Jennifer L Cannons

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc SAP-controlled T-B cell interactions underlie germinal centre formation
    Hai Qi
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 455:764-9. 2008
  2. pmc Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 32:253-65. 2010
  3. ncbi request reprint Fine-tuning lymphocyte regulation: what's new with tyrosine kinases and phosphatases?
    Jennifer L Cannons
    National Human Genome Research Institute, 49 4A38, 49 Convent Drive, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Opin Immunol 16:296-303. 2004
  4. doi request reprint SLAM family receptors and SAP adaptors in immunity
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 29:665-705. 2011
  5. pmc Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 185:2819-27. 2010
  6. doi request reprint SLAM receptors and SAP influence lymphocyte interactions, development and function
    Pamela L Schwartzberg
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 9:39-46. 2009
  7. pmc The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)
    Svenja Steinfelder
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:1681-90. 2009
  8. pmc SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:1551-65. 2006
  9. pmc A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes
    Mala Dutta
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 190:2121-8. 2013
  10. pmc A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine
    Quanyi Chen
    Department of Pathology, Uniformed Services University of the Health Sciences, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 181:8258-66. 2008

Collaborators

Detail Information

Publications27

  1. pmc SAP-controlled T-B cell interactions underlie germinal centre formation
    Hai Qi
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 455:764-9. 2008
    ..These results offer an explanation for the germinal centre defect due to SAP deficiency and provide new insights into the bi-directional communication between cognate T and B cells in vivo...
  2. pmc Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 32:253-65. 2010
    ..Our results reveal insight into the dynamic regulation of T cell:B cell interactions and identify SLAM family members as critical components of sustained T cell:B cell adhesion required for productive humoral immunity...
  3. ncbi request reprint Fine-tuning lymphocyte regulation: what's new with tyrosine kinases and phosphatases?
    Jennifer L Cannons
    National Human Genome Research Institute, 49 4A38, 49 Convent Drive, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Opin Immunol 16:296-303. 2004
    ....
  4. doi request reprint SLAM family receptors and SAP adaptors in immunity
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 29:665-705. 2011
    ..In this review, we cover recent findings on the roles of SLAM family receptors and the SAP family of adaptors, with a focus on their regulation of the pathways involved in the pathogenesis of XLP and other immune disorders...
  5. pmc Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 185:2819-27. 2010
    ....
  6. doi request reprint SLAM receptors and SAP influence lymphocyte interactions, development and function
    Pamela L Schwartzberg
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 9:39-46. 2009
    ..These data have revealed that SLAM family members and SAP have crucial roles in regulating lymphocyte interactions and adhesion, which are required for the normal development, homeostasis and function of the immune system...
  7. pmc The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)
    Svenja Steinfelder
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:1681-90. 2009
    ..Based on this evidence, we hypothesize that S. mansoni omega-1 acts by limiting the interaction of DCs with CD4(+) T lymphocytes, thereby lowering the strength of the activation signal delivered...
  8. pmc SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:1551-65. 2006
    ..Thus, SAP affects expression of key molecules required for T-B cell collaboration by mechanisms that are distinct from its role in cytokine regulation...
  9. pmc A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes
    Mala Dutta
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 190:2121-8. 2013
    ..Moreover, mice lacking Ly108 showed decreased numbers of PLZF-expressing CD4(+) T cells. Together, these results support a potential role for Ly108 in the induction of PLZF...
  10. pmc A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine
    Quanyi Chen
    Department of Pathology, Uniformed Services University of the Health Sciences, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 181:8258-66. 2008
    ..These data define a novel T cell-, SAP-, and B7-dependent, but ICOS-independent, extrafollicular pathway of Ig induction...
  11. pmc T follicular helper cell diversity and plasticity
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Immunol 34:200-7. 2013
    ..In this review, we highlight advances in our understanding of Tfh cell development, cytokine production, and the potential plasticity that allows Tfh cells to possess characteristics of other effector Th cell populations...
  12. pmc Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis
    Fang Zhao
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 36:1003-16. 2012
    ..Hence, SAP and SLAM receptors regulate positive and negative signals required for organizing the T cell:B cell synapse and setting thresholds for cytotoxicity against distinct cellular targets...
  13. pmc Requirements for selection of conventional and innate T lymphocyte lineages
    Reiko Horai
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 27:775-85. 2007
    ....
  14. pmc The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death
    Carl G Feng
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:1279-87. 2008
    ..Our studies identify a feedback mechanism in the T helper type 1 response that limits the detrimental effects of IFN-gamma on effector T lymphocyte survival while promoting the antimicrobial functions of IFN-gamma...
  15. pmc Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells
    Kristina T Lu
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 35:622-32. 2011
    ..ChIP-Seq analyses revealed positive epigenetic markings on Tbx21, Gata3, and Rorc in Tfh-like and ex vivo Tfh cells and on Bcl6 in non-Tfh cells, supporting the concept of plasticity between Tfh and other Th cell populations...
  16. ncbi request reprint SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 21:693-706. 2004
    ..SLAM engagement amplified PKC-theta recruitment in wt but not SAP- or Fyn-deficient cells, arguing that a SAP/Fyn-mediated pathway enhances PKC-theta/NF-kappaB1 activation and suggesting a role for this pathway in T(H)2 regulation...
  17. pmc CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus
    Ling Zhao
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892, USA
    Blood 109:3432-40. 2007
    ..Our data suggest that Cbfb-MYH11 suppressed Cbfb in several stages of T-cell development and provide a mechanism for CBFB-MYH11 association with myeloid but not lymphoid leukemia...
  18. pmc A mosaic activating mutation in AKT1 associated with the Proteus syndrome
    Marjorie J Lindhurst
    National Human Genome Research Institute, Bethesda, Maryland, USA
    N Engl J Med 365:611-9. 2011
    ..The Proteus syndrome is characterized by the overgrowth of skin, connective tissue, brain, and other tissues. It has been hypothesized that the syndrome is caused by somatic mosaicism for a mutation that is lethal in the nonmosaic state...
  19. doi request reprint Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency
    Carrie L Lucas
    1 Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 2
    Nat Immunol 15:88-97. 2014
    ..Notably, treatment with rapamycin to inhibit mTOR activity in vivo partially restored the abundance of naive T cells, largely 'rescued' the in vitro T cell defects and improved the clinical course. ..
  20. pmc Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation
    Aida M Andres
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Genet 6:e1001157. 2010
    ..Although the precise selective pressure that maintains polymorphism is unknown, the demonstrated differences between the ERAP2 splice forms provide important insights into the potential mechanism for the action of selection...
  21. pmc Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha
    Jason A Hall
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 34:435-47. 2011
    ....
  22. pmc Acinar cell apoptosis in Serpini2-deficient mice models pancreatic insufficiency
    Stacie K Loftus
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Genet 1:e38. 2005
    ....
  23. ncbi request reprint Molecular and cellular pathogenesis of X-linked lymphoproliferative disease
    Kim E Nichols
    Pediatric Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Immunol Rev 203:180-99. 2005
    ..Further studies of SAP and the SLAM family receptors will provide insights into XLP and elucidate the signaling events regulating lymphocyte ontogeny and function...
  24. ncbi request reprint Cutting edge: profound defect in T cell responses in TNF receptor-associated factor 2 dominant negative mice
    Jennifer L Cannons
    Department of Immunology, University of Toronto, Toronto, Ontario, Canada
    J Immunol 169:2828-31. 2002
    ..DN mice. These studies suggest an essential role of TRAF2-linked receptors in secondary CD4 and CD8 T cell responses and have important implications for transplantation...
  25. ncbi request reprint Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity
    Amanda K Cuss
    Centenary Institute of Cancer Medicine and Cell Biology, New South Wales, Australia
    J Immunol 176:1506-16. 2006
    ..Further investigation of transitional B cells will improve our understanding of human B cell development and how alterations to this process may precipitate immunodeficiency or autoimmunity...
  26. ncbi request reprint Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetes
    Jennifer L Cannons
    Department of Immunology, 1 King s College Circle, University of Toronto, Toronto, ON M5S 1A8, Canada
    J Autoimmun 25:13-20. 2005
    ..These data provide evidence in support of Idd9.3 as the locus encoding 4-1BB and suggest that the 4-1BB signaling pathway could have a primary function in the etiology of autoimmune disease...
  27. ncbi request reprint Regulation of NKT cell development by SAP, the protein defective in XLP
    Kim E Nichols
    Pediatric Oncology, Wood, 4th Floor, 3615 Civic Center Boulevard, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nat Med 11:340-5. 2005
    ..Thus, SAP is a crucial regulator of NKT cell ontogeny in humans and in mice. The absence of NKT cells may contribute to the phenotypes of SAP deficiency, including abnormal antiviral and antitumor immunity and hypogammaglobulinemia...