Research Topics
Genomes and Genes
| Jennifer L CannonsSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
SAP-controlled T-B cell interactions underlie germinal centre formationHai Qi
Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 455:764-9. 2008..These results offer an explanation for the germinal centre defect due to SAP deficiency and provide new insights into the bi-directional communication between cognate T and B cells in vivo...- Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84Jennifer L Cannons
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 32:253-65. 2010..Our results reveal insight into the dynamic regulation of T cell:B cell interactions and identify SLAM family members as critical components of sustained T cell:B cell adhesion required for productive humoral immunity... 
Fine-tuning lymphocyte regulation: what's new with tyrosine kinases and phosphatases?Jennifer L Cannons
National Human Genome Research Institute, 49 4A38, 49 Convent Drive, National Institutes of Health, Bethesda, MD 20892, USA
Curr Opin Immunol 16:296-303. 2004....
SLAM family receptors and SAP adaptors in immunityJennifer L Cannons
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Annu Rev Immunol 29:665-705. 2011..In this review, we cover recent findings on the roles of SLAM family receptors and the SAP family of adaptors, with a focus on their regulation of the pathways involved in the pathogenesis of XLP and other immune disorders...- Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulationJennifer L Cannons
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 185:2819-27. 2010.... - SLAM receptors and SAP influence lymphocyte interactions, development and functionPamela L Schwartzberg
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Immunol 9:39-46. 2009..These data have revealed that SLAM family members and SAP have crucial roles in regulating lymphocyte interactions and adhesion, which are required for the normal development, homeostasis and function of the immune system... - The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)Svenja Steinfelder
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 206:1681-90. 2009..Based on this evidence, we hypothesize that S. mansoni omega-1 acts by limiting the interaction of DCs with CD4(+) T lymphocytes, thereby lowering the strength of the activation signal delivered... 
SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulationJennifer L Cannons
National Human Genome Research Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Exp Med 203:1551-65. 2006..Thus, SAP affects expression of key molecules required for T-B cell collaboration by mechanisms that are distinct from its role in cytokine regulation...- A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccineQuanyi Chen
Department of Pathology, Uniformed Services University of the Health Sciences, National Institutes of Health, Bethesda, MD 20814, USA
J Immunol 181:8258-66. 2008..These data define a novel T cell-, SAP-, and B7-dependent, but ICOS-independent, extrafollicular pathway of Ig induction... - Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysisFang Zhao
Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 36:1003-16. 2012..Hence, SAP and SLAM receptors regulate positive and negative signals required for organizing the T cell:B cell synapse and setting thresholds for cytotoxicity against distinct cellular targets... - Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cellsKristina T Lu
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 35:622-32. 2011..ChIP-Seq analyses revealed positive epigenetic markings on Tbx21, Gata3, and Rorc in Tfh-like and ex vivo Tfh cells and on Bcl6 in non-Tfh cells, supporting the concept of plasticity between Tfh and other Th cell populations... - Requirements for selection of conventional and innate T lymphocyte lineagesReiko Horai
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 27:775-85. 2007.... - The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell deathCarl G Feng
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 9:1279-87. 2008..Our studies identify a feedback mechanism in the T helper type 1 response that limits the detrimental effects of IFN-gamma on effector T lymphocyte survival while promoting the antimicrobial functions of IFN-gamma... - CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymusLing Zhao
Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892, USA
Blood 109:3432-40. 2007..Our data suggest that Cbfb-MYH11 suppressed Cbfb in several stages of T-cell development and provide a mechanism for CBFB-MYH11 association with myeloid but not lymphoid leukemia... - SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1Jennifer L Cannons
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 21:693-706. 2004..SLAM engagement amplified PKC-theta recruitment in wt but not SAP- or Fyn-deficient cells, arguing that a SAP/Fyn-mediated pathway enhances PKC-theta/NF-kappaB1 activation and suggesting a role for this pathway in T(H)2 regulation... - A mosaic activating mutation in AKT1 associated with the Proteus syndromeMarjorie J Lindhurst
National Human Genome Research Institute, Bethesda, Maryland, USA
N Engl J Med 365:611-9. 2011..The Proteus syndrome is characterized by the overgrowth of skin, connective tissue, brain, and other tissues. It has been hypothesized that the syndrome is caused by somatic mosaicism for a mutation that is lethal in the nonmosaic state... - Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alphaJason A Hall
Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 34:435-47. 2011.... - Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentationAida M Andres
Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
PLoS Genet 6:e1001157. 2010..Although the precise selective pressure that maintains polymorphism is unknown, the demonstrated differences between the ERAP2 splice forms provide important insights into the potential mechanism for the action of selection... - Acinar cell apoptosis in Serpini2-deficient mice models pancreatic insufficiencyStacie K Loftus
Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
PLoS Genet 1:e38. 2005.... - Molecular and cellular pathogenesis of X-linked lymphoproliferative diseaseKim E Nichols
Pediatric Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Immunol Rev 203:180-99. 2005..Further studies of SAP and the SLAM family receptors will provide insights into XLP and elucidate the signaling events regulating lymphocyte ontogeny and function... - Cutting edge: profound defect in T cell responses in TNF receptor-associated factor 2 dominant negative miceJennifer L Cannons
Department of Immunology, University of Toronto, Toronto, Ontario, Canada
J Immunol 169:2828-31. 2002..DN mice. These studies suggest an essential role of TRAF2-linked receptors in secondary CD4 and CD8 T cell responses and have important implications for transplantation... - Regulation of NKT cell development by SAP, the protein defective in XLPKim E Nichols
Pediatric Oncology, Wood, 4th Floor, 3615 Civic Center Boulevard, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Nat Med 11:340-5. 2005..Thus, SAP is a crucial regulator of NKT cell ontogeny in humans and in mice. The absence of NKT cells may contribute to the phenotypes of SAP deficiency, including abnormal antiviral and antitumor immunity and hypogammaglobulinemia... - Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetesJennifer L Cannons
Department of Immunology, 1 King s College Circle, University of Toronto, Toronto, ON M5S 1A8, Canada
J Autoimmun 25:13-20. 2005..These data provide evidence in support of Idd9.3 as the locus encoding 4-1BB and suggest that the 4-1BB signaling pathway could have a primary function in the etiology of autoimmune disease... - Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunityAmanda K Cuss
Centenary Institute of Cancer Medicine and Cell Biology, New South Wales, Australia
J Immunol 176:1506-16. 2006..Further investigation of transitional B cells will improve our understanding of human B cell development and how alterations to this process may precipitate immunodeficiency or autoimmunity...