Neil Caporaso

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Genome-wide and candidate gene association study of cigarette smoking behaviors
    Neil Caporaso
    Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland, United States of America
    PLoS ONE 4:e4653. 2009
  2. ncbi request reprint Monoclonal B cell lymphocytosis: clinical and population perspectives
    Neil E Caporaso
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cytometry B Clin Cytom 78:S115-9. 2010
  3. ncbi request reprint Chronic lymphocytic leukaemia genetics overview
    Neil Caporaso
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Br J Haematol 139:630-4. 2007
  4. ncbi request reprint Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
    Lung Cancer 49:299-309. 2005
  5. ncbi request reprint Green tea consumption, genetic susceptibility, PAH-rich smoky coal, and the risk of lung cancer
    Matthew R Bonner
    Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8121, MSC 7240, Bethesda, MD 20892 7240, USA
    Mutat Res 582:53-60. 2005
  6. ncbi request reprint Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Int J Cancer 116:768-73. 2005
  7. ncbi request reprint Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia
    David Ng
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892 7231, USA
    Blood 109:916-25. 2007
  8. doi request reprint Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Nat Genet 44:1330-5. 2012
  9. pmc A report of cytokine polymorphisms and COPD risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
    Int J Hyg Environ Health 211:352-6. 2008
  10. pmc Common genetic variants in candidate genes and risk of familial lymphoid malignancies
    Xueying Sharon Liang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Br J Haematol 146:418-23. 2009

Detail Information

Publications54

  1. pmc Genome-wide and candidate gene association study of cigarette smoking behaviors
    Neil Caporaso
    Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland, United States of America
    PLoS ONE 4:e4653. 2009
    ..4x10(-5)), our analysis provides independent replication of the association between the chr15q25.1 region and smoking intensity and data for multiple other loci associated with smoking behavior that merit further follow-up...
  2. ncbi request reprint Monoclonal B cell lymphocytosis: clinical and population perspectives
    Neil E Caporaso
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cytometry B Clin Cytom 78:S115-9. 2010
    ..Further studies of MBL are needed to identify the molecular features and how they evolve during progression...
  3. ncbi request reprint Chronic lymphocytic leukaemia genetics overview
    Neil Caporaso
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Br J Haematol 139:630-4. 2007
    ..In this summary we highlight selected themes in the genetics of CLL emphasizing the opportunities and challenges of this malignancy...
  4. ncbi request reprint Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
    Lung Cancer 49:299-309. 2005
    ..002 and P=0.07, respectively). In summary, three genetic variants in folate metabolism genes are associated with an increased risk of lung cancer in Xuan Wei, China...
  5. ncbi request reprint Green tea consumption, genetic susceptibility, PAH-rich smoky coal, and the risk of lung cancer
    Matthew R Bonner
    Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8121, MSC 7240, Bethesda, MD 20892 7240, USA
    Mutat Res 582:53-60. 2005
    ..The chemopreventive effects of green tea in this population may be restricted to individuals who are particularly susceptible to oxidative stress and oxidative DNA damage...
  6. ncbi request reprint Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Int J Cancer 116:768-73. 2005
    ..However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and in other populations with substantial environmental exposure to PAHs...
  7. ncbi request reprint Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia
    David Ng
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892 7231, USA
    Blood 109:916-25. 2007
    ..In conclusion, we identified a novel candidate region that may predispose to familial CLL...
  8. doi request reprint Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Nat Genet 44:1330-5. 2012
    ..3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking...
  9. pmc A report of cytokine polymorphisms and COPD risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
    Int J Hyg Environ Health 211:352-6. 2008
    ..However, in view of our relatively small sample size, this study should be replicated in other populations with substantial exposure to indoor air pollutants such as polycyclic aromatic hydrocarbons (PAH) and particulate matter...
  10. pmc Common genetic variants in candidate genes and risk of familial lymphoid malignancies
    Xueying Sharon Liang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Br J Haematol 146:418-23. 2009
    ..Polymorphisms in TNFSF10 were associated with both CLL and WM. Future replication and functional studies are needed to clarify the role of these genetic variants. Finally, our data further support the close association of WM and CLL...
  11. pmc A flexible Bayesian model for studying gene-environment interaction
    Kai Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    PLoS Genet 8:e1002482. 2012
    ....
  12. ncbi request reprint CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, Italy
    Maria Teresa Landi
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd, EPS, Bethesda, MD 20892 7236, USA
    Toxicology 207:191-202. 2005
    ..Genetic variation in cytochrome P450 induction may identify subjects with variable responsiveness to TCDD and potentially increased risk of disease...
  13. ncbi request reprint Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892 7240, USA
    Anticancer Res 25:537-42. 2005
    ..34; 95% CI: 1.16-9.67). We found genetic variants in APEX1 and XRCC1 may alter the risk of lung cancer in a special population in China...
  14. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis...
  15. ncbi request reprint B-cell repertoire and clonal analysis in unaffected first degree relatives in familial chronic lymphocytic leukaemia kindred
    Fatima Abbasi
    Center for Biologics Evaluation and Research, US Food and Drug Administration, NIH, Bethesda, MD, USA
    Br J Haematol 139:820-3. 2007
    ..Three of these individuals all showed evidence of hyper-somatic mutations. The B-cell repertoire in unaffected FDR in familial CLL offers a new area to investigate the interface between the immune system and lymphoid neoplasm...
  16. ncbi request reprint Overview of monoclonal B-cell lymphocytosis
    Gerald Marti
    Center for Biologics Evaluation and Research CBER, US Food and Drug Administration FDA, NIH, Bethesda, MD, USA
    Br J Haematol 139:701-8. 2007
    ..Environmental health studies suggest that exposure to certain toxins may lead to MBL but further work is needed. MBL is a precursor to CLL but may also regress, remain stable or progress to clinical CLL...
  17. pmc A partially linear tree-based regression model for multivariate outcomes
    Kai Yu
    Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland 20892, USA
    Biometrics 66:89-96. 2010
    ..The proposed method is general enough to be used for the assessment of the joint effect of a set of multiple risk factors on a multivariate outcome in other biomedical research settings...
  18. pmc Pathway analysis by adaptive combination of P-values
    Kai Yu
    Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland 20892, USA
    Genet Epidemiol 33:700-9. 2009
    ..We also illustrate the advantage of the proposed methods using a study of the association between the nicotinic receptor pathway and cigarette smoking behaviors...
  19. pmc Common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Res 73:2211-20. 2013
    ..Our findings could have implications for targeted prevention strategies. However, other smoking-related diseases, as well as practical and ethical considerations, need to be considered before any recommendations could be made...
  20. pmc A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hum Mol Genet 20:4282-9. 2011
    ..Our findings suggest that genetic variation in SLC14A1 could provide new etiological insights into bladder carcinogenesis...
  21. ncbi request reprint Cigarette smoking and cancer risk: modeling total exposure and intensity
    Jay H Lubin
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Am J Epidemiol 166:479-89. 2007
    ..The intensity effects were statistically homogeneous, indicating that after accounting for risk from total pack-years, intensity patterns were comparable across the diverse cancer sites...
  22. pmc Childhood exposure to secondhand smoke and functional mannose binding lectin polymorphisms are associated with increased lung cancer risk
    Susan E Olivo-Marston
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, Division of Cancer Prevention, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD 20892 4258, USA
    Cancer Epidemiol Biomarkers Prev 18:3375-83. 2009
    ....
  23. ncbi request reprint Cigarette smoking and lung cancer: modeling effect modification of total exposure and intensity
    Jay H Lubin
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Epidemiology 18:639-48. 2007
    ..Above 20 cigarettes per day, there is an "inverse-exposure-rate" effect, ie, the excess odds ratio per pack-year for higher intensity smokers is smaller than for lower-intensity smokers...
  24. pmc Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8118, MCS 7240, Bethesda, MD 20892 7240, USA
    Hum Genet 131:1197-203. 2012
    ..037; allelic risk = 0.82, 95% CI = 0.67-0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking...
  25. ncbi request reprint TCDD-mediated alterations in the AhR-dependent pathway in Seveso, Italy, 20 years after the accident
    Maria Teresa Landi
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Carcinogenesis 24:673-80. 2003
    ....
  26. ncbi request reprint Diagnostic criteria for monoclonal B-cell lymphocytosis
    Gerald E Marti
    Center for Biologics Evaluation and Research CBER, US Food and Drug Administration FDA, NIH, Bethesda, MD, USA
    Br J Haematol 130:325-32. 2005
    ..Future studies of MBL should be directed towards determining its relationship to clinical disease, particularly in individuals from families with a genetic predisposition to developing CLL...
  27. ncbi request reprint Genome-wide interaction study of smoking and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA, Institute for Cancer Research, London, UK, Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA, Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain, Municipal Institute of Medical Research, Barcelona, Spain, CIBER Epidemiologia y Salud P├║blica CIBERESP, Barcelona, Spain, National School of Public Health, Athens, Greece, Maine Cancer Registry, Augusta, ME, USA, Spanish National Cancer Research Centre CNIO, Madrid, Spain, Vermont Cancer Registry, Burlington, VT, USA, Center for Genomics Research, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD, USA, Information Management Services, Inc, Rockville, MD, USA, Imperial College London, London, UK, Department of Preventive Medicine and Department of Obstetrics and Gynecology, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA
    Carcinogenesis 35:1737-44. 2014
    ..Our findings provide additional evidence of gene-environment interactions for tobacco and bladder cancer. ..
  28. ncbi request reprint Bioethical considerations of monoclonal B-cell lymphocytosis: donor transfer after haematopoietic stem cell transplantation
    Nancy M Hardy
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Br J Haematol 139:824-31. 2007
    ..Identification of MBL among prospective sibling transplant donors will become a common occurrence in transplant practice as transplantation is increasingly offered to older individuals and those with CLL...
  29. ncbi request reprint B-cell monoclonal lymphocytosis and B-cell abnormalities in the setting of familial B-cell chronic lymphocytic leukemia
    Gerald E Marti
    Flow and Image Cytometry Section, Laboratory Stem Cell Biology, Division of Cell and Gene Therapies, Center for Biologics Research and Evaluation, Food and Drug Administration, Bethesda, Maryland20892, USA
    Cytometry B Clin Cytom 52:1-12. 2003
    ..Familial BCLL can be used as a model to study the early pathogenesis of this disease...
  30. ncbi request reprint High-density mapping and follow-up studies on chromosomal regions 1, 3, 6, 12, 13 and 17 in 28 families with chronic lymphocytic leukaemia
    David Ng
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, DHHS, Bethesda, MD 20892 7236, USA
    Br J Haematol 133:59-61. 2006
    ..2, 3q22.1, 3q26.2, 6q22.31-q23.2, 12q24.23, 14q32.13, 17p13.3. Chromosome 13q21.33 remains a region of interest with a P-value of 0.013 (marker D13S1291) and warrants additional molecular investigation as a susceptibility region for CLL...
  31. ncbi request reprint The association of a tobacco-specific biomarker and cigarette consumption and its dependence on host characteristics
    Jay H Lubin
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 16:1852-7. 2007
    ..Variations in the ratio with host characteristics were generally similar to a recent epidemiologic analysis of effect modification of the association between lung cancer and cigarette smoking...
  32. pmc Genetic variation on 9p22 is associated with abnormal ovarian ultrasound results in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
    PLoS ONE 6:e21731. 2011
    ..The single nucleotide polymorphism (SNP) markers localize to the BNC2 gene, which has been associated with ovarian development...
  33. ncbi request reprint Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations
    Lois B Travis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Natl Cancer Inst 98:15-25. 2006
    ..These research areas warrant high priority to promote NCI's goal of eliminating pain and suffering related to cancer...
  34. pmc Genome-wide association study identifies multiple loci associated with bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hum Mol Genet 23:1387-98. 2014
    ....
  35. pmc Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking
    Sarah H Stephens
    Department of Epidemiology and Public Health, University of Maryland, Baltimore, Maryland, United States of America
    Genet Epidemiol 37:846-59. 2013
    ....
  36. pmc Second malignancy risks after non-Hodgkin's lymphoma and chronic lymphocytic leukemia: differences by lymphoma subtype
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
    J Clin Oncol 28:4935-44. 2010
    ....
  37. ncbi request reprint Perspectives on familial chronic lymphocytic leukemia: genes and the environment
    Neil Caporaso
    Genetic Epideimology Branch, Division of Cancer Epideiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    Semin Hematol 41:201-6. 2004
    ....
  38. pmc Familial and genetic risk of transitional cell carcinoma of the urinary tract
    Christine M Mueller
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, Rockville, MD 20852, USA
    Urol Oncol 26:451-64. 2008
    ....
  39. ncbi request reprint Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 25:2177-81. 2004
    ..However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and other populations with substantial exposure to PAHs...
  40. ncbi request reprint Waldenstr├Âm macroglobulinaemia and IgM monoclonal gammopathy of undetermined significance: emerging understanding of a potential precursor condition
    Mary L McMaster
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Br J Haematol 139:663-71. 2007
    ....
  41. pmc Immunologic effects of dioxin: new results from Seveso and comparison with other studies
    Andrea Baccarelli
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Environ Health Perspect 110:1169-73. 2002
    ..The possible long-term immunologic effects of TCDD exhibited by the participants of the present study, coupled with the increased incidence of lymphatic tumors in the area of the accident, warrant further investigation...
  42. ncbi request reprint Counterpoint: bias from population stratification is not a major threat to the validity of conclusions from epidemiological studies of common polymorphisms and cancer
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20854, USA
    Cancer Epidemiol Biomarkers Prev 11:513-20. 2002
  43. ncbi request reprint Relative validity of a food frequency questionnaire with a meat-cooking and heterocyclic amine module
    Marie Cantwell
    Nutrition Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    Cancer Epidemiol Biomarkers Prev 13:293-8. 2004
    ..In conclusion, although the FFQ and meat module underestimated absolute MeIQx and PhIP intake, its ability to rank individuals according to intake was acceptable...
  44. pmc Intermediacy and gene-environment interaction: the example of CHRNA5-A3 region, smoking, nicotine dependence, and lung cancer
    Sholom Wacholder
    J Natl Cancer Inst 100:1488-91. 2008
  45. ncbi request reprint The molecular epidemiology of oxidative damage to DNA and cancer
    Neil Caporaso
    J Natl Cancer Inst 95:1263-5. 2003
  46. ncbi request reprint Genetic polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the risk of advanced precancerous gastric lesions in a Chinese population
    Wei Cheng You
    Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, 52 Fu Cheng Road, Haidian District, Beijing 100036, People s Republic of China
    Cancer Epidemiol Biomarkers Prev 14:451-8. 2005
    ..These polymorphisms do not seem to govern progression from mild chronic atrophic gastritis to advanced precancerous gastric lesions, but the effects of smoking may be accentuated in individuals carrying variants of CYP2E1...
  47. ncbi request reprint Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review
    Paul Brennan
    International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 159:1-16. 2004
    ..These considerations suggest the potential for the organization of a consortium of investigators conducting studies in this field...
  48. ncbi request reprint Trinucleotide repeat dynamic mutation identifying susceptibility in familial and sporadic chronic lymphocytic leukaemia
    Rebecca L Auer
    Centre for Haematology, Institute of Cell and Molecular Science, Bart s and The London Queen Mary School of Medicine, London, UK
    Br J Haematol 136:73-9. 2007
    ..In addition, polymorphisms with prognostic significance were identified. These were high length (but not expanded) repeats at FRA11B (P = 0.01), ATXN1 (P = 0.032) and ATXN3 (P = 0.022), all associated with poor risk disease...
  49. pmc A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia
    Gabrielle S Sellick
    Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, UK
    Blood 110:3326-33. 2007
    ..002). None of the regions coincided with areas of common chromosomal abnormalities frequently observed in CLL. These findings provide direct evidence for Mendelian predisposition to CLL and evidence for the location of disease loci...
  50. ncbi request reprint Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson's disease
    Taku Furuno
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Auerbachstr 112, 70376 Stuttgart, Germany
    Pharmacogenetics 12:529-34. 2002
    ..In conclusion, MDR1 and other drug transporters represent plausible candidates as Parkinson's disease risk genes. Larger studies are required to confirm this role in the etiology of Parkinson's disease...
  51. ncbi request reprint Opportunities and barriers in the age of team science: strategies for success
    Thomas A Sellers
    Division of Cancer Prevention and Control, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Causes Control 17:229-37. 2006
    ..To provide the voice of experience to investigators contemplating engagement in the realm of "team science"...
  52. ncbi request reprint No association of ARLTS1 polymorphisms and risk for familial chronic lymphocytic leukaemia
    David Ng
    Br J Haematol 137:173-5. 2007
  53. ncbi request reprint Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer
    Sandra R Pereira-Faca
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 67:12000-6. 2007
    ..5 proteins previously identified as associated with autoantibodies in lung cancer, gave a sensitivity of 55% at 95% specificity (area under the curve, 0.838) in discriminating lung cancer at the preclinical stage from matched controls...
  54. ncbi request reprint Immunophenotypic features distinguishing familial chronic lymphocytic leukemia from sporadic chronic lymphocytic leukemia
    Ejaz Ahmad
    Good Samaritan Hospital, Dayton, Ohio, USA
    Cytometry B Clin Cytom 74:221-6. 2008
    ..To date no study has been conducted to evaluate and compare patterns of cell surface antigen expression in familial CLL and sporadic CLL...