Bradley A Carlson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Podocyte specific knock out of selenoproteins does not enhance nephropathy in streptozotocin diabetic C57BL/6 mice
    Marsha N Blauwkamp
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI 48109 5678, USA
    BMC Nephrol 9:7. 2008
  2. pmc Ribosomal frameshifting in response to hypomodified tRNAs in Xenopus oocytes
    Bradley A Carlson
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Room 6032, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 375:86-90. 2008
  3. pmc Mouse models targeting selenocysteine tRNA expression for elucidating the role of selenoproteins in health and development
    Bradley A Carlson
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Molecules 14:3509-27. 2009
  4. pmc Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression
    Bradley A Carlson
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Immunol 10:57. 2009
  5. pmc Role of selenium-containing proteins in T-cell and macrophage function
    Bradley A Carlson
    Molecular of Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Nutr Soc 69:300-10. 2010
  6. ncbi request reprint Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery
    Xue Ming Xu
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:41568-75. 2005
  7. pmc Targeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2
    Aniruddha Sengupta
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Invest Dermatol 133:1731-41. 2013
  8. pmc Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells
    Robert Irons
    Nutritional Science Research Group, Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, Rockville, MD 20892 7328, USA
    Cancer Prev Res (Phila) 3:630-9. 2010
  9. pmc Selenoproteins are essential for proper keratinocyte function and skin development
    Aniruddha Sengupta
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 5:e12249. 2010
  10. ncbi request reprint Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function
    Bradley A Carlson
    Section on the Molecular Biology of Selenium, Basic Research Laboratory, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland, 20892, USA
    J Biol Chem 279:8011-7. 2004

Collaborators

Detail Information

Publications54

  1. pmc Podocyte specific knock out of selenoproteins does not enhance nephropathy in streptozotocin diabetic C57BL/6 mice
    Marsha N Blauwkamp
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI 48109 5678, USA
    BMC Nephrol 9:7. 2008
    ..Since oxidative stress has been implicated in the pathogenesis of diabetic nephropathy, we hypothesized that selenoproteins protect against this complication of diabetes...
  2. pmc Ribosomal frameshifting in response to hypomodified tRNAs in Xenopus oocytes
    Bradley A Carlson
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Room 6032, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 375:86-90. 2008
    ..Both tRNAAsn+Q and tRNAAsn-Q were used indiscriminately in frameshifting, whether the frameshift site contained the wild-type AAC, or the mutant AAU codon, suggesting that Q base modification status does not influence this process...
  3. pmc Mouse models targeting selenocysteine tRNA expression for elucidating the role of selenoproteins in health and development
    Bradley A Carlson
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Molecules 14:3509-27. 2009
    ....
  4. pmc Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression
    Bradley A Carlson
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Immunol 10:57. 2009
    ..Incorporation of selenium into the amino acid selenocysteine (Sec), and subsequently into selenoproteins is mediated by Sec tRNA([Ser]Sec)...
  5. pmc Role of selenium-containing proteins in T-cell and macrophage function
    Bradley A Carlson
    Molecular of Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Nutr Soc 69:300-10. 2010
    ..These observations provided novel insights into the role of selenoproteins in the immune function and tissue homeostasis...
  6. ncbi request reprint Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery
    Xue Ming Xu
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:41568-75. 2005
    ..The data also reveal a role of SECp43 in regulation of selenoprotein expression by affecting the synthesis of Um34 on tRNA([Ser]Sec) and the intracellular location of SLA...
  7. pmc Targeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2
    Aniruddha Sengupta
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Invest Dermatol 133:1731-41. 2013
    ..These data link the activity of cutaneous GPx4 to the regulation of COX-2 and hair follicle morphogenesis, and provide insight into the function of individual selenoprotein activity in maintaining cutaneous homeostasis...
  8. pmc Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells
    Robert Irons
    Nutritional Science Research Group, Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, Rockville, MD 20892 7328, USA
    Cancer Prev Res (Phila) 3:630-9. 2010
    ..These data suggest tissue specificity in the cancer-protective effects of Sep15 downregulation, which are mediated, at least in part, by influencing the cell cycle...
  9. pmc Selenoproteins are essential for proper keratinocyte function and skin development
    Aniruddha Sengupta
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 5:e12249. 2010
    ..This study links severe selenoprotein deficiency to abnormalities in skin and hair and provides genetic evidence for the role of these proteins in keratinocyte function and cutaneous development...
  10. ncbi request reprint Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function
    Bradley A Carlson
    Section on the Molecular Biology of Selenium, Basic Research Laboratory, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland, 20892, USA
    J Biol Chem 279:8011-7. 2004
    ..Death appeared to be due to severe hepatocellular degeneration and necrosis with concomitant necrosis of peritoneal and retroperitoneal fat. These studies revealed an essential role of selenoproteins in liver function...
  11. pmc Biosynthesis of selenocysteine on its tRNA in eukaryotes
    Xue Ming Xu
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Biol 5:e4. 2007
    ..Conservation of the overall pathway of Sec biosynthesis suggests that this pathway is also active in other eukaryotes and archaea that synthesize selenoproteins...
  12. ncbi request reprint Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34
    Bradley A Carlson
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 282:32591-602. 2007
    ..High copy numbers of A34 transgene, but not G37 transgene, were not tolerated in the absence of wild type trsp, further suggesting insertion of Sec in place of Cys in selenoproteins...
  13. ncbi request reprint New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea
    Xue Ming Xu
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Biol Trace Elem Res 119:234-41. 2007
    ..Conservation of the overall pathway of Sec biosynthesis suggests that this pathway is also active in other eukaryotes and archaea that contain selenoproteins...
  14. pmc A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3'-UTR
    Min Hyuk Yoo
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    RNA 13:921-9. 2007
    ....
  15. pmc High error rates in selenocysteine insertion in mammalian cells treated with the antibiotic doxycycline, chloramphenicol, or geneticin
    Ryuta Tobe
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 288:14709-15. 2013
    ..The data reveal widespread errors in inserting Sec into proteins and in dysregulation of selenoprotein expression and function upon antibiotic treatment...
  16. pmc A functional link between housekeeping selenoproteins and phase II enzymes
    Aniruddha Sengupta
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, CCR, NCI, NIH, Bethesda, MD 20892, USA
    Biochem J 413:151-61. 2008
    ..Thus the present study provides evidence for a functional link between housekeeping selenoproteins and phase II enzymes...
  17. pmc Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease
    Min Hyuk Yoo
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Antioxid Redox Signal 12:819-27. 2010
    ..These data suggest a role of GPx4 in neurodegenerative diseases through its function in removal of lipid hydroperoxides...
  18. pmc Selenoproteins mediate T cell immunity through an antioxidant mechanism
    Rajeev K Shrimali
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
    J Biol Chem 283:20181-5. 2008
    ..These findings offer novel insights into immune function of selenium and physiological antioxidants...
  19. pmc Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery
    Xue Ming Xu
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:21430-4. 2010
    ..These data reveal a novel Sec machinery-based mechanism for biosynthesis and insertion of Cys into protein at UGA codons and suggest new biological functions for thiophosphate and sulfide in mammals...
  20. pmc Selenoprotein expression is essential in endothelial cell development and cardiac muscle function
    Rajeev K Shrimali
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Neuromuscul Disord 17:135-42. 2007
    ..The data suggest a direct connection between the loss of selenoprotein expression in these cell types and cardiovascular disease...
  21. pmc Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis
    Xue Ming Xu
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem J 404:115-20. 2007
    ..These in vivo studies indicate that SPS2 is essential for generating the selenium donor for selenocysteine biosynthesis in mammals, whereas SPS1 probably has a more specialized, non-essential role in selenoprotein metabolism...
  22. ncbi request reprint Selective rescue of selenoprotein expression in mice lacking a highly specialized methyl group in selenocysteine tRNA
    Bradley A Carlson
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 280:5542-8. 2005
    ..Overall, this study described a novel mechanism of regulation of protein expression by tRNA modification that is in turn regulated by levels of the trace element, selenium...
  23. pmc Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFα
    Mohamed E Moustafa
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e57389. 2013
    ..4 and 2.25 versus 0.1 ppm of selenium. Thus, selenium and selenoprotein deficiencies led to widespread pyogranuloma formation, while high selenium levels inhibited the size of TGFα-induced liver tumors...
  24. pmc Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis
    Bradley A Carlson
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 33:1806-13. 2012
    ..Overall, this study shows that TR1 protects against chemically induced hepatocarcinogenesis via the control of the cellular redox state, whereas its role in promoting this type of cancer is minimal...
  25. pmc Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages
    Bradley A Carlson
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Immunol 49:311-6. 2011
    ..These results reveal TR1 as both a regulator and a regulated target in the macrophage gene expression network, and suggest a link between selenium metabolism and immune signaling...
  26. pmc Simultaneous knockdown of the expression of two genes using multiple shRNAs and subsequent knock-in of their expression
    Xue Ming Xu
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Protoc 4:1338-48. 2009
    ..The entire knockdown or knock-in procedure can be completed in approximately 3-4 months...
  27. pmc Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication
    Min Hyuk Yoo
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 2:e1112. 2007
    ..These observations provide evidence that TR1 is critical for self-sufficiency in growth signals of malignant cells, that TR1 acts largely as a pro-cancer protein and it is indeed a primary target in cancer therapy...
  28. ncbi request reprint Selenocysteine tRNA identification in the model organisms Dictyostelium discoideum and Tetrahymena thermophila
    Rajeev K Shrimali
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 329:147-51. 2005
    ..discoideum is 91 nucleotides long making it the longest eukaryotic sequenced to date. Evolutionary analyses of known Sec tRNAs reveal the two forms identified herein are the most divergent eukaryotic Sec tRNAs thus far sequenced...
  29. pmc Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice
    Petra A Tsuji
    Department of Biological Sciences, Towson University, Towson, Maryland, United States of America
    PLoS ONE 7:e50574. 2012
    ..Overall, our results demonstrate for the first time, that Sep15 knockout mice are protected against chemically-induced aberrant crypt foci formation and that Sep15 appears to have oncogenic properties in colon carcinogenesis in vivo...
  30. pmc HIF-independent regulation of thioredoxin reductase 1 contributes to the high levels of reactive oxygen species induced by hypoxia
    Salvador Naranjo-Suarez
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e30470. 2012
    ..These results indicate that hypoxic TR1 down-regulation is important in maintaining high levels of ROS under hypoxic conditions and that HIF stabilization and activity do not require hypoxic generation of ROS...
  31. pmc Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism
    Ryuta Tobe
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem J 445:423-30. 2012
    ..The results also suggest that the enhanced selenite toxicity of cancer cells and simultaneous inhibition of TR1 can provide a new avenue for cancer therapy...
  32. pmc Alteration of thioredoxin reductase 1 levels in elucidating cancer etiology
    Min Hyuk Yoo
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Methods Enzymol 474:255-75. 2010
    ....
  33. pmc Loss of housekeeping selenoprotein expression in mouse liver modulates lipoprotein metabolism
    Aniruddha Sengupta
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 365:446-52. 2008
    ..These data correlate with reports that selenium deficiency results in increased levels of ApoE, indicating for the first time that housekeeping selenoproteins have a role in regulating lipoprotein biosynthesis and metabolism...
  34. pmc Regulation of HIF-1α activity by overexpression of thioredoxin is independent of thioredoxin reductase status
    Salvador Naranjo-Suarez
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cells 36:151-7. 2013
    ..Thus, regulation of HIF-1α by the thioredoxin system depends on the specific levels of this system's major components...
  35. pmc Deficiency in the 15 kDa selenoprotein inhibits human colon cancer cell growth
    Petra A Tsuji
    Cancer Prevention Fellowship Program, National Cancer Institute, Rockville, MD 20892, USA
    Nutrients 3:805-17. 2011
    ..The potential mechanism by which human colon cancer cells lacking Sep15 revert their cancer phenotype will need to be explored further...
  36. pmc Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells
    Aniruddha Sengupta
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Cell Biol 87:953-61. 2009
    ..Furthermore, we found that the loss of SelT elevates expression of another selenoprotein, selenoprotein W (SepW1). SelT and SepW1 belong to the same protein family, suggesting that SepW1 may functionally compensate for SelT...
  37. pmc The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice
    Bradley A Carlson
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, NCI National Cancer Institute, NIH National Institutes of Health, Bethesda, MD 20892, USA
    Biochem J 418:61-71. 2009
    ..The results indicate that STAF influences selenoprotein expression by enhancing Trsp synthesis in an organ-specific manner and by controlling Sec tRNA modification in each tissue examined...
  38. ncbi request reprint Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells
    Min Hyuk Yoo
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:13005-8. 2006
    ..These observations provide direct evidence that the reduction of TR1 levels in malignant cells is antitumorigenic and suggest that the enzyme is a prime target for cancer therapy...
  39. ncbi request reprint Both selenoproteins and low molecular weight selenocompounds reduce colon cancer risk in mice with genetically impaired selenoprotein expression
    Robert Irons
    Nutritional Science Research Group, National Cancer Institute, Rockville, MD 20852, USA
    J Nutr 136:1311-7. 2006
    ..These results are, to our knowledge, the first to provide evidence that both selenoproteins and low molecular weight selenocompounds are important for the cancer-protective effects of selenium...
  40. ncbi request reprint Selenocysteine incorporation machinery and the role of selenoproteins in development and health
    Dolph L Hatfield
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Prog Nucleic Acid Res Mol Biol 81:97-142. 2006
  41. ncbi request reprint Models for assessing the role of selenoproteins in health
    Mohamed E Moustafa
    Section on the Molecular Biology of Selenium, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Nutr 133:2494S-2496S. 2003
    ..Both approaches provide important tools for examining the role of selenoproteins in health...
  42. doi request reprint Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity
    Andrew D Patterson
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States
    Chem Res Toxicol 26:1088-96. 2013
    ..Yet, JNK was phosphorylated to a similar extent in APAP-treated control mice. The results suggest that Txnrd1(ΔLiv) mice are primed for xenobiotic detoxication primarily through NRF2 activation. ..
  43. ncbi request reprint Rhesus monkey simian immunodeficiency virus infection as a model for assessing the role of selenium in AIDS
    Xue Ming Xu
    Section on the Molecular Biology of Selenium, Basic Research Laboratory, National Cancer Institute NIH, Building 37, Room 2D09, Bethesda, MD 20892, USA
    J Acquir Immune Defic Syndr 31:453-63. 2002
    ....
  44. pmc Selenoproteins reduce susceptibility to DMBA-induced mammary carcinogenesis
    Tamaro S Hudson
    Transgenic Oncogenesis and Genomics Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Carcinogenesis 33:1225-30. 2012
    ....
  45. pmc The Drosophila selenoprotein BthD is required for survival and has a role in salivary gland development
    So Yeon Kwon
    Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 23:8495-504. 2003
    ..Duplex RNAi induced from this construct targeted BthD mRNA for destruction and reduced BthD protein levels. We found that loss of BthD compromised salivary gland morphogenesis and reduced animal viability...
  46. pmc Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase
    Bradley A Carlson
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:12848-53. 2004
    ..The fact that PSTK has been highly conserved in evolution suggests that it plays an important role in selenoprotein biosynthesis and/or regulation...
  47. pmc Abrogated thioredoxin system causes increased sensitivity to TNF-α-induced apoptosis via enrichment of p-ERK 1/2 in the nucleus
    Min Hyuk Yoo
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e71427. 2013
    ..Our data suggest that the thioredoxin system plays a critical role in protecting against TNF-α-induced apoptosis by regulating the levels of nuclear p-ERK 1/2 in a PI3K-dependent manner. ..
  48. pmc Chlamydomonas reinhardtii selenocysteine tRNA[Ser]Sec
    Mahadev Rao
    Section on the Molecular Biology of Selenium, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    RNA 9:923-30. 2003
    ..Evolutionary analyses of known Sec tRNAs identify the C. reinhardtii form as the most diverged eukaryotic Sec tRNA[Ser]Sec and reveal a common origin for this tRNA in bacteria, archaea, and eukaryotes...
  49. pmc Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium
    Easwari Kumaraswamy
    Section on Molecular Biology of Selenium, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 23:1477-88. 2003
    ..Thus, the conditional Trsp knockout mouse allows tissue-specific manipulation of Sec tRNA and selenoprotein expression, suggesting that this approach will provide a useful tool for studying the role of selenoproteins in health...
  50. pmc Role of secretoglobin 3A2 in lung development
    Reiko Kurotani
    Laboratory of Metabolism, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Respir Crit Care Med 178:389-98. 2008
    ..5 during mouse development, which markedly increases by E16.5, the time when lung undergoes dramatic morphologic changes, suggesting that SCGB3A2 may be involved in lung development in addition to a known role in lung inflammation...
  51. pmc Selenoproteins that function in cancer prevention and promotion
    Dolph L Hatfield
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 6032A Bethesda, MD 20892, USA
    Biochim Biophys Acta 1790:1541-5. 2009
    ..In addition, we discuss examples of inhibition of cancer development by selenoprotein deficiency in mouse models. These studies highlight the complex nature of selenium in relation to cancer...
  52. pmc Selenium and selenocysteine: roles in cancer, health, and development
    Dolph L Hatfield
    Molecular Biology of Selenium Section, Mouse Cancer Genetics Program, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Trends Biochem Sci 39:112-20. 2014
    ..Dietary selenium acts principally through selenoproteins, most of which are oxidoreductases involved in diverse cellular functions. ..
  53. ncbi request reprint Transfer RNAs that insert selenocysteine
    Bradley A Carlson
    Section on Molecular Biology of Selenium, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Methods Enzymol 347:24-39. 2002
  54. pmc A recoding element that stimulates decoding of UGA codons by Sec tRNA[Ser]Sec
    Michael T Howard
    Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    RNA 13:912-20. 2007
    ..The variation in recoding elements predicted near UGA-Sec codons implies that these elements may play a differential role in determining the amount of selenoprotein produced by acting as controllers of UGA decoding efficiency...