Mary Carrington

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi Identification of the ancestral killer immunoglobulin-like receptor gene in primates
    Jennifer G Sambrook
    Immunogenomics Laboratory, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 ISA, UK
    BMC Genomics 7:209. 2006
  2. ncbi KIR-HLA intercourse in HIV disease
    Mary Carrington
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Trends Microbiol 16:620-7. 2008
  3. ncbi The influence of HLA genotype on AIDS
    Mary Carrington
    Basic Research Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, Maryland 21702, USA
    Annu Rev Med 54:535-51. 2003
  4. ncbi Effects of MHC class I on HIV/SIV disease in primates
    Mary Carrington
    Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
    AIDS 16:S105-14. 2002
  5. ncbi Hierarchy of resistance to cervical neoplasia mediated by combinations of killer immunoglobulin-like receptor and human leukocyte antigen loci
    Mary Carrington
    Basic Research Program, Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    J Exp Med 201:1069-75. 2005
  6. ncbi The impact of variation at the KIR gene cluster on human disease
    M Carrington
    Basic Research Program, SAIC Frederick Inc, Laboratory of Genomic Diversity, National Cancer Institute, Bldg 560 Rm 21 89, P O Box B, Frederick, MD 21702, USA
    Curr Top Microbiol Immunol 298:225-57. 2006
  7. ncbi Justified chauvinism: advances in defining meiotic recombination through sperm typing
    Mary Carrington
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, National Institutes of Health, SAIC Frederick, MD 21702, USA
    Trends Genet 20:196-205. 2004
  8. ncbi Novel alleles of the chemokine-receptor gene CCR5
    M Carrington
    Intramural Research Support Program, Scientific Applications International Corporation Frederick, MD 21702, USA
    Am J Hum Genet 61:1261-7. 1997
  9. ncbi Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Medicine (Baltimore) 85:111-27. 2006
  10. ncbi A mutation in KIR3DS1 that results in truncation and lack of cell surface expression
    Maureen P Martin
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Immunogenetics 59:823-9. 2007

Detail Information

Publications107 found, 100 shown here

  1. ncbi Identification of the ancestral killer immunoglobulin-like receptor gene in primates
    Jennifer G Sambrook
    Immunogenomics Laboratory, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 ISA, UK
    BMC Genomics 7:209. 2006
    ..Since few KIR remain orthologous between species, with only one of them, KIR2DL4, shown to be common to human, apes and monkeys, the evolution of the KIR gene family in primates remains unclear...
  2. ncbi KIR-HLA intercourse in HIV disease
    Mary Carrington
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Trends Microbiol 16:620-7. 2008
    ..Here we concentrate on the interaction between the HLA-B and KIR3DL1/KIR3DS1 genes, describe the effects of these loci on HIV disease, and discuss questions that remain unresolved...
  3. ncbi The influence of HLA genotype on AIDS
    Mary Carrington
    Basic Research Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, Maryland 21702, USA
    Annu Rev Med 54:535-51. 2003
    ..Here we review the HLA associations with progression to AIDS that have been consistently affirmed and discuss the underlying mechanisms behind some of these associations based on functional studies of immune cell recognition...
  4. ncbi Effects of MHC class I on HIV/SIV disease in primates
    Mary Carrington
    Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
    AIDS 16:S105-14. 2002
    ..To prevent such an outcome, it will be necessary to approach the disease from many perspectives, andapply comprehensively the knowledge gained to the successful control of the virus...
  5. ncbi Hierarchy of resistance to cervical neoplasia mediated by combinations of killer immunoglobulin-like receptor and human leukocyte antigen loci
    Mary Carrington
    Basic Research Program, Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    J Exp Med 201:1069-75. 2005
    ....
  6. ncbi The impact of variation at the KIR gene cluster on human disease
    M Carrington
    Basic Research Program, SAIC Frederick Inc, Laboratory of Genomic Diversity, National Cancer Institute, Bldg 560 Rm 21 89, P O Box B, Frederick, MD 21702, USA
    Curr Top Microbiol Immunol 298:225-57. 2006
    ..Here we review a growing body of evidence purporting the influence of KIR polymorphism in human disease...
  7. ncbi Justified chauvinism: advances in defining meiotic recombination through sperm typing
    Mary Carrington
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, National Institutes of Health, SAIC Frederick, MD 21702, USA
    Trends Genet 20:196-205. 2004
    ..In this article, we review the novel discoveries in mammalian meiotic recombination that have been revealed through sperm typing...
  8. ncbi Novel alleles of the chemokine-receptor gene CCR5
    M Carrington
    Intramural Research Support Program, Scientific Applications International Corporation Frederick, MD 21702, USA
    Am J Hum Genet 61:1261-7. 1997
    ....
  9. ncbi Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Medicine (Baltimore) 85:111-27. 2006
    ....
  10. ncbi A mutation in KIR3DS1 that results in truncation and lack of cell surface expression
    Maureen P Martin
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Immunogenetics 59:823-9. 2007
    ..The data indicate that the null KIR3DS1 allele is uncommon, arose on a single haplotype, and spread across geographically distinct populations...
  11. ncbi HLA-B alleles associate consistently with HIV heterosexual transmission, viral load, and progression to AIDS, but not susceptibility to infection
    Xiaojiang Gao
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick Inc, NCI Frederick, Frederick, Maryland 21702, USA
    AIDS 24:1835-40. 2010
    ..Here we test the consistency of HLA-B allelic effects on progression to AIDS, heterosexual HIV transmission, and 'set point' viral levels...
  12. ncbi Consistent effects of TSG101 genetic variability on multiple outcomes of exposure to human immunodeficiency virus type 1
    Arman A Bashirova
    Laboratory of Genomic Diversity, SAIC-Frederick, Inc, National Cancer Institute, Frederick, Maryland 21702, USA
    J Virol 80:6757-63. 2006
    ..The data raise the hypothesis that noncoding variation in TSG101 affects the efficiency of TSG101-mediated release of viral particles from infected cells, thereby altering levels of plasma viral load and subsequent disease progression...
  13. ncbi Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
    Maureen P Martin
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Inc, National Cancer Institute, P O Box B, Building 560, Frederick, Maryland 21702, USA
    Nat Genet 39:733-40. 2007
    ....
  14. ncbi IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection
    Maureen P Martin
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, NCI Frederick, Frederick, Maryland, USA
    J Infect Dis 202:1749-53. 2010
    ..99), resistance to HIV infection (odds ratio, 0.97), or HIV disease progression (P > .05). This IL28B single-nucleotide polymorphism affects the immune response to HCV but not to HBV or HIV...
  15. ncbi Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progression
    Cheryl A Winkler
    Laboratory of Genomic Diversity, Division of Basic Research, SAIC Frederick, NCI, Frederick, MD, USA
    J Acquir Immune Defic Syndr 37:1534-8. 2004
    ....
  16. ncbi Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies
    Sophia S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Infect Dis 186:598-605. 2002
    ..Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia...
  17. ncbi Cutting edge: heterozygote advantage in autoimmune disease: hierarchy of protection/susceptibility conferred by HLA and killer Ig-like receptor combinations in psoriatic arthritis
    George W Nelson
    Basic Research Program, Science Applications International Corporation-Frederick, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 173:4273-6. 2004
    ..These data emphasize the remarkable influence of KIR/HLA combinations on this disease...
  18. ncbi HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN)
    Nancy P Y Chung
    HIV Drug Resistance Program, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 285:2100-12. 2010
    ..These data suggest that DC-SIGN structural elements distinct from the oligosaccharide-binding site are required for HIV-1 glycoprotein selectivity...
  19. ncbi Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection
    Maureen P Martin
    Basic Research Program, SAIC Frederick, National Cancer Institute, MD 21702, USA
    J Virol 78:14053-6. 2004
    ..87, P = 0.001). This association was not observed in those at risk for mucosally acquired infection. A potential role for DC-SIGN specific to systemic acquisition and dissemination of infection is suggested...
  20. ncbi AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis
    Xiaojiang Gao
    Laboratory of Genomic Diversity, NCI-Frederick, Basic Research Program, SAIC Frederick, P.O. Box B, Frederick, Maryland 21702, USA
    Nat Med 11:1290-2. 2005
    ..The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease...
  21. ncbi KIR/HLA pleiotropism: protection against both HIV and opportunistic infections
    Ying Qi
    Laboratory of Genomic Diversity, SAIC-Frederick, Inc, National Cancer Institute, Frederick, Maryland, USA
    PLoS Pathog 2:e79. 2006
    ..The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS...
  22. ncbi Diversity of MICA and linkage disequilibrium with HLA-B in two North American populations
    Xiaojiang Gao
    Laboratory of Genomic Diversity, NCI Frederick, Basic Research Program, SAIC Frederick, Frederick, MD 21702, USA
    Hum Immunol 67:152-8. 2006
    ..The lack of evidence for an active diversification of the MICA gene after racial separation indicates an evolutionary history distinct from that of the classical HLA genes...
  23. ncbi Detection of KIR3DS1 on the cell surface of peripheral blood NK cells facilitates identification of a novel null allele and assessment of KIR3DS1 expression during HIV-1 infection
    Veronique Pascal
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Immunol 179:1625-33. 2007
    ....
  24. ncbi Novel KIR3DL1 alleles and their expression levels on NK cells: convergent evolution of KIR3DL1 phenotype variation?
    Rasmi Thomas
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 180:6743-50. 2008
    ..These results raise the possibility that KIR3DL1 evolution maintains variation in KIR3DL1 cell-surface expression levels, potentially due to the effect of such variation on functional capacity...
  25. ncbi Genetic control of variegated KIR gene expression: polymorphisms of the bi-directional KIR3DL1 promoter are associated with distinct frequencies of gene expression
    Hongchuan Li
    Basic Research Program, SAIC Frederick Inc, National Cancer Institute Frederick, Frederick, MD, USA
    PLoS Genet 4:e1000254. 2008
    ..We propose that the polymorphisms shown in this study to regulate the frequency of KIR3DL1/S1 subtype expression on NK cells contribute substantially to the phenotypic variation across allotypes with respect to disease resistance...
  26. ncbi HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C
    Rasmi Thomas
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland, USA
    Nat Genet 41:1290-4. 2009
    ....
  27. ncbi HLA-B Bw4 alleles and HIV-1 transmission in heterosexual couples
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    AIDS 21:225-9. 2007
    ..Genetic factors may play a role in the transmission of HIV-1. Because HLA-B alleles influence HIV-1 disease progression and viral levels, they might also influence HIV-1 transmission...
  28. ncbi Influence of HLA-C expression level on HIV control
    Richard Apps
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, Science Applications International Corporation Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
    Science 340:87-91. 2013
    ..In contrast, high HLA-C expression had a deleterious effect in Crohn's disease, suggesting a broader influence of HLA expression levels in human disease...
  29. ncbi A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection
    Rasmi Thomas
    Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA
    J Virol 86:6979-85. 2012
    ....
  30. ncbi Cutting edge: susceptibility to psoriatic arthritis: influence of activating killer Ig-like receptor genes in the absence of specific HLA-C alleles
    Maureen P Martin
    Basic Research Program, SAIC-Frederick, MD 21702, USA
    J Immunol 169:2818-22. 2002
    ..Absence of ligands for inhibitory KIRs could potentially lower the threshold for NK (and/or T) cell activation mediated through activating receptors, thereby contributing to pathogenesis of psoriatic arthritis...
  31. ncbi Association of human leukocyte antigens with nasopharyngeal carcinoma in high-risk multiplex families in Taiwan
    Kelly J Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Hum Immunol 70:910-4. 2009
    ..This finding requires replication in larger studies...
  32. ncbi Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
    Maureen P Martin
    Basic Research Program, SAIC Frederick, Frederick, Maryland 21702 1201, USA
    Nat Genet 31:429-34. 2002
    ..The strongest synergistic effect of these loci was on progression to depletion of CD4(+) T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection...
  33. ncbi Balanced polymorphism selected by genetic versus infectious human disease
    Michael Dean
    Laboratory of Genomic Diversity, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland 21702 1201, USA
    Annu Rev Genomics Hum Genet 3:263-92. 2002
    ..The genome organization of the chemokine receptor and HLA gene clusters and their influence on the HIV/AIDS epidemic provides compelling evidence for the interaction of infectious and genetic diseases in recent human history...
  34. ncbi Novel member of the CD209 (DC-SIGN) gene family in primates
    Arman A Bashirova
    Science Application International Corporation at Frederick, Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Maryland 21702, USA
    J Virol 77:217-27. 2003
    ....
  35. ncbi Cutting edge: expansion of the KIR locus by unequal crossing over
    Maureen P Martin
    Basic Research Program, Science Applications International Corporation-Frederick, Frederick, MD 21702, USA
    J Immunol 171:2192-5. 2003
    ..These data raise the possibility that unequal crossing over may be responsible in part for the expansion/contraction of KIR haplotypes as well as other homologous gene families that map in tandem...
  36. ncbi Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission
    Li Wu
    Model Development Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Virology 318:17-23. 2004
    ..These data indicate that there are features common to B cells and DCs that facilitate transmission of HIV-1 and provide new insights toward the mechanism of DC-SIGN-mediated HIV-1 transmission...
  37. ncbi Differential microRNA regulation of HLA-C expression and its association with HIV control
    Smita Kulkarni
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland, USA
    Nature 472:495-8. 2011
    ..Variation in HLA-C expression adds another layer of diversity to this highly polymorphic locus that must be considered when deciphering the function of these molecules in health and disease...
  38. ncbi Maternal human leukocyte antigen A*2301 is associated with increased mother-to-child HIV-1 transmission
    Romel D Mackelprang
    Departments of 1Epidemiology, 2Medicine, 3Global Health, and 4Biostatistics, University of Washington, Seattle, Washington 5Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, National Cancer Institute at Frederick, Maryland and 6Department of Paediatrics, University of Nairobi, Kenya
    J Infect Dis 202:1273-7. 2010
    ..26-7.51; P =.01; Pcorr is not significant). That maternal HLA-A*2301 was associated with transmission independent of plasma HIV-1 RNA levels suggests that HLA may alter infectivity through mechanisms other than influencing HIV-1 load...
  39. ncbi Human leukocyte antigen class I alleles and cervical neoplasia: no heterozygote advantage
    Sophia S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 11:419-20. 2002
  40. ncbi Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types
    James J Goedert
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Int J Cancer 121:1092-7. 2007
    ..HAM/TSP risk did not differ consistently with common HLA types. Thus, ATL risk, but not HAM/TSP risk, was increased with higher prevalence HLA-B alleles. Perhaps breadth of cellular immunity affects risk of this viral leukemia/lymphoma...
  41. ncbi The molecular origin and consequences of escape from miRNA regulation by HLA-C alleles
    Colm O'hUigin
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, MD 21702, USA
    Am J Hum Genet 89:424-31. 2011
    ....
  42. ncbi Variation of the killer cell immunoglobulin-like receptors and HLA-C genes in nasopharyngeal carcinoma
    Melinda Butsch Kovacic
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Room 7101, Bethesda, MD 20853, USA
    Cancer Epidemiol Biomarkers Prev 14:2673-7. 2005
    ....
  43. ncbi Evaluation of the association with cervical cancer of polymorphisms in syndecan-1, a heparan sulfate proteoglycan involved with viral cell entry
    Kelly J Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, 6120 Executive Boulevard, Suite 550, Bethesda, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 16:2504-8. 2007
    ..S. Study. Our results indicate a lack of association between SDC-1 polymorphisms and risk of squamous cell carcinomas of the cervix. An association between SDC-1 Pro-27 polymorphism and cervical adenocarcinoma cannot be ruled out...
  44. ncbi Effect of chemokine receptor gene polymorphisms on the response to potent antiretroviral therapy
    T R O'Brien
    Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA
    AIDS 14:821-6. 2000
    ..In comparison with subjects with other genotypes, the prognosis for HIV-1-infected CCR5-delta32 heterozygotes is more favorable and that for CCR5 promoter allele 59029A homozygotes is less favorable...
  45. ncbi KIR locus polymorphisms: genotyping and disease association analysis
    Maureen P Martin
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Methods Mol Biol 415:49-64. 2008
    ..This chapter will describe a genotyping method for identifying the presence/absence of the KIR genes and general approaches to data analysis in disease association studies...
  46. ncbi Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV
    Eishiro Mizukoshi
    Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda 20892, USA
    J Infect Dis 198:203-12. 2008
    ..To identify immunological correlates for this apparent protection, we studied HCV-specific immune responses in long-term IDUs (duration, >10 years)...
  47. ncbi High-resolution patterns of meiotic recombination across the human major histocompatibility complex
    Michael Cullen
    Basic Research Program, SAIC-Frederick, National Cancer Institute, Frederick, MD 21702, USA
    Am J Hum Genet 71:759-76. 2002
    ..These data provide a plausible model for recombination patterns of the human genome overall...
  48. ncbi Analysis of binding of KIR3DS1*014 to HLA suggests distinct evolutionary history of KIR3DS1
    Geraldine M O'Connor
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Immunol 187:2162-71. 2011
    ..They also reveal that KIR3DS1 reactivity and specificity is dictated by complex interactions between the residues in this region, suggesting a unique functional evolution of KIR3DS1 within the activating KIR family...
  49. ncbi HLA-Cw group 1 ligands for KIR increase susceptibility to invasive cervical cancer
    Maureen P Martin
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc NCI Frederick, Frederick, MD 21702, USA
    Immunogenetics 62:761-5. 2010
    ..008). These data support the involvement of the HLA-C locus in modulating the risk of cervical neoplasia perhaps through its function as ligands for KIR, but functional studies are essential to confirm this hypothesis...
  50. ncbi Prediagnostic human T lymphotropic virus type I provirus loads were highest in Jamaican children who developed seborrheic dermatitis and severe anemia
    Elizabeth M Maloney
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    J Infect Dis 189:41-5. 2004
    ..Results of examination of HTLV-I viral markers in the 28 HTLV-I-infected children provided virologic support for the epidemiologic associations of HTLV-I with seborrheic dermatitis and severe anemia in childhood...
  51. ncbi Characterization of rhesus macaque natural killer activity against a rhesus-derived target cell line at the single-cell level
    Hanne Andersen
    AIDS Vaccine Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, Frederick, MD 21702 1201, USA
    Cell Immunol 231:85-95. 2004
    ..Use of these approaches should facilitate an improved understanding of NK activity in the rhesus macaque...
  52. ncbi Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN
    Li Wu
    HIV Drug Resistance Program, Laboratory of Genomic Diversity, and Basic Research Program, Science Applications International Corporation Frederick, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 99:1568-73. 2002
    ....
  53. ncbi KIR genotyping by multiplex PCR-SSP
    Smita Kulkarni
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick Inc, National Cancer Institute Frederick, Frederick, MD, USA
    Methods Mol Biol 612:365-75. 2010
    ..We describe here a simple and reliable multiplex PCR-SSP (sequence-specific priming) method for relatively rapid and inexpensive genotyping of 15 KIR genes using standard agarose gel electrophoresis...
  54. ncbi KIR haplotypes defined by segregation analysis in 59 Centre d'Etude Polymorphisme Humain (CEPH) families
    M P Martin
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, 21702, USA
    Immunogenetics 60:767-74. 2008
    ..These data provide a resource to aid in the interpretation of disease association data involving individuals of European descent...
  55. ncbi Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort
    M W Smith
    Science Applications International Corp Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
    Science 277:959-65. 1997
    ....
  56. ncbi HLA-DR, HLA-DQ, and TAP genes in familial Hodgkin disease
    Lea C Harty
    Genetic Epidemiology Branch and the Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892-7236, USA
    Blood 99:690-3. 2002
    ..These 3 markers were in linkage disequilibrium and may not represent independent susceptibility regions. Use of a family-based approach excludes population stratification as an explanation for these findings...
  57. ncbi Immunogenetics of viral infections
    Maureen P Martin
    Basic Research Program, Science Applications International Corporation-Frederick Inc, Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Curr Opin Immunol 17:510-6. 2005
    ..Combinations of HLA and KIR also appear to affect outcome to viral infection, supporting a role for HLA class I diversity in the innate immune response in addition to the acquired immune response...
  58. ncbi Considering genetic profiles in functional studies of immune responsiveness to HIV-1
    M Carrington
    Intramural Research Support Program, Science Applications International Corporation, and the Laboratory of Genomic Diversity, National Cancer Institute NCI, P O Box B, Frederick, MD 21702 1201, USA
    Immunol Lett 79:131-40. 2001
    ....
  59. ncbi Interleukin-1 polymorphisms associated with increased risk of gastric cancer
    E M El-Omar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nature 404:398-402. 2000
    ..Host genetic factors that affect interleukin-1-beta may determine why some individuals infected with H. pylori develop gastric cancer while others do not...
  60. ncbi Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 Co-receptor and ligand binding function
    O M Howard
    Intramural Research Support Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 274:16228-34. 1999
    ....
  61. ncbi Recombination within the human MHC
    M Carrington
    IRSP, SAIC Frederick National Cancer Institute, MD 21702, USA
    Immunol Rev 167:245-56. 1999
    ....
  62. ncbi Immunogenetics of spontaneous control of HIV
    Mary Carrington
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 20882, USA
    Annu Rev Med 63:131-45. 2012
    ..Here we progress beyond the genetic associations alone to consider the functional explanations for these correlations. In this process, the complex and multidimensional effects of HLA molecules in viral disease become apparent...
  63. ncbi Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial
    Tania Mara Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hepatology 49:1847-58. 2009
    ..006). CONCLUSION: Genetic polymorphisms in the interferon-alpha pathway may affect responses to antiviral therapy of chronic hepatitis C...
  64. ncbi Chemokine receptor gene polymorphisms and risk of human T lymphotropic virus type I infection in Jamaica
    Michie Hisada
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    J Infect Dis 185:1351-4. 2002
    ..These findings suggest that CCR2-64I, or alleles in linkage disequilibrium with it, may affect the risk of HTLV-I infection in a recessive manner...
  65. ncbi High-density map of short tandem repeats across the human major histocompatibility complex
    Michael Cullen
    Basic Research Program, SAIC-Frederick Inc, NCI Frederick, MD 21702-1201, USA
    Immunogenetics 54:900-10. 2003
    ....
  66. ncbi Impact of protective killer inhibitory receptor/human leukocyte antigen genotypes on natural killer cell and T-cell function in HIV-1-infected controllers
    Costin Tomescu
    HIV Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, PA 19104, USA
    AIDS 26:1869-78. 2012
    ..However, a comparative analysis of the genotype and function of the innate and adaptive immune compartments in HIV-1-infected controller individuals has been understudied to date...
  67. ncbi Capture of antigen-specific T lymphocytes from human blood by selective immortalization to establish long-term T-cell lines maintaining primary cell characteristics
    Eugene V Barsov
    AIDS Vaccine Program, SAIC Frederick, Inc, NCI Frederick, P O Box B, Frederick, MD 21702, USA
    Immunol Lett 105:26-37. 2006
    ..This approach provides a convenient, reproducible means for generating a stable, continuously renewable source of antigen-specific T lymphocytes for a variety of studies of T cell biology...
  68. ncbi HLA microsatellite analysis
    Mary Carrington
    National Cancer Institute, Frederick, MD, USA
    Methods Mol Biol 210:325-32. 2003
  69. ncbi Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS
    X Gao
    Intramural Research Support Program, Science Applications International Corporation Frederick and the National Cancer Institute, MD, USA
    N Engl J Med 344:1668-75. 2001
    ..We examined subtypes of HLA-B*35 in five cohorts and analyzed the relation of structural differences between HLA-B*35 subtypes to the risk of progression to AIDS...
  70. ncbi Haplotype-dependent HLA susceptibility to nasopharyngeal carcinoma in a Southern Chinese population
    M Tang
    Laboratory of Genomic Diversity National Cancer Institute Frederick, Frederick, MD, USA
    Genes Immun 11:334-42. 2010
    ..42 (P<0.0001). The overall high frequency of NPC-susceptible HLA factors in the Guangxi population is likely to have contributed to the high-NPC incidence in this region...
  71. ncbi Antibodies to varicella-zoster virus in blood donors with genetic variance in CC chemokine receptor 5
    Mingdong Zhang
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7248, Rockville, MD 20852, USA
    Lancet 359:1034-6. 2002
    ..We have therefore found no evidence that the CCR5-Delta32 allele is associated with decreased seroprevalence of varicella-zoster virus infection...
  72. ncbi Host factors associated with outcome from primary human immunodeficiency virus-1 infection
    Amalio Telenti
    aInstitute of Microbiology, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland bCancer and Inflammation Program, Laboratory of Experiment Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
    Curr Opin HIV AIDS 3:28-35. 2008
    ..SUMMARY: Host genetics and genomic analyses of precise quantitative study phenotypes offer an unprecedented opportunity to dissect critical steps in human immunodeficiency virus-1 pathogenesis...
  73. ncbi Human leukocyte antigen class I/II alleles and development of human papillomavirus-related cervical neoplasia: results from a case-control study conducted in the United States
    A Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7374, USA
    Cancer Epidemiol Biomarkers Prev 7:1035-41. 1998
    ....
  74. ncbi A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection
    A A Bashirova
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Frederick, MD 21702, USA
    J Exp Med 193:671-8. 2001
    ..We propose that L-SIGN may play an important role in the interaction between liver sinusoidal endothelium and trafficking lymphocytes, as well as function in the pathogenesis of HIV-1...
  75. ncbi Sequence analysis of two novel HLA-DMA alleles
    M Carrington
    Biological Carcinogenesis and Development Program, Program Resources Inc./DynCorp, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702
    Immunogenetics 40:165. 1994
  76. ncbi Human leukocyte antigen class I and II alleles and risk of cervical neoplasia: results from a population-based study in Costa Rica
    S S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Infect Dis 184:1310-4. 2001
    ..2-23.7). These results support the hypothesis that multiple risk alleles are needed in order to increase risk for cervical neoplasia, but a single protective allele may be sufficient for protection...
  77. ncbi Human leukocyte antigen class I and II haplotypes and risk of cervical cancer
    J D Carreon
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Tissue Antigens 66:321-4. 2005
    ..No HLA haplotype was significantly associated with cervical neoplasia, suggesting that individual allele associations reported to date (e.g. HLA-DR*13) are not likely explained by underlying haplotypes...
  78. ncbi A scan for linkage disequilibrium across the human genome
    G A Huttley
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
    Genetics 152:1711-22. 1999
    ....
  79. ncbi Partial activation and induction of apoptosis in CD4(+) and CD8(+) T lymphocytes by conformationally authentic noninfectious human immunodeficiency virus type 1
    M T Esser
    AIDS Vaccine Program, SAIC-Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA
    J Virol 75:1152-64. 2001
    ..The results suggest that the immunopathogenesis of HIV infection may not depend solely on direct cytopathic effects of HIV replication, but that effects due to noninfectious HIV-1 virions may also contribute importantly...
  80. ncbi Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002
    Steven G E Marsh
    Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK
    Immunogenetics 55:220-6. 2003
  81. ncbi Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002
    Steven G E Marsh
    Anthony Nolan Research Institute, Royal Free Hospital, Hampstead, London, United Kingdom
    Hum Immunol 64:648-54. 2003
  82. ncbi An integrated haplotype map of the human major histocompatibility complex
    Emily C Walsh
    Center for Genome Research, Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA
    Am J Hum Genet 73:580-90. 2003
    ..Furthermore, these data show that multi-SNP haplotypes will likely be a valuable means for refining association signals in this region...
  83. ncbi Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1 and -DQA1 allelic profiles and motifs define clinicopathologic groups in caucasians
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, Rockville, MD 20892 0958, USA
    Medicine (Baltimore) 84:338-49. 2005
    ..These variations in associated HLA polymorphisms may reflect responses to unique environmental triggers resulting in the tissue pathospecificity and distinct clinicopathologic syndromes of the IIM...
  84. ncbi Comprehensive analysis of class I and class II HLA antigens and chronic hepatitis B virus infection
    Chloe L Thio
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Virol 77:12083-7. 2003
    ..The associations with class I alleles are consistent with a previously implicated role for CD8-mediated cytolytic-T-cell response in determining the outcome of an acute HBV infection...
  85. ncbi Lack of associations between HLA class II alleles and resistance to HIV-1 infection among white, non-Hispanic homosexual men
    Chenglong Liu
    School of Public Health, University of California, Los Angeles, CA 90095 1772, USA
    J Acquir Immune Defic Syndr 37:1313-7. 2004
    ..Other genetic factors in the HLA class II-TAP region of the major histocompatibility complex might be involved...
  86. ncbi Single haplotype analysis demonstrates rapid evolution of the killer immunoglobulin-like receptor (KIR) loci in primates
    Jennifer G Sambrook
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kindgom
    Genome Res 15:25-35. 2005
    ..An analysis of the intronic regions of the two non-human primates reveals the presence of ancient repeat elements, which are indicative of the duplication events that have taken place since the last common ancestor...
  87. ncbi HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
    Salim I Khakoo
    Liver Group, Division of Infection, Inflammation, and Repair, Southampton University, Southampton 5016 6YD, UK
    Science 305:872-4. 2004
    ..The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV...
  88. ncbi Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success
    Susan E Hiby
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, England, UK
    J Exp Med 200:957-65. 2004
    ..In light of our findings, reproductive success may have been a factor in the evolution and maintenance of human HLA-C and KIR polymorphisms...
  89. ncbi Statistical resolution of ambiguous HLA typing data
    Jennifer Listgarten
    Microsoft Research, Redmond, Washington, United States of America
    PLoS Comput Biol 4:e1000016. 2008
    ..A tool based on our approach is freely available for research purposes at http://microsoft.com/science...
  90. ncbi Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history
    James A Traherne
    Department of Pathology, Immunology Division, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 2:e9. 2006
    ....
  91. ncbi HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, Bethesda, Maryland 20892, USA
    Arthritis Rheum 54:3670-81. 2006
    ..To investigate possible associations of HLA polymorphisms with idiopathic inflammatory myopathy (IIM) in African Americans, and to compare this with HLA associations in European American IIM patients with IIM...
  92. ncbi HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1
    Marcus Altfeld
    PLoS Med 3:e403. 2006
    ....
  93. ncbi Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B
    Hathairat Thananchai
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
    J Immunol 178:33-7. 2007
    ..This study shows that HLA-A*2402 is a ligand for KIR3DL1 and demonstrates how the binding of KIR3DL1 to Bw4(+) ligands depends upon the bound peptide as well as HLA and KIR3DL1 polymorphism...
  94. ncbi Human immunodeficiency virus type 1 (HIV-1)-specific CD8+-T-cell responses for groups of HIV-1-infected individuals with different HLA-B*35 genotypes
    Xia Jin
    Infectious Disease Unit, University of Rochester Medical Center, 601 Elmwood Avenue, Box 689, Rochester, NY 14642, USA
    J Virol 76:12603-10. 2002
    ..05). The data are consistent with the hypothesis that higher levels of virus-specific CTL contribute to protection against HIV disease progression in infected individuals with B*35-PY, but not in those with B*35-Px...
  95. ncbi Frequency of CCR5 variants among rural populations with low HIV-1 prevalence in Cameroon
    Judith N Torimiro
    Walter Reed Johns Hopkins Cameroon Program, Yaounde, Cameroon
    AIDS 21:527-8. 2007
    ..No individual was identified with the CCR5Delta32 allele, but homozygotes for the CCR5 promoter variant -2459G (27.5%) were relatively common. A seroprevalence of 3.1% of HIV-1 was reported...
  96. ncbi Lack of KIR3DS1 binding to MHC class I Bw4 tetramers in complex with CD8+ T cell epitopes
    Geraldine M A Gillespie
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    AIDS Res Hum Retroviruses 23:451-5. 2007
    ..We speculate that our negative finding may be a consequence of the MHC class I molecules and peptide epitopes chosen, but could also relate to key amino acid differences that distinguish KIR3DS1 from KIR3DL1...
  97. ncbi DNA methylation maintains allele-specific KIR gene expression in human natural killer cells
    Huei Wei Chan
    Department of Pathology, University of Iowa, Iowa City, IA 52242, USA
    J Exp Med 197:245-55. 2003
    ..Thus, NK cells use DNA methylation to maintain clonally restricted expression of highly homologous KIR genes and alleles...
  98. ncbi HIV-1 infection in individuals with the CCR5-Delta32/Delta32 genotype: acquisition of syncytium-inducing virus at seroconversion
    Haynes W Sheppard
    Viral and Rickettsial Disease Laboratory, California Department of Health Services, Richmond, California 94804, USA
    J Acquir Immune Defic Syndr 29:307-13. 2002
    ..The pathogenic potential of these viruses may be different from late-stage X4 virus or early X4 virus acquired by individuals with other CCR5 genotypes...
  99. ncbi Global diversity and evidence for coevolution of KIR and HLA
    Richard M Single
    The Department of Mathematics and Statistics, University of Vermont, Burlington, Vermont 05405, USA
    Nat Genet 39:1114-9. 2007
    ....
  100. ncbi Association of polymorphisms in human leukocyte antigen class I and transporter associated with antigen processing genes with resistance to human immunodeficiency virus type 1 infection
    Chenglong Liu
    School of Public Health, University of California, Los Angeles, CA 90095, USA
    J Infect Dis 187:1404-10. 2003
    ..In multivariate logistic analysis, only the A*0205 subgroup (OR, 5.56; 95% CI, 1.34-23.10; P=.018) and the TAP2 Ala665 (OR, 2.22; 95% CI, 1.28-3.84; P=.005) were associated with resistance...
  101. ncbi Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes
    Galit Alter
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA 02129, USA
    J Exp Med 204:3027-36. 2007
    ..These data provide the first functional evidence that variation at the KIR locus influences the effectiveness of NK cell activity in the containment of viral replication...