shows a more varying amount displaced. These results are consistent with (R,R)-[18F]-FMeQNB being M1 selective in vivo...
  6. ncbi request reprint Opiate receptor avidity is reduced in non-motor impaired MPTP-lesioned rhesus monkeys
    R M Cohen
    Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bldg 36, Room 1A05, 36 Convent Dr MSC 4030, Bethesda, MD 20892 4030, USA
    Brain Res 806:292-6. 1998
    ..The results suggest that opiate pathways make a significant contribution to the adjustment of cortico-striatal-thalamic pathway activity and thereby to behavior in rhesus monkeys following dopamine loss...
  7. ncbi request reprint Opiate receptor avidity is reduced bilaterally in rhesus monkeys unilaterally lesioned with MPTP
    R M Cohen
    Laboratory of Cerebral Metabolism, National Institute of Health, Bethesda, Maryland 20892 4030, USA
    Synapse 33:282-8. 1999
    ..In addition, opiate pathway(s) may contribute to the treatment responsiveness and progression of the disease either directly through effects on basal ganglia function or indirectly through effects on basal ganglia plasticity...
  8. ncbi request reprint PET imaging of 5-HT1A receptor binding in patients with temporal lobe epilepsy
    M T Toczek
    Clinical Epilepsy Section, Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, Warren Grant Magnuson Clinical Center, NIH, Bethesda, MD 20892 1408, USA
    Neurology 60:749-56. 2003
    ....
  9. ncbi request reprint In vivo muscarinic binding of 3-(alkylthio)-3-thiadiazolyl tetrahydropyridines
    D O Kiesewetter
    NIH PET Department, Warren G Magnusen Clinical Center, Bethesda, Maryland 20892 1180, USA
    Synapse 31:29-40. 1999
    ..Regional uptake, autoradiographic distribution, and clearance rates in the brain are consistent with the hypothesis that [18F]FP-TZTP is M2 selective in vivo...
  10. ncbi request reprint Dissociated pattern of activity in visual cortices and their projections during human rapid eye movement sleep
    A R Braun
    Language Section, Voice Speech and Language Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Science 279:91-5. 1998
    ....
  11. pmc Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method
    A Breier
    Experimental Therapeutics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:2569-74. 1997
    ..These data provide direct evidence for the hypothesis of elevated amphetamine-induced synaptic dopamine concentrations in schizophrenia...
  12. ncbi request reprint Device-dependent activity estimation and decay correction of radionuclide mixtures with application to Tc-94m PET studies
    M F Smith
    Nuclear Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1180, USA
    Med Phys 28:36-45. 2001
    ..Activity estimation and decay correction for Tc-94m mixtures enable routine use of Tc-94m in quantitative PET, as illustrated by application to a canine Tc-94m sestamibi study...
  13. ncbi request reprint Opiate receptor avidity in the thalamus is sexually dimorphic in the elderly
    R M Cohen
    Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20982 1274, USA
    Synapse 38:226-9. 2000
    ..CF avidity was 27.5% less in the thalamus of healthy women compared to healthy men and 48.5% less in Alzheimer disease female patients compared to male patients...
  14. ncbi request reprint Opiate receptor avidity is increased in rhesus monkeys following unilateral optic tract lesion combined with transections of corpus callosum and hippocampal and anterior commissures
    R M Cohen
    Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD 20892 1274, USA
    Brain Res 879:1-6. 2000
    ..The results suggest that opiate pathways undergo extensive alteration in response to changes in brain functional activities brought about through hemispheric visual deprivation...
  15. ncbi request reprint Axial slice width in 3D PET: characterization and potential improvement with axial interleaving
    M E Daube-Witherspoon
    Positron Emission Tomography Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 1180, USA
    Phys Med Biol 43:921-8. 1998
    ..3-1.1 mm with interleaving. This modest improvement would be accompanied by an increase in image noise, since an axial filter with a higher cut-off would be required in the 3D reconstruction to achieve this resolution in the image...
  16. ncbi request reprint Noise reduction in oncology FDG PET images by iterative reconstruction: a quantitative assessment
    C Riddell
    National Institutes of Health, Bethesda, Maryland, USA
    J Nucl Med 42:1316-23. 2001
    ..OSEM reconstruction failed to improve S/N in very hot tumors, in which S/N may already be adequate for tumor detection...
  17. ncbi request reprint Reduced muscarinic type 2 receptor binding in subjects with bipolar disorder
    Dara M Cannon
    Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 63:741-7. 2006
    ....
  18. ncbi request reprint Age and APOE-epsilon4 genotype influence the effect of physostigmine infusion on the in-vivo distribution volume of the muscarinic-2-receptor dependent tracer [18F]FP-TZTP
    Robert M Cohen
    Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Synapse 60:86-92. 2006
    ....
  19. ncbi request reprint The effect of antiepileptic drugs on 5-HT-receptor binding measured by positron emission tomography
    William H Theodore
    Clinical Epilepsy Section, National Institute of Neurological Diseases and Strokes, Bethesda, Maryland, USA
    Epilepsia 47:499-503. 2006
    ..Antiepileptic drugs may act on the serotonergic system, as shown in animal models, and thus affect receptor-binding measurements...
  20. pmc 5-HT 1A receptors are reduced in temporal lobe epilepsy after partial-volume correction
    Giampiero Giovacchini
    PET Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1408, USA
    J Nucl Med 46:1128-35. 2005
    ..Previous PET studies reported decreased 5-HT 1A binding ipsilateral to epileptic foci but did not correct for the partial-volume effect (PVE) due to structural atrophy...
  21. ncbi request reprint Differential effects of paroxetine on raphe and cortical 5-HT1A binding: a PET study in monkeys
    Giampiero Giovacchini
    PET Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 28:238-48. 2005
    ..These results lend promise to the use of these serotonergic neuroimaging techniques to study neuropsychiatric disorders...
  22. ncbi request reprint Measurement of regional rates of cerebral protein synthesis with L-[1-11C]leucine and PET with correction for recycling of tissue amino acids: II. Validation in rhesus monkeys
    Carolyn Beebe Smith
    Unit on Neuroadaptation and Protein Metabolism, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20892 4030, USA
    J Cereb Blood Flow Metab 25:629-40. 2005
    ....
  23. ncbi request reprint Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC
    Krystof S Bankiewicz
    Department of Neurosurgery, University of California at San Francisco, Room MCB 226, 1855 Folsom Street, San Francisco, CA 94103 0555, USA
    Mol Ther 14:564-70. 2006
    ..Introduction of this therapy into the clinic holds promise for Parkinson patients experiencing the motor complications that result from escalating l-Dopa requirements against a background of disease progression...
  24. pmc Imaging signal transduction via arachidonic acid in the human brain during visual stimulation, by means of positron emission tomography
    Giuseppe Esposito
    Brain Physiology and Metabolism Section, Bldg 9, Rm 1S128, National Institute on Aging, National Institutes of Health, 9 Memorial Drive, Bethesda, MD 20892, USA
    Neuroimage 34:1342-51. 2007
    ..This signaling process can be imaged in brain as a regional brain AA incorporation coefficient K*...
  25. ncbi request reprint Consensus nomenclature for in vivo imaging of reversibly binding radioligands
    Robert B Innis
    National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 27:1533-9. 2007
    ..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands...
  26. ncbi request reprint Noninvasive estimation of normalized distribution volume: application to the muscarinic-2 ligand [(18)F]FP-TZTP
    Masanori Ichise
    Kreitchman PET Center, Department of Radiology, Columbia University College of Physicians, New York, New York 10032, USA
    J Cereb Blood Flow Metab 28:420-30. 2008
    ..We conclude that MRTM2 V(T)(*) allows detection of group differences in receptor binding without arterial blood or a receptor-free reference region...
  27. ncbi request reprint Cerebral blood flow in temporal lobe epilepsy: a partial volume correction study
    Giampiero Giovacchini
    University Milano Bicocca, Via Olgettina 60, Milan, Italy
    Eur J Nucl Med Mol Imaging 34:2066-72. 2007
    ..The magnitude of this effect on cerebral blood flow (CBF) is unexplored. The aim of this study was to assess CBF deficits in TLE before and after magnetic resonance imaging-based partial volume correction (PVC)...
  28. ncbi request reprint Task-related interaction between basal ganglia and cortical dopamine release
    Gaetan Garraux
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:14434-41. 2007
    ....
  29. pmc Imaging neuroinflammation in Alzheimer's disease with radiolabeled arachidonic acid and PET
    Giuseppe Esposito
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Nucl Med 49:1414-21. 2008
    ..Data also indicate that neuroinflammation contributes to Alzheimer's disease (AD). On the basis of these observations, K* for AA was hypothesized to be elevated in patients with AD...
  30. doi request reprint Altered cerebral gamma-aminobutyric acid type A-benzodiazepine receptor binding in panic disorder determined by [11C]flumazenil positron emission tomography
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
    Arch Gen Psychiatry 65:1166-75. 2008
    ..However, the results of previous neuroimaging studies are in disagreement, possibly because of experimental design limitations related to sample size, matching between patients and controls, and confounding medication effects...
  31. ncbi request reprint No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder
    Omer Bonne
    Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 162:383-5. 2005
    ..In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD)...
  32. pmc Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease
    Navin Maswood
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:18171-6. 2004
    ....
  33. ncbi request reprint Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia
    Andreas Meyer-Lindenberg
    Unit on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, 10 4C101, 9000 Rockville Pike, Bethesda, Maryland 20892 1365, USA
    Nat Neurosci 5:267-71. 2002
    ....
  34. ncbi request reprint Strategies to improve neuroreceptor parameter estimation by linear regression analysis
    Masanori Ichise
    Molecular Imaging Branch, National Institutes of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 22:1271-81. 2002
    ..For tracers with slow kinetics and low to moderate noise, however, MA2 may provide the lowest bias while maintaining computational ease for pixelwise parameter estimation...
  35. ncbi request reprint Noise reduction in the simplified reference tissue model for neuroreceptor functional imaging
    Yanjun Wu
    Positron Emission Tomography Department, W G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1180, U S A
    J Cereb Blood Flow Metab 22:1440-52. 2002
    ..These studies demonstrate that SRTM2 should be a useful method to improve the quality of neuroreceptor functional images...
  36. ncbi request reprint Brain incorporation of [11C]arachidonic acid in young healthy humans measured with positron emission tomography
    Giampiero Giovacchini
    Brain Physiology and Metabolism Section, National Institute on Aging, Bethesda, Maryland, U S A
    J Cereb Blood Flow Metab 22:1453-62. 2002
    ..As brain incorporation of labeled AA has been shown in awake rats to be increased by pharmacological activation associated with phospholipase A2-signaling, PET and [11C]AA may be useful to measure signal transduction in the human brain...
  37. ncbi request reprint In vivo muscarinic 2 receptor imaging in cognitively normal young and older volunteers
    Teresa A Podruchny
    Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Synapse 48:39-44. 2003
    ..41, P < 0.01). A lower concentration of acetylcholine in the synapse of some older subjects is one possible explanation for the data...
  38. ncbi request reprint Determination of [18F]FCWAY, [18F]FP-TZTP, and their metabolites in plasma using rapid and efficient liquid-liquid and solid phase extractions
    Ying Ma
    PET Department, The Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Nucl Med Biol 30:233-40. 2003
    ....
  39. ncbi request reprint Higher in vivo muscarinic-2 receptor distribution volumes in aging subjects with an apolipoprotein E-epsilon4 allele
    Robert M Cohen
    Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Synapse 49:150-6. 2003
    ..65, P < 0.06). A lower concentration of acetylcholine in the synapse of APOE-epsilon4+ older individuals is a likely explanation for the greater [(18)F]FP-TZTP distribution volumes...
  40. ncbi request reprint A potential cholinergic mechanism of procaine's limbic activation
    Brenda E Benson
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892 1272, USA
    Neuropsychopharmacology 29:1239-50. 2004
    ..v. procaine's emotional and sensory effects in man. These findings are consistent with other evidence of cholinergic modulation of mood and emotion...
  41. ncbi request reprint Linearized reference tissue parametric imaging methods: application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain
    Masanori Ichise
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 23:1096-112. 2003
    ..MRTM2 allowed rapid generation of parametric images with the noise reductions consistent with the simulations. Rapid parametric imaging by MRTM2 should be a useful method for human [11C]DASB positron emission tomography studies...
  42. ncbi request reprint Nicotine-induced dopamine release in primates measured with [11C]raclopride PET
    Stefano Marenco
    Clinical Brain Disorders Branch, IRP, NIMH, USA
    Neuropsychopharmacology 29:259-68. 2004
    ....
  43. ncbi request reprint Reduced serotonin type 1A receptor binding in panic disorder
    Alexander Neumeister
    National Institutes of Health, National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, Maryland 20892 2670, USA
    J Neurosci 24:589-91. 2004
    ..These results provide for the first time in vivo evidence for the involvement of 5-HT(1A)Rs in the pathophysiology of PD...
  44. ncbi request reprint Species-specific calls evoke asymmetric activity in the monkey's temporal poles
    Amy Poremba
    Behavioral and Cognitive Neuroscience, Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
    Nature 427:448-51. 2004
    ....
  45. ncbi request reprint Brain incorporation of 11C-arachidonic acid, blood volume, and blood flow in healthy aging: a study with partial-volume correction
    Giampiero Giovacchini
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892 1180, USA
    J Nucl Med 45:1471-9. 2004
    ..Animal studies suggest reduction in the activity of this signaling system with age. The aim of this study was to evaluate the effect of healthy aging on brain incorporation of 11C-AA, before and after partial-volume correction (PVC)...
  46. ncbi request reprint Biodistribution, radiation dose estimates, and in vivo Pgp modulation studies of 18F-paclitaxel in nonhuman primates
    Karen A Kurdziel
    PET Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
    J Nucl Med 44:1330-9. 2003
    ..We obtained biodistribution and radiation dose estimates for (18)F-paclitaxel (FPAC) in monkeys and studied the effects of a Pgp blocker (XR9576, tariquidar) on FPAC kinetics...
  47. pmc Toward an evolutionary perspective on conceptual representation: species-specific calls activate visual and affective processing systems in the macaque
    Ricardo Gil-da-Costa
    National Institute on Deafness and Other Communication Disorders, National Institute of Mental Health, and Positron Emission Tomography Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:17516-21. 2004
    ..These findings shed light on the evolutionary precursors of conceptual representation in humans, suggesting that monkeys and humans have a common neural substrate for representing object concepts...