Mary Carrington

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Effects of MHC class I on HIV/SIV disease in primates
    Mary Carrington
    Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
    AIDS 16:S105-14. 2002
  2. pmc Identification of the ancestral killer immunoglobulin-like receptor gene in primates
    Jennifer G Sambrook
    Immunogenomics Laboratory, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 ISA, UK
    BMC Genomics 7:209. 2006
  3. pmc KIR-HLA intercourse in HIV disease
    Mary Carrington
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Trends Microbiol 16:620-7. 2008
  4. ncbi request reprint The influence of HLA genotype on AIDS
    Mary Carrington
    Basic Research Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, Maryland 21702, USA
    Annu Rev Med 54:535-51. 2003
  5. ncbi request reprint Justified chauvinism: advances in defining meiotic recombination through sperm typing
    Mary Carrington
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, National Institutes of Health, SAIC Frederick, MD 21702, USA
    Trends Genet 20:196-205. 2004
  6. pmc Novel alleles of the chemokine-receptor gene CCR5
    M Carrington
    Intramural Research Support Program, Scientific Applications International Corporation Frederick, MD 21702, USA
    Am J Hum Genet 61:1261-7. 1997
  7. pmc Hierarchy of resistance to cervical neoplasia mediated by combinations of killer immunoglobulin-like receptor and human leukocyte antigen loci
    Mary Carrington
    Basic Research Program, Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    J Exp Med 201:1069-75. 2005
  8. ncbi request reprint The impact of variation at the KIR gene cluster on human disease
    M Carrington
    Basic Research Program, SAIC Frederick Inc, Laboratory of Genomic Diversity, National Cancer Institute, Bldg 560 Rm 21 89, P O Box B, Frederick, MD 21702, USA
    Curr Top Microbiol Immunol 298:225-57. 2006
  9. ncbi request reprint Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies
    Sophia S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Infect Dis 186:598-605. 2002
  10. ncbi request reprint Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Medicine (Baltimore) 85:111-27. 2006

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint Effects of MHC class I on HIV/SIV disease in primates
    Mary Carrington
    Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
    AIDS 16:S105-14. 2002
    ..To prevent such an outcome, it will be necessary to approach the disease from many perspectives, andapply comprehensively the knowledge gained to the successful control of the virus...
  2. pmc Identification of the ancestral killer immunoglobulin-like receptor gene in primates
    Jennifer G Sambrook
    Immunogenomics Laboratory, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 ISA, UK
    BMC Genomics 7:209. 2006
    ..Since few KIR remain orthologous between species, with only one of them, KIR2DL4, shown to be common to human, apes and monkeys, the evolution of the KIR gene family in primates remains unclear...
  3. pmc KIR-HLA intercourse in HIV disease
    Mary Carrington
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Trends Microbiol 16:620-7. 2008
    ..Here we concentrate on the interaction between the HLA-B and KIR3DL1/KIR3DS1 genes, describe the effects of these loci on HIV disease, and discuss questions that remain unresolved...
  4. ncbi request reprint The influence of HLA genotype on AIDS
    Mary Carrington
    Basic Research Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, Maryland 21702, USA
    Annu Rev Med 54:535-51. 2003
    ..Here we review the HLA associations with progression to AIDS that have been consistently affirmed and discuss the underlying mechanisms behind some of these associations based on functional studies of immune cell recognition...
  5. ncbi request reprint Justified chauvinism: advances in defining meiotic recombination through sperm typing
    Mary Carrington
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, National Institutes of Health, SAIC Frederick, MD 21702, USA
    Trends Genet 20:196-205. 2004
    ..In this article, we review the novel discoveries in mammalian meiotic recombination that have been revealed through sperm typing...
  6. pmc Novel alleles of the chemokine-receptor gene CCR5
    M Carrington
    Intramural Research Support Program, Scientific Applications International Corporation Frederick, MD 21702, USA
    Am J Hum Genet 61:1261-7. 1997
    ....
  7. pmc Hierarchy of resistance to cervical neoplasia mediated by combinations of killer immunoglobulin-like receptor and human leukocyte antigen loci
    Mary Carrington
    Basic Research Program, Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    J Exp Med 201:1069-75. 2005
    ....
  8. ncbi request reprint The impact of variation at the KIR gene cluster on human disease
    M Carrington
    Basic Research Program, SAIC Frederick Inc, Laboratory of Genomic Diversity, National Cancer Institute, Bldg 560 Rm 21 89, P O Box B, Frederick, MD 21702, USA
    Curr Top Microbiol Immunol 298:225-57. 2006
    ..Here we review a growing body of evidence purporting the influence of KIR polymorphism in human disease...
  9. ncbi request reprint Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies
    Sophia S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Infect Dis 186:598-605. 2002
    ..Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia...
  10. ncbi request reprint Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Medicine (Baltimore) 85:111-27. 2006
    ....
  11. ncbi request reprint A mutation in KIR3DS1 that results in truncation and lack of cell surface expression
    Maureen P Martin
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Immunogenetics 59:823-9. 2007
    ..The data indicate that the null KIR3DS1 allele is uncommon, arose on a single haplotype, and spread across geographically distinct populations...
  12. pmc HLA-B alleles associate consistently with HIV heterosexual transmission, viral load, and progression to AIDS, but not susceptibility to infection
    Xiaojiang Gao
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick Inc, NCI Frederick, Frederick, Maryland 21702, USA
    AIDS 24:1835-40. 2010
    ..Here we test the consistency of HLA-B allelic effects on progression to AIDS, heterosexual HIV transmission, and 'set point' viral levels...
  13. ncbi request reprint Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progression
    Cheryl A Winkler
    Laboratory of Genomic Diversity, Division of Basic Research, SAIC Frederick, NCI, Frederick, MD, USA
    J Acquir Immune Defic Syndr 37:1534-8. 2004
    ....
  14. ncbi request reprint Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
    Maureen P Martin
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Inc, National Cancer Institute, P O Box B, Building 560, Frederick, Maryland 21702, USA
    Nat Genet 39:733-40. 2007
    ....
  15. pmc IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection
    Maureen P Martin
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, NCI Frederick, Frederick, Maryland, USA
    J Infect Dis 202:1749-53. 2010
    ..99), resistance to HIV infection (odds ratio, 0.97), or HIV disease progression (P > .05). This IL28B single-nucleotide polymorphism affects the immune response to HCV but not to HBV or HIV...
  16. ncbi request reprint Detection of KIR3DS1 on the cell surface of peripheral blood NK cells facilitates identification of a novel null allele and assessment of KIR3DS1 expression during HIV-1 infection
    Veronique Pascal
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Immunol 179:1625-33. 2007
    ....
  17. pmc KIR/HLA pleiotropism: protection against both HIV and opportunistic infections
    Ying Qi
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, National Cancer Institute, Frederick, Maryland, USA
    PLoS Pathog 2:e79. 2006
    ..The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS...
  18. ncbi request reprint Cutting edge: heterozygote advantage in autoimmune disease: hierarchy of protection/susceptibility conferred by HLA and killer Ig-like receptor combinations in psoriatic arthritis
    George W Nelson
    Basic Research Program, Science Applications International Corporation Frederick, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 173:4273-6. 2004
    ..These data emphasize the remarkable influence of KIR/HLA combinations on this disease...
  19. pmc HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN)
    Nancy P Y Chung
    HIV Drug Resistance Program, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 285:2100-12. 2010
    ..These data suggest that DC-SIGN structural elements distinct from the oligosaccharide-binding site are required for HIV-1 glycoprotein selectivity...
  20. pmc Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection
    Maureen P Martin
    Basic Research Program, SAIC Frederick, National Cancer Institute, MD 21702, USA
    J Virol 78:14053-6. 2004
    ..87, P = 0.001). This association was not observed in those at risk for mucosally acquired infection. A potential role for DC-SIGN specific to systemic acquisition and dissemination of infection is suggested...
  21. pmc Consistent effects of TSG101 genetic variability on multiple outcomes of exposure to human immunodeficiency virus type 1
    Arman A Bashirova
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, National Cancer Institute, Frederick, Maryland 21702, USA
    J Virol 80:6757-63. 2006
    ..The data raise the hypothesis that noncoding variation in TSG101 affects the efficiency of TSG101-mediated release of viral particles from infected cells, thereby altering levels of plasma viral load and subsequent disease progression...
  22. ncbi request reprint HLA-B Bw4 alleles and HIV-1 transmission in heterosexual couples
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    AIDS 21:225-9. 2007
    ..Genetic factors may play a role in the transmission of HIV-1. Because HLA-B alleles influence HIV-1 disease progression and viral levels, they might also influence HIV-1 transmission...
  23. pmc Novel KIR3DL1 alleles and their expression levels on NK cells: convergent evolution of KIR3DL1 phenotype variation?
    Rasmi Thomas
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 180:6743-50. 2008
    ..These results raise the possibility that KIR3DL1 evolution maintains variation in KIR3DL1 cell-surface expression levels, potentially due to the effect of such variation on functional capacity...
  24. ncbi request reprint Diversity of MICA and linkage disequilibrium with HLA-B in two North American populations
    Xiaojiang Gao
    Laboratory of Genomic Diversity, NCI Frederick, Basic Research Program, SAIC Frederick, Frederick, MD 21702, USA
    Hum Immunol 67:152-8. 2006
    ..The lack of evidence for an active diversification of the MICA gene after racial separation indicates an evolutionary history distinct from that of the classical HLA genes...
  25. ncbi request reprint AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis
    Xiaojiang Gao
    Laboratory of Genomic Diversity, NCI Frederick, Basic Research Program, SAIC Frederick, P O Box B, Frederick, Maryland 21702, USA
    Nat Med 11:1290-2. 2005
    ..The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease...
  26. ncbi request reprint Cutting edge: susceptibility to psoriatic arthritis: influence of activating killer Ig-like receptor genes in the absence of specific HLA-C alleles
    Maureen P Martin
    Basic Research Program, SAIC Frederick, MD 21702, USA
    J Immunol 169:2818-22. 2002
    ..Absence of ligands for inhibitory KIRs could potentially lower the threshold for NK (and/or T) cell activation mediated through activating receptors, thereby contributing to pathogenesis of psoriatic arthritis...
  27. pmc Influence of HLA-C expression level on HIV control
    Richard Apps
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, Science Applications International Corporation Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
    Science 340:87-91. 2013
    ..In contrast, high HLA-C expression had a deleterious effect in Crohn's disease, suggesting a broader influence of HLA expression levels in human disease...
  28. pmc HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C
    Rasmi Thomas
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland, USA
    Nat Genet 41:1290-4. 2009
    ....
  29. pmc Genetic control of variegated KIR gene expression: polymorphisms of the bi-directional KIR3DL1 promoter are associated with distinct frequencies of gene expression
    Hongchuan Li
    Basic Research Program, SAIC Frederick Inc, National Cancer Institute Frederick, Frederick, MD, USA
    PLoS Genet 4:e1000254. 2008
    ..We propose that the polymorphisms shown in this study to regulate the frequency of KIR3DL1/S1 subtype expression on NK cells contribute substantially to the phenotypic variation across allotypes with respect to disease resistance...
  30. pmc A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection
    Rasmi Thomas
    Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA
    J Virol 86:6979-85. 2012
    ....
  31. pmc Association of human leukocyte antigens with nasopharyngeal carcinoma in high-risk multiplex families in Taiwan
    Kelly J Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Hum Immunol 70:910-4. 2009
    ..This finding requires replication in larger studies...
  32. ncbi request reprint Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
    Maureen P Martin
    Basic Research Program, SAIC Frederick, Frederick, Maryland 21702 1201, USA
    Nat Genet 31:429-34. 2002
    ..The strongest synergistic effect of these loci was on progression to depletion of CD4(+) T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection...
  33. ncbi request reprint Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types
    James J Goedert
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Int J Cancer 121:1092-7. 2007
    ..HAM/TSP risk did not differ consistently with common HLA types. Thus, ATL risk, but not HAM/TSP risk, was increased with higher prevalence HLA-B alleles. Perhaps breadth of cellular immunity affects risk of this viral leukemia/lymphoma...
  34. ncbi request reprint Variation of the killer cell immunoglobulin-like receptors and HLA-C genes in nasopharyngeal carcinoma
    Melinda Butsch Kovacic
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Room 7101, Bethesda, MD 20853, USA
    Cancer Epidemiol Biomarkers Prev 14:2673-7. 2005
    ....
  35. ncbi request reprint Balanced polymorphism selected by genetic versus infectious human disease
    Michael Dean
    Laboratory of Genomic Diversity, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland 21702 1201, USA
    Annu Rev Genomics Hum Genet 3:263-92. 2002
    ..The genome organization of the chemokine receptor and HLA gene clusters and their influence on the HIV/AIDS epidemic provides compelling evidence for the interaction of infectious and genetic diseases in recent human history...
  36. pmc Novel member of the CD209 (DC-SIGN) gene family in primates
    Arman A Bashirova
    Science Application International Corporation at Frederick, Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Maryland 21702, USA
    J Virol 77:217-27. 2003
    ....
  37. ncbi request reprint Cutting edge: expansion of the KIR locus by unequal crossing over
    Maureen P Martin
    Basic Research Program, Science Applications International Corporation Frederick, Frederick, MD 21702, USA
    J Immunol 171:2192-5. 2003
    ..These data raise the possibility that unequal crossing over may be responsible in part for the expansion/contraction of KIR haplotypes as well as other homologous gene families that map in tandem...
  38. pmc The molecular origin and consequences of escape from miRNA regulation by HLA-C alleles
    Colm O'hUigin
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, MD 21702, USA
    Am J Hum Genet 89:424-31. 2011
    ....
  39. ncbi request reprint Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission
    Li Wu
    Model Development Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Virology 318:17-23. 2004
    ..These data indicate that there are features common to B cells and DCs that facilitate transmission of HIV-1 and provide new insights toward the mechanism of DC-SIGN-mediated HIV-1 transmission...
  40. pmc Maternal human leukocyte antigen A*2301 is associated with increased mother-to-child HIV-1 transmission
    Romel D Mackelprang
    Departments of 1Epidemiology, 2Medicine, 3Global Health, and 4Biostatistics, University of Washington, Seattle, Washington 5Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, National Cancer Institute at Frederick, Maryland and 6Department of Paediatrics, University of Nairobi, Kenya
    J Infect Dis 202:1273-7. 2010
    ..26-7.51; P =.01; Pcorr is not significant). That maternal HLA-A*2301 was associated with transmission independent of plasma HIV-1 RNA levels suggests that HLA may alter infectivity through mechanisms other than influencing HIV-1 load...
  41. pmc Differential microRNA regulation of HLA-C expression and its association with HIV control
    Smita Kulkarni
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland, USA
    Nature 472:495-8. 2011
    ..Variation in HLA-C expression adds another layer of diversity to this highly polymorphic locus that must be considered when deciphering the function of these molecules in health and disease...
  42. ncbi request reprint Human leukocyte antigen class I alleles and cervical neoplasia: no heterozygote advantage
    Sophia S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 11:419-20. 2002
  43. ncbi request reprint Evaluation of the association with cervical cancer of polymorphisms in syndecan-1, a heparan sulfate proteoglycan involved with viral cell entry
    Kelly J Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, 6120 Executive Boulevard, Suite 550, Bethesda, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 16:2504-8. 2007
    ..S. Study. Our results indicate a lack of association between SDC-1 polymorphisms and risk of squamous cell carcinomas of the cervix. An association between SDC-1 Pro-27 polymorphism and cervical adenocarcinoma cannot be ruled out...
  44. ncbi request reprint Effect of chemokine receptor gene polymorphisms on the response to potent antiretroviral therapy
    T R O'Brien
    Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA
    AIDS 14:821-6. 2000
    ..In comparison with subjects with other genotypes, the prognosis for HIV-1-infected CCR5-delta32 heterozygotes is more favorable and that for CCR5 promoter allele 59029A homozygotes is less favorable...
  45. pmc Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease
    Smita Kulkarni
    Cancer and Inflammation Program, Laboratory of Experimental Immunology and Basic Research Program, Center for Cancer Research Genetics Core, Science Applications International Corporation Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702
    Proc Natl Acad Sci U S A 110:20705-10. 2013
    ..These data illustrate a direct effect of HLA-C expression level on HIV control that cannot be attributed to other HLA loci in linkage disequilibrium with HLA-C and highlight the rich complexity of genetic interactions in human disease. ..
  46. pmc Analysis of binding of KIR3DS1*014 to HLA suggests distinct evolutionary history of KIR3DS1
    Geraldine M O'Connor
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Immunol 187:2162-71. 2011
    ..They also reveal that KIR3DS1 reactivity and specificity is dictated by complex interactions between the residues in this region, suggesting a unique functional evolution of KIR3DS1 within the activating KIR family...
  47. pmc HLA-Cw group 1 ligands for KIR increase susceptibility to invasive cervical cancer
    Maureen P Martin
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc NCI Frederick, Frederick, MD 21702, USA
    Immunogenetics 62:761-5. 2010
    ..008). These data support the involvement of the HLA-C locus in modulating the risk of cervical neoplasia perhaps through its function as ligands for KIR, but functional studies are essential to confirm this hypothesis...
  48. pmc High-resolution patterns of meiotic recombination across the human major histocompatibility complex
    Michael Cullen
    Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
    Am J Hum Genet 71:759-76. 2002
    ..These data provide a plausible model for recombination patterns of the human genome overall...
  49. doi request reprint KIR locus polymorphisms: genotyping and disease association analysis
    Maureen P Martin
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Methods Mol Biol 415:49-64. 2008
    ..This chapter will describe a genotyping method for identifying the presence/absence of the KIR genes and general approaches to data analysis in disease association studies...
  50. pmc Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV
    Eishiro Mizukoshi
    Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda 20892, USA
    J Infect Dis 198:203-12. 2008
    ..To identify immunological correlates for this apparent protection, we studied HCV-specific immune responses in long-term IDUs (duration, >10 years)...
  51. ncbi request reprint Characterization of rhesus macaque natural killer activity against a rhesus-derived target cell line at the single-cell level
    Hanne Andersen
    AIDS Vaccine Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, Frederick, MD 21702 1201, USA
    Cell Immunol 231:85-95. 2004
    ..Use of these approaches should facilitate an improved understanding of NK activity in the rhesus macaque...
  52. pmc KIR genotyping by multiplex PCR-SSP
    Smita Kulkarni
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick Inc, National Cancer Institute Frederick, Frederick, MD, USA
    Methods Mol Biol 612:365-75. 2010
    ..We describe here a simple and reliable multiplex PCR-SSP (sequence-specific priming) method for relatively rapid and inexpensive genotyping of 15 KIR genes using standard agarose gel electrophoresis...
  53. pmc Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN
    Li Wu
    HIV Drug Resistance Program, Laboratory of Genomic Diversity, and Basic Research Program, Science Applications International Corporation Frederick, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 99:1568-73. 2002
    ....
  54. ncbi request reprint Prediagnostic human T lymphotropic virus type I provirus loads were highest in Jamaican children who developed seborrheic dermatitis and severe anemia
    Elizabeth M Maloney
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    J Infect Dis 189:41-5. 2004
    ..Results of examination of HTLV-I viral markers in the 28 HTLV-I-infected children provided virologic support for the epidemiologic associations of HTLV-I with seborrheic dermatitis and severe anemia in childhood...
  55. pmc KIR haplotypes defined by segregation analysis in 59 Centre d'Etude Polymorphisme Humain (CEPH) families
    M P Martin
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, 21702, USA
    Immunogenetics 60:767-74. 2008
    ..These data provide a resource to aid in the interpretation of disease association data involving individuals of European descent...
  56. ncbi request reprint Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort
    M W Smith
    Science Applications International Corp Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
    Science 277:959-65. 1997
    ....
  57. doi request reprint Response to Comment on "Influence of HLA-C expression level on HIV control"
    Richard Apps
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, Science Applications International Corporation Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
    Science 341:1175. 2013
    ..Evidence remains far stronger that HLA-C expression levels as detected by the DT9 antibody specifically affect HIV control. ..
  58. ncbi request reprint Immunogenetics of viral infections
    Maureen P Martin
    Basic Research Program, Science Applications International Corporation Frederick Inc, Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Curr Opin Immunol 17:510-6. 2005
    ..Combinations of HLA and KIR also appear to affect outcome to viral infection, supporting a role for HLA class I diversity in the innate immune response in addition to the acquired immune response...
  59. ncbi request reprint HLA-DR, HLA-DQ, and TAP genes in familial Hodgkin disease
    Lea C Harty
    Genetic Epidemiology Branch and the Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Blood 99:690-3. 2002
    ..These 3 markers were in linkage disequilibrium and may not represent independent susceptibility regions. Use of a family-based approach excludes population stratification as an explanation for these findings...
  60. ncbi request reprint Interleukin-1 polymorphisms associated with increased risk of gastric cancer
    E M El-Omar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nature 404:398-402. 2000
    ..Host genetic factors that affect interleukin-1-beta may determine why some individuals infected with H. pylori develop gastric cancer while others do not...
  61. ncbi request reprint Considering genetic profiles in functional studies of immune responsiveness to HIV-1
    M Carrington
    Intramural Research Support Program, Science Applications International Corporation, and the Laboratory of Genomic Diversity, National Cancer Institute NCI, P O Box B, Frederick, MD 21702 1201, USA
    Immunol Lett 79:131-40. 2001
    ....
  62. ncbi request reprint Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 Co-receptor and ligand binding function
    O M Howard
    Intramural Research Support Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 274:16228-34. 1999
    ....
  63. ncbi request reprint Recombination within the human MHC
    M Carrington
    IRSP, SAIC Frederick National Cancer Institute, MD 21702, USA
    Immunol Rev 167:245-56. 1999
    ....
  64. pmc Immunogenetics of spontaneous control of HIV
    Mary Carrington
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 20882, USA
    Annu Rev Med 63:131-45. 2012
    ..Here we progress beyond the genetic associations alone to consider the functional explanations for these correlations. In this process, the complex and multidimensional effects of HLA molecules in viral disease become apparent...
  65. ncbi request reprint High-density map of short tandem repeats across the human major histocompatibility complex
    Michael Cullen
    Basic Research Program, SAIC Frederick Inc, NCI Frederick, MD 21702 1201, USA
    Immunogenetics 54:900-10. 2003
    ....
  66. pmc Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial
    Tania Mara Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hepatology 49:1847-58. 2009
    ..51; P = 0.05) and a strong relationship among African American patients; all 10 with SVR who were genotyped for TYK2 -2256 carried the A variant compared with 68 of 120 (57%) nonresponders (P = 0.006)...
  67. ncbi request reprint Chemokine receptor gene polymorphisms and risk of human T lymphotropic virus type I infection in Jamaica
    Michie Hisada
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    J Infect Dis 185:1351-4. 2002
    ..These findings suggest that CCR2-64I, or alleles in linkage disequilibrium with it, may affect the risk of HTLV-I infection in a recessive manner...
  68. pmc Diversity of the human LILRB3/A6 locus encoding a myeloid inhibitory and activating receptor pair
    Arman A Bashirova
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA
    Immunogenetics 66:1-8. 2014
    ..We suggest that the LILRA6 CNV may influence the level of the activating receptor on the cell surface, potentially affecting signaling upon LILRB3/A6 ligation. ..
  69. pmc Impact of protective killer inhibitory receptor/human leukocyte antigen genotypes on natural killer cell and T-cell function in HIV-1-infected controllers
    Costin Tomescu
    HIV Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, PA 19104, USA
    AIDS 26:1869-78. 2012
    ..However, a comparative analysis of the genotype and function of the innate and adaptive immune compartments in HIV-1-infected controller individuals has been understudied to date...
  70. ncbi request reprint HLA microsatellite analysis
    Mary Carrington
    National Cancer Institute, Frederick, MD, USA
    Methods Mol Biol 210:325-32. 2003
  71. ncbi request reprint Capture of antigen-specific T lymphocytes from human blood by selective immortalization to establish long-term T-cell lines maintaining primary cell characteristics
    Eugene V Barsov
    AIDS Vaccine Program, SAIC Frederick, Inc, NCI Frederick, P O Box B, Frederick, MD 21702, USA
    Immunol Lett 105:26-37. 2006
    ..This approach provides a convenient, reproducible means for generating a stable, continuously renewable source of antigen-specific T lymphocytes for a variety of studies of T cell biology...
  72. ncbi request reprint Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS
    X Gao
    Intramural Research Support Program, Science Applications International Corporation Frederick and the National Cancer Institute, MD, USA
    N Engl J Med 344:1668-75. 2001
    ..We examined subtypes of HLA-B*35 in five cohorts and analyzed the relation of structural differences between HLA-B*35 subtypes to the risk of progression to AIDS...
  73. pmc Haplotype-dependent HLA susceptibility to nasopharyngeal carcinoma in a Southern Chinese population
    M Tang
    Laboratory of Genomic Diversity National Cancer Institute Frederick, Frederick, MD, USA
    Genes Immun 11:334-42. 2010
    ..42 (P<0.0001). The overall high frequency of NPC-susceptible HLA factors in the Guangxi population is likely to have contributed to the high-NPC incidence in this region...
  74. pmc Immunogenetics of HIV disease
    Maureen P Martin
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Immunol Rev 254:245-64. 2013
    ..We review the HLA and KIR associations with HIV disease and discuss the mechanisms underlying these associations...
  75. ncbi request reprint Antibodies to varicella-zoster virus in blood donors with genetic variance in CC chemokine receptor 5
    Mingdong Zhang
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7248, Rockville, MD 20852, USA
    Lancet 359:1034-6. 2002
    ..We have therefore found no evidence that the CCR5-Delta32 allele is associated with decreased seroprevalence of varicella-zoster virus infection...
  76. ncbi request reprint Host factors associated with outcome from primary human immunodeficiency virus-1 infection
    Amalio Telenti
    aInstitute of Microbiology, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland bCancer and Inflammation Program, Laboratory of Experiment Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
    Curr Opin HIV AIDS 3:28-35. 2008
    ..SUMMARY: Host genetics and genomic analyses of precise quantitative study phenotypes offer an unprecedented opportunity to dissect critical steps in human immunodeficiency virus-1 pathogenesis...
  77. ncbi request reprint Human leukocyte antigen class I/II alleles and development of human papillomavirus-related cervical neoplasia: results from a case-control study conducted in the United States
    A Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7374, USA
    Cancer Epidemiol Biomarkers Prev 7:1035-41. 1998
    ....
  78. pmc A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection
    A A Bashirova
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Frederick, MD 21702, USA
    J Exp Med 193:671-8. 2001
    ..We propose that L-SIGN may play an important role in the interaction between liver sinusoidal endothelium and trafficking lymphocytes, as well as function in the pathogenesis of HIV-1...
  79. ncbi request reprint Human leukocyte antigen class I and II haplotypes and risk of cervical cancer
    J D Carreon
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Tissue Antigens 66:321-4. 2005
    ..No HLA haplotype was significantly associated with cervical neoplasia, suggesting that individual allele associations reported to date (e.g. HLA-DR*13) are not likely explained by underlying haplotypes...
  80. ncbi request reprint Human leukocyte antigen class I and II alleles and risk of cervical neoplasia: results from a population-based study in Costa Rica
    S S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Infect Dis 184:1310-4. 2001
    ..2-23.7). These results support the hypothesis that multiple risk alleles are needed in order to increase risk for cervical neoplasia, but a single protective allele may be sufficient for protection...
  81. pmc A scan for linkage disequilibrium across the human genome
    G A Huttley
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
    Genetics 152:1711-22. 1999
    ....
  82. ncbi request reprint Sequence analysis of two novel HLA-DMA alleles
    M Carrington
    Biological Carcinogenesis and Development Program, Program Resources Inc DynCorp, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702
    Immunogenetics 40:165. 1994
  83. pmc Partial activation and induction of apoptosis in CD4(+) and CD8(+) T lymphocytes by conformationally authentic noninfectious human immunodeficiency virus type 1
    M T Esser
    AIDS Vaccine Program, SAIC-Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA
    J Virol 75:1152-64. 2001
    ..The results suggest that the immunopathogenesis of HIV infection may not depend solely on direct cytopathic effects of HIV replication, but that effects due to noninfectious HIV-1 virions may also contribute importantly...
  84. pmc Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection
    Zabrina L Brumme
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 82:9216-27. 2008
    ..Dramatic differences in escape and reversion rates across codons, genes, and HLA restrictions are observed, highlighting the complexity of viral adaptation to the host immune response...
  85. pmc Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success
    Susan E Hiby
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, England, UK
    J Exp Med 200:957-65. 2004
    ..In light of our findings, reproductive success may have been a factor in the evolution and maintenance of human HLA-C and KIR polymorphisms...
  86. ncbi request reprint Frequency of CCR5 variants among rural populations with low HIV-1 prevalence in Cameroon
    Judith N Torimiro
    Walter Reed Johns Hopkins Cameroon Program, Yaounde, Cameroon
    AIDS 21:527-8. 2007
    ..No individual was identified with the CCR5Delta32 allele, but homozygotes for the CCR5 promoter variant -2459G (27.5%) were relatively common. A seroprevalence of 3.1% of HIV-1 was reported...
  87. pmc Drug-susceptible HIV-1 infection despite intermittent fixed-dose combination tenofovir/emtricitabine as prophylaxis is associated with low-level viremia, delayed seroconversion, and an attenuated clinical course
    Nicole Prada
    Aaron Diamond AIDS Research Center, Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    J Acquir Immune Defic Syndr 49:117-22. 2008
    ..Attenuated infection with failure of tenofovir as prophylaxis has been reported in animal models. Here, we report a case of HIV-1 infection despite intermittent use of fixed-dose combination tenofovir and emtricitabine (FTC)...
  88. ncbi request reprint Association of polymorphisms in human leukocyte antigen class I and transporter associated with antigen processing genes with resistance to human immunodeficiency virus type 1 infection
    Chenglong Liu
    School of Public Health, University of California, Los Angeles, CA 90095, USA
    J Infect Dis 187:1404-10. 2003
    ..In multivariate logistic analysis, only the A*0205 subgroup (OR, 5.56; 95% CI, 1.34-23.10; P=.018) and the TAP2 Ala665 (OR, 2.22; 95% CI, 1.28-3.84; P=.005) were associated with resistance...
  89. ncbi request reprint Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002
    Steven G E Marsh
    Anthony Nolan Research Institute, Royal Free Hospital, Hampstead, London, United Kingdom
    Hum Immunol 64:648-54. 2003
  90. ncbi request reprint Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002
    Steven G E Marsh
    Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK
    Immunogenetics 55:220-6. 2003
  91. ncbi request reprint Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility
    Huanliang Liu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
    J Infect Dis 193:698-702. 2006
    ..5% in high-risk HIV-1-seronegative individuals vs. 27.6% in HIV-1-seropositive individuals; P=.0291). These findings suggest that DC-SIGNR polymorphisms may influence susceptibility to HIV-1...
  92. pmc Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history
    James A Traherne
    Department of Pathology, Immunology Division, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 2:e9. 2006
    ....
  93. pmc An integrated haplotype map of the human major histocompatibility complex
    Emily C Walsh
    Center for Genome Research, Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA
    Am J Hum Genet 73:580-90. 2003
    ..Furthermore, these data show that multi-SNP haplotypes will likely be a valuable means for refining association signals in this region...
  94. pmc Comprehensive analysis of class I and class II HLA antigens and chronic hepatitis B virus infection
    Chloe L Thio
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Virol 77:12083-7. 2003
    ..The associations with class I alleles are consistent with a previously implicated role for CD8-mediated cytolytic-T-cell response in determining the outcome of an acute HBV infection...
  95. ncbi request reprint Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1 and -DQA1 allelic profiles and motifs define clinicopathologic groups in caucasians
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, Rockville, MD 20892 0958, USA
    Medicine (Baltimore) 84:338-49. 2005
    ..These variations in associated HLA polymorphisms may reflect responses to unique environmental triggers resulting in the tissue pathospecificity and distinct clinicopathologic syndromes of the IIM...
  96. ncbi request reprint HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
    Salim I Khakoo
    Liver Group, Division of Infection, Inflammation, and Repair, Southampton University, Southampton 5016 6YD, UK
    Science 305:872-4. 2004
    ..The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV...
  97. pmc Single haplotype analysis demonstrates rapid evolution of the killer immunoglobulin-like receptor (KIR) loci in primates
    Jennifer G Sambrook
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kindgom
    Genome Res 15:25-35. 2005
    ..An analysis of the intronic regions of the two non-human primates reveals the presence of ancient repeat elements, which are indicative of the duplication events that have taken place since the last common ancestor...
  98. pmc DNA methylation maintains allele-specific KIR gene expression in human natural killer cells
    Huei Wei Chan
    Department of Pathology, University of Iowa, Iowa City, IA 52242, USA
    J Exp Med 197:245-55. 2003
    ..Thus, NK cells use DNA methylation to maintain clonally restricted expression of highly homologous KIR genes and alleles...
  99. pmc A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC
    Paul I W de Bakker
    Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 38:1166-72. 2006
    ....
  100. ncbi request reprint HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, Bethesda, Maryland 20892, USA
    Arthritis Rheum 54:3670-81. 2006
    ..To investigate possible associations of HLA polymorphisms with idiopathic inflammatory myopathy (IIM) in African Americans, and to compare this with HLA associations in European American IIM patients with IIM...
  101. pmc Maternal HLA homozygosity and mother-child HLA concordance increase the risk of vertical transmission of HIV-1
    Romel D Mackelprang
    Department of Epidemiology, University of Washington, Seattle 98104, USA
    J Infect Dis 197:1156-61. 2008
    ..Mother-child human leukocyte antigen (HLA) concordance and maternal HLA homozygosity may increase the risk of vertical transmission of human immunodeficiency virus type 1 (HIV-1) risk by reducing infant immune responses...