Richard O Cannon

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Mechanisms, management and future directions for reperfusion injury after acute myocardial infarction
    Richard O Cannon
    Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Clin Pract Cardiovasc Med 2:88-94. 2005
  2. ncbi Microvascular angina and the continuing dilemma of chest pain with normal coronary angiograms
    Richard O Cannon
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Am Coll Cardiol 54:877-85. 2009
  3. ncbi Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery
    R O Cannon
    Cardiology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892 1650, USA
    J Clin Invest 108:279-87. 2001
  4. ncbi Transcriptional profiling of CD133(+) cells in coronary artery disease and effects of exercise on gene expression
    Delong Liu
    Genomics Core, National Institutes of Health, Bethesda, Maryland, USA
    Cytotherapy 13:227-36. 2011
  5. ncbi Targeted antagonism of CXCR4 mobilizes progenitor cells under investigation for cardiovascular disease
    Arnon Blum
    Translational Medicine Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland, USA
    Cytotherapy 11:1016-9. 2009
  6. ncbi Divergent nitric oxide bioavailability in men and women with sickle cell disease
    Mark T Gladwin
    Critical Care Medicine Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 1662, USA
    Circulation 107:271-8. 2003
  7. ncbi Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation
    Andre Dejam
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Circulation 116:1821-31. 2007
  8. ncbi Predictors of endothelial function in employees with sedentary occupations in a worksite exercise program
    Margaret F Lippincott
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Am J Cardiol 102:820-4. 2008
  9. ncbi Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction
    Felix M Gonzalez
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Circulation 117:2986-94. 2008
  10. ncbi Endothelial progenitor cell mobilization and increased intravascular nitric oxide in patients undergoing cardiac rehabilitation
    Jonathan D Paul
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Cardiopulm Rehabil Prev 27:65-73. 2007

Detail Information

Publications54

  1. ncbi Mechanisms, management and future directions for reperfusion injury after acute myocardial infarction
    Richard O Cannon
    Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Clin Pract Cardiovasc Med 2:88-94. 2005
    ....
  2. ncbi Microvascular angina and the continuing dilemma of chest pain with normal coronary angiograms
    Richard O Cannon
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Am Coll Cardiol 54:877-85. 2009
    ..Despite considerable efforts by many groups over 4 decades, the syndrome remains controversial with regard to pathophysiology, diagnosis, and management...
  3. ncbi Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery
    R O Cannon
    Cardiology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892 1650, USA
    J Clin Invest 108:279-87. 2001
    ..This effect may have application for the treatment of diseases characterized by endothelial dysfunction...
  4. ncbi Transcriptional profiling of CD133(+) cells in coronary artery disease and effects of exercise on gene expression
    Delong Liu
    Genomics Core, National Institutes of Health, Bethesda, Maryland, USA
    Cytotherapy 13:227-36. 2011
    ..Our aim was to identify differences in gene expression in CD133(+) cells of patients with coronary artery disease (CAD) and healthy controls, and determine whether exercise modifies gene expression...
  5. ncbi Targeted antagonism of CXCR4 mobilizes progenitor cells under investigation for cardiovascular disease
    Arnon Blum
    Translational Medicine Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland, USA
    Cytotherapy 11:1016-9. 2009
    ..The purpose of this study was to evaluate the effects of a novel CXCR4 inhibitor (plerixafor), previously shown to mobilize CD34+ stem cells, on CD133+ mobilization and markers of inflammation...
  6. ncbi Divergent nitric oxide bioavailability in men and women with sickle cell disease
    Mark T Gladwin
    Critical Care Medicine Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 1662, USA
    Circulation 107:271-8. 2003
    ..Although reduced endothelial nitric oxide (NO) bioavailability has been demonstrated in arteriosclerotic vascular disease, the integrity of this system in sickle cell disease remains uncertain...
  7. ncbi Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation
    Andre Dejam
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Circulation 116:1821-31. 2007
    ..However, important questions of potency, kinetics, mechanism of action, and possible induction of tolerance remain unanswered...
  8. ncbi Predictors of endothelial function in employees with sedentary occupations in a worksite exercise program
    Margaret F Lippincott
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Am J Cardiol 102:820-4. 2008
    ..In conclusion, daily exercise achievable at their work sites by employees with sedentary occupations improves endothelial function, even with the absence of weight loss, which may decrease cardiovascular risk, if sustained...
  9. ncbi Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction
    Felix M Gonzalez
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Circulation 117:2986-94. 2008
    ....
  10. ncbi Endothelial progenitor cell mobilization and increased intravascular nitric oxide in patients undergoing cardiac rehabilitation
    Jonathan D Paul
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Cardiopulm Rehabil Prev 27:65-73. 2007
    ....
  11. ncbi Microarray-based characterization of a colony assay used to investigate endothelial progenitor cells and relevance to endothelial function in humans
    Aditi Desai
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1454, USA
    Arterioscler Thromb Vasc Biol 29:121-7. 2009
    ..An assay proposed to quantify endothelial progenitor cell (EPC) colonies in humans was investigated to determine the phenotype of recovered cells and their relevance to in vivo endothelial function...
  12. ncbi Imaging hemoglobin oxygen saturation in sickle cell disease patients using noninvasive visible reflectance hyperspectral techniques: effects of nitric oxide
    Karel J Zuzak
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases/NIH, 9000 Rockville Pike, Bethesda, MD 20892-0510, USA
    Am J Physiol Heart Circ Physiol 285:H1183-9. 2003
    ....
  13. ncbi The emerging biology of the nitrite anion
    Mark T Gladwin
    Vascular Medicine Branch, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Chem Biol 1:308-14. 2005
    ..A recent two-day symposium at the US National Institutes of Health highlighted recent advances in the understanding of nitrite biochemistry, physiology and therapeutics...
  14. ncbi Lopinavir-ritonavir: effects on endothelial cell function in healthy subjects
    Jessica R Grubb
    Critical Care Medical Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 193:1516-9. 2006
    ..Thus, in this small cohort of subjects, short-term treatment with lopinavir-ritonavir does not appear to directly promote endothelial cell dysfunction...
  15. ncbi Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
    Kenyatta Cosby
    Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 7B15 Bethesda, Maryland 20892, USA
    Nat Med 9:1498-505. 2003
    ..These results suggest that nitrite represents a major bioavailable pool of NO, and describe a new physiological function for hemoglobin as a nitrite reductase, potentially contributing to hypoxic vasodilation...
  16. ncbi Variability of C-reactive protein levels among patients with stable coronary artery disease and on statin therapy
    Arnon Blum
    Translational Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Isr Med Assoc J 11:602-5. 2009
    ..However, the reproducibility of persistently elevated hs-CRP levels and association with other markers of inflammation in patients with stable CAD on aggressive statin therapy is unknown...
  17. ncbi Bone marrow-derived cells do not repair endothelium in a mouse model of chronic endothelial cell dysfunction
    Tashera E Perry
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Building 10 CRC, Room 6 3130, Bethesda, MD 20892, USA
    Cardiovasc Res 84:317-25. 2009
    ..We assessed the hypothesis that a BM transplant from healthy animals would restore normal arterial endothelium and prevent hypertension in young endothelial nitric oxide synthase-deficient (eNOS(-/-)) mice...
  18. ncbi High-density lipoprotein cholesterol efflux, nitration of apolipoprotein A-I, and endothelial function in obese women
    Edward Vazquez
    Cardiovascular Pulmonary Branch, Proteomics Core Facility and Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Cardiol 109:527-32. 2012
    ..This finding suggests that the functional measures of HDL might be better markers for cardiovascular risk than the HDL cholesterol levels in this population...
  19. ncbi Relation of endothelial function to cardiovascular risk in women with sedentary occupations and without known cardiovascular disease
    Margaret F Lippincott
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Am J Cardiol 102:348-52. 2008
    ..Even in the absence of routine exercise, cardiorespiratory fitness, rather than conventional risk factors or body mass, is the dominant predictor of endothelial function and suggests a modifiable approach to risk...
  20. ncbi Reproducibility and inter-observer variability of dobutamine stress CMR in patients with severe coronary disease: implications for clinical research
    Mushabbar A Syed
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Cardiovasc Magn Reson 7:763-8. 2005
    ..81 for wall motion and 0.70 for perfusion). CONCLUSION: Dobutamine CMR is a highly reproducible technique with very good inter-observer variability and could be used as a specific endpoint in a relatively small clinical trial...
  21. ncbi High-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance
    Hui Chen
    Diabetes Unit, National Center for Complementary and Alternative Medicine, NIH, Bldg. 10, Rm. 6C-205, 10 Center Dr. MSC 1632, Bethesda, MD 20892-1632, USA
    Am J Physiol Heart Circ Physiol 290:H137-45. 2006
    ..We conclude that high-dose oral vitamin C therapy, resulting in incomplete replenishment of vitamin C levels, is ineffective at improving endothelial dysfunction and insulin resistance in Type 2 diabetes...
  22. ncbi A discordance in rosiglitazone mediated insulin sensitization and skeletal muscle mitochondrial content/activity in Type 2 diabetes mellitus
    Ines Pagel Langenickel
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1454, USA
    Am J Physiol Heart Circ Physiol 293:H2659-66. 2007
    ..It remains to be determined whether longer-term insulin sensitization therapy with rosiglitazone will augment skeletal muscle mitochondrial bioenergetics in those diabetic subjects with relatively preserved basal aerobic capacity...
  23. ncbi Outcomes and risks of granulocyte colony-stimulating factor in patients with coronary artery disease
    Jonathan M Hill
    Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1650, USA
    J Am Coll Cardiol 46:1643-8. 2005
    ..Cytokine mobilization of progenitor cells from bone marrow may promote myocardial neovascularization with relief of ischemia...
  24. ncbi Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
    Christopher D Reiter
    Critical Care Medicine Department of the Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 8:1383-9. 2002
    ..Decompartmentalization of hemoglobin and subsequent dioxygenation of nitric oxide may explain the vascular complications shared by acute and chronic hemolytic disorders...
  25. ncbi The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine
    Leslie G Biesecker
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 19:1665-74. 2009
    ..The early experiences with ClinSeq illustrate how large-scale medical sequencing can be a practical, productive, and critical component of research in genomic medicine...
  26. ncbi Parameters of coagulant and fibrinolytic capacity and activity in postmenopausal women: within-subject variability
    McDonald K Horne
    Department of Laboratory Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Thromb Res 107:229-33. 2002
    ..We observed large differences in within-subject variability among the tests and have demonstrated how such data can be used to estimate the number of times a parameter must be measured to produce a statistically adequate sample...
  27. ncbi Role of nitric oxide in cardiovascular disease: focus on the endothelium
    R O Cannon
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Chem 44:1809-19. 1998
    ..Accordingly, causal relationships between improved endothelial function and reduction in myocardial ischemia and acute coronary events can now be investigated...
  28. ncbi Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans
    M T Gladwin
    Critical Care Medicine Department of the Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:11482-7. 2000
    ....
  29. ncbi Competition for p300 regulates transcription by estrogen receptors and nuclear factor-kappaB in human coronary smooth muscle cells
    E Speir
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1650, USA
    Circ Res 87:1006-11. 2000
    ..These actions of 17ss-estradiol may play an important role in the cytokine-induced expression of immune and inflammatory genes implicated in atherogenesis...
  30. ncbi Antioxidant effect of estrogen on cytomegalovirus-induced gene expression in coronary artery smooth muscle cells
    E Speir
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1650, USA
    Circulation 102:2990-6. 2000
    ..Because estrogen appears to have antioxidant properties, we wished to determine whether this hormone attenuates SMC responses to CMV infection...
  31. ncbi Noninvasive determination of spatially resolved and time-resolved tissue perfusion in humans during nitric oxide inhibition and inhalation by use of a visible-reflectance hyperspectral imaging technique
    K J Zuzak
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda MD 20892-0510, USA
    Circulation 104:2905-10. 2001
    ..This imaging method may provide an effective approach for time-resolved noninvasive monitoring of skin hemoglobin oxygen saturation and assessment of responses to therapeutic interventions in patients with vascular disease...
  32. ncbi BM-derived cell therapies for cardiovascular disease
    R O Cannon
    Cardiology Branch and Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cytotherapy 9:305-15. 2007
  33. ncbi Effect of L-arginine on human coronary endothelium-dependent and physiologic vasodilation
    A A Quyyumi
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1650, USA
    J Am Coll Cardiol 30:1220-7. 1997
    ..We hypothesized that L-arginine would improve abnormal coronary vasodilation in response to physiologic stress in patients with atherosclerosis and its risk factors by reversing coronary endothelial dysfunction...
  34. ncbi Diet-induced weight loss in overweight or obese women and changes in high-density lipoprotein levels and function
    Brittany O Aicher
    Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland, USA
    Obesity (Silver Spring) 20:2057-62. 2012
    ....
  35. ncbi Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, NIH, USA
    Circulation 106:2358-65. 2002
    ..Whether these conditions involve abnormal cardiac sympathetic innervation or function has been unclear...
  36. ncbi Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease
    Tiffany M Powell
    Cardiovascular Branch, National Heart, Lung, and Blood Institute and the Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892-1650, USA
    Arterioscler Thromb Vasc Biol 25:296-301. 2005
    ..Whether EPCs mobilized into the circulation will be useful for the purpose of initiating vascular growth and myocyte repair in coronary artery disease patients must be tested in clinical trials...
  37. ncbi Assessing risk in hypertrophic cardiomyopathy
    Richard O Cannon
    National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    N Engl J Med 349:1016-8. 2003
  38. ncbi Effect of hormone replacement therapy on carotid arterial compliance in healthy postmenopausal women
    Minh N Bui
    Cardiovascular Branch, Laboratory of Cardiac Energetics, Office of Biostatistics Research, National Heart, Lung and Blood Institute, Clinical Pathology Department, National Institutes of Health, Bethesda, Maryland 20892-1650, USA
    Am J Cardiol 90:82-5. 2002
  39. ncbi Cardiovascular potential of BM-derived stem and progenitor cells
    R O Cannon
    Cardiovascular Branch NHLBI, NIH, Bethesda, Maryland 20892, USA
    Cytotherapy 6:602-7. 2004
    ....
  40. ncbi NO solutions?
    Alan N Schechter
    Laboratory of Chemical Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 109:1149-51. 2002
  41. ncbi Search for predictors of nontherapeutic INR results with warfarin therapy
    Nayahmka J McGriff-Lee
    Primary Care Pharmacy Practice Resident, Pharmacy Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Ann Pharmacother 39:1996-2002. 2005
    ....
  42. ncbi Effects of oestrogens and selective oestrogen receptor modulators on serum lipoproteins and vascular function
    A Blum
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1650, USA
    Curr Opin Lipidol 9:575-86. 1998
    ..This review updates the current knowledge of the biological effects of oestrogen and selective oestrogen receptor modulators of potential cardiovascular importance in postmenopausal women...
  43. ncbi Raloxifene-mediated increase in matrix metalloproteinase-1 production by activated monocytes
    J A Ardans
    Immunopathology Section, National Institute of Dental and Craniofacial Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Arterioscler Thromb Vasc Biol 21:1265-8. 2001
    ..In summary, raloxifene increases the production of MMP-1 in activated monocytes; this effect may be favorable in atherosclerotic arterial wall remodeling but unfavorable for plaque stability...
  44. ncbi Phenotype and course of Hutchinson-Gilford progeria syndrome
    Melissa A Merideth
    National Human Genome Research Institute, Intramural Office of Rare Disease, National Institutes of Health, Bethesda, MD 20892 1851, USA
    N Engl J Med 358:592-604. 2008
    ....
  45. ncbi Effects of a single intracoronary injection of basic fibroblast growth factor in stable angina pectoris
    E F Unger
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20852 1428, USA
    Am J Cardiol 85:1414-9. 2000
    ..No subject had signs suggesting systemic angiogenesis. Thus, intracoronary bFGF, at doses of 3 to 30 microg/kg, was generally well tolerated in subjects with stable angina...
  46. ncbi Arterial wall MRI characteristics are associated with elevated serum markers of inflammation in humans
    C R Weiss
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Magn Reson Imaging 14:698-704. 2001
    ..MRI of large arteries may provide a new approach to investigate the contribution of inflammation to atherogenesis...
  47. ncbi Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002: Section 2: stable ischemia: pathophysiology and gender differences
    Rita F Redberg
    Circulation 109:e47-9. 2004
  48. ncbi How do red blood cells dilate blood vessels?--Reply
    Daniel B Kim-Shapiro
    Circ Res 95:e10. 2004
  49. ncbi Oral L-arginine (and other active ingredients) for ischemic heart disease?
    Richard O Cannon
    J Am Coll Cardiol 39:46-8. 2002
  50. ncbi CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: report from the clinical practice discussion group
    Sidney C Smith
    Circulation 110:e550-3. 2004
  51. ncbi Statin attenuates increase in C-reactive protein during estrogen replacement therapy in postmenopausal women
    Kwang Kon Koh
    Gachon Medical College, Inchon, South Korea
    Circulation 105:1531-3. 2002
    ..CONCLUSIONS: The combination of statin with estrogen may attenuate the potential harmful effects of estrogen therapy in postmenopausal women and maximize any benefit to cardiovascular risk...
  52. ncbi Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002 : Section 4: lessons from hormone replacement trials
    David D Waters
    Circulation 109:e53-5. 2004
  53. ncbi Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association
    Thomas A Pearson
    Circulation 107:499-511. 2003
  54. ncbi Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002: executive summary
    Noel Bairey Merz
    Circulation 109:805-7. 2004